The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors

Sleep

Volumn 35, Issue 12, 2012, Pages 1625-1635

  Mang, Géraldine M ^a,b   Dürst, Thomas ^a   Bürki, Hugo ^a   Imobersteg, Stefan ^a   Abramowski, Dorothee ^a   Schuepbach, Edi ^a   Hoyer, Daniel ^a,c   Fendt, Markus ^a,d   Gee, Christine E ^a,e  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d OTTO VON GUERICKE UNIVERSITY   (Germany)

^e UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Hypocretin; Locomotion; Mouse; Orexin; Sleep mechanisms

Indexed keywords

ALMOREXANT; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; OREXIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALEPSY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; EQUILIBRIUM CONSTANT; HUMAN; HUMAN CELL; LOCOMOTION; MALE; MOUSE; NONHUMAN; NONREM SLEEP; PRIORITY JOURNAL; RAT; REM SLEEP; SLEEP INDUCTION; SLEEP WAKING CYCLE;

ACETAMIDES; ANIMALS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOQUINOLINES; LOCOMOTION; MALE; MICE; MICE, INBRED C57BL; NEUROPEPTIDES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; SLEEP; SYMPATHOMIMETICS; WAKEFULNESS;

EID: 84870533443     PISSN: 01618105     EISSN: 15509109     Source Type: Journal    
DOI: 10.5665/sleep.2232     Document Type: Article

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