-
1
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
Masters, C. L.; Simms, G.; Weinmann, N. A.; Multhaup, G.; McDonald, B. L.; Beyreuther, K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc. Natl. Acad. Sci. U.S.A., 1985, 82(12), 4245-4249.
-
(1985)
Proc. Natl. Acad. Sci. U.S.A
, vol.82
, Issue.12
, pp. 4245-4249
-
-
Masters, C.L.1
Simms, G.2
Weinmann, N.A.3
Multhaup, G.4
McDonald, B.L.5
Beyreuther, K.6
-
2
-
-
5344277556
-
Deciphering the molecular basis of memory failure in Alzheimer's diseas
-
Walsh, D. M.; Selkoe, D. J. Deciphering the molecular basis of memory failure in Alzheimer's diseas. Neuron, 2004, 44(1), 181-193.
-
(2004)
Neuron
, vol.44
, Issue.1
, pp. 181-193
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
3
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid beta-peptide
-
Haass, C; Selkoe, D. J. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat. Rev. Mol. Cell. Biol., 2007, 8(2), 101-112.
-
(2007)
Nat. Rev. Mol. Cell. Biol
, vol.8
, Issue.2
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
4
-
-
34250819839
-
Intracellular amyloid-p in Alzheimer's disease
-
LaFerla, F.; Green, K. N.; Oddo, S. Intracellular amyloid-p in Alzheimer's disease. Nat. Rev. Neurosci., 2007, 8, 499-509.
-
(2007)
Nat. Rev. Neurosci
, vol.8
, pp. 499-509
-
-
Laferla, F.1
Green, K.N.2
Oddo, S.3
-
5
-
-
77953019895
-
Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease
-
Gouras, G. K.; Tampellini, D.; Takahashi, R. H.; Capetillo-Zarate, E. Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease. Acta Neuropathol, 2010, 119(5), 523-541.
-
(2010)
Acta Neuropathol
, vol.119
, Issue.5
, pp. 523-541
-
-
Gouras, G.K.1
Tampellini, D.2
Takahashi, R.H.3
Capetillo-Zarate, E.4
-
6
-
-
79952747862
-
Alzheimer's disease
-
Ballard, C; Gauthier, S.; Corbett, A.; Brayne, C; Aarsland, D.; Jones, E. Alzheimer's disease. The Lancet, 2011, 377(9770), 1019-1031.
-
(2011)
The Lancet
, vol.377
, Issue.9770
, pp. 1019-1031
-
-
Ballard, C.1
Gauthier, S.2
Corbett, A.3
Brayne, C.4
Aarsland, D.5
Jones, E.6
-
7
-
-
82355192272
-
The Ap oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease
-
Ferreira, S. T.; Klein, W. L. The Ap oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease. Neurobiol. Learn. Mem., 2011, 96(4), 529-543.
-
(2011)
Neurobiol. Learn. Mem
, vol.96
, Issue.4
, pp. 529-543
-
-
Ferreira, S.T.1
Klein, W.L.2
-
8
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar, R.; Bennet, B. D.; Babu-Khan, S.; Khan, S.; Mendiaz, E. A.; Denis, P.; Teplow, D. B.; Ross, S.; Amarante, P.; Loeloff, R.; Luo, Y.; Fisher, S.; Fuller, J.; Edenson, S.; Lile, J.; Jarosinski, M. A.; Biere, A. L.; Curran, E.; Burgess, T.; Louis, J. C; Collins, F.; Treanor, J.; Rogers, G.; Citron, M. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science, 1999, 286(5440), 735-741.
-
(1999)
Science
, vol.286
, Issue.5440
, pp. 735-741
-
-
Vassar, R.1
Bennet, B.D.2
Babu-Khan, S.3
Khan, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
Luo, Y.11
Fisher, S.12
Fuller, J.13
Edenson, S.14
Lile, J.15
Jarosinski, M.A.16
Biere, A.L.17
Curran, E.18
Burgess, T.19
Louis, J.C.20
Collins, F.21
Treanor, J.22
Rogers, G.23
Citron, M.24
more..
-
9
-
-
0035066332
-
Alzheimer's disease: Genes, proteins and therapy
-
Selkoe, D. J. Alzheimer's disease: genes, proteins and therapy. Physiol. Rev., 2001, 81(2), 741-766.
-
(2001)
Physiol. Rev
, vol.81
, Issue.2
, pp. 741-766
-
-
Selkoe, D.J.1
-
10
-
-
0242330363
-
Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: Role of BACE1 in the constitutive secretory pathway
-
Hook, V. Y.; Reisine, T. D. Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE1 in the constitutive secretory pathway. J. Neurosci. Res., 2003, 74(3), 393-405.
-
(2003)
J. Neurosci. Res
, vol.74
, Issue.3
, pp. 393-405
-
-
Hook, V.Y.1
Reisine, T.D.2
-
11
-
-
0026794746
-
Mass spectrometry of purified amyloid beta protein in Alzheimer's disease
-
Mori, H.; Takio, K.; Ogawara, M.; Selkoe, D. J. Mass spectrometry of purified amyloid beta protein in Alzheimer's disease. J. Biol. Chem., 1992, 267(24), 17082-17086.
-
(1992)
J. Biol. Chem
, vol.267
, Issue.24
, pp. 17082-17086
-
-
Mori, H.1
Takio, K.2
Ogawara, M.3
Selkoe, D.J.4
-
12
-
-
0026646605
-
Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids
-
Seubert, P.; Vigo-Pelfrey, C; Esch, F.; Lee, M.; Dovey, H.; Davis, D.; Sinha, S.; Schiossmacher, M.; Whaley, J.; Swindlehurst, C; McCormack, R.; Wolfert, R.; Selkoe, D.; Lieberburg, I.; Schenk, D. Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids. Nature, 1992, 359, 325-327.
-
(1992)
Nature
, vol.359
, pp. 325-327
-
-
Seubert, P.1
Vigo-Pelfrey, C.2
Esch, F.3
Lee, M.4
Dovey, H.5
Davis, D.6
Sinha, S.7
Schiossmacher, M.8
Whaley, J.9
Swindlehurst, C.10
McCormack, R.11
Wolfert, R.12
Selkoe, D.13
Lieberburg, I.14
Schenk, D.15
-
13
-
-
0027184611
-
Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease
-
Miller, D. L.; Papayannopoulos, I. A.; Styles, J.; Bobin, S. A.; Lin, Y. Y.; Biemann, K.; Iqbal, K. Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease. Arch. Biochem. Biophys., 1993, 301(1), 41-52.
-
(1993)
Arch. Biochem. Biophys
, vol.301
, Issue.1
, pp. 41-52
-
-
Miller, D.L.1
Papayannopoulos, I.A.2
Styles, J.3
Bobin, S.A.4
Lin, Y.Y.5
Biemann, K.6
Iqbal, K.7
-
14
-
-
0028855851
-
Dominant and differential deposition of distinct pi-amyloid peptide species, ApN3(pE), in senile plaques
-
Saido, T. C; Iwatsubo, T.; Mann, D. M. A.; Shimada, H.; Ihara, Y.; Kawashima, S. Dominant and differential deposition of distinct pi-amyloid peptide species, ApN3(pE), in senile plaques. Neuron, 1995, 14, 457-466.
-
(1995)
Neuron
, vol.14
, pp. 457-466
-
-
Saido, T.C.1
Iwatsubo, T.2
Mann, D.M.A.3
Shimada, H.4
Ihara, Y.5
Kawashima, S.6
-
15
-
-
0030582387
-
Amino- and carboxyl-terminal heterogeneity of p-amyloid peptides deposited in human brain
-
Saido, T. C; Yamao-Harigaya, W.; Iwatsubo, T.; Kawashima, S. Amino- and carboxyl-terminal heterogeneity of p-amyloid peptides deposited in human brain. Neurosci. Lett., 1996, 215, 173-176.
-
(1996)
Neurosci. Lett
, vol.215
, pp. 173-176
-
-
Saido, T.C.1
Yamao-Harigaya, W.2
Iwatsubo, T.3
Kawashima, S.4
-
16
-
-
0029889248
-
High-resolution separation of amyloid beta-peptides: Structural variants present in Alzheimer's disease amyloid
-
Naslund, J.; Karlstrom, A. R.; Tjernberg, L. O.; Schierhorn, A.; Terenius, L.; Nordstedt, C. High-resolution separation of amyloid beta-peptides: structural variants present in Alzheimer's disease amyloid. J. Neurochem., 1996, 67(1), 294-301.
