메뉴 건너뛰기




Volumn 23, Issue 5, 2013, Pages 831-840

Sites of action of sleep and wake drugs: Insights from model organisms

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ADENOSINE RECEPTOR STIMULATING AGENT; ALFADOLONE; ALMOREXANT; BF 2 649; CAFFEINE; CHLOROPYRAMINE; DOXEPIN; ESZOPICLONE; IIK 7; LORATADINE; MELATONIN; MEPYRAMINE; MODAFINIL; PITOLISANT; RAMELTEON; SUVOREXANT; UCM 765; UNCLASSIFIED DRUG; ZALEPLON; ZOLPIDEM; ZOLPIDEM TARTRATE;

EID: 84884352145     PISSN: 09594388     EISSN: 18736882     Source Type: Journal    
DOI: 10.1016/j.conb.2013.04.010     Document Type: Review
Times cited : (32)

References (97)
  • 2
    • 84856727649 scopus 로고    scopus 로고
    • Drug-induced sleep: theoretical and practical considerations
    • Ellenbogen J.M., Pace-Schott E.F. Drug-induced sleep: theoretical and practical considerations. Pflügers Arch 2011, 463:177-186.
    • (2011) Pflügers Arch , vol.463 , pp. 177-186
    • Ellenbogen, J.M.1    Pace-Schott, E.F.2
  • 4
    • 84856972043 scopus 로고    scopus 로고
    • Behavioral screening for neuroactive drugs in zebrafish
    • Rihel J., Schier A.F. Behavioral screening for neuroactive drugs in zebrafish. Dev Neurobiol 2012, 72:373-385.
    • (2012) Dev Neurobiol , vol.72 , pp. 373-385
    • Rihel, J.1    Schier, A.F.2
  • 5
    • 80052459505 scopus 로고    scopus 로고
    • From genetics to structure to function: exploring sleep in Drosophila
    • Bushey D., Cirelli C. From genetics to structure to function: exploring sleep in Drosophila. Int Rev Neurobiol 2011, 99:213-244.
    • (2011) Int Rev Neurobiol , vol.99 , pp. 213-244
    • Bushey, D.1    Cirelli, C.2
  • 6
    • 80052274158 scopus 로고    scopus 로고
    • Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes
    • Rudolph U., Knoflach F. Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes. Nat Rev Drug Discov 2011, 10:685-697.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 685-697
    • Rudolph, U.1    Knoflach, F.2
  • 10
    • 84866406441 scopus 로고    scopus 로고
    • GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness
    • Zecharia A.Y., Yu X., Gotz T., Ye Z., Carr D.R., Wulff P., Bettler B., Vyssotski A.L., Brickley S.G., Franks N.P., et al. GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness. J Neurosci 2012, 32:13062-13075.
    • (2012) J Neurosci , vol.32 , pp. 13062-13075
    • Zecharia, A.Y.1    Yu, X.2    Gotz, T.3    Ye, Z.4    Carr, D.R.5    Wulff, P.6    Bettler, B.7    Vyssotski, A.L.8    Brickley, S.G.9    Franks, N.P.10
  • 11
    • 77953048850 scopus 로고    scopus 로고
    • Amygdala-specific reduction of alpha1-GABAA receptors disrupts the anticonvulsant, locomotor, and sedative, but not anxiolytic, effects of benzodiazepines in mice
    • Heldt S.A., Ressler K.J. Amygdala-specific reduction of alpha1-GABAA receptors disrupts the anticonvulsant, locomotor, and sedative, but not anxiolytic, effects of benzodiazepines in mice. J Neurosci 2010, 30:7139-7151.
    • (2010) J Neurosci , vol.30 , pp. 7139-7151
    • Heldt, S.A.1    Ressler, K.J.2
  • 12
    • 79953675340 scopus 로고    scopus 로고
    • Central nervous system sites of the sleep promoting effects of eszopiclone in rats
    • Kumar S., Alam M.N., Rai S., Bashir T., McGinty D., Szymusiak R. Central nervous system sites of the sleep promoting effects of eszopiclone in rats. Neuroscience 2011, 181:67-78.
