Circadian aspects of energy metabolism and aging

Ageing Research Reviews

Volumn 12, Issue 4, 2013, Pages 931-940

  Froy, Oren ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Aging; Circadian rhythms; Clock; Life span; Metabolism

Indexed keywords

ARGIPRESSIN; CORTICOTROPIN RELEASING FACTOR; CRYPTOCHROME 1; CRYPTOCHROME 2; MAMMALIAN TARGET OF RAPAMYCIN; MELATONIN; PEPTIDES AND PROTEINS; PER1 PROTEIN; PER2 PROTEIN; PERIOD 3 PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN BMAL1; RETINOID RELATED ORPHAN RECEPTOR ALPHA; SIRTUIN 1; TRANSCRIPTION FACTOR CLOCK; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE;

AGING; ANTERIOR HYPOTHALAMUS; BODY TEMPERATURE; CALORIC RESTRICTION; CATARACT; CHOLESTEROL METABOLISM; CIRCADIAN RHYTHM; CITRIC ACID CYCLE; CORTICOSTERONE RELEASE; DIET RESTRICTION; DISORIENTATION; ENERGY METABOLISM; FATIGUE; FOOD AVAILABILITY; FOOD INTAKE; GASTROINTESTINAL MOTILITY; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE UTILIZATION; HEALTH; HORMONE RELEASE; HUMAN; INSOMNIA; LIFESPAN; LOCOMOTION; LONGEVITY; MORTALITY; NONHUMAN; OSTEOPOROSIS; PROTEIN EXPRESSION; REVIEW; SARCOPENIA; SLEEP WAKING CYCLE; SURVIVAL TIME;

AGING; CIRCADIAN RHYTHMS; CLOCK; LIFE SPAN; METABOLISM;

AGING; ANIMALS; CALORIC RESTRICTION; CIRCADIAN RHYTHM; CLOCK PROTEINS; ENERGY METABOLISM; HUMANS; SUPRACHIASMATIC NUCLEUS;

EID: 84885696095     PISSN: 15681637     EISSN: 18729649     Source Type: Journal    
DOI: 10.1016/j.arr.2013.09.002     Document Type: Review

References (205)

1. Ahima R.S., Prabakaran D., Flier J.S. Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function. J. Clin. Invest. 1998, 101:1020-1027.
2. Ahmet I., Wan R., Mattson M.P., Lakatta E.G., Talan M. Cardioprotection by intermittent fasting in rats. Circulation 2005, 112:3115-3121.
3. Akhtar R.A., Reddy A.B., Maywood E.S., Clayton J.D., King V.M., Smith A.G., Gant T.W., Hastings M.H., Kyriacou C.P. Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus. Curr. Biol. 2002, 12:540-550.
4. Ando H., Yanagihara H., Hayashi Y., Obi Y., Tsuruoka S., Takamura T., Kaneko S., Fujimura A. Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue. Endocrinology 2005, 146:5631-5636.
5. Anea C.B., Zhang M., Stepp D.W., Simkins G.B., Reed G., Fulton D.J., Rudic R.D. Vascular disease in mice with a dysfunctional circadian clock. Circulation 2009, 119:1510-1517.
6. Anisimov V.N., Berstein L.M., Egormin P.A., Piskunova T.S., Popovich I.G., Zabezhinski M.A., Tyndyk M.L., Yurova M.V., Kovalenko I.G., Poroshina T.E., Semenchenko A.V. Metformin slows down aging and extends life span of female SHR mice. Cell Cycle 2008, 7:2769-2773.
7. Anson R.M., Guo Z., de Cabo R., Iyun T., Rios M., Hagepanos A., Ingram D.K., Lane M.A., Mattson M.P. Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:6216-6220.
8. Antoch M.P., Gorbacheva V.Y., Vykhovanets O., Toshkov I.A., Kondratov R.V., Kondratova A.A., Lee C., Nikitin A.Y. Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis. Cell Cycle 2008, 7:1197-1204.
9. Asher G., Gatfield D., Stratmann M., Reinke H., Dibner C., Kreppel F., Mostoslavsky R., Alt F.W., Schibler U. SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 2008, 134:317-328.
10. Asher G., Schibler U. A CLOCK-less clock. Trends Cell Biol. 2006, 16:547-549.
11. Asher G., Schibler U. Crosstalk between components of circadian and metabolic cycles in mammals. Cell Metab. 2011, 13:125-137.
12. Aujard F., Herzog E.D., Block G.D. Circadian rhythms in firing rate of individual suprachiasmatic nucleus neurons from adult and middle-aged mice. Neuroscience 2001, 106:255-261.
13. Barnea M., Haviv L., Gutman R., Chapnik N., Madar Z., Froy O. Metformin affects the circadian clock and metabolic rhythms in a tissue-specific manner. Biochim. Biophys. Acta 2012, 1822:1796-1806.
14. Beynon A.L., Thome J., Coogan A.N. Age and time of day influences on the expression of transforming growth factor-beta and phosphorylated SMAD3 in the mouse suprachiasmatic and paraventricular nuclei. Neuroimmunomodulation 2009, 16:392-399.
15. Biello S.M. Circadian clock resetting in the mouse changes with age. Age (Dordr) 2009, 31:293-303.
16. Bodosi B., Gardi J., Hajdu I., Szentirmai E., Obal F., Krueger J.M. Rhythms of ghrelin, leptin, and sleep in rats: effects of the normal diurnal cycle, restricted feeding, and sleep deprivation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004, 287:R1071-R1079.
