Endothelial lipase: A new lipase on the block

Journal of Lipid Research

Volumn 43, Issue 11, 2002, Pages 1763-1769

  Choi, Sungshin Y ^a   Hirata, Ken Ichi ^c   Ishida, Tatsuro ^b   Quertermous, Thomas ^b   Cooper, Allen D ^a,b  

^a PALO ALTO MEDICAL FOUNDATION   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Atherosclerosis; Cytokines; Endothelium; HDL; Hepatic lipase; Lipoprotein lipase; Phospholipase; Regulation

Indexed keywords

CYTOKINE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIVER TRIACYLGLYCEROL LIPASE; PHOSPHOLIPASE A1; TRIACYLGLYCEROL LIPASE; LIPG PROTEIN, HUMAN; LIPOPROTEIN;

ANIMAL CELL; ATHEROSCLEROSIS; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIPOPROTEIN METABOLISM; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; TISSUE DISTRIBUTION; VASCULAR ENDOTHELIUM; ANIMAL; ARTERIOSCLEROSIS; ENZYMOLOGY; GENETICS; METABOLISM;

ANIMALS; ARTERIOSCLEROSIS; HUMANS; LIPASE; LIPOPROTEINS;

EID: 0036846029     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.R200011-JLR200     Document Type: Review

References (65)

