-
1
-
-
0036578783
-
AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34
-
DOI 10.1038/ng880
-
Agarwal, A. K., Arioglu, E., De Almeida, S., Akkoc, N., Taylor, S. I., Bowcock, A. M., Barnes, R. I. and Garg, A. (2002). AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34. Nat. Genet. 31, 21-23. (Pubitemid 34887633)
-
(2002)
Nature Genetics
, vol.31
, Issue.1
, pp. 21-23
-
-
Agarwal, A.K.1
Arioglu, E.2
De Almeida, S.3
Akkoc, N.4
Taylor, S.I.5
Bowcock, A.M.6
Barnes, R.I.7
Garg, A.8
-
2
-
-
33748937223
-
Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance
-
DOI 10.1016/j.cmet.2006.09.003, PII S1550413106003020
-
Agostini, M., Schoenmakers, E., Mitchell, C., Szatmari, I., Savage, D., Smith, A., Rajanayagam, O., Semple, R., Luan, J., Bath, L. et al. (2006). Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance. Cell Metab. 4, 303-311. (Pubitemid 44430916)
-
(2006)
Cell Metabolism
, vol.4
, Issue.4
, pp. 303-311
-
-
Agostini, M.1
Schoenmakers, E.2
Mitchell, C.3
Szatmari, I.4
Savage, D.5
Smith, A.6
Rajanayagam, O.7
Semple, R.8
Luan, J.9
Bath, L.10
Zalin, A.11
Labib, M.12
Kumar, S.13
Simpson, H.14
Blom, D.15
Marais, D.16
Schwabe, J.17
Barroso, I.18
Trembath, R.19
Wareham, N.20
Nagy, L.21
Gurnell, M.22
O'Rahilly, S.23
Chatterjee, K.24
more..
-
3
-
-
0029896530
-
Role of leptin in the neuroendocrine response to fasting
-
DOI 10.1038/382250a0
-
Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E. and Flier, J. S. (1996). Role of leptin in the neuroendocrine response to fasting. Nature 382, 250-252. (Pubitemid 26251358)
-
(1996)
Nature
, vol.382
, Issue.6588
, pp. 250-252
-
-
Ahlma, R.S.1
Prabakaran, D.2
Mantzoros, C.3
Qu, D.4
Lowell, B.5
Maratos-Flier, E.6
Flier, J.S.7
-
4
-
-
11144357287
-
Site and mechanism of leptin action in a rodent form of congenital lipodystrophy
-
DOI 10.1172/JCI200419511
-
Asilmaz, E., Cohen, P., Miyazaki, M., Dobrzyn, P., Ueki, K., Fayzikhodjaeva, G., Soukas, A. A., Kahn, C. R., Ntambi, J. M., Socci, N. D. et al. (2004). Site and mechanism of leptin action in a rodent form of congenital lipodystrophy. J. Clin. Invest. 113, 414-424. (Pubitemid 38544185)
-
(2004)
Journal of Clinical Investigation
, vol.113
, Issue.3
, pp. 414-424
-
-
Asilmaz, E.1
Cohen, P.2
Miyazaki, M.3
Dobrzyn, P.4
Ueki, K.5
Fayzikhodjaeva, G.6
Soukas, A.A.7
Kahn, C.R.8
Ntambi, J.M.9
Socci, N.D.10
Friedman, J.M.11
-
5
-
-
37349063135
-
Mouse models of lipodystrophy: Key reagents for the understanding of the metabolic syndrome
-
DOI 10.1016/j.ddmod.2007.10.003, PII S1740675707000242, Metabolic Disorders
-
Asterholm, I. W., Halberg, N. and Scherer, P. E. (2007). Mouse models of lipodystrophy key reagents for the understanding of the metabolic syndrome. Drug Discov. Today Dis. Models 4, 17-24. (Pubitemid 350286531)
-
(2007)
Drug Discovery Today: Disease Models
, vol.4
, Issue.1
, pp. 17-24
-
-
Asterholm, I.W.1
Halberg, N.2
Scherer, P.E.3
-
6
-
-
0033599038
-
Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension
-
DOI 10.1038/47254
-
Barroso, I., Gurnell, M., Crowley, V. E., Agostini, M., Schwabe, J. W., Soos, M. A., Maslen, G. L., Williams, T. D., Lewis, H., Schafer, A. J. et al. (1999). Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension. Nature 402, 880-883. (Pubitemid 30017170)
-
(1999)
Nature
, vol.402
, Issue.6764
, pp. 880-883
-
-
Barroso, I.1
Gurnell, M.2
Crowley, V.E.F.3
Agostini, M.4
Schwabe, J.W.5
Soos, M.A.6
Maslen, G.L.7
Williams, T.D.M.8
Lewis, H.9
Schafer, A.J.10
Chatterjee, V.K.K.11
O'Rahilly, S.12
-
7
-
-
33751545838
-
A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
-
DOI 10.1056/NEJMoa060326
-
Belfort, R., Harrison, S. A., Brown, K., Darland, C., Finch, J., Hardies, J., Balas, B., Gastaldelli, A., Tio, F., Pulcini, J. et al. (2006). A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N. Engl. J. Med. 355, 2297-2307. (Pubitemid 44837778)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.22
, pp. 2297-2307
-
-
Belfort, R.1
Harrison, S.A.2
Brown, K.3
Darland, C.4
Finch, J.5
Hardies, J.6
Balas, B.7
Gastaldelli, A.8
Tio, F.9
Pulcini, J.10
Berria, R.11
Ma, J.Z.12
Dwivedi, S.13
Havranek, R.14
Fincke, C.15
Defronzo, R.16
Bannayan, G.A.17
Schenker, S.18
Cusi, K.19
-
8
-
-
0036511213
-
ACRP30/adiponectin: An adipokine regulating glucose and lipid metabolism
-
DOI 10.1016/S1043-2760(01)00524-0, PII S1043276001005240
-
Berg, A. H., Combs, T. P. and Scherer, P. E. (2002). ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol. Metab. 13, 84-89. (Pubitemid 36740452)
-
(2002)
Trends in Endocrinology and Metabolism
, vol.13
, Issue.2
, pp. 84-89
-
-
Berg, A.H.1
Combs, T.P.2
Scherer, P.E.3
-
9
-
-
38649110496
-
Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis
-
DOI 10.1016/j.cmet.2007.11.013, PII S1550413107003683
-
Biddinger, S. B., Hernandez-Ono, A., Rask-Madsen, C., Haas, J. T., Aleman, J. O., Suzuki, R., Scapa, E. F., Agarwal, C., Carey, M. C., Stephanopoulos, G. et al. (2008). Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab. 7, 125-134. (Pubitemid 351168555)
-
(2008)
Cell Metabolism
, vol.7
, Issue.2
, pp. 125-134
-
-
Biddinger, S.B.1
Hernandez-Ono, A.2
Rask-Madsen, C.3
Haas, J.T.4
Aleman, J.O.5
Suzuki, R.6
Scapa, E.F.7
Agarwal, C.8
Carey, M.C.9
Stephanopoulos, G.10
Cohen, D.E.11
King, G.L.12
Ginsberg, H.13
Kahn, C.R.14
-
10
-
-
67349097875
-
Seipin deficiency alters fatty acid Delta9 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophy
-
Boutet, E., El Mourabit, H., Prot, M., Nemani, M., Khallouf, E., Colard, O., Maurice, M., Durand-Schneider, A. M., Chretien, Y., Gres, S. et al. (2009). Seipin deficiency alters fatty acid Delta9 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophy. Biochimie 91, 796-803.
