Amygdala-specific reduction of α1-GABAA receptors disrupts the anticonvulsant, locomotor, and sedative, but not anxiolytic, effects of benzodiazepines in mice

Journal of Neuroscience

Volumn 30, Issue 21, 2010, Pages 7139-7151

  Heldt, Scott A ^a   Ressler, Kerry J ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA2; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA3; CRE RECOMBINASE; DIAZEPAM; LIGAND; MESSENGER RNA; PENTETRAZOLE; RECEPTOR SUBUNIT; ZOLPIDEM;

AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ANXIETY; ARTICLE; BEHAVIOR; BRAIN REGION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; HUMAN; HUMAN CELL; LENTIVIRINAE; LOCOMOTION; LOW DRUG DOSE; LOXP SITE; MALE; MOUSE; NONHUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEDATION; TRANQUILIZING ACTIVITY;

AMYGDALA; ANIMALS; ANIMALS, NEWBORN; ANTI-ANXIETY AGENTS; ANTICONVULSANTS; BENZODIAZEPINES; CELL LINE, TRANSFORMED; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EPILEPSY; EXPLORATORY BEHAVIOR; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; HUMANS; HYPNOTICS AND SEDATIVES; LOCOMOTION; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PENTYLENETETRAZOLE; PYRIDINES; RECEPTORS, GABA-A; RNA, MESSENGER; TRANSFECTION;

EID: 77953048850     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0693-10.2010     Document Type: Article

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