Dopaminergic D1 and D2 receptors are essential for the arousal effect of modafinil

Journal of Neuroscience

Volumn 28, Issue 34, 2008, Pages 8462-8469

  Qu, Wei Min ^a   Huang, Zhi Li ^a,b   Xu, Xin Hong ^a,b   Matsumoto, Naomi ^a   Urade, Yoshihiro ^a  

^a OSAKA BIOSCIENCE INSTITUTE   (Japan)

^b FUDAN UNIVERSITY   (China)

Author keywords

Dopamine receptor; EEG; Knock out mice; Modafinil; Sleep; Wakefulness

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; MODAFINIL; RACLOPRIDE; BENZHYDRYL DERIVATIVE; CENTRAL STIMULANT AGENT; DOPAMINE RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; AROUSAL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; KNOCKOUT MOUSE; LOW DRUG DOSE; MOUSE; NARCOLEPSY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; ANIMAL; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; TIME; WAKEFULNESS;

(R)-2,3,4,5-TETRAHYDRO-8-CHLORO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL; ANIMALS; AROUSAL; BENZHYDRYL COMPOUNDS; CENTRAL NERVOUS SYSTEM STIMULANTS; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; MICE; MICE, KNOCKOUT; RACLOPRIDE; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; TIME FACTORS; WAKEFULNESS;

EID: 51649122289     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1819-08.2008     Document Type: Article

References (51)