1. Ben-Aviram, C. N., O. Ben-Zeev, R. D. Lee, K. Haaga, J. E. Shively, J. W. Goers, M. E. Pedersen, J. R. Reeve, Jr., and M. C. Schotz. 1986. Homology of lipoprotein lipase to pancreatic lipase. Proc. Natl. Acad. Sci. USA. 83: 4185-4189.
2. Ben-Zeev, O., C. M. Ben-Aviramn, H. Wong, J. Nikazy, J. E. Shively, and M. C. Schotz. 1987. Hepatic lipase: A member of a family of structurally related lipases. Biochim. Biophs. Acta. 919: 13-20.
3. Kirchgessner, T. G., J-C. Chuat, C. Heinzmann, J. Etienne, S. Guilhot, K. Svenson, D. Ameis, C. Pilon, L. D'Auriol, A. Andalibi, M. C. Schotz, F. Galivert, and A. J. Lusis. 1989. Organization of the human lipoprotein lipase gene and evolution of the lipase gene family. Proc. Natl. Acad. Sci. USA. 86: 9647-9651.
4. Hide, W. A., L. Chan, and W-H. Li. 1992. Structure and evolution of the lipase superfamily. J. Lipid Res. 33: 167-177.
5. Lowe, M. E. 1997. Molecular mechanisms of rat and human pancreatic triglyceride lipases. J. Nutr. 127: 549-557.
6. Olivecrona, T., and G. Bengtsson-Olivecrona. 1993. Lipoprotein lipase and hepatic lipase. Curr. Opin. Lipidol. 4: 187-196.
7. Lowe, M. E. 2000. Properties and function of pancreatic lipase related protein 2. Biochimie. 82: 997-1004.
8. Sato, T., J. Aoki, Y. Nagai, N. Dohmae, K. Takio, D. Takefumi, A. Hiroyuki, and K. Inoue. 1997. Serine phospholipid-specific phospholipase A that is secreted from activated platelets. J. Biol. Chem. 272: 2192-2198.
9. Jaye, M., K. J. Lunch, J. Krawiec, D. Marchadier, C. Maugeais, K. Doan, V. South, D. Amin, M. Perrone, and D. J. Rader. 1999. A novel endothelial-derived lipase that modulates HDL metabolism. Nat. Genet. 21: 424-428.
10. Hirata, K., H. L. Dichek, J. A., Cioffi, S. Y. Choi, N.J. Leeper, L. Quintana, G. S. Kronmal, A. D. Cooper, and T. Quertermous. 1999. Cloning of a unique lipase from endothelial cells extends the lipase gene family. J. Biol. Chem. 274: 14170-14175.
11. Sonoda, H., J. Aoki, T. Hiramatsu, M. Ishida, K. Bandoh, Y. Nagai, R. Taguchi, K. Inoue, and H. Arai. 2002. A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid. J. Biol. Chem. 277: 34254-34263.
12. Hirata, K., T. Ishida, H. Matsushita, P. S. Tsao, and T. Quertermous. 2000. Regulated expression of endothelial cell-derived lipase. Biochem. Biophys. Res. Commun. 272: 90-93.
13. van Tilbeurgh, H., A. Roussel, J. M. Lalouel, and C. Cambillau. 1994. Lipoprotein lipase. Molecular model based on the pancreatic lipase x-ray structure: Consequences for heparin binding and catalysis. J. Biol. Chem. 269: 4626-4633.
14. Dugi, K. A., H. L. Dichek, and S. Santamarina-Fojo. 1995. Human hepatic and lipoprotein lipase: Die loop covering the catalytic site mediates lipase substrate specificity. J. Biol. Chem. 270: 25396-25401.
15. Winkler, F. K., A. D'Arcy, and W. Hunziker. 1990. Structure of human pancreatic lipase. Nature. 343: 771-774.
16. Carrier, F., C. Withers-Martinez, H. van Tilbeurgh, A. Roussel, C. Cambillau, and R. Verger. 1998. Structural basis for the substrate selectivity of pancreatic lipases and some related proteins. Biochim. Biophys. Acta. 1376: 417-432.
17. Jennens, M. L., and M. E. Lowe. 1994. A surface loop covering the active site of human pancreatic lipase influences interfacial activation and lipid binding. J. Biol. Chem. 269: 25470-25474.
18. Yang, Y., and M. E. Lowe. 2000. The open lid mediates pancreatic lipase function. J. Lipid Res. 41: 48-57.
19. Hjorth, A., F. Carriere, C. Cudrey, H. Woldike, E. Boel, D. M. Lawson, F. Ferrato, C. Cambillau, G. G. Dogson, and L. Thim. 1993. A structural domain (the lid) found in pancreatic lipase is absent in the guinea pig (phospho)lipase. Biochemistry. 32: 4702-4707.
