The pH partition theory predicts the accumulation and toxicity of doxorubicin in normal and low-pH-adapted cells

British Journal of Cancer

Volumn 79, Issue 5-6, 1999, Pages 838-842

  Gerweck, L E ^a   Kozin, S V ^a   Stocks, S J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Cellular accumulation; Cellular toxicity; Doxorubicin; pH; pH gradient

Indexed keywords

DOXORUBICIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL PH; CELL TYPE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CYTOTOXICITY; DRUG UPTAKE; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL;

ANIMALS; BIOLOGICAL TRANSPORT; CELL MEMBRANE; CELL SURVIVAL; CHO CELLS; CRICETINAE; DOXORUBICIN; EXTRACELLULAR SPACE; HYDROGEN-ION CONCENTRATION; INTRACELLULAR FLUID; KINETICS;

EID: 0033001597     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690134     Document Type: Article

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