-
(2009)
Biochimie
, vol.91
, pp. 796-803
-
-
Boutet, E.1
El Mourabit, H.2
Prot, M.3
Nemani, M.4
Khallouf, E.5
Colard, O.6
Maurice, M.7
Durand-Schneider, A.M.8
Chretien, Y.9
Gres, S.10
-
11
-
-
38649116056
-
Selective versus total insulin resistance: A pathogenic paradox
-
Brown, M. S. and Goldstein, J. L. (2008). Selective versus total insulin resistance: a pathogenic paradox. Cell Metab. 7, 95-96.
-
(2008)
Cell Metab.
, vol.7
, pp. 95-96
-
-
Brown, M.S.1
Goldstein, J.L.2
-
12
-
-
0034059075
-
Nuclear lamin A/C R482Q mutation in Canadian kindreds with Dunnigan-type familial partial lipodystrophy
-
Cao, H. and Hegele, R. A. (2000). Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy. Hum. Mol. Genet. 9, 109-112. (Pubitemid 30145295)
-
(2000)
Human Molecular Genetics
, vol.9
, Issue.1
, pp. 109-112
-
-
Cao, H.1
Hegele, R.A.2
-
13
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
-
Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q., Crenshaw, E. B., 3rd, Kaestner, K. H., Bartolomei, M. S., Shulman, G. I. and Birnbaum, M. J. (2001). Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 292, 1728-1731.
-
(2001)
Science
, vol.292
, pp. 1728-1731
-
-
Cho, H.1
Mu, J.2
Kim, J.K.3
Thorvaldsen, J.L.4
Chu, Q.5
Crenshaw III, E.B.6
Kaestner, K.H.7
Bartolomei, M.S.8
Shulman, G.I.9
Birnbaum, M.J.10
-
14
-
-
0036724616
-
Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy
-
Colombo, C., Cutson, J. J., Yamauchi, T., Vinson, C., Kadowaki, T., Gavrilova, O. and Reitman, M. L. (2002). Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy. Diabetes 51, 2727-2733. (Pubitemid 34970925)
-
(2002)
Diabetes
, vol.51
, Issue.9
, pp. 2727-2733
-
-
Colombo, C.1
Cutson, J.J.2
Yamauchi, T.3
Vinson, C.4
Kadowaki, T.5
Gavrilova, O.6
Reitman, M.L.7
-
15
-
-
58749091644
-
Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy
-
Cortes, V. A., Curtis, D. E., Sukumaran, S., Shao, X., Parameswara, V., Rashid, S., Smith, A. R., Ren, J., Esser, V., Hammer, R. E. et al. (2009). Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy. Cell Metab. 9, 165-176.
-
(2009)
Cell Metab.
, vol.9
, pp. 165-176
-
-
Cortes, V.A.1
Curtis, D.E.2
Sukumaran, S.3
Shao, X.4
Parameswara, V.5
Rashid, S.6
Smith, A.R.7
Ren, J.8
Esser, V.9
Hammer, R.E.10
-
16
-
-
0036290274
-
Characterization of adiposity and metabolism in Lmna-deficient mice
-
DOI 10.1006/bbrc.2002.6466
-
Cutler, D. A., Sullivan, T., Marcus-Samuels, B., Stewart, C. L. and Reitman, M. L. (2002). Characterization of adiposity and metabolism in Lmna-deficient mice. Biochem. Biophys. Res. Commun. 291, 522-527. (Pubitemid 34687375)
-
(2002)
Biochemical and Biophysical Research Communications
, vol.291
, Issue.3
, pp. 522-527
-
-
Cutler, D.A.1
Sullivan, T.2
Marcus-Samuels, B.3
Stewart, C.L.4
Reitman, M.L.5
-
17
-
-
64349105205
-
Identification and importance of brown adipose tissue in adult humans
-
Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y. H., Doria, A. et al. (2009). Identification and importance of brown adipose tissue in adult humans. N. Engl. J. Med. 360, 1509-1517.
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 1509-1517
-
-
Cypess, A.M.1
Lehman, S.2
Williams, G.3
Tal, I.4
Rodman, D.5
Goldfine, A.B.6
Kuo, F.C.7
Palmer, E.L.8
Tseng, Y.H.9
Doria, A.10
-
18
-
-
0033817811
-
Failure of adipocyte differentiation causes type II diabetes mellitus?
-
Danforth, E., Jr (2000). Failure of adipocyte differentiation causes type II diabetes mellitus? Nat. Genet. 26, 13.
-
(2000)
Nat. Genet.
, vol.26
, pp. 13
-
-
Danforth Jr., E.1
-
19
-
-
18244382304
-
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
-
DOI 10.1172/JCI200523621
-
Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D. and Parks, E. J. (2005). Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J. Clin. Invest. 115, 1343-1351. (Pubitemid 40629054)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.5
, pp. 1343-1351
-
-
Donnelly, K.L.1
Smith, C.I.2
Schwarzenberg, S.J.3
Jessurun, J.4
Boldt, M.D.5
Parks, E.J.6
-
20
-
-
33847350685
-
Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality
-
Duan, S. Z., Ivashchenko, C. Y., Whitesall, S. E., D'Alecy, L. G., Duquaine, D. C., Brosius, F. C., 3rd, Gonzalez, F. J., Vinson, C., Pierre, M. A., Milstone, D. S. et al. (2007). Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality. J. Clin. Invest. 117, 812-822.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 812-822
-
-
Duan, S.Z.1
Ivashchenko, C.Y.2
Whitesall, S.E.3
D'Alecy, L.G.4
Duquaine, D.C.5
Brosius III, F.C.6
Gonzalez, F.J.7
Vinson, C.8
Pierre, M.A.9
Milstone, D.S.10
-
21
-
-
39049151385
-
Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast
-
DOI 10.1083/jcb.200711136
-
Fei, W., Shui, G., Gaeta, B., Du, X., Kuerschner, L., Li, P., Brown, A. J., Wenk, M. R., Parton, R. G. and Yang, H. (2008). Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast. J. Cell Biol. 180, 473-482. (Pubitemid 351240697)
-
(2008)
Journal of Cell Biology
, vol.180
, Issue.3
, pp. 473-482
-
-
Fei, W.1
Shui, G.2
Gaeta, B.3
Du, X.4
Kuerschner, L.5
Li, P.6
Brown, A.J.7
Wenk, M.R.8
Parton, R.G.9
Yang, H.10
-
22
-
-
58749091645
-
UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
-
Feldmann, H. M., Golozoubova, V., Cannon, B. and Nedergaard, J. (2009). UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 9, 203-209.