20. Roussel, A., Y. Yang, F. Ferrato, R. Verger, C. Cambillau, and M. Lowe. 1998. Structure and activity of rat pancreatic lipase-related protein 2. J. Biol. Chem. 273: 32122-32228.
21. McCoy, M. G., G-S. Sun, D. Marchadier, C. Maugeais, J. M. Glick, and D. J. Rader. 2002. Characterization of the lipolytic activity of endothelial lipase. J. Lipid Res. 43: 921-929.
22. Ross, R. 1999. Atherosclerosis - An inflammatory disease. N. Engl. J. Med. 340: 115-126.
23. Zhang, S. H., R. L. Reddick, J. A. Piedrahita, and N. Maeda. 1992. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science. 258: 468-471.
24. Rooney, S. A. 1985. The surfactant system and lung phospholipid biochemistry. Am. Rev. Respir. Dis. 131: 439-460.
25. Tall, A. R., P. H. R. Green, R. M. Glickman, and J. W. Riley. 1994. Metabolic fate of chylomicron phospholipids and apoproteins in the rat. J. Clin. Invest. 64: 977-989.
26. Redgrave, T. G., and D. M. Small. 1979. Quantitation of the transfer of surface phospholipid of chylomicrons to the high density lipoprotein fraction during the catabolism of chylomicrons in the rat. J. Clin. Invest. 64: 162-171.
27. Brasaemle, D. L., K. Cornely-Moss, and A. Bensadoun. 1993. Hepatic lipase treatment of chylomicron remnants increases exposure of apolipoprotein E. J. Lipid Res. 34: 455-465.
28. Miller, G. J., and N. E. Miller. 1975. Plasma high-density-lipoprotein concentration and development of ischaemic heart disease. Lancet. I: 16-19.
29. Gordon, T., W. P. Castelli, M. C. Hjortland, W. B. Kannel, and T. R. Dawber. 1977. High density lipoproteins as a protective factor against coronary heart disease: The Framingham study. Am. J. Med. 62: 707-714.
30. Frick, M. H., M. O. Elo, and K. Haapa. 1987. Helsinki heart study: primary prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. N. Engl. J. Med. 317: 1237-1245.
31. Navab, M., S. Y. Hama, G. P. Hough, C. C. Hedrick, R. Sorenson, B. N. La Du, J. A. Kobashigawa, G. C. Fonarow, J. A. Berliner, H. Laks, and A. M. Fogelman. 1998. High density associated enzymes: Their role in vascular biology. Curr. Opin. Lipidol. 9: 449-456.
32. Applebaum-Bowden, D., S. M. Haffner, P. W. Wahl, J. J. Hoover, G. R. Warnick, J. J. Albers, and W. R. Hazzard. 1985. Postheparin plasma triglyceride lipases. Relationships with very low density lipoprotein triglyceride and high density lipoprotein2 cholesterol. Arteriosclerosis. 5: 273-282.
33. Jackson, R. L., M. T. Yates, C. A. McNerney, and M. L. Kashyap. 1990. Relationship between post-heparin plasma lipases, triglycerides and high density lipoproteins in normal subjects. Horm. Metab. Res. 22: 289-294.
34. Blades, B., G. L. Vega, and S. M. Grundy. 1993. Activities of lipoprotein lipase and hepatic triglyceride lipase in postheparin plasma of patients with low concentrations of HDL cholesterol. Arterioscler Thromb. 13: 1227-1235.
35. Fan, J., J. Wang, A. Bensadoun, S. J. Lawer, Q. Dang, R. W. Mahley, and J. M. Taylor. 1994. Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins. Proc. Natl. Acad. Sci. USA. 91: 8724-8728.
36. Patsch, J. R., A. M. Gotto, Jr., T. Olivecrona, and S. Eisenberg. 1978. Formation of high density lipoprotein2-like particles during lipolysis of very low density lipoproteins in vitro. Proc. Natl. Acad. Sci. USA. 75: 4519-4523.
37. Goldberg, I. J., W. S. Blaner, T. M. Vanni, M. Moukides, and R. Ramakrishnan. 1990. Role of lipoprotein lipase in the regulation of high density lipoprotein apolipoprotein metabolism. Studies in normal and lipoprotein lipase-inhibited monkey. J. Clin. Invest. 86: 463-473.