-
(1996)
J. Neurochem
, vol.67
, Issue.1
, pp. 294-301
-
-
Naslund, J.1
Karlstrom, A.R.2
Tjernberg, L.O.3
Schierhorn, A.4
Terenius, L.5
Nordstedt, C.6
-
17
-
-
0030742712
-
Heterogeneity of water-soluble amyloid beta-peptide in Alzheimer's disease and Dowńs syndrome brains
-
Russo, C; Saido, T. C; DeBusk, L. M.; Tabaton, M.; Gambetti, P.; Teller, J. K. Heterogeneity of water-soluble amyloid beta-peptide in Alzheimer's disease and Dowńs syndrome brains. FEBS Lett., 1997, 409(3), 411-416.
-
(1997)
FEBS Lett
, vol.409
, Issue.3
, pp. 411-416
-
-
Russo, C.1
Saido, T.C.2
Debusk, L.M.3
Tabaton, M.4
Gambetti, P.5
Teller, J.K.6
-
18
-
-
0031985080
-
N-terminal heterogeneity of parenchymal and cerebrovascular Abeta deposits
-
Tekirian, T. L.; Markesbery, W. R.; Russel, M. J.; Wekstein, D. R.; Patel, E.; Geddes, J. W. N-terminal heterogeneity of parenchymal and cerebrovascular Abeta deposits. J. Neuropathol. Exp. Neurol., 1998, 57(1), 76-94.
-
(1998)
J. Neuropathol. Exp. Neurol
, vol.57
, Issue.1
, pp. 76-94
-
-
Tekirian, T.L.1
Markesbery, W.R.2
Russel, M.J.3
Wekstein, D.R.4
Patel, E.5
Geddes, J.W.6
-
19
-
-
0032815498
-
Hypothesis: Amyloid p-peptides truncated at the N-terminus contribute to the pathogenesis of Alzheimer's disease
-
Larner, A. J. Hypothesis: amyloid p-peptides truncated at the N-terminus contribute to the pathogenesis of Alzheimer's disease. Neurobiol. Aging, 1999, 20, 65-69.
-
(1999)
Neurobiol. Aging
, vol.20
, pp. 65-69
-
-
Larner, A.J.1
-
20
-
-
0034327364
-
Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease
-
Kumar-Singh, S.; De Jonghe, C; Cruts, M.; Kleinert, R.; Wang, R.; Mercken, M.; De Strooper, B.; Vanderstichele, H.; Lofgren, A; Vanderhoevens, H.; Vanmechelen, E.; Kroisel, P. M.; Van Broeckhoven, C. Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease. Hum. Mol. Genet, 2000, 9(18), 2589-2598.
-
(2000)
Hum. Mol. Genet
, vol.9
, Issue.18
, pp. 2589-2598
-
-
Kumar-Singh, S.1
de Jonghe, C.2
Cruts, M.3
Kleinert, R.4
Wang, R.5
Mercken, M.6
de Strooper, B.7
Vanderstichele, H.8
Lofgren, A.9
Vanderhoevens, H.10
Vanmechelen, E.11
Kroisel, P.M.12
van Broeckhoven, C.13
-
21
-
-
23844551164
-
Amino-terminally truncated Ap peptide species are the main component of cotton wool plaques
-
Miravalle, L.; Calero, M.; Takao, M.; Roher, A. E.; Ghetti, B.; Vidal, R. Amino-terminally truncated Ap peptide species are the main component of cotton wool plaques. Biochemistry, 2005, 44, 10810-10821.
-
(2005)
Biochemistry
, vol.44
, pp. 10810-10821
-
-
Miravalle, L.1
Calero, M.2
Takao, M.3
Roher, A.E.4
Ghetti, B.5
Vidal, R.6
-
22
-
-
24144443470
-
Amino-truncated p-amyloid 42 peptides in cerebrospinal fluid and prediction of progression of mild cognitive impairment
-
Vanderstichele, H.; De Meyer, G.; Andreasen, N.; Kostanjevecki, V.; Wallin, A.; Olsson, A.; Blennow, K.; Vanmechelen, E. Amino-truncated p-amyloid 42 peptides in cerebrospinal fluid and prediction of progression of mild cognitive impairment. Clin. Chem., 2005, 51(9), 1650-1660.
-
(2005)
Clin. Chem
, vol.51
, Issue.9
, pp. 1650-1660
-
-
Vanderstichele, H.1
de Meyer, G.2
Andreasen, N.3
Kostanjevecki, V.4
Wallin, A.5
Olsson, A.6
Blennow, K.7
Vanmechelen, E.8
-
23
-
-
0037013209
-
p-Secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain
-
Huse, J. T.; Liu, K.; Pijak, D. S.; Carlin, D.; Lee, V. M. -Y.; Doms, R. W. p-Secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain. J. Biol. Chem., 2002, 277(18), 16278-16284.
-
(2002)
J. Biol. Chem
, vol.277
, Issue.18
, pp. 16278-16284
-
-
Huse, J.T.1
Liu, K.2
Pijak, D.S.3
Carlin, D.4
Lee, V.M.-Y.5
Doms, R.W.6
-
24
-
-
0038751845
-
Secretion and intracellular generation of truncated Ap in p-site amyloid-p precursor protein-cleaving enzyme expressing human neurons
-
Lee, E. B.; Skovronsky, D. M.; Abtahian, F.; Doms, R. W.; Lee, V. M. Y. Secretion and intracellular generation of truncated Ap in p-site amyloid-p precursor protein-cleaving enzyme expressing human neurons. J. Biol. Chem., 2003, 278(7), 4458-4466.
-
(2003)
J. Biol. Chem
, vol.278
, Issue.7
, pp. 4458-4466
-
-
Lee, E.B.1
Skovronsky, D.M.2
Abtahian, F.3
Doms, R.W.4
Lee, V.M.Y.5
-
25
-
-
33947305482
-
Characterization of Ap11-40/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: Implication of N-terminally truncated Ap species in the pathogenesis of Alzheimer's disease
-
Liu, K.; Solano, I.; Mann, D.; Lemere, C; Mercken, M.; Trojanowski, J. Q.; Lee, V. M. Y. Characterization of Ap11-40/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: implication of N-terminally truncated Ap species in the pathogenesis of Alzheimer's disease. Acta Neuropathol., 2006, 112(2), 163-174.
-
(2006)
Acta Neuropathol
, vol.112
, Issue.2
, pp. 163-174
-
-
Liu, K.1
Solano, I.2
Mann, D.3
Lemere, C.4
Mercken, M.5
Trojanowski, J.Q.6
Lee, V.M.Y.7
-
26
-
-
26644445247
-
p-Amyloid Is Different in Normal Aging and in Alzheimer Disease
-
Piccini, A.; Russo, C; Gliozzi, A.; Relini, A; Vitali, A.; Borghi, R.; Giliberto, L.; Armirotti, A.; D'Arrigo, C; Bachi, A.; Cattaneo, A.; Canale, C; Torrassa, S.; Saido, T. C; Markesbery, W.; Gambetti, P.; Tabaton, M. p-Amyloid Is Different in Normal Aging and in Alzheimer Disease. J. Biol. Chem., 2005, 280(40), 34186-34192.
-
(2005)
J. Biol. Chem
, vol.280
, Issue.40
, pp. 34186-34192
-
-
Piccini, A.1
Russo, C.2
Gliozzi, A.3
Relini, A.4
Vitali, A.5
Borghi, R.6
Giliberto, L.7
Armirotti, A.8
D'Arrigo, C.9
Bachi, A.10
Cattaneo, A.11
Canale, C.12
Torrassa, S.13
Saido, T.C.14
Markesbery, W.15
Gambetti, P.16
Tabaton, M.17
-
27
-
-
33750825049
-
High sensitivity analysis of amyloid-beta peptide composition in amyloid deposits from human and PS2APP mouse brain
-
Guntert, A.; Dobeli, H.; Bohrmann, B. High sensitivity analysis of amyloid-beta peptide composition in amyloid deposits from human and PS2APP mouse brain. Neuroscience, 2006, 143, 461-475.