17. Boulamery-Velly A., Simon N., Vidal J., Mouchet J., Bruguerolle B. Effects of three-hour restricted food access during the light period on circadian rhythms of temperature, locomotor activity, and heart rate in rats. Chronobiol. Int. 2005, 22:489-498.
18. Bray M.S., Young M.E. Circadian rhythms in the development of obesity: potential role for the circadian clock within the adipocyte. Obes. Rev. 2007, 8:169-181.
19. Cai A., Scarbrough K., Hinkle D.A., Wise P.M. Fetal grafts containing suprachiasmatic nuclei restore the diurnal rhythm of CRH and POMC mRNA in aging rats. Am. J. Physiol. 1997, 273:R1764-R1770.
20. Cailotto C., La Fleur S.E., Van Heijningen C., Wortel J., Kalsbeek A., Feenstra M., Pevet P., Buijs R.M. The suprachiasmatic nucleus controls the daily variation of plasma glucose via the autonomic output to the liver: are the clock genes involved?. Eur. J. Neurosci. 2005, 22:2531-2540.
21. Canaple L., Rambaud J., Dkhissi-Benyahya O., Rayet B., Tan N.S., Michalik L., Delaunay F., Wahli W., Laudet V. Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor alpha defines a novel positive feedback loop in the rodent liver circadian clock. Mol. Endocrinol. 2006, 20:1715-1727.
22. Canto C., Auwerx J. Caloric restriction, SIRT1 and longevity. Trends Endocrinol. Metab. 2009, 20:325-331.
23. Canto C., Gerhart-Hines Z., Feige J.N., Lagouge M., Noriega L., Milne J.C., Elliott P.J., Puigserver P., Auwerx J. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 2009, 458:1056-1060.
24. Cao R., Lee B., Cho H.Y., Saklayen S., Obrietan K. Photic regulation of the mTOR signaling pathway in the suprachiasmatic circadian clock. Mol. Cell. Neurosci. 2008, 38:312-324.
25. Carling D. AMP-activated protein kinase: balancing the scales. Biochimie 2005, 87:87-91.
26. Cassone V.M., Stephan F.K. Central and peripheral regulation of feeding and nutrition by the mammalian circadian clock: implications for nutrition during manned space flight. Nutrition 2002, 18:814-819.
27. Challet E., Caldelas I., Graff C., Pevet P. Synchronization of the molecular clockwork by light- and food-related cues in mammals. Biol. Chem. 2003, 384:711-719.
28. Challet E., Solberg L.C., Turek F.W. Entrainment in calorie-restricted mice: conflicting zeitgebers and free-running conditions. Am. J. Physiol. 1998, 274:R1751-R1761.
29. Chang H.C., Guarente L. SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell 2013, 153:1448-1460.
30. Chawla A., Lazar M.A. Induction of Rev-ErbA alpha, an orphan receptor encoded on the opposite strand of the alpha-thyroid hormone receptor gene, during adipocyte differentiation. J. Biol. Chem. 1993, 268:16265-16269.
31. Cheng M.Y., Bullock C.M., Li C., Lee A.G., Bermak J.C., Belluzzi J., Weaver D.R., Leslie F.M., Zhou Q.Y. Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature 2002, 417:405-410.
32. Cho H., Zhao X., Hatori M., Yu R.T., Barish G.D., Lam M.T., Chong L.W., DiTacchio L., Atkins A.R., Glass C.K., Liddle C., Auwerx J., Downes M., Panda S., Evans R.M. Regulation of circadian behaviour and metabolism by REV-ERB-alpha and REV-ERB-beta. Nature 2012, 485:123-127.
33. Colman R.J., Anderson R.M., Johnson S.C., Kastman E.K., Kosmatka K.J., Beasley T.M., Allison D.B., Cruzen C., Simmons H.A., Kemnitz J.W., Weindruch R. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 2009, 325:201-204.
34. Comperatore C.A., Stephan F.K. Entrainment of duodenal activity to periodic feeding. J. Biol. Rhythms 1987, 2:227-242.
35. Contestabile A., Ciani E. Dietary restriction differentially protects from neurodegeneration in animal models of excitotoxicity. Brain Res. 2004, 1002:162-166.
36. Damiola F., Le Minh N., Preitner N., Kornmann B., Fleury-Olela F., Schibler U. Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev. 2000, 14:2950-2961.
37. Davidson A.J. Search for the feeding-entrainable circadian oscillator: a complex proposition. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006, 290:R1524-R1526.
38. Davidson A.J., Cappendijk S.L., Stephan F.K. Feeding-entrained circadian rhythms are attenuated by lesions of the parabrachial region in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2000, 278:R1296-R1304.
39. Davidson A.J., Castanon-Cervantes O., Stephan F.K. Daily oscillations in liver function: diurnal vs circadian rhythmicity. Liver Int. 2004, 24:179-186.
40. Davidson A.J., Sellix M.T., Daniel J., Yamazaki S., Menaker M., Block G.D. Chronic jet-lag increases mortality in aged mice. Curr. Biol. 2006, 16:R914-R916.
41. Davidson A.J., Yamazaki S., Arble D.M., Menaker M., Block G.D. Resetting of central and peripheral circadian oscillators in aged rats. Neurobiol. Aging 2008, 29:471-477.
