The effect and pathophysiological mechanism of high free fatty acids(FFAs)on the cardiac structure and function

Journal of Sichuan University (Medical Science)

Volumn 40, Issue 1, 2009, Pages 24-28

  Ke, Liu ^a   Yu, Ye Rong ^a   Zhang, Xuan E ^a   Zhang, Xiang Xun ^a   Lu, Zhi Ming ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Ectopic fat storage; Free fatty acids; Insulin resistance; Myocardiac dysfunction

Indexed keywords

ANGIOTENSIN II; FATTY ACID; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, RAT; TRIACYLGLYCEROL;

ANIMAL; BLOOD; HEART CONTRACTION; HEART MUSCLE; INSULIN RESISTANCE; MALE; METABOLISM; OBESITY; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION; RAT; SPRAGUE DAWLEY RAT;

ANGIOTENSIN II; ANIMALS; FATTY ACIDS, NONESTERIFIED; I-KAPPA B PROTEINS; INSULIN RESISTANCE; MALE; MYOCARDIAL CONTRACTION; MYOCARDIUM; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; OBESITY; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TRIGLYCERIDES;

EID: 59549092630     PISSN: 1672173X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Yan TZ, Paul G, Asad K, et al. Lipotoxic heart disease in obese rats: implications for human obesity. PNAS, 2000; 97 (4): 1748-1789.
2. Ito H, Hiroe M, Hirata Y, et al. ENC othelin ETA receptor antagonist blocks cardiac hypertrophy provoked by hemodynamic overload. Circulation, 1994;89(5): 2198-2203.
3. Christoffersen C, BollanoE, Lindegaard ML. Cardiac lipid accumulation associated with diastolic dysfunction in obese mice. Endocrinology, 2003;144(8): 3483-3490.
4. Susan LMC, Danng MH, Debby PYK, et al. Enhanced sarcolemmal fAT/CD36 content and triacylglycerol storage in cardiac myocytes from obese zucker rats. Diabetes, 2004; 53(7): 1655-1663.
5. Kelly DP, Hale DE, Rutledge SL, et al. Molecular basis of inherited medium-chain acyl-CoA dehydrogenase deficiency causing sudden child death. J Inherit Metab Dis, 1992; 15(2): 171-180.
6. Sharma S, Adrogue JV, Golfman L, et al. Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart. FASEB J, 2004; 18(14): 1692-1700.
7. Young ME, Guthrie PH, Razeghi P, et al. Impaired longchain fatty acid oxidation and contractile dysfunction in the obese Zucker rat heart. Diabetes, 2002; 51(8): 2587-2595.
8. Kurtz DM, Rinaldo P, Rhead WJ, et al. Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation. Proc Natl Acad Sci USA, 1998; 95(26): 15592-15597.
9. Dyntar D, Eppenberger-Eberhardt M, Maedler K, et al. Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes. Diabetes, 2001; 50(9): 2105-2113.
10. Kurtz DM, Rinaldo P, Rhead WJ, et al. Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation. Proc Natl Acad Sci USA, 1998; 95(26): 15592-15597.
11. Bell DS. Diabetic cardiomyopathy. Diabetes Care, 2003; 26 (10): 2949-2951.
12. Chiu H, Kovacs A, Ford D, et al. A novel mouse model of lipotoxic cardiomyopathy. J Clin Invest, 2001; 107(7): 813-822.
13. Yagyu H, Chen G, Yokoyama M, et al. Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy. J Clin Invest, 2003; 111(3): 419-426.
14. Finck BN, Lehman JJ, Leone TC, et al. The cardiac pheno-type induced by PPARα overexpression mimics that caused by diabetes mellitus. J Clin Invest, 2002; 109(1): 121-130.
15. Chiu HC, Kovacs A, Blanton RM, et al. Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy. Circ Res, 2005; 96(2): 225-233.
16. Zhou YT, Grayburn P, Karim A, et al. Lipotoxic heart disease in obese rats: implications for human obesity. Proc Natl Acad Sci USA, 2000; 97(4): 1748-1789.
17. Chinese source
18. Nicole HP, Tang Guilin, Yu Chenfei, et al. Activation of NF- κB is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes. Natl Acad Sci USA, 2001; 98(12): 6668-6673.
19. Kan H, Xie ZR, Mitchell S, etal. TNF enhances cardiac myocyte NO production through MAP kinase-mediated NF-κB activation. Am J Physiol Heart Circ Physiol, 1999; 277(4): H1641-H1646.
20. Chinese source
21. Ghanim H, Aljada A, Hofmeyer D, et al. Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation, 2004; 110(12): 1564-1571.