Modulation of behavior by scaffolding proteins of the post-synaptic density

Neurobiology of Learning and Memory

Volumn 105, Issue , 2013, Pages 3-12

  Gao, Can ^a   Tronson, Natalie C ^b   Radulovic, Jelena ^c  

^a XUZHOU MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF MICHIGAN   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Behavior; Glutamate receptor; Psychiatric disorders; Scaffold

Indexed keywords

BINDING PROTEIN; GLUTAMATE RECEPTOR; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 1; KALIRIN 7; MEMBRANE ASSOCIATED GUANYLATE CYCLASE KINASE; MEMBRANE PROTEIN; METABOTROPIC RECEPTOR 5; MUTANT PROTEIN; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; NCK INTERACTING KINASE; PHOSPHOTRANSFERASE; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN HOMER 1; PROTEIN HOMER 2; PROTEIN HOMER 3; PROTEIN PSD 93; PROTEIN SAP102; PROTEIN SAP97; PROTEIN SYNGAP1; REGULATOR PROTEIN; SCAFFOLD PROTEIN; SHANK1 PROTEIN; SHANK2 PROTEIN; SHANK3 PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG; VEZATIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BEHAVIOR DISORDER; CARBOXY TERMINAL SEQUENCE; CELL STRUCTURE; COGNITIVE DEFECT; COMORBIDITY; HUMAN; LONG TERM POTENTIATION; NERVE CELL; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; PATHOPHYSIOLOGY; POSTSYNAPTIC DENSITY; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

BEHAVIOR; GLUTAMATE RECEPTOR; PSYCHIATRIC DISORDERS; SCAFFOLD;

ANIMALS; BRAIN; CARRIER PROTEINS; COGNITION; GENE TARGETING; GUANYLATE KINASE; LEARNING; MICE; POST-SYNAPTIC DENSITY; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 84884153013     PISSN: 10747427     EISSN: 10959564     Source Type: Journal    
DOI: 10.1016/j.nlm.2013.04.014     Document Type: Article

References (134)

