메뉴 건너뛰기




Volumn 73, Issue 11, 1996, Pages 1328-1334

The chronic administration of drugs that inhibit the regulation of intracellular pH: In vitro and anti-tumour effects

Author keywords

Continuous infusion; Inhibition of pH regulation; Tumour acidification

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 5 (N ETHYL N ISOPROPYL)AMILORIDE; ANTIHYPERTENSIVE AGENT; HYDRALAZINE; ION TRANSPORT AFFECTING AGENT; NIGERICIN; POLYENE ANTIBIOTIC AGENT; SODIUM CHANNEL BLOCKING AGENT; SULFONIC ACID DERIVATIVE;

EID: 0030013044     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.254     Document Type: Article
Times cited : (82)

References (31)
  • 1
    • 0019975497 scopus 로고
    • + exchanger in renal microvillus membrane vesicles
    • + exchanger in renal microvillus membrane vesicles. Nature, 299, 161-163.
    • (1982) Nature , vol.299 , pp. 161-163
    • Aronson, P.S.1    Nee, J.2    Suhm, M.A.3
  • 3
    • 0026795032 scopus 로고
    • Regulation of intracellular pH in tumour cell lines: Influence of microenvironmental conditions
    • BOYER MJ AND TANNOCK IF. (1992). Regulation of intracellular pH in tumour cell lines: influence of microenvironmental conditions. Cancer Res., 52, 4441-4447.
    • (1992) Cancer Res. , vol.52 , pp. 4441-4447
    • Boyer, M.J.1    Tannock, I.F.2
  • 5
    • 0028465482 scopus 로고
    • 31P-MRS measurements of extracelluar pH of tumors using 3-aminopropylphosphonate
    • 31P-MRS measurements of extracelluar pH of tumors using 3-aminopropylphosphonate. Am. J. Physiol., 267, C195-203.
    • (1994) Am. J. Physiol. , vol.267
    • Gillies, R.J.1    Liu, Z.2    Bhujwalla, Z.3
  • 6
    • 0024529464 scopus 로고
    • + exchanger and growth factor-induced cytosolic pH changes. Role in cellular proliferation
    • + exchanger and growth factor-induced cytosolic pH changes. Role in cellular proliferation. Biochim Biophys. Acta, 988, 73-97.
    • (1989) Biochim Biophys. Acta , vol.988 , pp. 73-97
    • Grinstein, S.1    Rotin, D.2    Mason, M.J.3
  • 7
    • 0028076037 scopus 로고
    • Anti-tumor activity of nigericin and 5-(N-ethyl-N-isopropyl) amiloride: An approach to therapy based on cellular acidification and the inhibition of regulation of intracellular pH
    • HASUDA K, LEE C AND TANNOCK IF. (1994). Anti-tumor activity of nigericin and 5-(N-ethyl-N-isopropyl) amiloride: an approach to therapy based on cellular acidification and the inhibition of regulation of intracellular pH. Oncol. Res., 6, 259-268.
    • (1994) Oncol. Res. , vol.6 , pp. 259-268
    • Hasuda, K.1    Lee, C.2    Tannock, I.F.3
  • 9
    • 0026488675 scopus 로고
    • pH in human tumor xenografts and transplanted rat tumors: Effect of insulin, inorganic phosphate, and m-iodobenzylguanidine
    • JÄHDE E, VOLK T, ATEMA A, SMETS LA, GLÜSENKAMP K-H AND RAJEWSKY MF. (1992). pH in human tumor xenografts and transplanted rat tumors: effect of insulin, inorganic phosphate, and m-iodobenzylguanidine. Cancer Res., 52, 6209-6215.
    • (1992) Cancer Res. , vol.52 , pp. 6209-6215
    • Jähde, E.1    Volk, T.2    Atema, A.3    Smets, L.A.4    Glüsenkamp, K.-H.5    Rajewsky, M.F.6
  • 10
    • 9344241824 scopus 로고
    • Intracellular pH and activation of sea urchin eggs after fertilizaton
