Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate Aβ formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice

Journal of Biological Chemistry

Volumn 286, Issue 6, 2011, Pages 4454-4460

  Jawhar, Sadim ^a   Wirths, Oliver ^a   Schilling, Stephan ^b   Graubner, Sigrid ^c   Demuth, Hans Ulrich ^b   Bayer, Thomas A ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b PROBIODRUG AG   (Germany)

^c Ingenium Pharmaceuticals AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATION PROPENSITY; ALZHEIMER DISEASE; CELLULAR TOXICITIES; CYCLASES; GLUTAMINYL; IN-VITRO; IN-VIVO; KNOCK OUTS; MOUSE MODELS; OVER-EXPRESSION; TRANSGENIC MICE; TRANSGENICS; WILD TYPES; WORKING MEMORIES;

FORMIC ACID; PEPTIDES;

ENZYMES;

AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; DODECYL SULFATE SODIUM; FORMIC ACID; GLUTAMINYLCYCLASE; LYASE; PYROGLUTAMATE A BETA; PYROGLUTAMIC ACID; UNCLASSIFIED DRUG; AMINOACYLTRANSFERASE; AMYLOID BETA PROTEIN; GLUTAMINYL PEPTIDE CYCLOTRANSFERASE; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE;

ALZHEIMER DISEASE; AMYLOIDOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN TISSUE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; FRONTAL CORTEX; GENE OVEREXPRESSION; KNOCKOUT MOUSE; MEMORY DISORDER; MOTOR DYSFUNCTION; MOUSE; NEURITE; NONHUMAN; PEPTIDE ANALYSIS; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; TRANSGENE; WILD TYPE; WORKING MEMORY; ANIMAL; ANIMAL BEHAVIOR; GENETICS; HUMAN; MEMORY; METABOLISM; MOUSE MUTANT;

MUS; MUS MUSCULUS;

ALZHEIMER DISEASE; AMINOACYLTRANSFERASES; AMYLOID BETA-PEPTIDES; ANIMALS; BEHAVIOR, ANIMAL; HUMANS; MEMORY; MICE; MICE, KNOCKOUT; PHENOTYPE; PYRROLIDONECARBOXYLIC ACID;

EID: 79953002787     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.185819     Document Type: Article

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