-
(2009)
Cell Metab.
, vol.9
, pp. 203-209
-
-
Feldmann, H.M.1
Golozoubova, V.2
Cannon, B.3
Nedergaard, J.4
-
23
-
-
0036381998
-
Adipose tissue as a buffer for daily lipid flux
-
Frayn, K. N. (2002). Adipose tissue as a buffer for daily lipid flux. Diabetologia 45, 1201-1210.
-
(2002)
Diabetologia
, vol.45
, pp. 1201-1210
-
-
Frayn, K.N.1
-
24
-
-
0034455698
-
Gender differences in the prevalence of metabolic complications in familial partial lipodystrophy (Dunnigan variety)
-
Garg, A. (2000). Gender differences in the prevalence of metabolic complications in familial partial lipodystrophy (Dunnigan variety). J. Clin. Endocrinol. Metab. 85, 1776-1782.
-
(2000)
J. Clin. Endocrinol. Metab.
, vol.85
, pp. 1776-1782
-
-
Garg, A.1
-
25
-
-
1542510700
-
Acquired and inherited lipodystrophies
-
Garg, A. (2004). Acquired and inherited lipodystrophies. N. Engl. J. Med. 350, 1220-1234.
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 1220-1234
-
-
Garg, A.1
-
26
-
-
0026767508
-
Peculiar distribution of adipose tissue in patients with congenital generalized lipodystrophy
-
Garg, A., Fleckenstein, J. L., Peshock, R. M. and Grundy, S. M. (1992). Peculiar distribution of adipose tissue in patients with congenital generalized lipodystrophy. J. Clin. Endocrinol. Metab. 75, 358-361.
-
(1992)
J. Clin. Endocrinol. Metab.
, vol.75
, pp. 358-361
-
-
Garg, A.1
Fleckenstein, J.L.2
Peshock, R.M.3
Grundy, S.M.4
-
27
-
-
85047693348
-
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta
-
DOI 10.1172/JCI200316885
-
Garofalo, R. S., Orena, S. J., Rafidi, K., Torchia, A. J., Stock, J. L., Hildebrandt, A. L., Coskran, T., Black, S. C., Brees, D. J., Wicks, J. R. et al. (2003). Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. J. Clin. Invest. 112, 197-208. (Pubitemid 38056356)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.2
, pp. 197-208
-
-
Garofalo, R.S.1
Orena, S.J.2
Rafidi, K.3
Torchia, A.J.4
Stock, J.L.5
Hildebrandt, A.L.6
Coskran, T.7
Black, S.C.8
Brees, D.J.9
Wicks, J.R.10
McNeish, J.D.11
Coleman, K.G.12
-
28
-
-
0033965557
-
Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice
-
Gavrilova, O., Marcus-Samuels, B., Graham, D., Kim, J. K., Shulman, G. I., Castle, A. L., Vinson, C., Eckhaus, M. and Reitman, M. L. (2000). Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. J. Clin. Invest. 105, 271-278. (Pubitemid 30094446)
-
(2000)
Journal of Clinical Investigation
, vol.105
, Issue.3
, pp. 271-278
-
-
Gavrilova, O.1
Marcus-Samuels, B.2
Graham, D.3
Kim, J.K.4
Shulman, G.I.5
Castle, A.L.6
Vinson, C.7
Eckhaus, M.8
Reitman, M.L.9
-
29
-
-
0141446024
-
Liver Peroxisome Proliferator-activated Receptor gamma Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass
-
DOI 10.1074/jbc.M300043200
-
Gavrilova, O., Haluzik, M., Matsusue, K., Cutson, J. J., Johnson, L., Dietz, K. R., Nicol, C. J., Vinson, C., Gonzalez, F. J. and Reitman, M. L. (2003). Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J. Biol. Chem. 278, 34268-34276. (Pubitemid 37553270)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.36
, pp. 34268-34276
-
-
Gavrilova, O.1
Haluzik, M.2
Matsusue, K.3
Cutson, J.J.4
Johnson, L.5
Dietz, K.R.6
Nicol, C.J.7
Vinson, C.8
Gonzalez, F.J.9
Reitman, M.L.10
-
30
-
-
2542528670
-
A family with severe insulin resistance and diabetes due to a mutation in AKT2
-
DOI 10.1126/science.1096706
-
George, S., Rochford, J. J., Wolfrum, C., Gray, S. L., Schinner, S., Wilson, J. C., Soos, M. A., Murgatroyd, P. R., Williams, R. M., Acerini, C. L. et al. (2004). A family with severe insulin resistance and diabetes due to a mutation in AKT2. Science 304, 1325-1328. (Pubitemid 38697429)
-
(2004)
Science
, vol.304
, Issue.5675
, pp. 1325-1328
-
-
George, S.1
Rochford, J.J.2
Wolfrum, C.3
Gray, S.L.4
Schinner, S.5
Wilson, J.C.6
Soos, M.A.7
Murgatroyd, P.R.8
Williams, R.M.9
Acerini, C.L.10
Dunger, D.B.11
Barford, D.12
Umpleby, A.M.13
Wareham, N.J.14
Davies, H.A.15
Schafer, A.J.16
Stoffel, M.17
O'Rahilly, S.18
Barroso, I.19
-
31
-
-
0033860359
-
Insulin resistance and cardiovascular disease
-
Ginsberg, H. N. (2000). Insulin resistance and cardiovascular disease. J. Clin. Invest. 106, 453-458.