    • (2011) Neuroscience , vol.181 , pp. 67-78
    • Kumar, S.1    Alam, M.N.2    Rai, S.3    Bashir, T.4    McGinty, D.5    Szymusiak, R.6
  • 13
    • 84868541589 scopus 로고    scopus 로고
    • Direct activation of sleep-promoting VLPO neurons by volatile anesthetics contributes to anesthetic hypnosis
    • Moore J.T., Chen J., Han B., Meng Q.C., Veasey S.C., Beck S.G., Kelz M.B. Direct activation of sleep-promoting VLPO neurons by volatile anesthetics contributes to anesthetic hypnosis. Curr Biol 2012, 22:2008-2016.
    • (2012) Curr Biol , vol.22 , pp. 2008-2016
    • Moore, J.T.1    Chen, J.2    Han, B.3    Meng, Q.C.4    Veasey, S.C.5    Beck, S.G.6    Kelz, M.B.7
  • 15
    • 39749083327 scopus 로고    scopus 로고
    • Modulation of GABAA receptor desensitization uncouples sleep onset and maintenance in Drosophila
    • Agosto J., Choi J.C., Parisky K.M., Stilwell G., Rosbash M., Griffith L.C. Modulation of GABAA receptor desensitization uncouples sleep onset and maintenance in Drosophila. Nat Neurosci 2008, 11:354-359.
    • (2008) Nat Neurosci , vol.11 , pp. 354-359
    • Agosto, J.1    Choi, J.C.2    Parisky, K.M.3    Stilwell, G.4    Rosbash, M.5    Griffith, L.C.6
  • 17
    • 61449266413 scopus 로고    scopus 로고
    • The GABAA receptor RDL acts in peptidergic PDF neurons to promote sleep in Drosophila
    • Chung B.Y., Kilman V.L., Keath J.R., Pitman J.L., Allada R. The GABAA receptor RDL acts in peptidergic PDF neurons to promote sleep in Drosophila. Curr Biol 2009, 19:386-390.
    • (2009) Curr Biol , vol.19 , pp. 386-390
    • Chung, B.Y.1    Kilman, V.L.2    Keath, J.R.3    Pitman, J.L.4    Allada, R.5
  • 18
    • 84865603296 scopus 로고    scopus 로고
    • Update on emerging drugs for insomnia
    • Sullivan S. Update on emerging drugs for insomnia. Expert Opin Emerg Drugs 2012, 17:295-298.
    • (2012) Expert Opin Emerg Drugs , vol.17 , pp. 295-298
    • Sullivan, S.1
  • 19
    • 84878379048 scopus 로고    scopus 로고
    • Review of the histamine system and the clinical effects of H(1) antagonists: basis for a new model for understanding the effects of insomnia medications
    • Krystal A.D., Richelson E., Roth T. Review of the histamine system and the clinical effects of H(1) antagonists: basis for a new model for understanding the effects of insomnia medications. Sleep Med Rev 2013, 10.1016/j.smrv.2012.08.001.
    • (2013) Sleep Med Rev
    • Krystal, A.D.1    Richelson, E.2    Roth, T.3
  • 20
    • 33645229309 scopus 로고    scopus 로고
    • Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice
    • Huang Z.-L., Mochizuki T., Qu W.-M., Hong Z.-Y., Watanabe T., Urade Y., Hayaishi O. Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice. Proc Natl Acad Sci U S A 2006, 103:4687-4692.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 4687-4692
    • Huang, Z.-L.1    Mochizuki, T.2    Qu, W.-M.3    Hong, Z.-Y.4    Watanabe, T.5    Urade, Y.6    Hayaishi, O.7
  • 21
    • 84860454499 scopus 로고    scopus 로고
    • First and second generation H1 histamine receptor antagonists produce different sleep-inducing profiles in rats
    • Unno K., Ozaki T., Mohammad S., Tsuno S., Ikeda-Sagara M., Honda K., Ikeda M. First and second generation H1 histamine receptor antagonists produce different sleep-inducing profiles in rats. Eur J Pharmacol 2012, 683:179-185.
