Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 11, 2011, Pages 4471-4476

  Mochizuki, Takatoshi ^a   Arrigoni, Elda ^a   Marcus, Jacob N ^a,b   Clark, Erika L ^a   Yamamoto, Mihoko ^a   Honer, Michael ^c   Borroni, Edilio ^c   Lowell, Bradford B ^a   Elmquist, Joel K ^a,d   Scammell, Thomas E ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Arousal; Cre loxP; G protein coupled receptors; Histamine

Indexed keywords

CRE RECOMBINASE; OREXIN 2 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FEMALE; GERMLINE MICRONUCLEUS; MALE; MOUSE; NARCOLEPSY; NONHUMAN; POSTERIOR HYPOTHALAMUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOMNOLENCE; TUBEROMAMMILLARY NUCLEUS;

ANIMALS; ANTIGENS, SURFACE; DEPENDOVIRUS; ELECTROPHYSIOLOGICAL PHENOMENA; FEMALE; HYPOTHALAMIC AREA, LATERAL; HYPOTHALAMUS; INTEGRASES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, TRANSGENIC; MICROINJECTIONS; NARCOLEPSY; NEUROPEPTIDES; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SLEEP; TRANSCRIPTION, GENETIC; WAKEFULNESS;

MUS;

EID: 79952719541     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1012456108     Document Type: Article

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