Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms

Acta Neuropathologica

Volumn 121, Issue 6, 2011, Pages 705-719

  Hartlage Rübsamen, Maike ^a   Morawski, Markus ^a   Waniek, Alexander ^a   Jäger, Carsten ^a   Zeitschel, Ulrike ^a   Koch, Birgit ^b   Cynis, Holger ^b   Schilling, Stephan ^b   Schliebs, Reinhard ^a   Demuth, Hans Ulrich ^b,c   Roßner, Steffen ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b PROBIODRUG AG   (Germany)

^c Ingenium Pharmaceuticals AG   (Germany)

Author keywords

Alzheimer's disease; Glutaminyl cyclase; Hippocampus; Pyroglutamate A ; Seeding

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BRAIN ENZYME; GLUTAMINYL CYCLASE; PYROGLUTAMIC ACID; UNCLASSIFIED DRUG;

AGED; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEAFFERENTATION; DISEASE ASSOCIATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME RELEASE; FEMALE; FETUS; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; INTERNEURON; LOCUS CERULEUS; MALE; MOUSE; NERVE PROJECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; SYNAPTIC TRANSMISSION; TEMPORAL LOBE;

ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; ADRENERGIC ALPHA-2 RECEPTOR ANTAGONISTS; ADRENERGIC BETA-ANTAGONISTS; AGE FACTORS; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMINOACYLTRANSFERASES; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; AUTORADIOGRAPHY; CELLS, CULTURED; DIHYDROALPRENOLOL; FEMALE; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; HUMANS; MALE; MICE; MICE, TRANSGENIC; NEURONS; POTASSIUM CHLORIDE; PRAZOSIN; PROTEIN BINDING; PYRROLIDONECARBOXYLIC ACID; RECEPTORS, ADRENERGIC; TIME FACTORS; TRITIUM; YOHIMBINE;

EID: 79958166017     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-011-0806-2     Document Type: Article

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