42. Davis S., Mirick D.K. Circadian disruption, shift work and the risk of cancer: a summary of the evidence and studies in Seattle. Cancer Causes Control 2006, 17:539-545.
43. De Boer S.F., Van der Gugten J. Daily variations in plasma noradrenaline, adrenaline and corticosterone concentrations in rats. Physiol. Behav. 1987, 40:323-328.
44. Debruyne J.P., Noton E., Lambert C.M., Maywood E.S., Weaver D.R., Reppert S.M. A clock shock: mouse CLOCK is not required for circadian oscillator function. Neuron 2006, 50:465-477.
45. Descamps O., Riondel J., Ducros V., Roussel A.M. Mitochondrial production of reactive oxygen species and incidence of age-associated lymphoma in OF1 mice: effect of alternate-day fasting. Mech. Ageing Dev. 2005, 126:1185-1191.
46. Downs J.L., Mattison J.A., Ingram D.K., Urbanski H.F. Effect of age and caloric restriction on circadian adrenal steroid rhythms in rhesus macaques. Neurobiol. Aging 2008, 29:1412-1422.
47. Downs J.L., Urbanski H.F. Aging-related sex-dependent loss of the circulating leptin 24-h rhythm in the rhesus monkey. J. Endocrinol. 2006, 190:117-127.
48. Dubrovsky Y.V., Samsa W.E., Kondratov R.V. Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice. Aging (Albany NY) 2010, 2:936-944.
49. Duffield G.E., Best J.D., Meurers B.H., Bittner A., Loros J.J., Dunlap J.C. Circadian programs of transcriptional activation, signaling, and protein turnover revealed by microarray analysis of mammalian cells. Curr. Biol. 2002, 12:551-557.
50. Duffy J.F., Zeitzer J.M., Rimmer D.W., Klerman E.B., Dijk D.J., Czeisler C.A. Peak of circadian melatonin rhythm occurs later within the sleep of older subjects. Am. J. Physiol. Endocrinol. Metab. 2002, 282:E297-E303.
51. Dunlap J.C. Molecular bases for circadian clocks. Cell 1999, 96:271-290.
52. Feillet C.A., Ripperger J.A., Magnone M.C., Dulloo A., Albrecht U., Challet E. Lack of food anticipation in Per2 mutant mice. Curr. Biol. 2006, 16:2016-2022.
53. Filipski E., King V.M., Li X., Granda T.G., Mormont M.C., Claustrat B., Hastings M.H., Levi F. Disruption of circadian coordination accelerates malignant growth in mice. Pathol. Biol. 2003, 51:216-219.
54. Fontana L. Modulating human aging and age-associated diseases. Biochim. Biophys. Acta 2009, 1790:1133-1138.
55. Froy O. Circadian rhythms, aging, and life span in mammals. Physiology (Bethesda) 2011, 26:225-235.
56. Froy O. Cytochrome P450 and the biological clock in mammals. Curr. Drug Metab. 2009, 10:104-115.
57. Froy O. Metabolism and circadian rhythms-implications for obesity. Endocr. Rev. 2010, 31:1-24.
58. Froy O., Chang D.C., Reppert S.M. Redox potential: differential roles in dCRY and mCRY1 functions. Curr. Biol. 2002, 12:147-152.
59. Froy O., Chapnik N. Circadian oscillation of innate immunity components in mouse small intestine. Mol. Immunol. 2007, 44:1954-1960.
60. Froy O., Chapnik N., Miskin R. Effect of intermittent fasting on circadian rhythms in mice depends on feeding time. Mech. Ageing Dev. 2009, 130:154-160.
61. Froy O., Chapnik N., Miskin R. Long-lived alphaMUPA transgenic mice exhibit pronounced circadian rhythms. Am. J. Physiol. Endocrinol. Metab. 2006, 291:E1017-E1024.
62. Froy O., Chapnik N., Miskin R. The suprachiasmatic nuclei are involved in determining circadian rhythms during restricted feeding. Neuroscience 2008, 155:1152-1159.
63. Froy O., Miskin R. Effect of feeding regimens on circadian rhythms: implications for aging and longevity. Aging (Albany NY) 2010, 2:7-27.
64. Froy O., Miskin R. The interrelations among feeding, circadian rhythms and ageing. Prog. Neurobiol. 2007, 82:142-150.
65. Fu L., Pelicano H., Liu J., Huang P., Lee C. The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 2002, 111:41-50.
66. Garaulet M., Madrid J.A. Chronobiological aspects of nutrition, metabolic syndrome and obesity. Adv. Drug Deliv. Rev. 2010, 62:967-978.
67. Gibson E.M., Williams W.P., Kriegsfeld L.J. Aging in the circadian system: considerations for health, disease prevention and longevity. Exp. Gerontol. 2009, 44:51-56.
68. Goodrick C.L., Ingram D.K., Reynolds M.A., Freeman J.R., Cider N. Effects of intermittent feeding upon body weight and lifespan in inbred mice: interaction of genotype and age. Mech. Ageing Dev. 1990, 55:69-87.
69. Gooley J.J., Schomer A., Saper C.B. The dorsomedial hypothalamic nucleus is critical for the expression of food-entrainable circadian rhythms. Nat. Neurosci. 2006, 9:398-407.
70. Grasl-Kraupp B., Bursch W., Ruttkay-Nedecky B., Wagner A., Lauer B., Schulte-Hermann R. Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver. Proc. Natl. Acad. Sci. U.S.A. 1994, 91:9995-9999.