    • JOHNSON JD AND EPEL D. (1976). Intracellular pH and activation of sea urchin eggs after fertilizaton. Nature, 304, 371-374.
    • (1976) Nature , vol.304 , pp. 371-374
    • Johnson, J.D.1    Epel, D.2
  • 11
  • 13
    • 0028133574 scopus 로고
    • Inhibition of the regulation of intracellular pH: Potential of 5-(N,N-hexamethylene) amiloride in tumour selective therapy
    • LUO J AND TANNOCK IF. (1994). Inhibition of the regulation of intracellular pH: potential of 5-(N,N-hexamethylene) amiloride in tumour selective therapy. Br. J. Cancer, 70, 617-624.
    • (1994) Br. J. Cancer , vol.70 , pp. 617-624
    • Luo, J.1    Tannock, I.F.2
  • 15
    • 0027477597 scopus 로고
    • Therapeutic potential of analogues of amiloride: Inhibition of the regulation of intracellular pH as a possible mechanism of tumour selective therapy
    • MAIDORN RP, CRAGOE JR EJ AND TANNOCK IF. (1993). Therapeutic potential of analogues of amiloride: inhibition of the regulation of intracellular pH as a possible mechanism of tumour selective therapy. Br. J. Cancer, 67, 297-303.
    • (1993) Br. J. Cancer , vol.67 , pp. 297-303
    • Maidorn, R.P.1    Cragoe Jr., E.J.2    Tannock, I.F.3
  • 16
    • 0022702374 scopus 로고
    • Effects of amiloride on thermosensitivity of Chinese hamster cells under neutral and acidic pH
    • MIYAKOSHI J, ODA W, HIRATA M, FUKUHORI N AND INAGAKI C. (1986). Effects of amiloride on thermosensitivity of Chinese hamster cells under neutral and acidic pH. Cancer Res., 46, 1840-1843.
    • (1986) Cancer Res. , vol.46 , pp. 1840-1843
    • Miyakoshi, J.1    Oda, W.2    Hirata, M.3    Fukuhori, N.4    Inagaki, C.5
  • 17
  • 18
    • 0026720341 scopus 로고
    • Effects of agents which inhibit the regulation of intracellular pH on murine solid tumours
    • NEWELL K, WOOD P, STRATFORD I AND TANNOCK I. (1992). Effects of agents which inhibit the regulation of intracellular pH on murine solid tumours. Br. J. Cancer, 66, 311-317.
    • (1992) Br. J. Cancer , vol.66 , pp. 311-317
    • Newell, K.1    Wood, P.2    Stratford, I.3    Tannock, I.4
  • 19
    • 0027388949 scopus 로고
    • Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity
    • NEWELLK, FRANCHI A, POUYSSÉGUR J AND TANNOCK I. (1993). Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity. Proc. Natl Acad. Sci. USA, 90, 1127-1131.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 1127-1131
    • Newell, K.1    Franchi, A.2    Pouysségur, J.3    Tannock, I.4
  • 20
    • 0028027951 scopus 로고
    • Enhancement of chlorambucil cytotoxity by combination with flavone acetic acid in a murine tumour
    • PARKINS C, CHADWICK JA AND CHAPLIN DJ. (1994). Enhancement of chlorambucil cytotoxity by combination with flavone acetic acid in a murine tumour. Anticancer Res., 14, 1603-1608.
    • (1994) Anticancer Res. , vol.14 , pp. 1603-1608
    • Parkins, C.1    Chadwick, J.A.2    Chaplin, D.J.3
  • 21
    • 0023205463 scopus 로고
    • Effects of amiloride on hyperthermic cell killing of normal and thermotolerant mouse fibroblast LM cells
    • RUIFROK ACC AND KONINGS AWT. (1987). Effects of amiloride on hyperthermic cell killing of normal and thermotolerant mouse fibroblast LM cells. Int. J. Radiat. Biol., 52, 385-392.
    • (1987) Int. J. Radiat. Biol. , vol.52 , pp. 385-392
