Ectopic lipid accumulation: A potential cause for metabolic disturbances and a contributor to the alteration of kidney function

Biochimie

Volumn 95, Issue 11, 2013, Pages 1971-1979

  Guebre Egziabher, Fitsum ^a,b   Alix, Pascaline M ^a,b   Koppe, Laetitia ^a,b   Pelletier, Caroline C ^a,b   Kalbacher, Emilie ^a,b   Fouque, Denis ^a,b   Soulage, Christophe O ^a  

^a UNIVERSITÉ LYON 1   (France)

^b EDOUARD HERRIOT HOSPITAL   (France)

Author keywords

Chronic kidney disease; Diacylglycerols; Insulin resistance; Lipodystrophy; Lipotoxicity

Indexed keywords

CERAMIDE DERIVATIVE; DIACYLGLYCEROL; INSULIN; LIPID;

ADIPOSE TISSUE; AGING; CHRONIC KIDNEY DISEASE; DYSLIPIDEMIA; ENDOPLASMIC RETICULUM STRESS; FATTY LIVER; HUMAN; INSULIN RESISTANCE; LIPID STORAGE; LIPODYSTROPHY; MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; REVIEW; SKELETAL MUSCLE;

ANIMALIA;

ACC; ACETYL-COA CARBOXYLASE; ADIPOSE TISSUE MACROPHAGES; AMP-ACTIVATED PROTEIN KINASE; AMPK; ATMS; BMI; BODY MASS INDEX; C-JUN N-TERMINAL KINASE; C/EBP-Α; CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN; CARNITINE PALMITOYL TRANSFERASE-1; CCAAT/ENHANCER BINDING PROTEIN ALPHA; CHREBP; CHRONIC KIDNEY DISEASE; CKD; CPT-1; DAG; DIABETIC NEPHROPATHY; DIACYLGLYCEROLS; DN; ENDOPLASMIC RETICULUM; ER; FA; FA-COA; FABP-4; FAS; FAT SPECIFIC PROTEIN 27; FATTY ACID BINDING PROTEIN-4; FATTY ACID SYNTHASE; FATTY ACIDS; FATTY ACYL-CO-ENZYME A; FSP27; GLUCOSE TRANSPORTER TYPE 4; GLUT-4; HOMA-IR; HOMEOSTATIC MODEL ASSESSMENT OF INSULIN RESISTANCE; IKK-Β; INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE BETA; INSULIN RECEPTOR SUBSTRATES 1 AND 2; INSULIN RESISTANCE; IRS-1/2; JNK; LIPODYSTROPHY; LIPOPOLYSACCHARIDE; LIPOTOXICITY; LPS; MET-S; METABOLIC SYNDROME; MMPC; MULTIPOTENT MESENCHYMAL PROGENITOR CELLS; NAFLD; NEFA; NFΚB; NON-ALCOHOLIC FATTY LIVER DISEASE; NON-ESTERIFIED FATTY ACIDS; NUCLEAR FACTOR KAPPA-B; PAMPS; PATHOGEN-ASSOCIATED MOLECULAR PATTERNS; PKB/AKT; PKC-Ε; PKC-Θ; PPAR-ΑPEROXISOME; PPAR-ΓPEROXISOME; PROLIFERATOR-ACTIVATED RECEPTOR ALPHA; PROLIFERATOR-ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B/AKT; PROTEIN KINASE C EPSILON; PROTEIN KINASE C THETA; REACTIVE OXYGEN SPECIES; ROS; SATURATED FATTY ACIDS; SFA; SREBP-1; STEROL REGULATORY ELEMENT BINDING PROTEIN-1; TLR-2; TLR-4; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; UNFOLDED PROTEIN RESPONSE; UPR; WAT; WHITE ADIPOSE TISSUE;

AGING; DIABETES MELLITUS, TYPE 2; DIGLYCERIDES; FATTY ACIDS; HUMANS; INSULIN; INSULIN RESISTANCE; KIDNEY; LIPID METABOLISM; LIPODYSTROPHY; OBESITY; RENAL INSUFFICIENCY, CHRONIC;

EID: 84885059873     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2013.07.017     Document Type: Review

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