71. Grimaldi B., Sassone-Corsi P. Circadian rhythms: metabolic clockwork. Nature 2007, 447:386-387.
72. Guan X.M., Hess J.F., Yu H., Hey P.J., van der Ploeg L.H. Differential expression of mRNA for leptin receptor isoforms in the rat brain. Mol. Cell. Endocrinol. 1997, 133:1-7.
73. Guarente L., Picard F. Calorie restriction-the SIR2 connection. Cell 2005, 120:473-482.
74. Gutman R., Barnea M., Haviv L., Chapnik N., Froy O. Peroxisome proliferator-activated receptor alpha (PPARalpha) activation advances locomotor activity and feeding daily rhythms in mice. Int. J. Obes. (Lond.) 2012, 36:1131-1134.
75. Gutman R., Genzer Y., Chapnik N., Miskin R., Froy O. Long-lived mice Exhibit 24h locomotor circadian rhythms at young and old age. Exp. Gerontol. 2011, 46:606-609.
76. Haigis M.C., Guarente L.P. Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction. Genes Dev. 2006, 20:2913-2921.
77. Hara R., Wan K., Wakamatsu H., Aida R., Moriya T., Akiyama M., Shibata S. Restricted feeding entrains liver clock without participation of the suprachiasmatic nucleus. Genes Cells 2001, 6:269-278.
78. Hardie D.G., Hawley S.A., Scott J.W. AMP-activated protein kinase-development of the energy sensor concept. J. Physiol. 2006, 574:7-15.
79. Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 1956, 11:298-300.
80. Harrison D.E., Strong R., Sharp Z.D., Nelson J.F., Astle C.M., Flurkey K., Nadon N.L., Wilkinson J.E., Frenkel K., Carter C.S., Pahor M., Javors M.A., Fernandez E., Miller R.A. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009, 460:392-395.
81. Herzog E.D., Takahashi J.S., Block G.D. Clock controls circadian period in isolated suprachiasmatic nucleus neurons. Nat. Neurosci. 1998, 1:708-713.
82. Hirao J., Arakawa S., Watanabe K., Ito K., Furukawa T. Effects of restricted feeding on daily fluctuations of hepatic functions including p450 monooxygenase activities in rats. J. Biol. Chem. 2006, 281:3165-3171.
83. Hirota T., Fukada Y. Resetting mechanism of central and peripheral circadian clocks in mammals. Zoolog. Sci. 2004, 21:359-368.
84. Hofman M.A., Swaab D.F. Living by the clock: the circadian pacemaker in older people. Ageing Res. Rev. 2006, 5:33-51.
85. Honma K.I., Honma S., Hiroshige T. Critical role of food amount for prefeeding corticosterone peak in rats. Am. J. Physiol. 1983, 245:R339-R344.
86. Horikawa K., Minami Y., Iijima M., Akiyama M., Shibata S. Rapid damping of food-entrained circadian rhythm of clock gene expression in clock-defective peripheral tissues under fasting conditions. Neuroscience 2005, 134:335-343.
87. Hurd M.W., Ralph M.R. The significance of circadian organization for longevity in the golden hamster. J. Biol. Rhythms 1998, 13:430-436.
88. Hurd M.W., Zimmer K.A., Lehman M.N., Ralph M.R. Circadian locomotor rhythms in aged hamsters following suprachiasmatic transplant. Am. J. Physiol. 1995, 269:R958-R968.
89. Inoue I., Shinoda Y., Ikeda M., Hayashi K., Kanazawa K., Nomura M., Matsunaga T., Xu H., Kawai S., Awata T., Komoda T., Katayama S. CLOCK/BMAL1 is involved in lipid metabolism via transactivation of the peroxisome proliferator-activated receptor (PPAR) response element. J. Atheroscler. Thromb. 2005, 12:169-174.
90. Jung-Hynes B., Reiter R.J., Ahmad N. Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer. J. Pineal Res. 2010, 48:9-19.
91. Kallo I., Kalamatianos T., Piggins H.D., Coen C.W. Ageing and the diurnal expression of mRNAs for vasoactive intestinal peptide and for the VPAC2 and PAC1 receptors in the suprachiasmatic nucleus of male rats. J. Neuroendocrinol. 2004, 16:758-766.
92. Kalra S.P., Bagnasco M., Otukonyong E.E., Dube M.G., Kalra P.S. Rhythmic, reciprocal ghrelin and leptin signaling: new insight in the development of obesity. Regul. Pept. 2003, 111:1-11.
93. Kalsbeek A., Fliers E., Romijn J.A., La Fleur S.E., Wortel J., Bakker O., Endert E., Buijs R.M. The suprachiasmatic nucleus generates the diurnal changes in plasma leptin levels. Endocrinology 2001, 142:2677-2685.
94. Kalsbeek A., Ruiter M., La Fleur S.E., Cailotto C., Kreier F., Buijs R.M. The hypothalamic clock and its control of glucose homeostasis. Prog. Brain Res. 2006, 153:283-307.
95. Kawakami F., Okamura H., Tamada Y., Maebayashi Y., Fukui K., Ibata Y. Loss of day-night differences in VIP mRNA levels in the suprachiasmatic nucleus of aged rats. Neurosci. Lett. 1997, 222:99-102.
96. Kersten S., Desvergne B., Wahli W. Roles of PPARs in health and disease. Nature 2000, 405:421-424.
97. Kita Y., Shiozawa M., Jin W., Majewski R.R., Besharse J.C., Greene A.S., Jacob H.J. Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies. Pharmacogenetics 2002, 12:55-65.