    • (2012) Eur J Pharmacol , vol.683 , pp. 179-185
    • Unno, K.1    Ozaki, T.2    Mohammad, S.3    Tsuno, S.4    Ikeda-Sagara, M.5    Honda, K.6    Ikeda, M.7
  • 22
    • 62449321971 scopus 로고    scopus 로고
    • Selective histamine H1 antagonism: novel hypnotic and pharmacologic actions challenge classical notions of antihistamines
    • Stahl S.M. Selective histamine H1 antagonism: novel hypnotic and pharmacologic actions challenge classical notions of antihistamines. CNS Spectr 2008, 13:1027-1038.
    • (2008) CNS Spectr , vol.13 , pp. 1027-1038
    • Stahl, S.M.1
  • 23
    • 2942562762 scopus 로고    scopus 로고
    • Wakefulness-inducing effects of histamine in the basal forebrain of freely moving rats
    • Ramesh V., Thakkar M.M., Strecker R.E., Basheer R., McCarley R.W. Wakefulness-inducing effects of histamine in the basal forebrain of freely moving rats. Behav Brain Res 2004, 152:271-278.
    • (2004) Behav Brain Res , vol.152 , pp. 271-278
    • Ramesh, V.1    Thakkar, M.M.2    Strecker, R.E.3    Basheer, R.4    McCarley, R.W.5
  • 24
    • 0029962956 scopus 로고    scopus 로고
    • Histaminergic descending inputs to the mesopontine tegmentum and their role in the control of cortical activation and wakefulness in the cat
    • Lin J.S., Hou Y., Sakai K., Jouvet M. Histaminergic descending inputs to the mesopontine tegmentum and their role in the control of cortical activation and wakefulness in the cat. J Neurosci 1996, 16:1523-1537.
    • (1996) J Neurosci , vol.16 , pp. 1523-1537
    • Lin, J.S.1    Hou, Y.2    Sakai, K.3    Jouvet, M.4
  • 25
    • 82655181503 scopus 로고    scopus 로고
    • The histaminergic system regulates wakefulness and orexin/hypocretin neuron development via histamine receptor H1 in zebrafish
    • Sundvik M., Kudo H., Toivonen P., Rozov S., Chen Y.-C., Panula P. The histaminergic system regulates wakefulness and orexin/hypocretin neuron development via histamine receptor H1 in zebrafish. FASEB J 2011, 25:4338-4347.
    • (2011) FASEB J , vol.25 , pp. 4338-4347
    • Sundvik, M.1    Kudo, H.2    Toivonen, P.3    Rozov, S.4    Chen, Y.-C.5    Panula, P.6
  • 26
    • 84867134043 scopus 로고    scopus 로고
    • Organization of the histaminergic system in adult zebrafish (Danio rerio) brain: neuron number, location, and cotransmitters
    • Sundvik M., Panula P. Organization of the histaminergic system in adult zebrafish (Danio rerio) brain: neuron number, location, and cotransmitters. J Comp Neurol 2012, 520:3827-3845.
    • (2012) J Comp Neurol , vol.520 , pp. 3827-3845
    • Sundvik, M.1    Panula, P.2
  • 29
  • 30
    • 58949088982 scopus 로고    scopus 로고
    • The role of cytokines in sleep regulation
    • Krueger J.M. The role of cytokines in sleep regulation. Curr Pharm Des 2008, 14:3408-3416.
    • (2008) Curr Pharm Des , vol.14 , pp. 3408-3416
    • Krueger, J.M.1
  • 31
    • 82155176834 scopus 로고    scopus 로고
    • Prostaglandin D2 and sleep/wake regulation
    • Urade Y., Hayaishi O. Prostaglandin D2 and sleep/wake regulation. Sleep Med Rev 2011, 15:411-418.
    • (2011) Sleep Med Rev , vol.15 , pp. 411-418
    • Urade, Y.1    Hayaishi, O.2
  • 34
    • 0034674938 scopus 로고    scopus 로고
    • Brain site-specificity of extracellular adenosine concentration changes during sleep deprivation and spontaneous sleep: an in vivo microdialysis study
    • Porkka-Heiskanen T., Strecker R.E., McCarley R.W. Brain site-specificity of extracellular adenosine concentration changes during sleep deprivation and spontaneous sleep: an in vivo microdialysis study. Neuroscience 2000, 99:507-517.