-
(2006)
Neuroscience
, vol.143
, pp. 461-475
-
-
Guntert, A.1
Dobeli, H.2
Bohrmann, B.3
-
28
-
-
0031729335
-
Quantification of modified amyloid beta peptides in Alzheimer disease and Down syndrome brains
-
Hosoda, R.; Saido, T. C; Otvos, L. Jr.; Arai, T.; Mann, D. M.; Lee, V. M.; Trojanowski, J. Q.; Iwatsubo, T. Quantification of modified amyloid beta peptides in Alzheimer disease and Down syndrome brains. J. Neuropathol. Exp. Neurol., 1998, 57(11), 1089-1095.
-
(1998)
J. Neuropathol. Exp. Neurol
, vol.57
, Issue.11
, pp. 1089-1095
-
-
Hosoda, R.1
Saido, T.C.2
Otvos Jr., L.3
Arai, T.4
Mann, D.M.5
Lee, V.M.6
Trojanowski, J.Q.7
Iwatsubo, T.8
-
29
-
-
78149281327
-
Pyroglutamate-Ap: Role in the natural history of Alzheimer's disease
-
Gunn, A. P.; Masters, C. L.; Cherny, R. A. Pyroglutamate-Ap: role in the natural history of Alzheimer's disease. Int. J. Biochem. Cell Biol, 2010, 42(12), 1915-1918.
-
(2010)
Int. J. Biochem. Cell Biol
, vol.42
, Issue.12
, pp. 1915-1918
-
-
Gunn, A.P.1
Masters, C.L.2
Cherny, R.A.3
-
30
-
-
80655144756
-
Pyroglutamate amyloid p (Ap): A hatchet man in Alzheimer Disease
-
Jawhar, S.; Wirths, O.; Bayer, T. A. Pyroglutamate amyloid p (Ap): a hatchet man in Alzheimer Disease. J. Biol. Chem., 2011, 286(45), 38825-38832.
-
(2011)
J. Biol. Chem
, vol.286
, Issue.45
, pp. 38825-38832
-
-
Jawhar, S.1
Wirths, O.2
Bayer, T.A.3
-
31
-
-
81055155827
-
Pyroglutamate-Ap 3 and 11 colocalize in amyloid plaques in Alzheimer's disease cerebral cortex with pyroglutamate-Ap 11 forming central core
-
Sullivan, C. P.; Berg, E. A.; Elliot-Bryant, R.; Fishman, J. B.; McKee, A. C; Morin, P. J.; Shia, M. A.; Fine, R. E. Pyroglutamate-Ap 3 and 11 colocalize in amyloid plaques in Alzheimer's disease cerebral cortex with pyroglutamate-Ap 11 forming central core. Neurosci. Lett., 2011, 505(2), 109-112.
-
(2011)
Neurosci. Lett
, vol.505
, Issue.2
, pp. 109-112
-
-
Sullivan, C.P.1
Berg, E.A.2
Elliot-Bryant, R.3
Fishman, J.B.4
McKee, A.C.5
Morin, P.J.6
Shia, M.A.7
Fine, R.E.8
-
32
-
-
0034710784
-
Amyloid p protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimers disease brain
-
Harigaya, Y.; Saido, T. C; Eckman, C. B.; Prada, C. M.; Shoji, M.; Younkin, S. G. Amyloid p protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimers disease brain. Biochem. Biophys. Res. Comm., 2000, 276(2), 422-427.
-
(2000)
Biochem. Biophys. Res. Comm
, vol.276
, Issue.2
, pp. 422-427
-
-
Harigaya, Y.1
Saido, T.C.2
Eckman, C.B.3
Prada, C.M.4
Shoji, M.5
Younkin, S.G.6
-
33
-
-
77957279325
-
Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease
-
Portelius, E.; Bogdanovic, N.; Gustavsson, M. K.; Volkmann, I.; Brinkmalm, G.; Zetterberg, H.; Winblad, B.; Blennow, K. Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease. Acta Neuropathol, 2010, 120(2), 185-193.
-
(2010)
Acta Neuropathol
, vol.120
, Issue.2
, pp. 185-193
-
-
Portelius, E.1
Bogdanovic, N.2
Gustavsson, M.K.3
Volkmann, I.4
Brinkmalm, G.5
Zetterberg, H.6
Winblad, B.7
Blennow, K.8
-
34
-
-
76949102099
-
Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases
-
Wirths, O.; Bethge, T.; Marcello, A.; Harmeier, A.; Jawhar, S.; Lucassen, P. J.; Milthaup, G. Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases. J. Neural. Transm., 2010, 117(1), 85-96.
-
(2010)
J. Neural. Transm
, vol.117
, Issue.1
, pp. 85-96
-
-
Wirths, O.1
Bethge, T.2
Marcello, A.3
Harmeier, A.4
Jawhar, S.5
Lucassen, P.J.6
Milthaup, G.7
-
35
-
-
78650637437
-
Identification of low molecular weight pyroglutamate Ap oligomers in Alzheimer Disiease. A novel tool for therapy and diagnosis
-
Wirths, O.; Erck, C; Martens, H.; Harmeier, A.; Geumann, C; Jawhar, S.; Kumar, S.; Multhaup, G.; Walter, J.; Ingelsson, M.; Degerman-Gunnarsson, M.; Kalimo, H.; Huitinga, I.; Lannfelt, L.; Bayer, T. A. Identification of low molecular weight pyroglutamate Ap oligomers in Alzheimer Disiease. A novel tool for therapy and diagnosis. J. Biol. Chem., 2010, 285(53), 41517-41524.
-
(2010)
J. Biol. Chem
, vol.285
, Issue.53
, pp. 41517-41524
-
-
Wirths, O.1
Erck, C.2
Martens, H.3
Harmeier, A.4
Geumann, C.5
Jawhar, S.6
Kumar, S.7
Multhaup, G.8
Walter, J.9
Ingelsson, M.10
Degerman-Gunnarsson, M.11
Kalimo, H.12
Huitinga, I.13
Lannfelt, L.14
Bayer, T.A.15
-
36
-
-
12444337654
-
Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach
-
Sergeant, N.; Bombois, S.; Ghestem, A.; Drobecq, H.; Kostanjevecki, V.; Missiaen, C; Wattez, A.; David, J. P.; Vanmechelen, E.; Sergheraert, C; Delacourte, A. Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach. J. Neurochem., 2003, 85, 1581-1591.
-
(2003)
J. Neurochem
, vol.85
, pp. 1581-1591
-
-
Sergeant, N.1
Bombois, S.2
Ghestem, A.3
Drobecq, H.4
Kostanjevecki, V.5
Missiaen, C.6
Wattez, A.7
David, J.P.8
Vanmechelen, E.9
Sergheraert, C.10
Delacourte, A.11
-
37
-
-
0028885682
-
Amino-terminal Deletions Enhance Aggregation of beta-Amyloid Peptides in vitro
-
Pike, C. J.; Overman, M. J.; Cotman, C. W. Amino-terminal Deletions Enhance Aggregation of beta-Amyloid Peptides in vitro. J. Biol. Chem., 1995, 270(41), 23895-23898.
-
(1995)
J. Biol. Chem
, vol.270
, Issue.41
, pp. 23895-23898
-
-
Pike, C.J.1
Overman, M.J.2
Cotman, C.W.3
-
38
-
-
0033578402
-
The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta
-
He, W.; Barrow, C. J. The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta. Biochemistry, 1999, 38, 10871-10877.
-
(1999)
Biochemistry
, vol.38
, pp. 10871-10877
-
-
He, W.1
Barrow, C.J.2
-
39
-
-
17644443469
-
Pyrglutamate-modified amyloid p-peptides -ApN3(pE) - strongly affect cultured neuron and astrocyte survival
-
Russo, C; Violani, E., Salis, S.; Venezia, V.; Dolcini, V.; Damonte, G.; Benatti, U.; D'Ariigo, C; Patrone, E.; Carlo, P.; Schettini, G. Pyrglutamate-modified amyloid p-peptides -ApN3(pE) - strongly affect cultured neuron and astrocyte survival. J. Neurochem., 2002, 82, 1480-1489.
-
(2002)
J. Neurochem
, vol.82
, pp. 1480-1489
-
-
Russo, C.1
Violani, E.2
Salis, S.3
Venezia, V.4
Dolcini, V.5
Damonte, G.6
Benatti, U.7
D'Ariigo, C.8
Patrone, E.9
Carlo, P.10
Schettini, G.11
-
40
-
-
33749617597
-
On the seeding and oligomerization of pGlu-amyloid peptides (in vitro)
-
Schilling, S.; Lauber, T.; Schaupp, M.; Manhart, S.; Scheel, E.; Bohm, G.; Demuth, H. U. On the seeding and oligomerization of pGlu-amyloid peptides (in vitro). Biochemistry, 2006, 45(41), 12393-12399.