98. Kohsaka A., Bass J. A sense of time: how molecular clocks organize metabolism. Trends Endocrinol. Metab. 2007, 18:4-11.
99. Kolker D.E., Fukuyama H., Huang D.S., Takahashi J.S., Horton T.H., Turek F.W. Aging alters circadian and light-induced expression of clock genes in golden hamsters. J. Biol. Rhythms 2003, 18:159-169.
100. Kondratov R.V., Kondratova A.A., Gorbacheva V.Y., Vykhovanets O.V., Antoch M.P. Early aging and age-related pathologies in mice deficient in BMAL1, the core component of the circadian clock. Genes Dev. 2006, 20:1868-1873.
101. Kornmann B., Preitner N., Rifat D., Fleury-Olela F., Schibler U. Analysis of circadian liver gene expression by ADDER, a highly sensitive method for the display of differentially expressed mRNAs. Nucleic Acids Res. 2001, 29:E51.
102. Kornmann B., Schaad O., Bujard H., Takahashi J.S., Schibler U. System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biol. 2007, 5:e34.
103. Kramer A., Yang F.C., Snodgrass P., Li X., Scammell T.E., Davis F.C., Weitz C.J. Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Science 2001, 294:2511-2515.
104. Kraves S., Weitz C.J. A role for cardiotrophin-like cytokine in the circadian control of mammalian locomotor activity. Nat. Neurosci. 2006, 9:212-219.
105. La Fleur S.E. Daily rhythms in glucose metabolism: suprachiasmatic nucleus output to peripheral tissue. J. Neuroendocrinol. 2003, 15:315-322.
106. La Fleur S.E., Kalsbeek A., Wortel J., Buijs R.M. A suprachiasmatic nucleus generated rhythm in basal glucose concentrations. J. Neuroendocrinol. 1999, 11:643-652.
107. Lamia K.A., Sachdeva U.M., DiTacchio L., Williams E.C., Alvarez J.G., Egan D.F., Vasquez D.S., Juguilon H., Panda S., Shaw R.J., Thompson C.B., Evans R.M. AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science 2009, 326:437-440.
108. Landry G.J., Simon M.M., Webb I.C., Mistlberger R.E. Persistence of a behavioral food-anticipatory circadian rhythm following dorsomedial hypothalamic ablation in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006, 290:R1527-R1534.
109. Landry G.J., Yamakawa G.R., Webb I.C., Mear R.J., Mistlberger R.E. The dorsomedial hypothalamic nucleus is not necessary for the expression of circadian food-anticipatory activity in rats. J. Biol. Rhythms 2007, 22:467-478.
110. Lee C., Etchegaray J.P., Cagampang F.R., Loudon A.S., Reppert S.M. Posttranslational mechanisms regulate the mammalian circadian clock. Cell 2001, 107:855-867.
111. Lee C.C. The circadian clock and tumor suppression by mammalian period genes. Methods Enzymol. 2005, 393:852-861.
112. Lefebvre P., Chinetti G., Fruchart J.C., Staels B. Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. J. Clin. Invest. 2006, 116:571-580.
113. Lemos D.R., Downs J.L., Urbanski H.F. Twenty-four-hour rhythmic gene expression in the rhesus macaque adrenal gland. Mol. Endocrinol. 2006, 20:1164-1176.
114. Li F., Yin Y., Tan B., Kong X., Wu G. Leucine nutrition in animals and humans: mTOR signaling and beyond. Amino Acids 2011, 41:1185-1193.
115. Li H., Satinoff E. Changes in circadian rhythms of body temperature and sleep in old rats. Am. J. Physiol. 1995, 269:R208-R214.
116. Li H., Satinoff E. Fetal tissue containing the suprachiasmatic nucleus restores multiple circadian rhythms in old rats. Am. J. Physiol. 1998, 275:R1735-R1744.
117. Lin J.D., Liu C., Li S. Integration of energy metabolism and the mammalian clock. Cell Cycle 2008, 7:453-457.
118. Liu C., Li S., Liu T., Borjigin J., Lin J.D. Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism. Nature 2007, 447:477-481.
119. Liu C., Weaver D.R., Strogatz S.H., Reppert S.M. Cellular construction of a circadian clock: period determination in the suprachiasmatic nuclei. Cell 1997, 91:855-860.
120. Madeira M.D., Sousa N., Santer R.M., Paula-Barbosa M.M., Gundersen H.J. Age and sex do not affect the volume, cell numbers, or cell size of the suprachiasmatic nucleus of the rat: an unbiased stereological study. J. Comp. Neurol. 1995, 361:585-601.
121. Mager D.E., Wan R., Brown M., Cheng A., Wareski P., Abernethy D.R., Mattson M.P. Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats. FASEB J. 2006, 20:631-637.
122. Mair W., Dillin A. Aging and survival: the genetics of life span extension by dietary restriction. Annu. Rev. Biochem 2008, 77:727-754.
123. Masoro E.J. Overview of caloric restriction and ageing. Mech. Ageing Dev. 2005, 126:913-922.
124. Masoro E.J., Shimokawa I., Higami Y., McMahan C.A., Yu B.P. Temporal pattern food intake not a factor in the retardation of aging processes by dietary restriction. J. Gerontol. A. Biol. Sci. Med. Sci. 1995, 50A:B48-B53.
