HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition

EMBO Journal

Volumn 31, Issue 9, 2012, Pages 2103-2116

  Zhou, Wenyu ^a   Choi, Michael ^a,b   Margineantu, Daciana ^c   Margaretha, Lilyana ^a   Hesson, Jennifer ^a   Cavanaugh, Christopher ^a   Blau, C Anthony ^a   Horwitz, Marshall S ^a   Hockenbery, David ^c   Ware, Carol ^a   Ruohola Baker, Hannele ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

human embryonic stem cell; hypoxia inducible factor 1 alpha; metabolism; mouse embryonic stem cell; mouse epiblast stem cell

Indexed keywords

CYTOCHROME C OXIDASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ECTODERM; EMBRYO; EMBRYONIC STEM CELL; ENERGY YIELD; FEMALE; GLYCOLYSIS; HUMAN; HUMAN CELL; IN VIVO STUDY; MITOCHONDRIAL RESPIRATION; MOUSE; NEOPLASM; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACTIVINS; ADENOSINE TRIPHOSPHATE; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; DNA, MITOCHONDRIAL; EMBRYONIC STEM CELLS; FEMALE; GLYCOLYSIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED C57BL; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES;

EID: 84860531487     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2012.71     Document Type: Article

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