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 453-458
-
-
Ginsberg, H.N.1
-
32
-
-
27844491139
-
Mouse models of PPAR-gamma deficiency: Dissecting PPAR-gamma's role in metabolic homoeostasis
-
DOI 10.1042/BST20051053
-
Gray, S. L., Dalla Nora, E. and Vidal-Puig, A. J. (2005). Mouse models of PPAR-gamma deficiency: dissecting PPAR-gamma's role in metabolic homoeostasis. Biochem. Soc. Trans. 33, 1053-1058. (Pubitemid 41659112)
-
(2005)
Biochemical Society Transactions
, vol.33
, Issue.5
, pp. 1053-1058
-
-
Gray, S.L.1
Dalla Nora, E.2
Vidal-Puig, A.J.3
-
33
-
-
33750856072
-
Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor gamma function (P465L PPARgamma) in mice
-
DOI 10.2337/db06-0389
-
Gray, S. L., Nora, E. D., Grosse, J., Manieri, M., Stoeger, T., Medina-Gomez, G., Burling, K., Wattler, S., Russ, A., Yeo, G. S. et al. (2006). Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor gamma function (P465L PPARgamma) in mice. Diabetes 55, 2669-2677. (Pubitemid 44923664)
-
(2006)
Diabetes
, vol.55
, Issue.10
, pp. 2669-2677
-
-
Gray, S.L.1
Dalla Nora, E.2
Grosse, J.3
Manieri, M.4
Stoeger, T.5
Medina-Gomez, G.6
Burling, K.7
Wattler, S.8
Russ, A.9
Yeo, G.S.H.10
Chatterjee, V.K.11
O'Rahilly, S.12
Voshol, P.J.13
Cinti, S.14
Vidal-Puig, A.15
-
34
-
-
0031028991
-
Dunnigan-Kobberling syndrome: An autosomal dominant form of partial lipodystrophy
-
Jackson, S. N., Howlett, T. A., McNally, P. G., O'Rahilly, S. and Trembath, R. C. (1997). Dunnigan-Kobberling syndrome: an autosomal dominant form of partial lipodystrophy. QJM 90, 27-36. (Pubitemid 27075849)
-
(1997)
QJM - Monthly Journal of the Association of Physicians
, vol.90
, Issue.1
, pp. 27-36
-
-
Jackson, S.N.J.1
Howlett, T.A.2
Mcnally, P.G.3
O'Rahilly, S.4
Trembath, R.C.5
-
36
-
-
41549146084
-
Association of a homozygous nonsense caveolin-1 mutation with berardinelli-seip congenital lipodystrophy
-
DOI 10.1210/jc.2007-1328
-
Kim, C. A., Delepine, M., Boutet, E., El Mourabit, H., Le Lay, S., Meier, M., Nemani, M., Bridel, E., Leite, C. C., Bertola, D. R. et al. (2008). Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy. J. Clin. Endocrinol. Metab. 93, 1129-1134. (Pubitemid 351540679)
-
(2008)
Journal of Clinical Endocrinology and Metabolism
, vol.93
, Issue.4
, pp. 1129-1134
-
-
Kim, C.A.1
Delepine, M.2
Boutet, E.3
El Mourabit, H.4
Le Lay, S.5
Meier, M.6
Nemani, M.7
Bridel, E.8
Leite, C.C.9
Bertola, D.R.10
Semple, R.K.11
O'Rahilly, S.12
Dugail, I.13
Capeau, J.14
Lathrop, M.15
Magre, J.16
-
37
-
-
1542299096
-
HIV-associated lipodystrophy: Pathogenesis, prognosis, treatment, and controversies
-
DOI 10.1146/annurev.med.55.091902.104412
-
Koutkia, P. and Grinspoon, S. (2004). HIV-associated lipodystrophy: pathogenesis, prognosis, treatment, and controversies. Annu. Rev. Med. 55, 303-317. (Pubitemid 38316729)
-
(2004)
Annual Review of Medicine
, vol.55
, pp. 303-317
-
-
Koutkia, P.1
Grinspoon, S.2
-
39
-
-
0035940360
-
C/EBPalpha is required for differentiation of white but not brown adipose tissue
-
DOI 10.1073/pnas.211416898
-
Linhart, H. G., Ishimura-Oka, K., DeMayo, F., Kibe, T., Repka, D., Poindexter, B., Bick, R. J. and Darlington, G. J. (2001). C/EBPalpha is required for differentiation of white, but not brown, adipose tissue. Proc. Natl. Acad. Sci. USA 98, 12532-12537. (Pubitemid 33019980)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.22
, pp. 12532-12537
-
-
Linhart, H.G.1
Ishimura-Oka, K.2
Demayo, F.3
Kibe, T.4
Repka, D.5
Poindexter, B.6
Bick, R.J.7
Darlington, G.J.8
-
40
-
-
0034941121
-
Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13
-
DOI 10.1038/ng585
-
Magre, J., Delepine, M., Khallouf, E., Gedde-Dahl, T., Jr, Van Maldergem, L., Sobel, E., Papp, J., Meier, M., Megarbane, A., Bachy, A. et al. (2001). Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13. Nat. Genet. 28, 365-370. (Pubitemid 32702427)
-
(2001)
Nature Genetics
, vol.28
, Issue.4
, pp. 365-370
-
-
Magre, J.1
Delepine, M.2
Khallouf, E.3
Gedde-Dahl Jr., T.4
Van Maldergem, L.5
Sobel, E.6
Papp, J.7
Meier, M.8
Megarbane, A.9
Bachy, A.10
Verloes, A.11
D'Abronzo, F.H.12
Seemanova, E.13
Assan, R.14
Baudic, N.15
Bourut, C.16
Czernichow, P.17
Huet, F.18
Grigorescu, F.19
De Kerdanet, M.20
Lacombe, D.21
Labrune, P.22
Lanza, M.23
Loret, H.24
Matsuda, F.25
Navarro, J.26
Nivelon-Chevalier, A.27
Polak, M.28
Robert, J.J.29
Tric, P.30
Tubiana-Rufi, N.31
Vigouroux, C.32
Weissenbach, J.33
Savasta, S.34
Maassen, J.A.35
Trygstad, O.36
Bogalho, P.37
Freitas, P.38
Medina, J.L.39
Bonnicci, F.40
Joffe, B.I.41
Loyson, G.42
Panz, V.R.43
Raal, F.J.44
O'Rahilly, S.45
Stephenson, T.46
Kahn, C.R.47
Lathrop, M.48
Capeau, J.49
more..
