Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases

Journal of Neural Transmission

Volumn 117, Issue 1, 2010, Pages 85-96

  Wirths, Oliver ^a,f   Bethge, Tobias ^b,f   Marcello, Andrea ^a,f   Harmeier, Anja ^b   Jawhar, Sadim ^a,f   Lucassen, Paul J ^c,f   Multhaup, Gerd ^b,f   Brody, David L ^d   Esparza, Thomas ^d   Ingelsson, Martin ^e   Kalimo, Hannu ^e   Lannfelt, Lars ^e   Bayer, Thomas A ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UPPSALA UNIVERSITY   (Sweden)

^f NEURAD International Alzheimer Graduate School   (Germany)

Author keywords

Antibody specificity; Arctic mutation; Biacore; Presenilin 1 mutation; Pyroglutamate Abeta; Sporadic Alzheimer's disease; Swedish mutation; Transgenic mice

Indexed keywords

AMYLOID BETA PROTEIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1-57; MONOCLONAL ANTIBODY 2-48; PYROGLUTAMIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; FRONTAL CORTEX; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN STABILITY; SENILE PLAQUE; SURFACE PLASMON RESONANCE; TRANSGENIC MOUSE; WESTERN BLOTTING;

AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MALE; MICE; MICE, TRANSGENIC; MIDDLE AGED; MUTATION; PEPTIDE FRAGMENTS; PRESENILIN-1; PYRROLIDONECARBOXYLIC ACID; RECEPTORS, CELL SURFACE; SENILE PLAQUES;

EID: 76949102099     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-009-0314-x     Document Type: Article

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