    • (2000) Neuroscience , vol.99 , pp. 507-517
    • Porkka-Heiskanen, T.1    Strecker, R.E.2    McCarley, R.W.3
  • 36
    • 84861116203 scopus 로고    scopus 로고
    • Adenosine inhibits glutamatergic input to basal forebrain cholinergic neurons
    • Hawryluk J.M., Ferrari L.L., Keating S.A., Arrigoni E. Adenosine inhibits glutamatergic input to basal forebrain cholinergic neurons. J Neurophysiol 2012, 107:2769-2781.
    • (2012) J Neurophysiol , vol.107 , pp. 2769-2781
    • Hawryluk, J.M.1    Ferrari, L.L.2    Keating, S.A.3    Arrigoni, E.4
  • 37
    • 0037704412 scopus 로고    scopus 로고
    • A1 receptor and adenosinergic homeostatic regulation of sleep-wakefulness: effects of antisense to the A1 receptor in the cholinergic basal forebrain
    • Thakkar M.M., Winston S., McCarley R.W. A1 receptor and adenosinergic homeostatic regulation of sleep-wakefulness: effects of antisense to the A1 receptor in the cholinergic basal forebrain. J Neurosci 2003, 23:4278-4287.
    • (2003) J Neurosci , vol.23 , pp. 4278-4287
    • Thakkar, M.M.1    Winston, S.2    McCarley, R.W.3
  • 38
    • 77950368593 scopus 로고    scopus 로고
    • A1 receptor mediated adenosinergic regulation of perifornical-lateral hypothalamic area neurons in freely behaving rats
    • Rai S., Kumar S., Alam M.A., Szymusiak R., McGinty D., Alam M.N. A1 receptor mediated adenosinergic regulation of perifornical-lateral hypothalamic area neurons in freely behaving rats. Neuroscience 2010, 167:40-48.
    • (2010) Neuroscience , vol.167 , pp. 40-48
    • Rai, S.1    Kumar, S.2    Alam, M.A.3    Szymusiak, R.4    McGinty, D.5    Alam, M.N.6
  • 39
    • 58149396841 scopus 로고    scopus 로고
    • Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep
    • Oishi Y., Huang Z.-L., Fredholm B.B., Urade Y., Hayaishi O. Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep. Proc Natl Acad Sci U S A 2008, 105:19992-19997.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 19992-19997
    • Oishi, Y.1    Huang, Z.-L.2    Fredholm, B.B.3    Urade, Y.4    Hayaishi, O.5
  • 40
    • 23944470341 scopus 로고    scopus 로고
    • The endogenous somnogen adenosine excites a subset of sleep-promoting neurons via A2A receptors in the ventrolateral preoptic nucleus
    • Gallopin T., Luppi P.-H., Cauli B., Urade Y., Rossier J., Hayaishi O., Lambolez B., Fort P. The endogenous somnogen adenosine excites a subset of sleep-promoting neurons via A2A receptors in the ventrolateral preoptic nucleus. Neuroscience 2005, 134:1377-1390.
    • (2005) Neuroscience , vol.134 , pp. 1377-1390
    • Gallopin, T.1    Luppi, P.-H.2    Cauli, B.3    Urade, Y.4    Rossier, J.5    Hayaishi, O.6    Lambolez, B.7    Fort, P.8
  • 41
  • 46
    • 69749098440 scopus 로고    scopus 로고
    • The effects of caffeine on sleep in Drosophila require PKA activity, but not the adenosine receptor
    • Wu M.N., Ho K., Crocker A., Yue Z., Koh K., Sehgal A. The effects of caffeine on sleep in Drosophila require PKA activity, but not the adenosine receptor. J Neurosci 2009, 29:11029-11037.
