First and second generation H1 histamine receptor antagonists produce different sleep-inducing profiles in rats

European Journal of Pharmacology

Volumn 683, Issue 1-3, 2012, Pages 179-185

  Unno, Katsuya ^a   Ozaki, Tomoya ^a   Mohammad, Shahid ^a   Tsuno, Saki ^a   Ikeda Sagara, Masami ^a   Honda, Kazuki ^b   Ikeda, Masayuki ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b Hamri Co Ltd   (Japan)

Author keywords

(Rat); First generation antihistamine; Over the counter sleep aid; Second generation antihistamine; Sleep encephalogram

Indexed keywords

DIPHENHYDRAMINE; HISTAMINE H1 RECEPTOR; KETOTIFEN FUMARATE;

ANIMAL EXPERIMENT; AROUSAL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG TOLERANCE; ELECTROMYOGRAM; EVENING DOSAGE; MALE; MORNING DOSAGE; NONHUMAN; NONREM SLEEP; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; REM SLEEP; SLEEP INDUCTION; SLEEP WAKING CYCLE; SLOW BRAIN WAVE; WAKEFULNESS;

ANIMALS; CENTRAL NERVOUS SYSTEM STIMULANTS; CIRCADIAN RHYTHM; DIPHENHYDRAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; ELECTROENCEPHALOGRAPHY; HISTAMINE H1 ANTAGONISTS; HYPNOTICS AND SEDATIVES; INJECTIONS, INTRAPERITONEAL; KETOTIFEN; MALE; NONPRESCRIPTION DRUGS; RATS; RATS, SPRAGUE-DAWLEY; SLEEP; SLEEP STAGES; SLEEP, REM; WAKEFULNESS;

EID: 84860454499     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.03.017     Document Type: Article

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