    • Ruifrok, A.C.C.1    Konings, A.W.T.2
  • 22
    • 0023125425 scopus 로고
    • Cytotoxity of compounds that interfere with the regulation of intracellular pH: A potential new class of anticancer drugs
    • ROTIN D, WAN P, GRINSTEIN S AND TANNOCK I. (1987). Cytotoxity of compounds that interfere with the regulation of intracellular pH: a potential new class of anticancer drugs. Cancer Res., 47, 1497-1504.
    • (1987) Cancer Res. , vol.47 , pp. 1497-1504
    • Rotin, D.1    Wan, P.2    Grinstein, S.3    Tannock, I.4
  • 25
    • 0020661015 scopus 로고
    • Effects of amiloride on tumor growth and intracellular element contact of tumor cells in vitro
    • SPARKS RL, POOL TB, SMIKTH NKR AND CANERON IL. (1983). Effects of amiloride on tumor growth and intracellular element contact of tumor cells in vitro. Cancer Res. 43, 73-77.
    • (1983) Cancer Res. , vol.43 , pp. 73-77
    • Sparks, R.L.1    Pool, T.B.2    Smikth, N.K.R.3    Caneron, I.L.4
  • 26
    • 0025981656 scopus 로고
    • Effects of amiloride treatment on U-118 MG and U-251 MG human glioma and HT-29 human colon carcinoma cells
    • SZOLGAY-DANIEL E, CARLSSON J, ZIFROLD K, HOLTERMANN G, DUFAU F, AND ACKER H. (1991). Effects of amiloride treatment on U-118 MG and U-251 MG human glioma and HT-29 human colon carcinoma cells. Cancer Res., 51, 1039-1044.
    • (1991) Cancer Res. , vol.51 , pp. 1039-1044
    • Szolgay-Daniel, E.1    Carlsson, J.2    Zifrold, K.3    Holtermann, G.4    Dufau, F.5    Acker, H.6
  • 27
    • 0014292997 scopus 로고
    • The relation between cell proliferation and vascular system in a transplanted mouse mammary tumour
    • TANNOCK IF. (1968). The relation between cell proliferation and vascular system in a transplanted mouse mammary tumour. Br. J. Cancer, 22, 258-273.
    • (1968) Br. J. Cancer , vol.22 , pp. 258-273
    • Tannock, I.F.1
  • 28
    • 0024379967 scopus 로고
    • Acid pH in tumors and its potential for therapeutic exploitation
    • TANNOCK IF AND ROTIN D. (1989). Acid pH in tumors and its potential for therapeutic exploitation. Cancer Res., 49, 4313-4384.
    • (1989) Cancer Res. , vol.49 , pp. 4313-4384
    • Tannock, I.F.1    Rotin, D.2
  • 29
    • 0017760271 scopus 로고
    • The role of bicarbonate, chloride and sodium ions in the regulation of intracellular pH in snail neurones
    • THOMAS RC. (1977). The role of bicarbonate, chloride and sodium ions in the regulation of intracellular pH in snail neurones. J. Physiol., 273, 317-338.
    • (1977) J. Physiol. , vol.273 , pp. 317-338
    • Thomas, R.C.1
  • 30
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • VAUPEL P, KALLINOWSKY F AND OKUNIEFF P. (1989). Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res., 49, 6449-6465.
    • (1989) Cancer Res. , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowsky, F.2    Okunieff, P.3
  • 31
    • 0021732164 scopus 로고
    • The relevance of tumour pH to the treatment of malignant disease
    • WIKE-HOOLEY JL, HAVEMAN J AND REINHOLD JS. (1984). The relevance of tumour pH to the treatment of malignant disease. Radiother. Oncol., 2, 343-366.
    • (1984) Radiother. Oncol. , vol.2 , pp. 343-366
    • Wike-Hooley, J.L.1    Haveman, J.2    Reinhold, J.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.