-
(2006)
Biochemistry
, vol.45
, Issue.41
, pp. 12393-12399
-
-
Schilling, S.1
Lauber, T.2
Schaupp, M.3
Manhart, S.4
Scheel, E.5
Bohm, G.6
Demuth, H.U.7
-
41
-
-
47249113393
-
N-truncated amyloid-p oligomers induce learning impairment and neuronal apoptosis
-
Youssef, I.; Florent-Bechard, S.; Malaplate-Armand, C; Koziel, V.; Bihain, B.; Olivier, J. L.; Leininger-Muller, B.; Kriem, B.; Oster, T.; Pillot, T. N-truncated amyloid-p oligomers induce learning impairment and neuronal apoptosis. Neurobiol. Aging, 2007, 29, 1319-1333.
-
(2007)
Neurobiol. Aging
, vol.29
, pp. 1319-1333
-
-
Youssef, I.1
Florent-Bechard, S.2
Malaplate-Armand, C.3
Koziel, V.4
Bihain, B.5
Olivier, J.L.6
Leininger-Muller, B.7
Kriem, B.8
Oster, T.9
Pillot, T.10
-
42
-
-
70349787118
-
N-terminal truncated pyroglutamyl p amyloid peptide Appy3-42 shows a faster aggregation kinetics than the full-length Ap1-42
-
D'Arrigo, C; Tabaton, M.; Perico, A. N-terminal truncated pyroglutamyl p amyloid peptide Appy3-42 shows a faster aggregation kinetics than the full-length Ap1-42. Biopolymers, 2009, 91(10), 861-873.
-
(2009)
Biopolymers
, vol.91
, Issue.10
, pp. 861-873
-
-
D'Arrigo, C.1
Tabaton, M.2
Perico, A.3
-
43
-
-
84863762839
-
Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-p
-
Nussbaum, J. M.; Schilling, S.; Cynis, H.; Silva, A.; Swanson, E.; Wangsanut, T.; Tayler, K.; Wiltgen, B.; Hatami, A.; Ronicke, R.; Reymann, K.; Hutter-Paier, B.; Alexandru, A.; Jagla, W.; Graubner, S.; Glabe, C. G.; Demuth, H. U.; Bloom, G. S. Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-p. Nature, 2012, 485, 651-655.
-
(2012)
Nature
, vol.485
, pp. 651-655
-
-
Nussbaum, J.M.1
Schilling, S.2
Cynis, H.3
Silva, A.4
Swanson, E.5
Wangsanut, T.6
Tayler, K.7
Wiltgen, B.8
Hatami, A.9
Ronicke, R.10
Reymann, K.11
Hutter-Paier, B.12
Alexandru, A.13
Jagla, W.14
Graubner, S.15
Glabe, C.G.16
Demuth, H.U.17
Bloom, G.S.18
-
44
-
-
84867898641
-
Structural analysis of the pyroglutamate-modified isoform of the Alzheimer's disease-related amyloid-p using NMR stectroscopy
-
Sun, N.; Hartmann, R.; Lecher, J.; Stoldt, M.; Funke, S. A.; Gremer, L.; Ludwig, H. H.; Demuth, H. U.; Kleinschmidt, M.; Willbold, D. Structural analysis of the pyroglutamate-modified isoform of the Alzheimer's disease-related amyloid-p using NMR stectroscopy. J. Pept. Sci., 2012, 18, 691-695.
-
(2012)
J. Pept. Sci
, vol.18
, pp. 691-695
-
-
Sun, N.1
Hartmann, R.2
Lecher, J.3
Stoldt, M.4
Funke, S.A.5
Gremer, L.6
Ludwig, H.H.7
Demuth, H.U.8
Kleinschmidt, M.9
Willbold, D.10
-
45
-
-
0022654027
-
Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease
-
Selkoe, D. J.; Abraham, C. R.; Podlisny, M. B.; Duffy, L. K. Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease. J. Neurochem., 1986, 46(6), 1820-1834.
-
(1986)
J. Neurochem
, vol.46
, Issue.6
, pp. 1820-1834
-
-
Selkoe, D.J.1
Abraham, C.R.2
Podlisny, M.B.3
Duffy, L.K.4
-
46
-
-
0024370108
-
Relationships among the cerebral amyloid peptides and their precursors
-
Miller, D. L.; Currie, J. R.; Iqbal, K.; Potempska, A.; Styles, J. Relationships among the cerebral amyloid peptides and their precursors. Ann. Med., 1989, 21(2), 83-87.
-
(1989)
Ann. Med
, vol.21
, Issue.2
, pp. 83-87
-
-
Miller, D.L.1
Currie, J.R.2
Iqbal, K.3
Potempska, A.4
Styles, J.5
-
47
-
-
0028106152
-
Relative abundance of Alzheimer Ap amyloid peptide variants in Alzheimer disease and normal aging
-
Naslund, J.; Schierhorn, A.; Hellman, U.; Lannfelt, L.; Roses, A. D.; Tjernberg, L. O.; Silberring, J.; Gandy, S. E.; Winblad, B.; Greengard, P.; Nordstedt, C; Terenius, L. Relative abundance of Alzheimer Ap amyloid peptide variants in Alzheimer disease and normal aging. Proc. Natl. Acad. Sci. USA, 1994, 91, 8378-8382.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 8378-8382
-
-
Naslund, J.1
Schierhorn, A.2
Hellman, U.3
Lannfelt, L.4
Roses, A.D.5
Tjernberg, L.O.6
Silberring, J.7
Gandy, S.E.8
Winblad, B.9
Greengard, P.10
Nordstedt, C.11
Terenius, L.12
-
48
-
-
77952551031
-
Concomitant detection of p-amyloid peptides with N-terminal truncation and diffeent C-terminal endings in cortical plaques from cases with Alzheimer's disease, senile monkeys and triple transgenic mice
-
Hartig, W.; Goldhammer, S.; Bauer, U.; Wegner, F.; Wirths, O.; Bayer, T. A.; Grosche, J. Concomitant detection of p-amyloid peptides with N-terminal truncation and diffeent C-terminal endings in cortical plaques from cases with Alzheimer's disease, senile monkeys and triple transgenic mice. J. Chem. Neuroanatomy, 2010, 40, 82-92.
-
(2010)
J. Chem. Neuroanatomy
, vol.40
, pp. 82-92
-
-
Hartig, W.1
Goldhammer, S.2
Bauer, U.3
Wegner, F.4
Wirths, O.5
Bayer, T.A.6
Grosche, J.7
-
49
-
-
0029849644
-
Full-length amyloid beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques
-
Iwatsubo, T.; Saido, T. C; Mann, D. M.; Lee, V. M.; Trojanowski, J. Q. Full-length amyloid beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques. Am. J. Pathol, 1996, 149(6), 1823-1830.
-
(1996)
Am. J. Pathol
, vol.149
, Issue.6
, pp. 1823-1830
-
-
Iwatsubo, T.1
Saido, T.C.2
Mann, D.M.3
Lee, V.M.4
Trojanowski, J.Q.5
-
50
-
-
0031559602
-
Isolation, Chemicalm characterization and quantitation of Ap 3-pyroglutamyl peptide from neuritic plaques and vascular amyloid deposits
-
Kuo, Y. M.; Emmerling, M. R.; Woods, A. S.; Cotter, R. J.; Roher, A. E. Isolation, Chemicalm characterization and quantitation of Ap 3-pyroglutamyl peptide from neuritic plaques and vascular amyloid deposits. Biochem. Biophys. Res. Commun., 1997, 237, 188-191.
-
(1997)
Biochem. Biophys. Res. Commun
, vol.237
, pp. 188-191
-
-
Kuo, Y.M.1
Emmerling, M.R.2
Woods, A.S.3
Cotter, R.J.4
Roher, A.E.5
-
51
-
-
84858051817
-
Detection of peri-synaptic amyloid-b pyroglutamate aggregates in early stages of Alzheimer's disease and in AbPP transgenic mice using a novel monoclonal antibody
-
Mandler, M.; Rockenstein, E.; Ubhi, K.; Hansen, L.; Adame, A.; Michael, S.; Galasko, D.; Santic, R.; Mattner, F.; Masliah, E. Detection of peri-synaptic amyloid-b pyroglutamate aggregates in early stages of Alzheimer's disease and in AbPP transgenic mice using a novel monoclonal antibody. J. Alzheimers Dis., 2012, 28(4), 783-794.
