Selective inhibition of ion transport mechanisms regulating intracellular pH reduces proliferation and induces apoptosis in cholangiocarcinoma cells

Digestive and Liver Disease

Volumn 39, Issue 1, 2007, Pages 60-69

  Di Sario, A ^a   Bendia, E ^a   Omenetti, A ^a   De Minicis, S ^a   Marzioni, M ^a   Kleemann, H W ^b   Candelaresi, C ^a   Saccomanno, S ^a   Alpini, G ^c   Benedetti, A ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^c SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

Author keywords

Apoptosis; Cholangiocarcinoma; Intracellular pH; Na+ dependent Cl HCO3 exchanger; Na+ H+ exchanger

Indexed keywords

CARIPORIDE; CASPASE 3; ION TRANSPORT AFFECTING AGENT; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN BAD; PROTEIN KINASE B; S 370; S 3705; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BILE DUCT CARCINOMA; CANCER CELL CULTURE; CANCER SURVIVAL; CARCINOMA CELL; CELL PH; CELL PROLIFERATION; COLORIMETRY; CONTROLLED STUDY; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; ION TRANSPORT;

APOPTOSIS; BLOTTING, WESTERN; CELL LINE; CELL PROLIFERATION; CHLORIDE-BICARBONATE ANTIPORTERS; CHOLANGIOCARCINOMA; GUANIDINES; HUMANS; HYDROGEN-ION CONCENTRATION; INTRACELLULAR FLUID; IONOPHORES; NIGERICIN; SODIUM-HYDROGEN ANTIPORTER; SULFONES;

EID: 33845892762     PISSN: 15908658     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dld.2006.07.013     Document Type: Article

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