    • (2009) J Neurosci , vol.29 , pp. 11029-11037
    • Wu, M.N.1    Ho, K.2    Crocker, A.3    Yue, Z.4    Koh, K.5    Sehgal, A.6
  • 48
    • 51649122289 scopus 로고    scopus 로고
    • Dopaminergic D1 and D2 receptors are essential for the arousal effect of modafinil
    • Qu W.-M., Huang Z.-L., Xu X.-H., Matsumoto N., Urade Y. Dopaminergic D1 and D2 receptors are essential for the arousal effect of modafinil. J Neurosci 2008, 28:8462-8469.
    • (2008) J Neurosci , vol.28 , pp. 8462-8469
    • Qu, W.-M.1    Huang, Z.-L.2    Xu, X.-H.3    Matsumoto, N.4    Urade, Y.5
  • 49
    • 79955993476 scopus 로고    scopus 로고
    • Dopamine receptor mediation of the exploratory/hyperactivity effects of modafinil
    • Young J.W., Kooistra K., Geyer M.A. Dopamine receptor mediation of the exploratory/hyperactivity effects of modafinil. Neuropsychopharmacology 2011, 36:1385-1396.
    • (2011) Neuropsychopharmacology , vol.36 , pp. 1385-1396
    • Young, J.W.1    Kooistra, K.2    Geyer, M.A.3
  • 50
    • 33751186720 scopus 로고    scopus 로고
    • Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro
    • Madras B.K., Xie Z., Lin Z., Jassen A., Panas H., Lynch L., Johnson R., Livni E., Spencer T.J., Bonab A.A., et al. Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. J Pharmacol Exp Ther 2006, 319:561-569.
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 561-569
    • Madras, B.K.1    Xie, Z.2    Lin, Z.3    Jassen, A.4    Panas, H.5    Lynch, L.6    Johnson, R.7    Livni, E.8    Spencer, T.J.9    Bonab, A.A.10
  • 53
    • 80054728808 scopus 로고    scopus 로고
    • The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors
    • Schmitt K.C., Reith M.E.A. The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors. PLoS ONE 2011, 6:e25790.
    • (2011) PLoS ONE , vol.6
    • Schmitt, K.C.1    Reith, M.E.A.2
  • 54
    • 23744439861 scopus 로고    scopus 로고
    • Dopamine is a regulator of arousal in the fruit fly
    • Kume K., Kume S., Park S.K., Hirsh J., Jackson F.R. Dopamine is a regulator of arousal in the fruit fly. J Neurosci 2005, 25:7377-7384.
    • (2005) J Neurosci , vol.25 , pp. 7377-7384
    • Kume, K.1    Kume, S.2    Park, S.K.3    Hirsh, J.4    Jackson, F.R.5
  • 55
    • 43749102730 scopus 로고    scopus 로고
    • A genetic screen for sleep and circadian mutants reveals mechanisms underlying regulation of sleep in Drosophila
    • Wu M.N., Koh K., Yue Z., Joiner W.J., Sehgal A. A genetic screen for sleep and circadian mutants reveals mechanisms underlying regulation of sleep in Drosophila. Sleep 2008, 31:465-472.
    • (2008) Sleep , vol.31 , pp. 465-472
    • Wu, M.N.1    Koh, K.2    Yue, Z.3    Joiner, W.J.4    Sehgal, A.5
  • 56
    • 70449753456 scopus 로고    scopus 로고
    • Two different forms of arousal in Drosophila are oppositely regulated by the dopamine D1 receptor ortholog DopR via distinct neural circuits
    • Lebestky T., Chang J.-S.C., Dankert H., Zelnik L., Kim Y.-C., Han K.-A., Wolf F.W., Perona P., Anderson D.J. Two different forms of arousal in Drosophila are oppositely regulated by the dopamine D1 receptor ortholog DopR via distinct neural circuits. Neuron 2009, 64:522-536.
    • (2009) Neuron , vol.64 , pp. 522-536
    • Lebestky, T.1    Chang, J.-S.C.2    Dankert, H.3    Zelnik, L.4    Kim, Y.-C.5    Han, K.-A.6    Wolf, F.W.7    Perona, P.8    Anderson, D.J.9
  • 57
    • 84155177082 scopus 로고    scopus 로고
    • Insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila
    • Stavropoulos N., Young M.W. Insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila. Neuron 2011, 72:964-976.