38. Newnham, H. H., and P. J. Barter. 1992. Changes in particle size of high density lipoproteins during incubation with very low density lipoproteins, cholesteryl ester transfer protein and lipoprotein lipase. Biochim. Biophys. Acta. 1125: 297-304.
39. Chen, W., S. R. Srinivasan, A. Elkasabany, D. L. Ellsworth, E. Boerwinkle, and G. S. Berenson. 2001. Influence of lipoprotein lipase serine 447 stop polymorphism on tracking of triglycerides and HDL cholesterol from childhood to adulthood and familial risk of coronary artery disease: The Bogalusa heart study. Atherosclerosis. 159: 367-373.
40. Carr, M. C., A. F. Ayyobi, S. J. Murdoch, S. S. Deeb, and J. D. Brunzell. 2002. Contribution of heart disease, lipoprotein lipase, and cholesteryl ester transfer protein to LDL and HDL heterogeneity in healthy women. Arterioscler. Thomb. Vasc. Biol. 22: 667-673.
41. Francone, O. L., E. L. Gong, D. S. Ng, C. J. Fielding, and E. M. Rubin. 1995. Expression of human lecithin-cholesterol acyltransferase in transgenic mice. Effect of human apolipoprotein AI and human apolipoprotein AII on plasma lipoprotein cholesterol metabolism. J. Clin. Invest. 96: 1440-1448.
42. Rader, D. J., K. Ikewaki, N. Duverger, H. Schmidt, J. Frohlich, M. Clerc, M. F. Dumon, T. Fairwell, L. Zech, S. Santamarina-Fojo, and H. B. Brewer, Jr. 1994. Markedly accelerated catabolism of apolipoprotein AII (ApoA-II) and high density lipoproteins containing apoA-II in classic lecithin:cholesterol-acyltransferase deficiency and fish-eye disease. J. Clin. Invest. 93: 321-330.
43. Inazu, A., M. I. Brown, C. B. Hesler, L. B. Agellon, J. Koizumi, K. Takata, Y. Maruhama, H. Mabuchi, and A. R. Tall. 1990. Increased high-density lipoprotein levels caused by a common cholesterylester transfer protein gene mutation. N. Engl. J. Med. 323: 1234-1238.
44. Lusa S., M. Jauhiainen, J. Metso, P. Somerharju, and C. Ehnholm. 1996. The mechanism of human plasma phospholipid transfer protein-induced enlargement of high-density lipoprotein particles: Evidence for particle fusion. Biochem. J. 313: 275-282.
45. Allayee, H., K. M. Dominguez, B. E. Aouizeart, R. M. Krauss, J. I. Rotter, J. Lu, R. M. Cantor, et al. 2000. Contribution of the hepatic lipase gene to the atherogenic lipoprotein phenotype in familial combined hyperlipidemia. J. Lipid Res. 41: 245-252.
46. Komaromy, M., S. Azhar, and A. D. Cooper. 1996. Chinese hamster ovary cells expressing a cell surface-anchored form of hepatic lipase. Characterization of low density lipoprotein and chylomicron remnant uptake and selective uptake of high density lipoprotein-cholesteryl ester. J. Biol. Chem. 271: 16906-16914.
47. Rinninger, F., W. A. Mann, T. Kaiser, S. Ahle, N. Meyer, and H. Greten. 1998. Hepatic lipase mediates an increase in selective uptake of high-density lipoprotein-associated cholesteryl esters by human Hep 3B hepatoma cells in culture. Atherosclerosis. 141: 273-285.
48. Amar, M. J., K. A. Dugi, C. C. Haudenschild, R. D. Shamburek, B. Foger, M. Chase, A. Bensadoun, R. F. Hoyt, Jr., H. B. Brewer, and S. Santamarina-Fojo. 1998. Hepatic lipase facilitates the selective uptake of cholesteryl esters from remnant lipoproteins in apoE-deficient mice. J. Lipid Res. 39: 2436-2442.
49. Lambert, G., M. J. Amar, M. P. Martin, J. Fruchart-Najib, B. Foger, R. D. Shamburek, H. B. Brewer, Jr., and S. Santamarina-Fojo. 2000. Hepatic lipase deficiency decreases the selective uptake of HDL-cholesteryl esters in vivo. J. Lipid Res. 41: 667-672.
50. Goldberg, I. J. 1996. Lipoprotein lipase and lipolysis: Central roles in ipoprotein metabolism and atherogenesis. J. Lipid Res. 37: 693-707.