-
(2012)
J. Alzheimers Dis
, vol.28
, Issue.4
, pp. 783-794
-
-
Mandler, M.1
Rockenstein, E.2
Ubhi, K.3
Hansen, L.4
Adame, A.5
Michael, S.6
Galasko, D.7
Santic, R.8
Mattner, F.9
Masliah, E.10
-
52
-
-
79960882442
-
Intraneuronal Ap is a trigger for neuronal loss: Can this be translated into human pathology?
-
Bayer, T. A.; Wirths, O. Intraneuronal Ap is a trigger for neuronal loss: can this be translated into human pathology? Biochem. Soc. Trans., 2011, 39(4), 857-861.
-
(2011)
Biochem. Soc. Trans
, vol.39
, Issue.4
, pp. 857-861
-
-
Bayer, T.A.1
Wirths, O.2
-
53
-
-
84880570156
-
-
AGE 2012, DOI 10.1007/s11357-012-9403-0
-
De Kimpe, L.; van Haastert, E. S.; Kaminari, A.; Zwart, R.; Rutjes, H.; Hoozemans, J. J. M.; Scheper, W. Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Ap pathology at the lysosome. AGE 2012, DOI 10.1007/s11357-012-9403-0.
-
Intracellular Accumulation of Aggregated Pyroglutamate Amyloid Beta: Convergence of Aging and Ap Pathology At the Lysosome
-
-
de Kimpe, L.1
van Haastert, E.S.2
Kaminari, A.3
Zwart, R.4
Rutjes, H.5
Hoozemans, J.J.M.6
Scheper, W.7
-
54
-
-
84860519322
-
N-terminal pyroglutamate formation of Ap38 and Ap40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation
-
Schlenzig, D.; Ronicke, R.; Cynis, H.; Ludwig, H. H.; Scheel, E.; Reymann, K.; Saido, T.; Hause, G.; Schilling, S.; Demuth, H. U. N-terminal pyroglutamate formation of Ap38 and Ap40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation. J. Neurochem., 2012, 121(5), 774-784.
-
(2012)
J. Neurochem
, vol.121
, Issue.5
, pp. 774-784
-
-
Schlenzig, D.1
Ronicke, R.2
Cynis, H.3
Ludwig, H.H.4
Scheel, E.5
Reymann, K.6
Saido, T.7
Hause, G.8
Schilling, S.9
Demuth, H.U.10
-
55
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
Kayed, R.; Head, E.; Thompson, J. L.; McIntire, T. M.; Milton, S. C; Cotman, C. W.; Glabe, C. G. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science, 2003, 300(5618), 486-489.
-
(2003)
Science
, vol.300
, Issue.5618
, pp. 486-489
-
-
Kayed, R.1
Head, E.2
Thompson, J.L.3
McIntire, T.M.4
Milton, S.C.5
Cotman, C.W.6
Glabe, C.G.7
-
56
-
-
68049116924
-
Immunodominant epitope and properties of pyroglutamate-modified Ap-specific antibodies produced in rabbits
-
Acero, G.; Manoutcharian, K.; Vasilevko, V.; Munguia, M. E.; Govezensky, T.; Coronas, G.; Luz-Madrigal, A.; Cribas, D. H.; Gevorkian, G. Immunodominant epitope and properties of pyroglutamate-modified Ap-specific antibodies produced in rabbits. J. Neuroimmunol, 2009, 213, 39-46.
-
(2009)
J. Neuroimmunol
, vol.213
, pp. 39-46
-
-
Acero, G.1
Manoutcharian, K.2
Vasilevko, V.3
Munguia, M.E.4
Govezensky, T.5
Coronas, G.6
Luz-Madrigal, A.7
Cribas, D.H.8
Gevorkian, G.9
-
57
-
-
0035863055
-
Age-dependent changes in brain, CSF, and plasma amyloid(beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease
-
Kawarabashi, T.; Younkin, L. H.; Saido, T. C; Shoji, M.; Ashe, K. H.; Younkin, S. G. Age-dependent changes in brain, CSF, and plasma amyloid(beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J. Neurosci., 2001, 21(2), 372-381.
-
(2001)
J. Neurosci
, vol.21
, Issue.2
, pp. 372-381
-
-
Kawarabashi, T.1
Younkin, L.H.2
Saido, T.C.3
Shoji, M.4
Ashe, K.H.5
Younkin, S.G.6
-
58
-
-
0037154117
-
APP transgenic mice Tg2576 accumulate Ap peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques
-
Kalback, W.; Watson, M. D.; Kokjohn, T. A.; Kuo, Y. M.; Weiss, N.; Luehrs, D. C; Lopez, J.; Brune, D.; Sisodia, S. S.; Staufenbiel, M.; Emmerling, M.; Roher, A. E. APP transgenic mice Tg2576 accumulate Ap peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques. Biochemistry, 2002, 41, 922-928.
-
(2002)
Biochemistry
, vol.41
, pp. 922-928
-
-
Kalback, W.1
Watson, M.D.2
Kokjohn, T.A.3
Kuo, Y.M.4
Weiss, N.5
Luehrs, D.C.6
Lopez, J.7
Brune, D.8
Sisodia, S.S.9
Staufenbiel, M.10
Emmerling, M.11
Roher, A.E.12
-
59
-
-
53549099647
-
Glutaminyl cyclase inhibition attenuates pyroglutamate Ap and Alzheimer's disease-like pathology
-
Schilling, S.; Zeitschel, U.; Hoffmann, T.; Heiser, U.; Francke, M.; Kehlen, A.; Holzer, M.; Hutter-Paier, B.; Prokesch, M.; Windisch, M.; Jagla, W.; Schlenzig, D.; Lindler, C; Rudolph, T.; Reuter, G.; Cynis, H.; Montag, D.; Demuth, H. U.; Rossner, S. Glutaminyl cyclase inhibition attenuates pyroglutamate Ap and Alzheimer's disease-like pathology. Nat. Med., 2008, 14(10), 1106-1111.
-
(2008)
Nat. Med
, vol.14
, Issue.10
, pp. 1106-1111
-
-
Schilling, S.1
Zeitschel, U.2
Hoffmann, T.3
Heiser, U.4
Francke, M.5
Kehlen, A.6
Holzer, M.7
Hutter-Paier, B.8
Prokesch, M.9
Windisch, M.10
Jagla, W.11
Schlenzig, D.12
Lindler, C.13
Rudolph, T.14
Reuter, G.15
Cynis, H.16
Montag, D.17
Demuth, H.U.18
Rossner, S.19
-
60
-
-
4644276796
-
Massive CA1/2 Neuronal Loss with Intraneuronal and N-Terminal Truncated Ap42 Accumulation in a Novel Alzheimer Transgenic Model
-
Casas, C; Sergeant, N.; Itier, J. M.; Blanchard, V.; Wirths, O.; van der Kolk, N.; Vingtdeux, V.; van de Steeg, E.; Ret, G.; Canton, T.; Drobecq, H.; Clark, A.; Bonici, B.; Delacourte, A.; Benavides, J.; Schmitz, C; Tremp, G.; Bayer, T. A.; Benoit, P.; Pradier, L. Massive CA1/2 Neuronal Loss with Intraneuronal and N-Terminal Truncated Ap42 Accumulation in a Novel Alzheimer Transgenic Model. Am. J. Pathol., 2004, 165(4), 1289-1300.
-
(2004)
Am. J. Pathol
, vol.165
, Issue.4
, pp. 1289-1300
-
-
Casas, C.1
Sergeant, N.2
Itier, J.M.3
Blanchard, V.4
Wirths, O.5
van der Kolk, N.6
Vingtdeux, V.7
van de Steeg, E.8
Ret, G.9
Canton, T.10
Drobecq, H.11
Clark, A.12
Bonici, B.13
Delacourte, A.14
Benavides, J.15
Schmitz, C.16
Tremp, G.17
Bayer, T.A.18
Benoit, P.19
Pradier, L.20
more..
-
61
-
-
40449115788
-
Intraneuronal p-amyloid is a major risk factor - novel evidence from the APP/PS1KI mouse model
-
Bayer, T. A.; Breyhan, H.; Duan, K.; Rettig, J.; Wirths, O. Intraneuronal p-amyloid is a major risk factor - novel evidence from the APP/PS1KI mouse model. Neurodegener. Dis., 2008, 5(3-4), 140-142.