-
41
-
-
34247636362
-
PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism
-
DOI 10.1371/journal.pgen.0030064
-
Medina-Gomez, G., Gray, S. L., Yetukuri, L., Shimomura, K., Virtue, S., Campbell, M., Curtis, R. K., Jimenez-Linan, M., Blount, M., Yeo, G. S. et al. (2007). PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genet. 3, e64. (Pubitemid 46683479)
-
(2007)
PLoS Genetics
, vol.3
, Issue.4
, pp. 634-647
-
-
Medina-Gomez, G.1
Gray, S.L.2
Yetukuri, L.3
Shimomura, K.4
Virtue, S.5
Campbell, M.6
Curtis, R.K.7
Jimenez-Linan, M.8
Blount, M.9
Yeo, G.S.H.10
Lopez, M.11
Seppanen-Laakso, T.12
Ashcroft, F.M.13
Oresic, M.14
Vidal-Puig, A.15
-
42
-
-
66549103618
-
Clinical and translational implications of the caveolin gene family: Lessons from mouse models and human genetic disorders
-
Mercier, I., Jasmin, J. F., Pavlides, S., Minetti, C., Flomenberg, N., Pestell, R. G., Frank, P. G., Sotgia, F. and Lisanti, M. P. (2009). Clinical and translational implications of the caveolin gene family: lessons from mouse models and human genetic disorders. Lab. Invest. 89, 614-623.
-
(2009)
Lab. Invest.
, vol.89
, pp. 614-623
-
-
Mercier, I.1
Jasmin, J.F.2
Pavlides, S.3
Minetti, C.4
Flomenberg, N.5
Pestell, R.G.6
Frank, P.G.7
Sotgia, F.8
Lisanti, M.P.9
-
43
-
-
0037339129
-
Clinical features and metabolic derangements in acquired generalized lipodystrophy case reports and review of the literature
-
DOI 10.1097/00005792-200303000-00007
-
Misra, A. and Garg, A. (2003). Clinical features and metabolic derangements in acquired generalized lipodystrophy: case reports and review of the literature. Medicine (Baltimore) 82, 129-146. (Pubitemid 36331644)
-
(2003)
Medicine
, vol.82
, Issue.2
, pp. 129-146
-
-
Misra, A.1
Garg, A.2
-
44
-
-
1542642958
-
Clinical Features and Metabolic and Autoimmune Derangements in Acquired Partial Lipodystrophy: Report of 35 Cases and Review of the Literature
-
DOI 10.1097/01.md.0000111061.69212.59
-
Misra, A., Peethambaram, A. and Garg, A. (2004). Clinical features and metabolic and autoimmune derangements in acquired partial lipodystrophy: report of 35 cases and review of the literature. Medicine (Baltimore) 83, 18-34. (Pubitemid 38124853)
-
(2004)
Medicine
, vol.83
, Issue.1
, pp. 18-34
-
-
Misra, A.1
Peethambaram, A.2
Garg, A.3
-
45
-
-
0032532753
-
Life without white fat: A transgenic mouse
-
Moitra, J., Mason, M. M., Olive, M., Krylov, D., Gavrilova, O., Marcus-Samuels, B., Feigenbaum, L., Lee, E., Aoyama, T., Eckhaus, M. et al. (1998). Life without white fat: a transgenic mouse. Genes Dev. 12, 3168-3181. (Pubitemid 28496262)
-
(1998)
Genes and Development
, vol.12
, Issue.20
, pp. 3168-3181
-
-
Moitra, J.1
Mason, M.M.2
Olive, M.3
Krylov, D.4
Gavrilova, O.5
Marcus-Samuels, B.6
Feigenbaum, L.7
Lee, E.8
Aoyama, T.9
Eckhaus, M.10
Reitman, M.L.11
Vinson, C.12
-
46
-
-
0037148928
-
Leptin-replacement therapy for lipodystrophy
-
Oral, E. A., Simha, V., Ruiz, E., Andewelt, A., Premkumar, A., Snell, P., Wagner, A. J., DePaoli, A. M., Reitman, M. L., Taylor, S. I. et al. (2002). Leptin-replacement therapy for lipodystrophy. N. Engl. J. Med. 346, 570-578.
-
(2002)
N. Engl. J. Med.
, vol.346
, pp. 570-578
-
-
Oral, E.A.1
Simha, V.2
Ruiz, E.3
Andewelt, A.4
Premkumar, A.5
Snell, P.6
Wagner, A.J.7
DePaoli, A.M.8
Reitman, M.L.9
Taylor, S.I.10
-
47
-
-
22544456545
-
Fat apoptosis through targeted activation of caspase 8: A new mouse model of inducible and reversible lipoatrophy
-
DOI 10.1038/nm1262
-
Pajvani, U. B., Trujillo, M. E., Combs, T. P., Iyengar, P., Jelicks, L., Roth, K. A., Kitsis, R. N. and Scherer, P. E. (2005). Fat apoptosis through targeted activation of caspase 8, a new mouse model of inducible and reversible lipoatrophy. Nat. Med. 11, 797-803. (Pubitemid 41021214)
-
(2005)
Nature Medicine
, vol.11
, Issue.7
, pp. 797-803
-
-
Pajvani, U.B.1
Trujillo, M.E.2
Combs, T.P.3
Iyengar, P.4
Jelicks, L.5
Roth, K.A.6
Kitsis, R.N.7
Scherer, P.E.8
-
48
-
-
0031732754
-
Leptin levels, beta-cell function, and insulin sensitivity in families with congenital and acquired generalized lipoatropic diabetes
-
DOI 10.1210/jc.83.2.503
-
Pardini, V. C., Victoria, I. M., Rocha, S. M., Andrade, D. G., Rocha, A. M., Pieroni, F. B., Milagres, G., Purisch, S. and Velho, G. (1998). Leptin levels, beta-cell function, and insulin sensitivity in families with congenital and acquired generalized lipoatropic diabetes. J. Clin. Endocrinol. Metab. 83, 503-508. (Pubitemid 28496530)
-
(1998)
Journal of Clinical Endocrinology and Metabolism
, vol.83
, Issue.2
, pp. 503-508
-
-
Pardini, V.C.1
Victoria, I.M.N.2
Rocha, S.M.V.3
Andrade, D.G.4
Rocha, A.M.5
Pieroni, F.B.6
Milagres, G.7
Purisch, S.8
Velho, G.9
-
49
-
-
50949112676
-
The human lipodystrophy gene BSCL2/seipin may be essential for normal adipocyte differentiation
-
Payne, V. A., Grimsey, N., Tuthill, A., Virtue, S., Gray, S. L., Nora, E. D., Semple, R. K., O'Rahilly, S. and Rochford, J. J. (2008). The human lipodystrophy gene BSCL2/seipin may be essential for normal adipocyte differentiation. Diabetes 57, 2055-2060.