125. Mattison J.A., Roth G.S., Beasley T.M., Tilmont E.M., Handy A.M., Herbert R.L., Longo D.L., Allison D.B., Young J.E., Bryant M., Barnard D., Ward W.F., Qi W., Ingram D.K., de Cabo R. Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 2012, 489:318-321.
126. Mattson M.P. Dietary factors, hormesis and health. Ageing Res. Rev. 2008, 7:43-48.
127. Mattson M.P. Energy intake, meal frequency, and health: a neurobiological perspective. Annu. Rev. Nutr. 2005, 25:237-260.
128. Mattson M.P., Duan W., Wan R., Guo Z. Prophylactic activation of neuroprotective stress response pathways by dietary and behavioral manipulations. NeuroRx 2004, 1:111-116.
129. McCarthy J.J., Andrews J.L., McDearmon E.L., Campbell K.S., Barber B.K., Miller B.H., Walker J.R., Hogenesch J.B., Takahashi J.S., Esser K.A. Identification of the circadian transcriptome in adult mouse skeletal muscle. Physiol. Genomics 2007, 31:86-95.
130. Mendoza J., Angeles-Castellanos M., Escobar C. Differential role of the accumbens Shell and Core subterritories in food-entrained rhythms of rats. Behav. Brain Res. 2005, 158:133-142.
131. Mendoza J., Drevet K., Pevet P., Challet E. Daily meal timing is not necessary for resetting the main circadian clock by calorie restriction. J. Neuroendocrinol. 2008, 20:251-260.
132. Mendoza J., Graff C., Dardente H., Pevet P., Challet E. Feeding cues alter clock gene oscillations and photic responses in the suprachiasmatic nuclei of mice exposed to a light/dark cycle. J. Neurosci. 2005, 25:1514-1522.
133. Mieda M., Williams S.C., Richardson J.A., Tanaka K., Yanagisawa M. The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:12150-12155.
134. Mistlberger R.E. Circadian food-anticipatory activity: formal models and physiological mechanisms. Neurosci. Biobehav. Rev. 1994, 18:171-195.
135. Mistlberger R.E. Circadian rhythms: perturbing a food-entrained clock. Curr. Biol. 2006, 16:R968-R969.
136. Mistlberger R.E., Marchant E.G. Enhanced food-anticipatory circadian rhythms in the genetically obese Zucker rat. Physiol. Behav. 1999, 66:329-335.
137. Mistlberger R.E., Mumby D.G. The limbic system and food-anticipatory circadian rhythms in the rat: ablation and dopamine blocking studies. Behav. Brain Res. 1992, 47:159-168.
138. Montagnana M., Salvagno G.L., Lippi G. Circadian variation within hemostasis: an underrecognized link between biology and disease?. Semin. Thromb. Hemost. 2009, 35:23-33.
139. Nadon N.L. Exploiting the rodent model for studies on the pharmacology of lifespan extension. Aging Cell 2006, 5:9-15.
140. Nakahata Y., Kaluzova M., Grimaldi B., Sahar S., Hirayama J., Chen D., Guarente L.P., Sassone-Corsi P. The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 2008, 134:329-340.
141. Nakahata Y., Sahar S., Astarita G., Kaluzova M., Sassone-Corsi P. Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science 2009, 324:654-657.
142. Nakamura T.J., Nakamura W., Yamazaki S., Kudo T., Cutler T., Colwell C.S., Block G.D. Age-related decline in circadian output. J. Neurosci. 2011, 31:10201-10205.
143. Nygard M., Hill R.H., Wikstrom M.A., Kristensson K. Age-related changes in electrophysiological properties of the mouse suprachiasmatic nucleus in vitro. Brain Res. Bull. 2005, 65:149-154.
144. Oishi K., Miyazaki K., Ishida N. Functional CLOCK is not involved in the entrainment of peripheral clocks to the restricted feeding: entrainable expression of mPer2 and Bmal1 mRNAs in the heart of Clock mutant mice on Jcl:ICR background. Biochem. Biophys. Res. Commun. 2002, 298:198-202.
145. Oishi K., Shirai H., Ishida N. CLOCK is involved in the circadian transactivation of peroxisome-proliferator-activated receptor alpha (PPARalpha) in mice. Biochem. J 2005, 386:575-581.
146. Ozturk N., Lee J.H., Gaddameedhi S., Sancar A. Loss of cryptochrome reduces cancer risk in p53 mutant mice. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:2841-2846.
147. Panda S., Antoch M.P., Miller B.H., Su A.I., Schook A.B., Straume M., Schultz P.G., Kay S.A., Takahashi J.S., Hogenesch J.B. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 2002, 109:307-320.
148. Panda S., Hogenesch J.B., Kay S.A. Circadian rhythms from flies to human. Nature 2002, 417:329-335.
149. Pendergast J.S., Nakamura W., Friday R.C., Hatanaka F., Takumi T., Yamazaki S. Robust food anticipatory activity in BMAL1-deficient mice. PLoS ONE 2009, 4:e4860.
150. Penev P.D., Kolker D.E., Zee P.C., Turek F.W. Chronic circadian desynchronization decreases the survival of animals with cardiomyopathic heart disease. Am. J. Physiol. 1998, 275:H2334-H2337.
151. Pitts S., Perone E., Silver R. Food-entrained circadian rhythms are sustained in arrhythmic Clk/Clk mutant mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2003, 285:R57-R67.