1. Abbas A.I., Yadav P.N., Yao W.D., Arbuckle M.I., Grant S.G., Caron M.G., et al. PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors. Journal of Neuroscience 2009, 29:7124-7136.
2. Ango F., Prezeau L., Muller T., Tu J.C., Xiao B., Worley P.F., et al. Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Nature 2001, 411:962-965.
3. Berkel S., Marshall C.R., Weiss B., Howe J., Roeth R., Moog U., et al. Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation. Nature Genetics 2010, 42:489-491.
4. Bonaglia M.C., Giorda R., Mani E., Aceti G., Anderlid B.M., Baroncini A., et al. Identification of a recurrent breakpoint within the SHANK3 gene in the 22q13.3 deletion syndrome. Journal of Medical Genetics 2006, 43:822-828.
5. Cahill M.E., Xie Z., Day M., Photowala H., Barbolina M.V., Miller C.A., et al. Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:13058-13063.
6. Camp M.C., Feyder M., Ihne J., Palachick B., Hurd B., Karlsson R.M., et al. A novel role for PSD-95 in mediating ethanol intoxication, drinking and place preference. Addiction Biology 2011, 16:428-439.
7. Carlisle H.J., Fink A.E., Grant S.G., O'Dell T.J. Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticity. The Journal of Physiology 2008, 586:5885-5900.
8. Carlisle H.J., Luong T.N., Medina-Marino A., Schenker L., Khorosheva E., Indersmitten T., et al. Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction. Journal of Neuroscience 2011, 31:16194-16207.
9. Chen H.J., Rojas-Soto M., Oguni A., Kennedy M.B. A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II. Neuron 1998, 20:895-904.
10. Cheng D., Hoogenraad C.C., Rush J., Ramm E., Schlager M.A., Duong D.M., et al. Relative and absolute quantification of postsynaptic density proteome isolated from rat forebrain and cerebellum. Molecular and Cellular Proteomics 2006, 5:1158-1170.
11. Choi J., Ko J., Racz B., Burette A., Lee J.R., Kim S., et al. Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases. Journal of Neuroscience 2005, 25:869-879.
12. Choudhury P.R., Lahiri S., Rajamma U. Glutamate mediated signaling in the pathophysiology of autism spectrum disorders. Pharmacology, Biochemistry and Behavior 2012, 100:841-849.
13. Coba M.P., Komiyama N.H., Nithianantharajah J., Kopanitsa M.V., Indersmitten T., Skene N.G., et al. TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function. Journal of Neuroscience 2012, 32:13987-13999.
14. Cohen J.W., Louneva N., Han L.Y., Hodes G.E., Wilson R.S., Bennett D.A., et al. Chronic corticosterone exposure alters postsynaptic protein levels of PSD-95, NR1, and synaptopodin in the mouse brain. Synapse 2011, 65:763-770.
15. Cuthbert P.C., Stanford L.E., Coba M.P., Ainge J.A., Fink A.E., Opazo P., et al. Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies. Journal of Neuroscience 2007, 27:2673-2682.
16. Dahl J.P., Kampman K.M., Oslin D.W., Weller A.E., Lohoff F.W., Ferraro T.N., et al. Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population. Psychiatric Genetics 2005, 15:277-283.
17. Danglot L., Freret T., Le Roux N., Narboux Neme N., Burgo A., Hyenne V., et al. Vezatin is essential for dendritic spine morphogenesis and functional synaptic maturation. Journal of Neuroscience 2012, 32:9007-9022.
18. Duarte D.B., Duan J.H., Nicol G.D., Vasko M.R., Hingtgen C.M. Reduced expression of SynGAP, a neuronal GTPase-activating protein, enhances capsaicin-induced peripheral sensitization. Journal of Neurophysiology 2011, 106:309-318.
19. Ehrlich I., Klein M., Rumpel S., Malinow R. PSD-95 is required for activity-driven synapse stabilization. Proceedings of the National Academy of Sciences of the United States of America 2007, 104:4176-4181.
20. Emes R.D., Grant S.G. Evolution of synapse complexity and diversity. Annual Review of Neuroscience 2012, 35:111-131.
21. Fagni L., Ango F., Perroy J., Bockaert J. Identification and functional roles of metabotropic glutamate receptor-interacting proteins. Seminars in Cell and Developmental Biology 2004, 15:289-298.
22. Feyder M., Karlsson R.M., Mathur P., Lyman M., Bock R., Momenan R., et al. Association of mouse Dlg4 (PSD-95) gene deletion and human DLG4 gene variation with phenotypes relevant to autism spectrum disorders and Williams' syndrome. American Journal of Psychiatry 2010, 167:1508-1517.
23. Feyissa A.M., Chandran A., Stockmeier C.A., Karolewicz B. Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2009, 33:70-75.
24. Gao C., Frausto S.F., Guedea A.L., Tronson N.C., Jovasevic V., Leaderbrand K., et al. IQGAP1 regulates NR2A signaling, spine density, and cognitive processes. Journal of Neuroscience 2011, 31:8533-8542.