-
(2008)
Neurodegener. Dis
, vol.5
, Issue.3-4
, pp. 140-142
-
-
Bayer, T.A.1
Breyhan, H.2
Duan, K.3
Rettig, J.4
Wirths, O.5
-
62
-
-
67349160489
-
APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy
-
Breyhan, H.; Wirths, O.; Duan, K.; Marcello, A.; Rettig, J.; Bayer, T. A. APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy. Acta Neuropathol., 2009, 117(6), 677-685.
-
(2009)
Acta Neuropathol
, vol.117
, Issue.6
, pp. 677-685
-
-
Breyhan, H.1
Wirths, O.2
Duan, K.3
Marcello, A.4
Rettig, J.5
Bayer, T.A.6
-
63
-
-
34548553576
-
Age-dependent axonal degeneration in an Alzheimer mouse model
-
Wirths, O.; Weis, J.; Kayed, R.; Saido, T. C; Bayer, T. A. Age-dependent axonal degeneration in an Alzheimer mouse model. Neurobiol. Aging, 2007, 28, 1689-1699.
-
(2007)
Neurobiol. Aging
, vol.28
, pp. 1689-1699
-
-
Wirths, O.1
Weis, J.2
Kayed, R.3
Saido, T.C.4
Bayer, T.A.5
-
64
-
-
69949135716
-
Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model
-
Wirths, O.; Breyhan, H.; Cynis, H.; Schilling, S.; Demuth, H. U.; Bayer, T. A. Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model. Acta Neuropathol., 2009, 118(4), 487-496.
-
(2009)
Acta Neuropathol
, vol.118
, Issue.4
, pp. 487-496
-
-
Wirths, O.1
Breyhan, H.2
Cynis, H.3
Schilling, S.4
Demuth, H.U.5
Bayer, T.A.6
-
65
-
-
80052578595
-
Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Ab is induced by pyroglutamate-Ap formation
-
Alexandru, A.; Jagla, W.; Graubner, S.; Becker, A.; Bauscher, C; Kohlmann, S.; Sedlmeier, R.; Raber, K. A.; Cynis, H.; Ronicke, R.; Reymann, K. G.; Petrasch-Parwez, E.; Hartlage-Rubsamen, M.; Waniek, A.; Rossner, S.; Schilling, S.; Osmand, A. P.; Demuth, H. U.; von Horsten, S. Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Ab is induced by pyroglutamate-Ap formation. J. Neurosci., 2011, 31(36), 12780-12801.
-
(2011)
J. Neurosci
, vol.31
, Issue.36
, pp. 12780-12801
-
-
Alexandru, A.1
Jagla, W.2
Graubner, S.3
Becker, A.4
Bauscher, C.5
Kohlmann, S.6
Sedlmeier, R.7
Raber, K.A.8
Cynis, H.9
Ronicke, R.10
Reymann, K.G.11
Petrasch-Parwez, E.12
Hartlage-Rubsamen, M.13
Waniek, A.14
Rossner, S.15
Schilling, S.16
Osmand, A.P.17
Demuth, H.U.18
von Horsten, S.19
-
66
-
-
79953002787
-
Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate Ab formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice
-
Jawhar, S.; Wirths, O.; Schilling, S.; Graubner, S.; Demuth, H. U.; Bayer, T. A. Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate Ab formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice. J. Biol. Chem., 2011, 286(6), 4454-4460.
-
(2011)
J. Biol. Chem
, vol.286
, Issue.6
, pp. 4454-4460
-
-
Jawhar, S.1
Wirths, O.2
Schilling, S.3
Graubner, S.4
Demuth, H.U.5
Bayer, T.A.6
-
67
-
-
84858040971
-
Pyroglutamate amyloid p (Ap) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer's disease
-
Wittnam, J. L.; Portelius, E.; Zetterberg, H.; Gustavsson, M. K.; Schilling, S.; Koch, B.; Demuth, H. U.; Blennow, K.; Wirths, O.; Bayer, T. A. Pyroglutamate amyloid p (Ap) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer's disease. J. Biol. Chem., 2012, 287(11), 8154-8162.
-
(2012)
J. Biol. Chem
, vol.287
, Issue.11
, pp. 8154-8162
-
-
Wittnam, J.L.1
Portelius, E.2
Zetterberg, H.3
Gustavsson, M.K.4
Schilling, S.5
Koch, B.6
Demuth, H.U.7
Blennow, K.8
Wirths, O.9
Bayer, T.A.10
-
68
-
-
1842636794
-
Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions
-
Schilling, S.; Hoffmann, T.; Manhart, S.; Hoffmann, M.; Demuth, H. U. Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions. FEBS Lett, 2004, 563, 191-196.
-
(2004)
FEBS Lett
, vol.563
, pp. 191-196
-
-
Schilling, S.1
Hoffmann, T.2
Manhart, S.3
Hoffmann, M.4
Demuth, H.U.5
-
69
-
-
0000495632
-
Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides
-
Fischer, W. H.; Spiess, J. Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides. Proc. Natl. Acad. Sci. USA, 1987, 84(11), 3628-3632.
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, Issue.11
, pp. 3628-3632
-
-
Fischer, W.H.1
Spiess, J.2
-
70
-
-
47249117092
-
Amyloidogenic processing of amyloid precursor protein: Evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-p
-
Cynis, H.; Scheel, E.; Saido, T. C; Schilling, S.; Demuth, H. U. Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-p. Biochemistry, 2008, 47, 7405-7413.
-
(2008)
Biochemistry
, vol.47
, pp. 7405-7413
-
-
Cynis, H.1
Scheel, E.2
Saido, T.C.3
Schilling, S.4
Demuth, H.U.5
-
71
-
-
48249145775
-
Inhibition of glutaminyl cyclase prevents prevents pGlu-Ap formation after intracortical/hippocampal microinjection in vivo/insitu
-
Schilling, S.; Appl, T.; Hoffmann, T.; Cynis, H.; Schulz, K.; Jagla, W.; Friedrich, D.; Wermann, M.; Buchholz, M.; Heiser, U.; von Horsten, S.; Demuth, H. U. Inhibition of glutaminyl cyclase prevents prevents pGlu-Ap formation after intracortical/hippocampal microinjection in vivo/insitu. J. Neurochem., 2008, 106(3), 1225-1236.
-
(2008)
J. Neurochem
, vol.106
, Issue.3
, pp. 1225-1236
-
-
Schilling, S.1
Appl, T.2
Hoffmann, T.3
Cynis, H.4
Schulz, K.5
Jagla, W.6
Friedrich, D.7
Wermann, M.8
Buchholz, M.9
Heiser, U.10
von Horsten, S.11
Demuth, H.U.12
-
72
-
-
84866107329
-
Disturbed Ca2+ homeostasis increases glutaminyl cyclase expression; connecting two early pathogenic events in Alzheimer's disease in vitro
-
De Kimpe, L.; Bennis, A.; Zwart, R.; van Haastert, E. S.; Hoozemans, J. J. Disturbed Ca2+ homeostasis increases glutaminyl cyclase expression; connecting two early pathogenic events in Alzheimer's disease in vitro. PLoS ONE 2012, 7(9), e44674.
-
(2012)
PLoS ONE
, vol.7
, Issue.9
-
-
de Kimpe, L.1
Bennis, A.2
Zwart, R.3
van Haastert, E.S.4
Hoozemans, J.J.5
-
73
-
-
84874337215
-
Increased glutaminyl cyclase expression in peripheral blood of Alzheimer's disease patients
-
DOI: 10.3233/JAD-120517
-
Valenti, M. T.; Bolognin, S.; Zanatta, C; Donatelli, L.; Innamorati, G.; Pampanin, M.; Zanusso, G.; Zatta, P.; Carbonare, L. D. Increased glutaminyl cyclase expression in peripheral blood of Alzheimer's disease patients. J. Alzheimers Dis., 2013, DOI: 10.3233/JAD-120517.
-
(2013)
J. Alzheimers Dis
-
-
Valenti, M.T.1
Bolognin, S.2
Zanatta, C.3
Donatelli, L.4
Innamorati, G.5
Pampanin, M.6
Zanusso, G.7
Zatta, P.8
Carbonare, L.D.9
-
74
-
-
79958166017
-
Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Ap deposits in hippocampus via distinct cellular mechanisms
-
Hartlage-Rubsamen, M.; Morawski, M.; Waniek, A.; Jager, C; Zeitschel, U.; Koch, B.; Cynis, H.; Schilling, S.; Schliebs, R.; Demuth, H. U.; Rossner, S. Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Ap deposits in hippocampus via distinct cellular mechanisms. Acta neuropathol, 2011, 121(6), 705-719.