-
(2008)
Diabetes
, vol.57
, pp. 2055-2060
-
-
Payne, V.A.1
Grimsey, N.2
Tuthill, A.3
Virtue, S.4
Gray, S.L.5
Nora, E.D.6
Semple, R.K.7
O'Rahilly, S.8
Rochford, J.J.9
-
50
-
-
0037026745
-
Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus
-
Petersen, K. F. and Shulman, G. I. (2002). Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus. Am. J. Cardiol. 90, 11G-18G.
-
(2002)
Am. J. Cardiol.
, vol.90
-
-
Petersen, K.F.1
Shulman, G.I.2
-
51
-
-
53849106114
-
Glucolipotoxicity of the pancreatic beta-cell: Myth or reality?
-
Poitout, V. (2008). Glucolipotoxicity of the pancreatic beta-cell: myth or reality? Biochem. Soc. Trans. 36, 901-904.
-
(2008)
Biochem. Soc. Trans.
, vol.36
, pp. 901-904
-
-
Poitout, V.1
-
52
-
-
33748296316
-
The laminopathies: A clinical review
-
Rankin, J. and Ellard, S. (2006). The laminopathies: a clinical review. Clin. Genet. 70, 261-274.
-
(2006)
Clin. Genet.
, vol.70
, pp. 261-274
-
-
Rankin, J.1
Ellard, S.2
-
53
-
-
0035851197
-
Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities
-
Razani, B., Engelman, J. A., Wang, X. B., Schubert, W., Zhang, X. L., Marks, C. B., Macaluso, F., Russell, R. G., Li, M., Pestell, R. G. et al. (2001). Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J. Biol. Chem. 276, 38121-38138. (Pubitemid 37384066)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.41
, pp. 38121-38138
-
-
Razani, B.1
Engelman, J.A.2
Wang, X.B.3
Schubert, W.4
Zhang, X.L.5
Marks, C.B.6
Macalusol, F.7
Russell, R.G.8
Li, M.9
Pestell, R.G.10
Di Vizio, D.11
Hou Jr., H.12
Kneitz, B.13
Lagaud, G.14
Christ, G.J.15
Edelmann, W.16
Lisanti, M.P.17
-
54
-
-
0037040994
-
Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities
-
DOI 10.1074/jbc.M110970200
-
Razani, B., Combs, T. P., Wang, X. B., Frank, P. G., Park, D. S., Russell, R. G., Li, M., Tang, B., Jelicks, L. A., Scherer, P. E. et al. (2002). Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities. J. Biol. Chem. 277, 8635-8647. (Pubitemid 34968330)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.10
, pp. 8635-8647
-
-
Razani, B.1
Combs, T.P.2
Wang, X.B.3
Frank, P.G.4
Park, D.S.5
Russell, R.G.6
Li, M.7
Tang, B.8
Jelicks, L.A.9
Scherer, P.E.10
Lisanti, M.P.11
-
55
-
-
0036402110
-
Metabolic lessons from genetically lean mice
-
Reitman, M. L. (2002). Metabolic lessons from genetically lean mice. Annu. Rev. Nutr. 22, 459-482.
-
(2002)
Annu. Rev. Nutr.
, vol.22
, pp. 459-482
-
-
Reitman, M.L.1
-
56
-
-
0033711146
-
A-ZIP/F-1 mice lacking white fat: A model for understanding lipoatrophic diabetes
-
Reitman, M. L. and Gavrilova, O. (2000). A-ZIP/F-1 mice lacking white fat: a model for understanding lipoatrophic diabetes. Int. J. Obes. Relat. Metab. Disord. 24 Suppl. 4, S11-S14.
-
(2000)
Int. J. Obes. Relat. Metab. Disord.
, vol.24
, Issue.SUPPL. 4
-
-
Reitman, M.L.1
Gavrilova, O.2
-
57
-
-
33746253894
-
Metabolic consequences of lipodystrophy in mouse models
-
DOI 10.1097/01.mco.0000232904.82038.db, PII 0007519720060700000015
-
Reue, K. and Phan, J. (2006). Metabolic consequences of lipodystrophy in mouse models. Curr. Opin. Clin. Nutr. Metab. Care 9, 436-441. (Pubitemid 44097814)
-
(2006)
Current Opinion in Clinical Nutrition and Metabolic Care
, vol.9
, Issue.4
, pp. 436-441
-
-
Reue, K.1
Phan, J.2
-
58
-
-
53549134683
-
Identification of white adipocyte progenitor cells in vivo
-
Rodeheffer, M. S., Birsoy, K. and Friedman, J. M. (2008). Identification of white adipocyte progenitor cells in vivo. Cell 135, 240-249.