    • (2011) Neuron , vol.72 , pp. 964-976
    • Stavropoulos, N.1    Young, M.W.2
  • 58
    • 84868089899 scopus 로고    scopus 로고
    • Cul3 and the BTB adaptor insomniac are key regulators of sleep homeostasis and a dopamine arousal pathway in Drosophila
    • Pfeiffenberger C., Allada R. Cul3 and the BTB adaptor insomniac are key regulators of sleep homeostasis and a dopamine arousal pathway in Drosophila. PLoS Genet. 2012, 8:e1003003.
    • (2012) PLoS Genet. , vol.8
    • Pfeiffenberger, C.1    Allada, R.2
  • 60
    • 84868199388 scopus 로고    scopus 로고
    • Identification of a dopamine pathway that regulates sleep and arousal in Drosophila
    • Ueno T., Tomita J., Tanimoto H., Endo K., Ito K., Kume S., Kume K. Identification of a dopamine pathway that regulates sleep and arousal in Drosophila. Nat Neurosci 2012, 15:1516-1523.
    • (2012) Nat Neurosci , vol.15 , pp. 1516-1523
    • Ueno, T.1    Tomita, J.2    Tanimoto, H.3    Endo, K.4    Ito, K.5    Kume, S.6    Kume, K.7
  • 61
    • 84869495917 scopus 로고    scopus 로고
    • Two dopaminergic neurons signal to the dorsal fan-shaped body to promote wakefulness in Drosophila
    • Liu Q., Liu S., Kodama L., Driscoll M.R., Wu M.N. Two dopaminergic neurons signal to the dorsal fan-shaped body to promote wakefulness in Drosophila. Curr Biol 2012, 22:2114-2123.
    • (2012) Curr Biol , vol.22 , pp. 2114-2123
    • Liu, Q.1    Liu, S.2    Kodama, L.3    Driscoll, M.R.4    Wu, M.N.5
  • 62
    • 79959503371 scopus 로고    scopus 로고
    • Inducing sleep by remote control facilitates memory consolidation in Drosophila
    • Donlea J.M., Thimgan M.S., Suzuki Y., Gottschalk L., Shaw P.J. Inducing sleep by remote control facilitates memory consolidation in Drosophila. Science 2011, 332:1571-1576.
    • (2011) Science , vol.332 , pp. 1571-1576
    • Donlea, J.M.1    Thimgan, M.S.2    Suzuki, Y.3    Gottschalk, L.4    Shaw, P.J.5
  • 64
    • 77953175426 scopus 로고    scopus 로고
    • Endogenous melatonin is not obligatory for the regulation of the rat sleep-wake cycle
    • Fisher S.P., Sugden D. Endogenous melatonin is not obligatory for the regulation of the rat sleep-wake cycle. Sleep 2010, 33:833-840.
    • (2010) Sleep , vol.33 , pp. 833-840
    • Fisher, S.P.1    Sugden, D.2
  • 65
    • 11844250002 scopus 로고    scopus 로고
    • Melatonin as a hypnotic: pro
    • Zhdanova I.V. Melatonin as a hypnotic: pro. Sleep Med Rev 2005, 9:51-65.
    • (2005) Sleep Med Rev , vol.9 , pp. 51-65
    • Zhdanova, I.V.1
  • 67
    • 84873504658 scopus 로고    scopus 로고
    • Sleep-wake characterization of double MT(1)/MT(2) receptor knockout mice and comparison with MT(1) and MT(2) receptor knockout mice
    • Comai S., Ochoa-Sanchez R., Gobbi G. Sleep-wake characterization of double MT(1)/MT(2) receptor knockout mice and comparison with MT(1) and MT(2) receptor knockout mice. Behav Brain Res 2013, 243C:231-238.
    • (2013) Behav Brain Res , vol.243 C , pp. 231-238
    • Comai, S.1    Ochoa-Sanchez, R.2    Gobbi, G.3
  • 68
    • 67349108317 scopus 로고    scopus 로고
    • Sleep-promoting action of IIK7, a selective MT2 melatonin receptor agonist in the rat
    • Fisher S.P., Sugden D. Sleep-promoting action of IIK7, a selective MT2 melatonin receptor agonist in the rat. Neurosci Lett 2009, 457:93-96.