152. Preitner N., Damiola F., Lopez-Molina L., Zakany J., Duboule D., Albrecht U., Schibler U. The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 2002, 110:251-260.
153. Ramsey K.M., Marcheva B., Kohsaka A., Bass J. The clockwork of metabolism. Annu. Rev. Nutr. 2007, 27:219-240.
154. Reddy A.B., Karp N.A., Maywood E.S., Sage E.A., Deery M., O'Neill J.S., Wong G.K., Chesham J., Odell M., Lilley K.S., Kyriacou C.P., Hastings M.H. Circadian orchestration of the hepatic proteome. Curr. Biol. 2006, 16:1107-1115.
155. Reppert S.M., Weaver D.R. Coordination of circadian timing in mammals. Nature 2002, 418:935-941.
156. Reppert S.M., Weaver D.R. Molecular analysis of mammalian circadian rhythms. Annu. Rev. Physiol. 2001, 63:647-676.
157. Resuehr D., Olcese J. Caloric restriction and melatonin substitution: effects on murine circadian parameters. Brain Res. 2005, 1048:146-152.
158. Roozendaal B., van Gool W.A., Swaab D.F., Hoogendijk J.E., Mirmiran M. Changes in vasopressin cells of the rat suprachiasmatic nucleus with aging. Brain Res. 1987, 409:259-264.
159. Roth G.S., Lane M.A., Ingram D.K., Mattison J.A., Elahi D., Tobin J.D., Muller D., Metter E.J. Biomarkers of caloric restriction may predict longevity in humans. Science 2002, 297:811.
160. Roth G.S., Mattison J.A., Ottinger M.A., Chachich M.E., Lane M.A., Ingram D.K. Aging in rhesus monkeys: relevance to human health interventions. Science 2004, 305:1423-1426.
161. Rudic R.D., McNamara P., Curtis A.M., Boston R.C., Panda S., Hogenesch J.B., Fitzgerald G.A. BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biol. 2004, 2:e377.
162. Ruiter M., La Fleur S.E., van Heijningen C., van der Vliet J., Kalsbeek A., Buijs R.M. The daily rhythm in plasma glucagon concentrations in the rat is modulated by the biological clock and by feeding behavior. Diabetes 2003, 52:1709-1715.
163. Rutter J., Reick M., Wu L.C., McKnight S.L. Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. Science 2001, 293:510-514.
164. Rutter J., Reick M., McKnight S.L. Metabolism and the control of circadian rhythms. Annu. Rev. Biochem 2002, 71:307-331.
165. Saito M., Murakami E., Suda M. Circadian rhythms in disaccharidases of rat small intestine and its relation to food intake. Biochim. Biophys. Acta 1976, 421:177-179.
166. Salminen A., Kaarniranta K. AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Res. Rev. 2012, 11:230-241.
167. Satinoff E., Li H., Tcheng T.K., Liu C., McArthur A.J., Medanic M., Gillette M.U. Do the suprachiasmatic nuclei oscillate in old rats as they do in young ones?. Am. J. Physiol. 1993, 265:R1216-R1222.
168. Sato T.K., Panda S., Miraglia L.J., Reyes T.M., Rudic R.D., McNamara P., Naik K.A., FitzGerald G.A., Kay S.A., Hogenesch J.B. A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron 2004, 43:527-537.
169. Scarbrough K., Losee-Olson S., Wallen E.P., Turek F.W. Aging and photoperiod affect entrainment and quantitative aspects of locomotor behavior in Syrian hamsters. Am. J. Physiol. 1997, 272:R1219-R1225.
170. Schibler U., Ripperger J., Brown S.A. Peripheral circadian oscillators in mammals: time and food. J. Biol. Rhythms 2003, 18:250-260.
171. Sharma S., Kaur G. Neuroprotective potential of dietary restriction against kainate-induced excitotoxicity in adult male Wistar rats. Brain Res. Bull. 2005, 67:482-491.
172. Sherman H., Frumin I., Gutman R., Chapnik N., Lorentz A., Meylan J., le Coutre J., Froy O. Long-term restricted feeding alters circadian expression and reduces the level of inflammatory and disease markers. J. Cell. Mol. Med. 2011, 15:2745-2759.
173. Shimba S., Ishii N., Ohta Y., Ohno T., Watabe Y., Hayashi M., Wada T., Aoyagi T., Tezuka M. Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:12071-12076.
174. Sohal R.S., Weindruch R. Oxidative stress, caloric restriction, and aging. Science 1996, 273:59-63.
175. Solt L.A., Wang Y., Banerjee S., Hughes T., Kojetin D.J., Lundasen T., Shin Y., Liu J., Cameron M.D., Noel R., Yoo S.H., Takahashi J.S., Butler A.A., Kamenecka T.M., Burris T.P. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature 2012, 485:62-68.
176. Spindler S.R. Caloric restriction: from soup to nuts. Ageing Res. Rev. 2009, 9:324-353.
177. Stephan F.K. The other circadian system: food as a Zeitgeber. J. Biol. Rhythms 2002, 17:284-292.
178. Stephan F.K., Swann J.M., Sisk C.L. Anticipation of 24-hr feeding schedules in rats with lesions of the suprachiasmatic nucleus. Behav. Neural Biol. 1979, 25:346-363.
179. Stokkan K.A., Yamazaki S., Tei H., Sakaki Y., Menaker M. Entrainment of the circadian clock in the liver by feeding. Science 2001, 291:490-493.