-
(2008)
Cell
, vol.135
, pp. 240-249
-
-
Rodeheffer, M.S.1
Birsoy, K.2
Friedman, J.M.3
-
59
-
-
0033213631
-
PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro
-
DOI 10.1016/S1097-2765(00)80211-7
-
Rosen, E. D., Sarraf, P., Troy, A. E., Bradwin, G., Moore, K., Milstone, D. S., Spiegelman, B. M. and Mortensen, R. M. (1999). PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol. Cell 4, 611-617. (Pubitemid 29531140)
-
(1999)
Molecular Cell
, vol.4
, Issue.4
, pp. 611-617
-
-
Rosen, E.D.1
Sarraf, P.2
Troy, A.E.3
Bradwin, G.4
Moore, K.5
Milstone, D.S.6
Spiegelman, B.M.7
Mortensen, R.M.8
-
60
-
-
0027268308
-
Targeted expression of a toxin gene to adipose tissue: Transgenic mice resistant to obesity
-
Ross, S. R., Graves, R. A. and Spiegelman, B. M. (1993). Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity. Genes Dev. 7, 1318-1324. (Pubitemid 23210881)
-
(1993)
Genes and Development
, vol.7
, Issue.7 B
, pp. 1318-1324
-
-
Ross, S.R.1
Graves, R.A.2
Spiegelman, B.M.3
-
61
-
-
0344375097
-
Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma
-
DOI 10.2337/diabetes.52.4.910
-
Savage, D. B., Tan, G. D., Acerini, C. L., Jebb, S. A., Agostini, M., Gurnell, M., Williams, R. L., Umpleby, A. M., Thomas, E. L., Bell, J. D. et al. (2003). Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma. Diabetes 52, 910-917. (Pubitemid 36384259)
-
(2003)
Diabetes
, vol.52
, Issue.4
, pp. 910-917
-
-
Savage, D.B.1
Tan, G.D.2
Acerini, C.L.3
Jebb, S.A.4
Agostini, M.5
Gurnell, M.6
Williams, R.L.7
Umpleby, A.M.8
Thomas, E.L.9
Bell, J.D.10
Dixon, A.K.11
Dunne, F.12
Boiani, R.13
Cinti, S.14
Vidal-Puig, A.15
Karpe, F.16
Chatterjee, V.K.V.17
O'Rahilly, S.18
-
62
-
-
34248581989
-
Disordered lipid metabolism and the pathogenesis of insulin resistance
-
DOI 10.1152/physrev.00024.2006
-
Savage, D. B., Petersen, K. F. and Shulman, G. I. (2007). Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol. Rev. 87, 507-520. (Pubitemid 47084679)
-
(2007)
Physiological Reviews
, vol.87
, Issue.2
, pp. 507-520
-
-
Savage, D.B.1
Petersen, K.F.2
Shulman, G.I.3
-
63
-
-
0029895842
-
Generalized lipodystrophy, congenital and acquired (lipoatrophy)
-
Seip, M. and Trygstad, O. (1996). Generalized lipodystrophy, congenital and acquired (lipoatrophy). Acta Paediatr. Suppl. 413, 2-28. (Pubitemid 26189575)
-
(1996)
Acta Paediatrica, International Journal of Paediatrics, Supplement
, vol.85
, Issue.413
, pp. 2-28
-
-
Seip, M.1
Trygstad, O.2
-
64
-
-
33644644599
-
PPAR gamma and human metabolic disease
-
DOI 10.1172/JCI28003
-
Semple, R. K., Chatterjee, V. K. and O'Rahilly, S. (2006). PPAR gamma and human metabolic disease. J. Clin. Invest. 116, 581-589. (Pubitemid 43326862)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.3
, pp. 581-589
-
-
Semple, R.K.1
Chatterjee, V.K.K.2
O'Rahilly, S.3
-
65
-
-
61749100743
-
Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis
-
Semple, R. K., Sleigh, A., Murgatroyd, P. R., Adams, C. A., Bluck, L., Jackson, S., Vottero, A., Kanabar, D., Charlton-Menys, V., Durrington, P. et al. (2009). Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis. J. Clin. Invest. 119, 315-322.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 315-322
-
-
Semple, R.K.1
Sleigh, A.2
Murgatroyd, P.R.3
Adams, C.A.4
Bluck, L.5
Jackson, S.6
Vottero, A.7
Kanabar, D.8
Charlton-Menys, V.9
Durrington, P.10
-
66
-
-
0033951216
-
LMNA, encoding lamin A/C, is mutated in partial lipodystrophy
-
DOI 10.1038/72807
-
Shackleton, S., Lloyd, D. J., Jackson, S. N., Evans, R., Niermeijer, M. F., Singh, B. M., Schmidt, H., Brabant, G., Kumar, S., Durrington, P. N. et al. (2000). LMNA, encoding lamin A/C, is mutated in partial lipodystrophy. Nat. Genet. 24, 153-156. (Pubitemid 30094715)
-
(2000)
Nature Genetics
, vol.24
, Issue.2
, pp. 153-156
-
-
Shackleton, S.1
Lloyd, D.J.2
Jackson, S.N.J.3
Evans, R.4
Niermeijer, M.F.5
Singh, B.M.6
Schmidt, H.7
Brabant, G.8
Kumar, S.9
Durrington, P.N.10
Gregory, S.11
O'Rahilly, S.12
Trembath, R.C.13
-
67
-
-
0032532152
-
Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: Model for congenital generalized lipodystrophy
-
Shimomura, I., Hammer, R. E., Richardson, J. A., Ikemoto, S., Bashmakov, Y., Goldstein, J. L. and Brown, M. S. (1998). Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev. 12, 3182-3194. (Pubitemid 28496263)
-
(1998)
Genes and Development
, vol.12
, Issue.20
, pp. 3182-3194
-
-
Shimomura, I.1
Hammer, R.E.2
Richardson, J.A.3
Ikemoto, S.4
Bashmakov, Y.5
Goldstein, J.L.6
Brown, M.S.7
-
68
-
-
0033517284
-
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
-
DOI 10.1038/43448
-
Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S. and Goldstein, J. L. (1999). Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 401, 73-76. (Pubitemid 29418444)
-
(1999)
Nature
, vol.401
, Issue.6748
, pp. 73-76
-
-
Shimomura, I.1
Hammer, R.E.2
Ikemoto, S.3
Brown, M.S.4
Goldstein, J.L.5
-
69
-
-
0033636780
-
Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
-
Shimomura, I., Matsuda, M., Hammer, R. E., Bashmakov, Y., Brown, M. S. and Goldstein, J. L. (2000). Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol. Cell 6, 77-86.
-
(2000)
Mol. Cell
, vol.6
, pp. 77-86
-
-
Shimomura, I.1
Matsuda, M.2
Hammer, R.E.3
Bashmakov, Y.4
Brown, M.S.5
Goldstein, J.L.6
-
70
-
-
0033927667
-
Cellular mechanisms of insulin resistance
-
Shulman, G. I. (2000). Cellular mechanisms of insulin resistance. J. Clin. Invest. 106, 171-176.
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 171-176
-
-
Shulman, G.I.1
-
71
-
-
0344442411
-
Phenotypic Heterogeneity in Body Fat Distribution in Patients with Congenital Generalized Lipodystrophy Caused by Mutations in the AGPAT2 or Seipin Genes
-
DOI 10.1210/jc.2003-030835
-
Simha, V. and Garg, A. (2003). Phenotypic heterogeneity in body fat distribution in patients with congenital generalized lipodystrophy caused by mutations in the AGPAT2 or seipin genes. J. Clin. Endocrinol. Metab. 88, 5433-5437. (Pubitemid 37452750)
-
(2003)
Journal of Clinical Endocrinology and Metabolism
, vol.88
, Issue.11
, pp. 5433-5437
-
-
Simha, V.1
Garg, A.2
-
72
-
-
0035936764
-
Obesity and the regulation of energy balance
-
Spiegelman, B. M. and Flier, J. S. (2001). Obesity and the regulation of energy balance. Cell 104, 531-543.
-
(2001)
Cell
, vol.104
, pp. 531-543
-
-
Spiegelman, B.M.1
Flier, J.S.2
-
73
-
-
0033615969
-
Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy
-
Sullivan, T., Escalante-Alcalde, D., Bhatt, H., Anver, M., Bhat, N., Nagashima, K., Stewart, C. L. and Burke, B. (1999). Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy. J. Cell Biol. 147, 913-920.