    • (2009) Neurosci Lett , vol.457 , pp. 93-96
    • Fisher, S.P.1    Sugden, D.2
  • 71
    • 84858439689 scopus 로고    scopus 로고
    • Melatonin: both master clock output and internal time-giver in the circadian clocks network
    • Pevet P., Challet E. Melatonin: both master clock output and internal time-giver in the circadian clocks network. J Physiol-Paris 2011, 105:170-182.
    • (2011) J Physiol-Paris , vol.105 , pp. 170-182
    • Pevet, P.1    Challet, E.2
  • 74
    • 33845728490 scopus 로고    scopus 로고
    • Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafish
    • Prober D.A., Rihel J., Onah A.A., Sung R.-J., Schier A.F. Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafish. J Neurosci 2006, 26:13400-13410.
    • (2006) J Neurosci , vol.26 , pp. 13400-13410
    • Prober, D.A.1    Rihel, J.2    Onah, A.A.3    Sung, R.-J.4    Schier, A.F.5
  • 75
    • 77950188759 scopus 로고    scopus 로고
    • Monitoring neural activity with bioluminescence during natural behavior
    • Naumann E.A., Kampff A.R., Prober D.A., Schier A.F., Engert F. Monitoring neural activity with bioluminescence during natural behavior. Nat Neurosci 2010, 13:513-520.
    • (2010) Nat Neurosci , vol.13 , pp. 513-520
    • Naumann, E.A.1    Kampff, A.R.2    Prober, D.A.3    Schier, A.F.4    Engert, F.5
  • 76
    • 84866241638 scopus 로고    scopus 로고
    • Genetic ablation of hypocretin neurons alters behavioral state transitions in zebrafish
    • Elbaz I., Yelin-Bekerman L., Nicenboim J., Vatine G., Appelbaum L. Genetic ablation of hypocretin neurons alters behavioral state transitions in zebrafish. J Neurosci 2012, 32:12961-12972.
    • (2012) J Neurosci , vol.32 , pp. 12961-12972
    • Elbaz, I.1    Yelin-Bekerman, L.2    Nicenboim, J.3    Vatine, G.4    Appelbaum, L.5
  • 78
    • 77954731181 scopus 로고    scopus 로고
    • Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia
    • Cox C.D., Breslin M.J., Whitman D.B., Schreier J.D., McGaughey G.B., Bogusky M.J., Roecker A.J., Mercer S.P., Bednar R.A., Lemaire W., et al. Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia. J Med Chem 2010, 53:5320-5332.
    • (2010) J Med Chem , vol.53 , pp. 5320-5332
    • Cox, C.D.1    Breslin, M.J.2    Whitman, D.B.3    Schreier, J.D.4    McGaughey, G.B.5    Bogusky, M.J.6    Roecker, A.J.7    Mercer, S.P.8    Bednar, R.A.9    Lemaire, W.10
  • 79
    • 84873388862 scopus 로고    scopus 로고
    • Effects of suvorexant, an orexin receptor antagonist, on sleep parameters as measured by polysomnography in healthy men
    • Sun H., Kennedy W.P., Wilbraham D., Lewis N., Calder N., Li X., Ma J., Yee K.L., Ermlich S., Mangin E., et al. Effects of suvorexant, an orexin receptor antagonist, on sleep parameters as measured by polysomnography in healthy men. Sleep 2013, 36:259-267.
    • (2013) Sleep , vol.36 , pp. 259-267
    • Sun, H.1    Kennedy, W.P.2    Wilbraham, D.3    Lewis, N.4    Calder, N.5    Li, X.6    Ma, J.7    Yee, K.L.8    Ermlich, S.9    Mangin, E.10
  • 82
    • 79955777621 scopus 로고    scopus 로고
    • Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep
    • Mieda M., Hasegawa E., Kisanuki Y.Y., Sinton C.M., Yanagisawa M., Sakurai T. Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep. J Neurosci 2011, 31:6518-6526.