1. 2 dopamine receptor colocalization in neostriatal neurons. Nat Neurosci 3:226-230.
2. Akaoka H, Roussel B, Lin JS, Chouvet G, Jouvet M (1991) Effect of modafinil and amphetamine on the rat catecholaminergic neuron activity. Neurosci Lett 123:20-22.
3. Billiard M, Besset A, Montplaisir J, Laffont F, Goldenberg F, Weill JS, Lubin S (1994) Modafinil: a double-blind multicentric study. Sleep 17:S107-S112.
4. Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y, Fitch TE, Nakazato M, Hammer RE, Saper CB, Yanagisawa M (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98:437-451.
5. Deroche-Gamonet V, Darnaudéry M, Bruins-Slot L, Piat F, Le Moal M, Piazza PV (2002) Study of the addictive potential of modafinil in naive and cocaine-experienced rats. Psychopharmacology 161:387-395.
6. de Saint Hilaire Z, Orosco M, Rouch C, Blanc G, Nicolaidis S (2001) Variations in extracellular monoamines in the prefrontal cortex and medial hypothalamus after modafinil administration: a microdialysis study in rats. Neuroreport 12:3533-3537.
7. 2 receptor-deficient mice exhibit decreased dopamine transporter function but no changes in dopamine release in dorsal striatum. J Neurochem 72:148-156.
8. 2 receptor-null mice. Nat Neurosci 9:732-734.
9. Duteil J, Rambert FA, Pessonnier J, Hermant JF, Gombert R, Assous E (1990) Central alpha 1-adrenergic stimulation in relation to the behaviour stimulating effect of modafinil; studies with experimental animals. Eur J Pharmacol 180:49-58.
10. 3 receptor gene expression and changes in the phenotype of the striatal neurons in mice lacking the dopamine transporter. Eur J Neurosci 12:19-26.
11. Ferraro L, Tanganelli S, O'Connor WT, Antonelli T, Rambert F, Fuxe K (1996) The vigilance promoting drug modafinil decreases GABA release in the medial preoptic area and in the posterior hypothalamus of the awake rat: possible involvement of the serotonergic 5-HT3 receptor. Neurosci Lett 220:5-8.
12. Ferraro L, Antonelli T, O'Connor WT, Tanganelli S, Rambert FA, Fuxe K (1998) The effects of modafinil on striatal, pallidal and nigral GABA and glutamate release in the conscious rat: evidence for a preferential inhibition of striato-pallidal GABA transmission. Neurosci Lett 253:135-138.
13. Franklin KBJ, Paxinos G (1997) The mouse brain in stereotaxic coordinates. San Diego: Academic.
14. Haj-Dahmane S (2001) D2-like dopamine receptor activation excites rat dorsal raphe 5-HT neurons in vitro. Eur J Neurosci 14:125-134.
15. 2A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats. J Neurochem 92:1542-1549.
16. Huang ZL, Qu WM, Li WD, Mochizuki T, Eguchi N, Watanabe T, Urade Y, Hayaishi O (2001) Arousal effect of orexin A depends on activation of the histaminergic system. Proc Natl Acad Sci U S A 98:9965-9970.
17. 1, receptors mediate the arousal effect of caffeine. Nat Neurosci 8:858-859.
18. 3 receptor antagonist in histamine H1 receptor knockout mice. Proc Natl Acad Sci U S A 103:4687-4692.
19. Huang ZL, Urade Y, Hayaishi O (2007) Prostaglandins and adenosine in the regulation of sleep and wakefulness. Curr Opin Pharmacol 7:33-38.
20. Ishizuka T, Sakamoto Y, Sakurai T, Yamatodani A (2003) Modafinil increases histamine release in the anterior hypothalamus of rats. Neurosci Lett 339:143-146.
21. Jasinski DR (2000) An evaluation of the abuse potential of modafinil using methylphenidate as a reference. J Psychopharmacol 14:53-60.
22. Jones SR, Gainetdinov RR, Hu XT, Cooper DC, Wightman RM, White FJ, Caron MG (1999) Loss of autoreceptor functions in mice lacking the dopamine transporter. Nat Neurosci 2:649-655.
23. 2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations. J Neurosci 18:3470-3479.
24. 2 receptor-mediated signaling is lethal in mice. Proc Natl Acad Sci U S A 101:11465-11470.
25. Kohtoh S, Taguchi Y, Matsumoto N, Wada M, Huang ZL, Urade Y (2008) Algorithm for sleep scoring in experimental animals based on fast Fourier transform power spectrum analysis of the electroencephalogram. Sleep Biol Rhythms 6:163-171.
26. 2-like receptors. Neuropharmacology 52:626-633.
27. Lin JS, Roussel B, Akaoka H, Fort P, Debilly G, Jouvet M (1992) Role of catecholamines in the modafinil and amphetamine induced wakefulness, a comparative pharmacological study in the cat. Brain Res 591:319-326.
28. Mignot E, Nishino S, Guilleminault C, Dement WC (1994) Modafinil binds to the dopamine uptake carrier site with low affinity. Sleep 17:436-437.
29. Minzenberg MJ, Carter CS (2008) Modafinil: a review of neurochemical actions and effects on cognition. Neuropsychopharmacology 33:1477-1502.
30. Missale C, Nash SR, Robinson SW, Jaber M, Caron MG (1998) Dopamine receptors: from structure to function. Physiol Rev 78:189-225.
31. Monti JM, Monti D (2007) The involvement of dopamine in the modulation of sleep and waking. Sleep Med Rev 11:113-133.
32. Murillo-Rodríguez E, Haro R, Palomero-Rivero M, Millán-Aldaco D, Drucker-Colín R (2007) Modafinil enhances extracellular levels of dopamine in the nucleus accumbens and increases wakefulness in rats. Behav Brain Res 176:353-357.
33. Nishino S, Mignot E (1997) Pharmacological aspects of human and canine narcolepsy. Prog Neurobiol 52:27-78.
34. Nishino S, Mao J, Sampathkumaran R, Shelton J (1998) Increased dopaminergic transmission mediates the wake-promoting effects of CNS stimulants. Sleep Res Online 1:49-61.
35. Ongini E, Bonizzoni E, Ferri N, Milani S, Trampus M (1993) Differential effects of dopamine D-1 and D-2 receptor antagonist antipsychotics on sleep-wake patterns in the rat. J Pharmacol Exp Ther 266:726-731.
36. Parish CL, Finkelstein DI, Drago J, Borrelli E, Horne MK (2001) The role of dopamine receptors in regulating the size of axonal arbors. J Neurosci 21:5147-5157.
37. 3-receptor as a novel therapeutic target for vigilance and sleep-wake disorders. Biochem Pharmacol 73:1157-1171.
38. 2 involved in regulation of physiological sleep. Proc Natl Acad Sci U S A 103:17949-17954.
39. Rao Y, Liu ZW, Borok E, Rabenstein RL, Shanabrough M, Lu M, Picciotto MR, Horvath TL, Gao XB (2007) Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons. J Clin Invest 117:4022-4033.
40. Scammell TE, Estabrooke IV, McCarthy MT, Chemelli RM, Yanagisawa M, Miller MS, Saper CB (2000) Hypothalamic arousal regions are activated during modafinil-induced wakefulness. J Neurosci 20:8620-8628.
41. Shelton J, Nishino S, Vaught J, Dement WC, Mignot E (1995) Comparative effects of modafinil and amphetamine on daytime sleepiness and cataplexy of narcoleptic dogs. Sleep 18:817-826.
42. Simon P, Hémet C, Ramassamy C, Costentin J (1995) Non-amphetaminic mechanism of stimulant locomotor effect of modafinil in mice. Eur Neuropsychopharmacol 5:509-514.
43. Stone EA, Cotecchia S, Lin Y, Quartermain D (2002) Role of brain alpha 1B-adrenoceptors in modafinil-induced behavioral activity. Synapse 46:269-270.
44. Usiello A, Baik JH, Rougé-Pont F, Picetti R, Dierich A, LeMeur M, Piazza PV, Borrelli E (2000) Distinct functions of the two isoforms of dopamine D2 receptors. Nature 408:199-203.
45. 2 dopamine receptor mRNA in rat brain. Proc Natl Acad Sci U S A 88:1859-1863.
46. Wieland HA, Söll RM, Doods HN, Stenkamp D, Hurnaus R, Lämmle B, Beck-Sickinger AG (2002) The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor. Eur J Biochem 269:1128-1135.
47. Willie JT, Renthal W, Chemelli RM, Miller MS, Scammell TE, Yanagisawa M, Sinton CM (2005) Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates. Neuroscience 130:983-995.
48. Wisor JP, Eriksson KS (2005) Dopaminergic-adrenergic interactions in the wake promoting mechanism of modafinil. Neuroscience 132:1027-1034.
49. Wisor JP, Nishino S, Sora I, Uhl GH, Mignot E, Edgar DM (2001) Dopaminergic role in stimulant-induced wakefulness. J Neurosci 21:1787-1794.
50. 2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary. Genes Cells 1:253-268.
51. Zeitzer JM, Nishino S, Mignot E (2006) The neurobiology of hypocretins (orexins), narcolepsy and related therapeutic interventions. Trends Pharmacol Sci 27:368-374.