-
(2011)
Acta Neuropathol
, vol.121
, Issue.6
, pp. 705-719
-
-
Hartlage-Rubsamen, M.1
Morawski, M.2
Waniek, A.3
Jager, C.4
Zeitschel, U.5
Koch, B.6
Cynis, H.7
Schilling, S.8
Schliebs, R.9
Demuth, H.U.10
Rossner, S.11
-
75
-
-
33749615367
-
Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells
-
Cynis, H.; Schilling, S.; Bodnar, M.; Hoffmann, T.; Heiser, U.; Saido, T. C; Demuth, H. U. Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells. Biochim. Biophys. Acta, 2006, 1764, 1618-1625.
-
(2006)
Biochim. Biophys. Acta
, vol.1764
, pp. 1618-1625
-
-
Cynis, H.1
Schilling, S.2
Bodnar, M.3
Hoffmann, T.4
Heiser, U.5
Saido, T.C.6
Demuth, H.U.7
-
76
-
-
0033536163
-
Immunization with amyloid-p attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk, D.; Barbour, R.; Dunn, W.; Gordon, G.; Grajeda, H.; Guido, T.; Hu, K.; Huang, J.; Johnson-Wood, K.; Khan, K.; Kholodenko, D.; Lee, M.; Liao, Z.; Lieberburg, I.; Motter, R.; Mutter, L.; Soriano, F.; Shopp, G.; Vasquez, N.; Vandevert, C; Walker, S.; Wogulis, M.; Yednock, T.; Games, D.; Seubert, P. Immunization with amyloid-p attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature, 1999, 400(6740), 173-177.
-
(1999)
Nature
, vol.400
, Issue.6740
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
Gordon, G.4
Grajeda, H.5
Guido, T.6
Hu, K.7
Huang, J.8
Johnson-Wood, K.9
Khan, K.10
Kholodenko, D.11
Lee, M.12
Liao, Z.13
Lieberburg, I.14
Motter, R.15
Mutter, L.16
Soriano, F.17
Shopp, G.18
Vasquez, N.19
Vandevert, C.20
Walker, S.21
Wogulis, M.22
Yednock, T.23
Games, D.24
Seubert, P.25
more..
-
77
-
-
0033835996
-
Peripherally administered antibodies against amyloid-p peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer's disease
-
Bard, F.; Cannon, C; Barbour, R.; Burke, R. L.; Games, D.; Grajeda, H.; Guido, T.; Hu, K.; Huang, J.; Johnson-Wood, K.; Khan, K.; Kholodenko, D.; Lee, M.; Lieberburg, I.; Motter, R.; Nguyen, M.; Soriano, F., Vasquez, N.; Weiss, K.; Welch, B.; Seubert, P.; Schenk, D.; Yednock, T. Peripherally administered antibodies against amyloid-p peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer's disease. Nat. Med., 2000, 6(8), 916-919.
-
(2000)
Nat. Med
, vol.6
, Issue.8
, pp. 916-919
-
-
Bard, F.1
Cannon, C.2
Barbour, R.3
Burke, R.L.4
Games, D.5
Grajeda, H.6
Guido, T.7
Hu, K.8
Huang, J.9
Johnson-Wood, K.10
Khan, K.11
Kholodenko, D.12
Lee, M.13
Lieberburg, I.14
Motter, R.15
Nguyen, M.16
Soriano, F.17
Vasquez, N.18
Weiss, K.19
Welch, B.20
Seubert, P.21
Schenk, D.22
Yednock, T.23
more..
-
78
-
-
3042692322
-
Alzheimer's disease Ap vaccine reduces central nervous system Ap levels in a non-human primate, the Caribbean vervet
-
Lemere, C.A.; Beierschmitt, A.; Iglesias, M.; Spooner, E.T.; Bloom, J.K.; Leverone, J.F.; Zheng, J.B.; Seabrook, T.J.; Louard, D.; Li, D.; Selkoe, D.J.; Palmour, R.M.; Ervin, F.R. Alzheimer's disease Ap vaccine reduces central nervous system Ap levels in a non-human primate, the Caribbean vervet. Am. J. Pathol, 2004, 165(1), 283-297.
-
(2004)
Am. J. Pathol
, vol.165
, Issue.1
, pp. 283-297
-
-
Lemere, C.A.1
Beierschmitt, A.2
Iglesias, M.3
Spooner, E.T.4
Bloom, J.K.5
Leverone, J.F.6
Zheng, J.B.7
Seabrook, T.J.8
Louard, D.9
Li, D.10
Selkoe, D.J.11
Palmour, R.M.12
Ervin, F.R.13
-
79
-
-
3042839092
-
Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition
-
Wilcock, D. M.; Rojiani, A.; Rosenthal, A.; Levkowitz, G.; Subbarao, S.; Alamed, J.; Wilson, D.; Wilson, N.; Freeman, M. J.; Gordon, M. N.; Morgan, D. Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition. J. Neurosci., 2004, 24(27), 6144-6151.
-
(2004)
J. Neurosci
, vol.24
, Issue.27
, pp. 6144-6151
-
-
Wilcock, D.M.1
Rojiani, A.2
Rosenthal, A.3
Levkowitz, G.4
Subbarao, S.5
Alamed, J.6
Wilson, D.7
Wilson, N.8
Freeman, M.J.9
Gordon, M.N.10
Morgan, D.11
-
80
-
-
47949132196
-
Active and passive immunotherapy for neurodegenerative disorders
-
Brody, D. L.; Holtzman, D. M. Active and passive immunotherapy for neurodegenerative disorders. Annu. Rev. Neurosci., 2008, 31, 175-193.
-
(2008)
Annu. Rev. Neurosci
, vol.31
, pp. 175-193
-
-
Brody, D.L.1
Holtzman, D.M.2
-
81
-
-
43649096717
-
A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: Effects on cognitive function and brain Abeta
-
Head, E.; Pop, V.; Vasilevko, V.; Hill, M.; Saing, T.; Sarsoza, F.; Nistor, M.; Christie, L. A.; Milton, S.; Glabe, C; Barrett, E.; Cribbs, D. A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta. J. Neurosci., 2008, 28(14), 3555-3566.
-
(2008)
J. Neurosci
, vol.28
, Issue.14
, pp. 3555-3566
-
-
Head, E.1
Pop, V.2
Vasilevko, V.3
Hill, M.4
Saing, T.5
Sarsoza, F.6
Nistor, M.7
Christie, L.A.8
Milton, S.9
Glabe, C.10
Barrett, E.11
Cribbs, D.12
-
82
-
-
70449669057
-
Ap immunotherapy protects morphology and survival of adult-born neurons in doubly transgenic APP/PS1 mice
-
Biscaro, B.; Lindvall, O.; Hock, C; Ekdahl, C. T.; Nitsch, R. M. Ap immunotherapy protects morphology and survival of adult-born neurons in doubly transgenic APP/PS1 mice. J. Neurosci., 2009, 29(45), 14108-14119.
-
(2009)
J. Neurosci
, vol.29
, Issue.45
, pp. 14108-14119
-
-
Biscaro, B.1
Lindvall, O.2
Hock, C.3
Ekdahl, C.T.4
Nitsch, R.M.5
-
83
-
-
78650210590
-
Immunotherapy for Alzheimer's disease
-
Morgan, D. Immunotherapy for Alzheimer's disease. J. Intern. Med., 2011, 269(1), 54-63.
-
(2011)
J. Intern. Med
, vol.269
, Issue.1
, pp. 54-63
-
-
Morgan, D.1
-
84
-
-
76849091134
-
Can Alzheimer disease be prevented by amyloid-p immunotherapy?
-
Lemere, C. A.; Masliah, E. Can Alzheimer disease be prevented by amyloid-p immunotherapy? Nat. Rev. Neurol, 2010, 6(2), 108-119.
-
(2010)
Nat. Rev. Neurol
, vol.6
, Issue.2
, pp. 108-119
-
-
Lemere, C.A.1
Masliah, E.2
-
85
-
-
79955607727
-
Neuropathology and amyloid-b spectrum in a bapineuzumab immunotherapy recipient
-
Roher, A. E.; Maarouf, C. L.; Daugs, I. D.; Kokjohn, T. A.; Hunter, J. M.; Sabbagh, M. N.; Beach, T. G. Neuropathology and amyloid-b spectrum in a bapineuzumab immunotherapy recipient. J. Alzheimers Dis., 2011, 24, 315-325.