    • (2011) J Neurosci , vol.31 , pp. 6518-6526
    • Mieda, M.1    Hasegawa, E.2    Kisanuki, Y.Y.3    Sinton, C.M.4    Yanagisawa, M.5    Sakurai, T.6
  • 83
    • 84870533443 scopus 로고    scopus 로고
    • The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors
    • Mang G.M., Dürst T., Bürki H., Imobersteg S., Abramowski D., Schuepbach E., Hoyer D., Fendt M., Gee C.E. The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors. Sleep 2012, 35:1625-1635.
    • (2012) Sleep , vol.35 , pp. 1625-1635
    • Mang, G.M.1    Dürst, T.2    Bürki, H.3    Imobersteg, S.4    Abramowski, D.5    Schuepbach, E.6    Hoyer, D.7    Fendt, M.8    Gee, C.E.9
  • 88
    • 84871895020 scopus 로고    scopus 로고
    • Effects of orexin gene transfer in the dorsolateral pons in orexin knockout mice
    • Blanco-Centurion C., Liu M., Konadhode R., Pelluru D., Shiromani P.J. Effects of orexin gene transfer in the dorsolateral pons in orexin knockout mice. Sleep 2013, 36:31-40.
    • (2013) Sleep , vol.36 , pp. 31-40
    • Blanco-Centurion, C.1    Liu, M.2    Konadhode, R.3    Pelluru, D.4    Shiromani, P.J.5
  • 89
    • 22244443005 scopus 로고    scopus 로고
    • Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle
    • Lee M.G., Hassani O.K., Jones B.E. Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle. J Neurosci 2005, 25:6716-6720.
    • (2005) J Neurosci , vol.25 , pp. 6716-6720
    • Lee, M.G.1    Hassani, O.K.2    Jones, B.E.3
  • 90
    • 36248996490 scopus 로고    scopus 로고
    • Neural substrates of awakening probed with optogenetic control of hypocretin neurons
    • Adamantidis A.R., Zhang F., Aravanis A.M., Deisseroth K., De Lecea L. Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature 2007, 450:420-424.
    • (2007) Nature , vol.450 , pp. 420-424
    • Adamantidis, A.R.1    Zhang, F.2    Aravanis, A.M.3    Deisseroth, K.4    De Lecea, L.5
  • 93
    • 69749116172 scopus 로고    scopus 로고
    • Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions
    • Carter M.E., Adamantidis A., Ohtsu H., Deisseroth K., De Lecea L. Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions. J Neurosci 2009, 29:10939-10949.
    • (2009) J Neurosci , vol.29 , pp. 10939-10949
    • Carter, M.E.1    Adamantidis, A.2    Ohtsu, H.3    Deisseroth, K.4    De Lecea, L.5
  • 94
    • 84859419389 scopus 로고    scopus 로고
    • Distinct models of induced hyperactivity in zebrafish larvae
    • Ellis L.D., Seibert J., Soanes K.H. Distinct models of induced hyperactivity in zebrafish larvae. Brain Res 2012, 1449:46-59.
    • (2012) Brain Res , vol.1449 , pp. 46-59
    • Ellis, L.D.1    Seibert, J.2    Soanes, K.H.3
  • 96
    • 39749148311 scopus 로고    scopus 로고
    • Control of visually guided behavior by distinct populations of spinal projection neurons
    • Orger M.B., Kampff A.R., Severi K.E., Bollmann J.H., Engert F. Control of visually guided behavior by distinct populations of spinal projection neurons. Nat Neurosci 2008, 11:327-333.
    • (2008) Nat Neurosci , vol.11 , pp. 327-333
    • Orger, M.B.1    Kampff, A.R.2    Severi, K.E.3    Bollmann, J.H.4    Engert, F.5
  • 97
    • 84856952241 scopus 로고    scopus 로고
    • Optogenetics: a new enlightenment age for zebrafish neurobiology
    • Del Bene F., Wyart C. Optogenetics: a new enlightenment age for zebrafish neurobiology. Dev Neurobiol 2012, 72:404-414.
    • (2012) Dev Neurobiol , vol.72 , pp. 404-414
    • Del Bene, F.1    Wyart, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.