51. Yla-Herttuala, S., B. Lipton, M. Rosenfield, I. Goldberg, D. Steinberg, and J. Witztum. 1991. Macrophages and smooth muscle cells express lipoprotein lipase in human and rabbit atherosclerotic lesions. Proc. Natl. Acad. Sci. USA. 88: 10143-10147.
52. O'Brien, K., D. Gordon, S. Deeb, M. Ferguson, and A. Chait. 1992. Lipoprotein lipase is synthesized by macrophage-derived foam cells in human coronary atherosclerotic plaques. J. Clin. Invest. 89: 1544-1550.
53. Mattson, L., H. Johansson, M. Ottosson, G. Bondjers, and O. Wiflund. 1993. Expression of lipoprotein lipase mRNA and secretion in macrophages isolated from human atherosclerotic aorta. J. Clin. Invest. 92: 1759-1765.
54. Eisenberg, S., E. Sehayek, T. Olivecrona, and I. Vlodavsky. 1992. Lipoprotein lipase enhances the binding of lipoprotein to heparan sulfate on cell surface and extracellular matrix. J. Clin. Invest. 90: 2013-2021.
55. Saxena, U., M. G. Klein, T. M. Vanni, and I. J. Goldberg. 1992. Lipoprotein lipase increases low density lipoprotein (LDL) retention by subendothelial cell matrix. J. Clin. Invest. 89: 373-380.
56. Rutledge, J. C., and I. J. Goldberg. 1994. Lipoprotein lipase (LPL) affects low density lipoprotein (LDL) flux through vascular tissue: Evidence that LPL increases LDL accumulation in vascular tissue. J. Lipid Res. 35: 1152-1160.
57. Santamarina-Fojo, S., C. Haudenschild, and M. Amar. 1998. The role of hepatic lipase in lipoprotein metabolism and atherosclerosis. Curr. Opin. Lipidol. 9: 211-219.
58. Dichek, H. L., W. Brecht, J. Fan, Z. S. Ji, S. P. McCormick, H. Akeefe, L. Conzo, D. A. Sanan, K. H. Weisgraber, S. G. Young, J. M. Taylor, and R. W. Mahley. 1998. Overexpression of hepatic lipase in transgenic mice decreases apolipoprotein B-containing and high density lipoprotein. Evidence that hepatic lipase acts as a ligand for lipoprotein uptake. J. Biol. Chem. 273: 1896-1903.
59. Rumsey, S. C., J. C. Obunike, Y. Arad, R. J. Deckelbaum, and I. J. Goldberg. 1992. Lipoprotein lipase-mediated uptake and degradation of low density lipoproteins by fibroblasts and macrophages. J. Clin. Invest. 90: 1504-1512.
60. Obunike, J. C., I. J. Edwards, S. C. Rumsey, L. K. Curtiss, W. D. Wagner, R. J. Deckelbaum, and I. J. Goldberg. 1994. Cellular differences in lipoprotein lipase-mediated uptake of low density lipoproteins. J. Biol. Chem. 269: 13129-13135.
61. Choi, S. Y., P. Sivaram, D. E. Walker, L. K. Curtiss, D. G. Gretch, S. L. Sturley, A. D. Attie, R. J. Deckelbaum, and I. J. Goldberg. 1995. Lipoprotein lipase association with lipoproteins involves protein-protein interaction with apolipoprotein B. J. Biol. Chem. 270: 8081-8086.
62. Choi, S. Y., I. J. Goldberg, L. K. Curtiss, and A. D. Cooper. 1998. Interaction between apoB and hepatic lipase mediates the uptake of apoB-containing lipoproteins. J. Biol. Chem. 273: 20456-20462.
63. Merkel, M., Y. Kako, H. Radner, I. S. Cho, R. Ramasamy, J. D. Brunzell, I. J. Goldberg, and J. L. Breslow. 1998. Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases very low density lipoprotein uptake: Direct evidence that lipoprotein lipase bridging occurs in vivo. Proc. Natl. Acad. Sci. USA. 95: 13841-13846.
64. Dichek, H. L., S. M. Johnson, H. Akeefe, G. T. Lo, E. Sage, C. E. Yap, and R. W. Mahley. 2001. Hepatic lipase overexpression lowers remnant and LDL levels by a noncatalytic mechanism in LDL receptor-deficient mice. J. Lipid Res. 42: 201-210.
65. Zambon, A., S. S. Deeb, A. Bensadoun, K. E. Foster, and J. D. Brunzell. 2000. In vivo evidence of a role for hepatic lipase in human apoB-containing lipoprotein metabolism, independent of its lipolytic activity. J. Lipid Res. 41: 2094-2099.