The role of a Schiff base scaffold, N-(2-hydroxy acetophenone) glycinate-in overcoming multidrug resistance in cancer

European Journal of Pharmaceutical Sciences

Volumn 51, Issue 1, 2014, Pages 96-109

  Ganguly, Avishek ^a   Chakraborty, Paramita ^a   Banerjee, Kaushik ^a   Choudhuri, Soumitra Kumar ^a  

^a CHITTARANJAN NATIONAL CANCER INSTITUTE   (India)

Author keywords

ABC transporter; Apoptosis; MAP kinase signalling; Multidrug resistance; Reactive oxygen species; Schiff base metal chelates

Indexed keywords

LONAFARNIB; METAL CHELATE; METAL COMPLEX; MOLECULAR SCAFFOLD; N (2 HYDROXY ACETOPHENONE)GLYCINATE; SCHIFF BASE; SORAFENIB; TIPIFARNIB; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; CARCINOGENESIS; CELL DEATH; HUMAN; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; IMMUNOSUPPRESSIVE TREATMENT; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; TUMOR MICROENVIRONMENT;

ABC TRANSPORTER; APOPTOSIS; COPPER N-(2-HYDROXYACETOPHENONE)GLYCINATE; CUNG; DOXORUBICIN RESISTANT EHRLICH ASCITES CARCINOMA CELLS; EAC/DOX; FENG; FORKHEAD BOX P3; FOXP3; GLUTATHIONE; GSH; IRON N-(2-HYDROXY ACETOPHENONE)GLYCINATE; MAP KINASE SIGNALLING; MAPK; MDR; MDSC; MITOGEN-ACTIVATED PROTEIN KINASE; MRP1; MULTIDRUG RESISTANCE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1; MYELOID DERIVED SUPPRESSOR CELL; N-(2-HYDROXY ACETOPHENONE)GLYCINATE; NG; REACTIVE OXYGEN SPECIES; ROS; SCHIFF BASE METAL CHELATES; T REGULATORY CELL (CD4(+)CD25(+)FOXP3(+)); T(REG); TAM; TUMOR-ASSOCIATED MACROPHAGE; ZN N-(2-HYDROXYACETOPHENONE)GLYCINATE.; ZNNG;

ANIMALS; CHELATING AGENTS; COORDINATION COMPLEXES; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HUMANS; SCHIFF BASES;

EID: 84884919320     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.09.003     Document Type: Review

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