-
(2011)
J. Alzheimers Dis
, vol.24
, pp. 315-325
-
-
Roher, A.E.1
Maarouf, C.L.2
Daugs, I.D.3
Kokjohn, T.A.4
Hunter, J.M.5
Sabbagh, M.N.6
Beach, T.G.7
-
86
-
-
0037107177
-
Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy
-
Bacskai, B. J.; Kajdasz, S. T.; McLellan, M. E.; Games, D.; Seubert, P.; Schenk, D.; Hyman, B. T. Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy. J. Neurosci., 2002, 22, 7873-7878.
-
(2002)
J. Neurosci
, vol.22
, pp. 7873-7878
-
-
Bacskai, B.J.1
Kajdasz, S.T.2
McLellan, M.E.3
Games, D.4
Seubert, P.5
Schenk, D.6
Hyman, B.T.7
-
87
-
-
84857261943
-
Neutralization of soluble, synaptotoxic amyloid p species by antibodies is epitope speicifc
-
Zago, W.; Buttini, M.; Comery, T. A.; Nishioka, C; Gardai, S. J.; Seubert, P.; Games, D.; Bard, F.; Schenk, D.; Kinney, G. G. Neutralization of soluble, synaptotoxic amyloid p species by antibodies is epitope speicifc. J. Neurosci., 2012, 32, 2696-2702.
-
(2012)
J. Neurosci
, vol.32
, pp. 2696-2702
-
-
Zago, W.1
Buttini, M.2
Comery, T.A.3
Nishioka, C.4
Gardai, S.J.5
Seubert, P.6
Games, D.7
Bard, F.8
Schenk, D.9
Kinney, G.G.10
-
88
-
-
78649443534
-
Anti-11 [E]-pyroglutamate-modified amyloid p antibodies cross-react with other pathological Ap species: Relevante for immunotherapy
-
Perez-Garmendia, R.; Ibarra-Bracamontes, V.; Vasilevko, V.; Luna-Munoz, J.; Mena, R.; Govezensky, T.; Acero, G.; Manoutcharian, K.; Cribs, D. H.; Gevorkian, G. Anti-11 [E]-pyroglutamate-modified amyloid p antibodies cross-react with other pathological Ap species: relevante for immunotherapy. J. Neuroimmunol, 2010, 229, 248-255.
-
(2010)
J. Neuroimmunol
, vol.229
, pp. 248-255
-
-
Perez-Garmendia, R.1
Ibarra-Bracamontes, V.2
Vasilevko, V.3
Luna-Munoz, J.4
Mena, R.5
Govezensky, T.6
Acero, G.7
Manoutcharian, K.8
Cribs, D.H.9
Gevorkian, G.10
-
89
-
-
84859408039
-
Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-b in a fraction of amyloid-b deposits in Alzheimer's disease without cross-reactivity with other protein aggregates
-
Venkataramani, V.; Wirths, O.; Budka, H.; Hartig, W.; Kovacs, G. G.; Bayer, T. A. Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-b in a fraction of amyloid-b deposits in Alzheimer's disease without cross-reactivity with other protein aggregates. J. Alzheimers Dis., 2012, 29(2), 361-371.
-
(2012)
J. Alzheimers Dis
, vol.29
, Issue.2
, pp. 361-371
-
-
Venkataramani, V.1
Wirths, O.2
Budka, H.3
Hartig, W.4
Kovacs, G.G.5
Bayer, T.A.6
-
90
-
-
84862816040
-
Passive immunization against pyroglutamate-3 amyloid-b reduces plaque burden in Alzheimer-like transgenic mice: A pilot study
-
Frost, J. L.; Liu, B.; Kleinschmidt, M.; Schilling, S.; Demuth, H. U.; Lemere, C. A. Passive immunization against pyroglutamate-3 amyloid-b reduces plaque burden in Alzheimer-like transgenic mice: a pilot study. Neurodegenerative Dis., 2012, 10, 265-270.
-
(2012)
Neurodegenerative Dis
, vol.10
, pp. 265-270
-
-
Frost, J.L.1
Liu, B.2
Kleinschmidt, M.3
Schilling, S.4
Demuth, H.U.5
Lemere, C.A.6
-
91
-
-
84872144291
-
A plaque-specific antibody clears existing p-amyloid plaques in Alzheimer's disease mice
-
DeMattos, R.; Lu, J.; Tang, Y.; Racke, M. M.; DeLong, C. A; Tzaferis, J. A.; Hole, J. T.; Forster, B. M.; McDonnell, P. C; Liu, F.; Kinley, R. D.; Jordan, W. H.; Hutton, M. L. A plaque-specific antibody clears existing p-amyloid plaques in Alzheimer's disease mice. Neuron, 2012, 76, 908-920.
-
(2012)
Neuron
, vol.76
, pp. 908-920
-
-
Demattos, R.1
Lu, J.2
Tang, Y.3
Racke, M.M.4
Delong, C.A.5
Tzaferis, J.A.6
Hole, J.T.7
Forster, B.M.8
McDonnell, P.C.9
Liu, F.10
Kinley, R.D.11
Jordan, W.H.12
Hutton, M.L.13
-
92
-
-
79957951065
-
Aluminum vaccine adjuvants: Are they safe?
-
Tomljenovic, L.; Shaw, C. A. Aluminum vaccine adjuvants: are they safe? Curr. Med. Chem., 2011, 18, 2630-2637.
-
(2011)
Curr. Med. Chem
, vol.18
, pp. 2630-2637
-
-
Tomljenovic, L.1
Shaw, C.A.2
-
93
-
-
77951086901
-
Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease
-
Siemers, E. R.; Friedrich, S.; Dean, R A.; Gonzalez, C. R.; Farlow, M. R.; Paul, S. M.; DeMattos, R. B. Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease. Clin. Neuropharmacol, 2010, 33(2), 67-73.
-
(2010)
Clin. Neuropharmacol
, vol.33
, Issue.2
, pp. 67-73
-
-
Siemers, E.R.1
Friedrich, S.2
Dean, R.A.3
Gonzalez, C.R.4
Farlow, M.R.5
Paul, S.M.6
Demattos, R.B.7
-
94
-
-
79955803502
-
Solanezumab for Alzheimer's disease
-
Samadi, H.; Sultzer, D. Solanezumab for Alzheimer's disease. Expert Opin. Biol. Ther., 2011, 11(6), 787-798.
-
(2011)
Expert Opin. Biol. Ther
, vol.11
, Issue.6
, pp. 787-798
-
-
Samadi, H.1
Sultzer, D.2
-
95
-
-
84863221661
-
Safety and biomarker effects of solanezumab in patients with Alzheimer's disease
-
Farlow, M.; Arnold, S. E.; van Dyck, C. H.; Aisen, P. S.; Snider, B. J.; Porsteinsson, A. P.; Friedrich, S.; Dean, R. A; Gonzalez, C; Sethuraman, G.; DeMattos, R. B.; Mohs, R.; Paul, S. M.; Siemers, E. R. Safety and biomarker effects of solanezumab in patients with Alzheimer's disease. Alzheimers Dement., 2012, 8, 261-271.
-
(2012)
Alzheimers Dement
, vol.8
, pp. 261-271
-
-
Farlow, M.1
Arnold, S.E.2
van Dyck, C.H.3
Aisen, P.S.4
Snider, B.J.5
Porsteinsson, A.P.6
Friedrich, S.7
Dean, R.A.8
Gonzalez, C.9
Sethuraman, G.10
Demattos, R.B.11
Mohs, R.12
Paul, S.M.13
Siemers, E.R.14
-
96
-
-
84856608579
-
Solanezumab for the treatment of mild-to-moderate Alzheimer's disease
-
Imbimbo, B. P.; Ottonello, S.; Frisardi, V.; Solfrizzi, V.; Greco, A.; Seripa, D.; Pilotto, A; Panza, F. Solanezumab for the treatment of mild-to-moderate Alzheimer's disease. Expert Rev. Clin. Immunol, 2012, 8(2), 135-149.
-
(2012)
Expert. Rev. Clin. Immunol
, vol.8
, Issue.2
, pp. 135-149
-
-
Imbimbo, B.P.1
Ottonello, S.2
Frisardi, V.3
Solfrizzi, V.4
Greco, A.5
Seripa, D.6
Pilotto, A.7
Panza, F.8
|