180. Storch K.F., Lipan O., Leykin I., Viswanathan N., Davis F.C., Wong W.H., Weitz C.J. Extensive and divergent circadian gene expression in liver and heart. Nature 2002, 417:78-83.
181. Storch K.F., Weitz C.J. Daily rhythms of food-anticipatory behavioral activity do not require the known circadian clock. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:6808-6813.
182. Sukumaran S., Almon R.R., DuBois D.C., Jusko W.J. Circadian rhythms in gene expression: Relationship to physiology, disease, drug disposition and drug action. Adv. Drug Deliv. Rev. 2010, 62:904-917.
183. Torra I.P., Tsibulsky V., Delaunay F., Saladin R., Laudet V., Fruchart J.C., Kosykh V., Staels B. Circadian and glucocorticoid regulation of Rev-erbalpha expression in liver. Endocrinology 2000, 141:3799-3806.
184. Ueda H.R., Chen W., Adachi A., Wakamatsu H., Hayashi S., Takasugi T., Nagano M., Nakahama K., Suzuki Y., Sugano S., Iino M., Shigeyoshi Y., Hashimoto S. A transcription factor response element for gene expression during circadian night. Nature. 2002, 418:534-539.
185. Um J.H., Yang S., Yamazaki S., Kang H., Viollet B., Foretz M., Chung J.H. Activation of 5'-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPER2. J. Biol. Chem. 2007, 282:20794-20798.
186. Urbanski H.F. Role of circadian neuroendocrine rhythms in the control of behavior and physiology. Neuroendocrinology 2011, 93:211-222.
187. Van Gool W.A., Mirmiran M. Aging and circadian rhythms. Prog. Brain Res. 1986, 70:255-277.
188. Vitaterna M.H., King D.P., Chang A.M., Kornhauser J.M., Lowrey P.L., McDonald J.D., Dove W.F., Pinto L.H., Turek F.W., Takahashi J.S. Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 1994, 264:719-725.
189. Watanabe A., Shibata S., Watanabe S. Circadian rhythm of spontaneous neuronal activity in the suprachiasmatic nucleus of old hamster in vitro. Brain Res. 1995, 695:237-239.
190. Weindruch R., Sohal R.S. Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging. N. Engl. J. Med. 1997, 337:986-994.
191. Weinert D. Age-dependent changes of the circadian system. Chronobiol. Int. 2000, 17:261-283.
192. Welsh D.K., Logothetis D.E., Meister M., Reppert S.M. Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms. Neuron 1995, 14:697-706.
193. Witting W., Mirmiran M., Bos N.P., Swaab D.F. The effect of old age on the free-running period of circadian rhythms in rat. Chronobiol. Int. 1994, 11:103-112.
194. Wood J.G., Rogina B., Lavu S., Howitz K., Helfand S.L., Tatar M., Sinclair D. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 2004, 430:686-689.
195. Wu M.W., Li X.M., Xian L.J., Levi F. Effects of meal timing on tumor progression in mice. Life Sci. 2004, 75:1181-1193.
196. Wyse C.A., Coogan A.N., Selman C., Hazlerigg D.G., Speakman J.R. Association between mammalian lifespan and circadian free-running period: the circadian resonance hypothesis revisited. Biol. Lett. 2010, 6:696-698.
197. Yamazaki S., Ishida Y., Inouye S. Circadian rhythms of adenosine triphosphate contents in the suprachiasmatic nucleus, anterior hypothalamic area and caudate putamen of the rat-negative correlation with electrical activity. Brain Res. 1994, 664:237-240.
198. Yamazaki S., Straume M., Tei H., Sakaki Y., Menaker M., Block G.D. Effects of aging on central and peripheral mammalian clocks. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:10801-10806.
199. Yang X., Downes M., Yu R.T., Bookout A.L., He W., Straume M., Mangelsdorf D.J., Evans R.M. Nuclear receptor expression links the circadian clock to metabolism. Cell 2006, 126:801-810.
200. Yi C.X., van der Vliet J., Dai J., Yin G., Ru L., Buijs R.M. Ventromedial arcuate nucleus communicates peripheral metabolic information to the suprachiasmatic nucleus. Endocrinology 2006, 147:283-294.
201. Yoon I.Y., Kripke D.F., Elliott J.A., Youngstedt S.D., Rex K.M., Hauger R.L. Age-related changes of circadian rhythms and sleep-wake cycles. J. Am. Geriatr. Soc. 2003, 51:1085-1091.
202. Young M.E. The circadian clock within the heart: potential influence on myocardial gene expression, metabolism, and function. Am. J. Physiol. Heart Circ. Physiol. 2006, 290:H1-H16.
203. Zhang Y., Brainard G.C., Zee P.C., Pinto L.H., Takahashi J.S., Turek F.W. Effects of aging on lens transmittance and retinal input to the suprachiasmatic nucleus in golden hamsters. Neurosci. Lett. 1998, 258:167-170.
204. Zigman J.M., Jones J.E., Lee C.E., Saper C.B., Elmquist J.K. Expression of ghrelin receptor mRNA in the rat and the mouse brain. J. Comp. Neurol. 2006, 494:528-548.
205. Zvonic S., Ptitsyn A.A., Conrad S.A., Scott L.K., Floyd Z.E., Kilroy G., Wu X., Goh B.C., Mynatt R.L., Gimble J.M. Characterization of peripheral circadian clocks in adipose tissues. Diabetes 2006, 55:962-970.