-
(1999)
J. Cell Biol.
, vol.147
, pp. 913-920
-
-
Sullivan, T.1
Escalante-Alcalde, D.2
Bhatt, H.3
Anver, M.4
Bhat, N.5
Nagashima, K.6
Stewart, C.L.7
Burke, B.8
-
74
-
-
38049184643
-
The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology
-
Szymanski, K. M., Binns, D., Bartz, R., Grishin, N. V., Li, W. P., Agarwal, A. K., Garg, A., Anderson, R. G. and Goodman, J. M. (2007). The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology. Proc. Natl. Acad. Sci. USA 104, 20890-20895.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 20890-20895
-
-
Szymanski, K.M.1
Binns, D.2
Bartz, R.3
Grishin, N.V.4
Li, W.P.5
Agarwal, A.K.6
Garg, A.7
Anderson, R.G.8
Goodman, J.M.9
-
75
-
-
57349113235
-
Fatty acid metabolism in patients with PPARgamma mutations
-
DOI 10.1210/jc.2007-2356
-
Tan, G. D., Savage, D. B., Fielding, B. A., Collins, J., Hodson, L., Humphreys, S. M., O'Rahilly, S., Chatterjee, K., Frayn, K. N. and Karpe, F. (2008). Fatty acid metabolism in patients with PPARgamma mutations. J. Clin. Endocrinol. Metab. 93, 4462-4470. (Pubitemid 352789548)
-
(2008)
Journal of Clinical Endocrinology and Metabolism
, vol.93
, Issue.11
, pp. 4462-4470
-
-
Tan, G.D.1
Savage, D.B.2
Fielding, B.A.3
Collins, J.4
Hodson, L.5
Humphreys, S.M.6
O'Rahilly, S.7
Chatterjee, K.8
Frayn, K.N.9
Karpe, F.10
-
76
-
-
14344268795
-
Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity
-
DOI 10.1073/pnas.101042998
-
Tansey, J. T., Sztalryd, C., Gruia-Gray, J., Roush, D. L., Zee, J. V., Gavrilova, O., Reitman, M. L., Deng, C. X., Li, C., Kimmel, A. R. et al. (2001). Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc. Natl. Acad. Sci. USA 98, 6494-6499. (Pubitemid 32488265)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.11
, pp. 6494-6499
-
-
Tansey, J.T.1
Sztalryd, C.2
Gruia-Gray, J.3
Roush, D.L.4
Zee, J.V.5
Gavrilova, O.6
Reitman, M.L.7
Deng, C.-X.8
Li, C.9
Kimmel, A.R.10
Londos, C.11
-
77
-
-
0026761432
-
Mutations in the insulin receptor gene
-
Taylor, S. I., Cama, A., Accili, D., Barbetti, F., Quon, M. J., de la Luz Sierra, M., Suzuki, Y., Koller, E., Levy-Toledano, R., Wertheimer, E. et al. (1992). Mutations in the insulin receptor gene. Endocr. Rev. 13, 566-595.
-
(1992)
Endocr. Rev.
, vol.13
, pp. 566-595
-
-
Taylor, S.I.1
Cama, A.2
Accili, D.3
Barbetti, F.4
Quon, M.J.5
De La Luz Sierra, M.6
Suzuki, Y.7
Koller, E.8
Levy-Toledano, R.9
Wertheimer, E.10
-
78
-
-
4043151601
-
Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma
-
DOI 10.1172/JCI200420964
-
Tsai, Y. S., Kim, H. J., Takahashi, N., Kim, H. S., Hagaman, J. R., Kim, J. K. and Maeda, N. (2004). Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma. J. Clin. Invest. 114, 240-249. (Pubitemid 39071629)
-
(2004)
Journal of Clinical Investigation
, vol.114
, Issue.2
, pp. 240-249
-
-
Tsai, Y.-S.1
Kim, H.-J.2
Takahashi, N.3
Kim, H.-S.4
Hagaman, J.R.5
Kim, J.K.6
Maeda, N.7
-
79
-
-
64349095231
-
Coldactivated brown adipose tissue in healthy men
-
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M., Kemerink, G. J., Bouvy, N. D., Schrauwen, P. and Teule, G. J. (2009). Coldactivated brown adipose tissue in healthy men. N. Engl. J. Med. 360, 1500-1508.
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 1500-1508
-
-
Van Marken Lichtenbelt, W.D.1
Vanhommerig, J.W.2
Smulders, N.M.3
Drossaerts, J.M.4
Kemerink, G.J.5
Bouvy, N.D.6
Schrauwen, P.7
Teule, G.J.8
-
80
-
-
64349123664
-
Functional brown adipose tissue in healthy adults
-
Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N. J., Enerback, S. et al. (2009). Functional brown adipose tissue in healthy adults. N. Engl. J. Med. 360, 1518-1525.
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 1518-1525
-
-
Virtanen, K.A.1
Lidell, M.E.2
Orava, J.3
Heglind, M.4
Westergren, R.5
Niemi, T.6
Taittonen, M.7
Laine, J.8
Savisto, N.J.9
Enerback, S.10
-
81
-
-
0029160028
-
Impaired energy homeostasis in C/EBP alpha knockout mice
-
Wang, N. D., Finegold, M. J., Bradley, A., Ou, C. N., Abdelsayed, S. V., Wilde, M. D., Taylor, L. R., Wilson, D. R. and Darlington, G. J. (1995). Impaired energy homeostasis in C/EBP alpha knockout mice. Science 269, 1108-1112.
-
(1995)
Science
, vol.269
, pp. 1108-1112
-
-
Wang, N.D.1
Finegold, M.J.2
Bradley, A.3
Ou, C.N.4
Abdelsayed, S.V.5
Wilde, M.D.6
Taylor, L.R.7
Wilson, D.R.8
Darlington, G.J.9
-
82
-
-
67650566605
-
The role of LMNA in adipose: A novel mouse model of lipodystrophy based on the Dunnigan's partial lipodystrophy mutation
-
Wojtanik, K. M., Edgemon, K., Viswanadha, S., Lindsey, B., Haulzik, M., Chen, W., Poy, G., Reitman, M. and Londos, C. (2009). The role of LMNA in adipose: a novel mouse model of lipodystrophy based on the Dunnigan's partial lipodystrophy mutation. J. Lipid Res. 50, 1068-1079.
-
(2009)
J. Lipid Res.
, vol.50
, pp. 1068-1079
-
-
Wojtanik, K.M.1
Edgemon, K.2
Viswanadha, S.3
Lindsey, B.4
Haulzik, M.5
Chen, W.6
Poy, G.7
Reitman, M.8
Londos, C.9
|