25. Gerstein H., O'Riordan K., Osting S., Schwarz M., Burger C. Rescue of synaptic plasticity and spatial learning deficits in the hippocampus of Homer1 knockout mice by recombinant Adeno-associated viral gene delivery of Homer1c. Neurobiology of Learning and Memory 2012, 97:17-29.
26. Ghasemzadeh M.B., Permenter L.K., Lake R., Worley P.F., Kalivas P.W. Homer1 proteins and AMPA receptors modulate cocaine-induced behavioural plasticity. European Journal of Neuroscience 2003, 18:1645-1651.
27. Ghasemzadeh M.B., Windham L.K., Lake R.W., Acker C.J., Kalivas P.W. Cocaine activates Homer1 immediate early gene transcription in the mesocorticolimbic circuit: Differential regulation by dopamine and glutamate signaling. Synapse 2009, 63:42-53.
28. Gilks W.P., Allott E.H., Donohoe G., Cummings E., Gill M., Corvin A.P., et al. Replicated genetic evidence supports a role for HOMER2 in schizophrenia. Neuroscience Letters 2010, 468:229-233.
29. Glatt S.J., Everall I.P., Kremen W.S., Corbeil J., Sasik R., Khanlou N., et al. Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:15533-15538.
30. Gong Y., Lippa C.F. Review: Disruption of the postsynaptic density in Alzheimer's disease and other neurodegenerative dementias. American Journal of Alzheimer's Disease and Other Dementias 2010, 25:547-555.
31. Gong Y., Lippa C.F., Zhu J., Lin Q., Rosso A.L. Disruption of glutamate receptors at Shank-postsynaptic platform in Alzheimer's disease. Brain Research 2009, 1292:191-198.
32. Grabrucker A.M., Schmeisser M.J., Schoen M., Boeckers T.M. Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies. Trends in Cell Biology 2011, 21:594-603.
33. Grant S.G. Synaptopathies: Diseases of the synaptome. Current Opinion in Neurobiology 2012, 22:522-529.
34. Guo X., Hamilton P.J., Reish N.J., Sweatt J.D., Miller C.A., Rumbaugh G. Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of Schizophrenia. Neuropsychopharmacology 2009, 34:1659-1672.
35. Hamdan F.F., Daoud H., Piton A., Gauthier J., Dobrzeniecka S., Krebs M.O., et al. De novo SYNGAP1 mutations in nonsyndromic intellectual disability and autism. Biological Psychiatry 2011, 69:898-901.
36. Hamdan F.F., Gauthier J., Spiegelman D., Noreau A., Yang Y., Pellerin S., et al. Mutations in SYNGAP1 in autosomal nonsyndromic mental retardation. New England Journal of Medicine 2009, 360:599-605.
37. Hayashi-Takagi A., Takaki M., Graziane N., Seshadri S., Murdoch H., Dunlop A.J., et al. Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1. Nature Neuroscience 2010, 13:327-332.
38. Hermes G., Li N., Duman C., Duman R. Post-weaning chronic social isolation produces profound behavioral dysregulation with decreases in prefrontal cortex synaptic-associated protein expression in female rats. Physiology and Behavior 2011, 104:354-359.
39. Hill J.J., Hashimoto T., Lewis D.A. Molecular mechanisms contributing to dendritic spine alterations in the prefrontal cortex of subjects with schizophrenia. Molecular Psychiatry 2006, 11:557-566.
40. Howard M.A., Elias G.M., Elias L.A., Swat W., Nicoll R.A. The role of SAP97 in synaptic glutamate receptor dynamics. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:3805-3810.
41. Hung A.Y., Futai K., Sala C., Valtschanoff J.G., Ryu J., Woodworth M.A., et al. Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1. Journal of Neuroscience 2008, 28:1697-1708.
42. Iasevoli F., Tomasetti C., de Bartolomeis A. Scaffolding proteins of the post-synaptic density contribute to synaptic plasticity by regulating receptor localization and distribution: Relevance for neuropsychiatric diseases. Neurochemical Research 2013, 38:1-22.
43. Ide M., Lewis D.A. Altered cortical CDC42 signaling pathways in schizophrenia: Implications for dendritic spine deficits. Biological Psychiatry 2010, 68:25-32.
44. Inoue N., Nakao H., Migishima R., Hino T., Matsui M., Hayashi F., et al. Requirement of the immediate early gene vesl-1S/homer-1a for fear memory formation. Molecular Brain 2009, 2:7.
45. Jaubert P.J., Golub M.S., Lo Y.Y., Germann S.L., Dehoff M.H., Worley P.F., et al. Complex, multimodal behavioral profile of the Homer1 knockout mouse. Genes, Brain, and Behavior 2007, 6:141-154.
46. Kalivas P.W., McFarland K., Bowers S., Szumlinski K., Xi Z.X., Baker D. Glutamate transmission and addiction to cocaine. Annals of the New York Academy of Sciences 2003, 1003:169-175.
47. Karolewicz B., Szebeni K., Gilmore T., Maciag D., Stockmeier C.A., Ordway G.A. Elevated levels of NR2A and PSD-95 in the lateral amygdala in depression. International Journal of Neuropsychopharmacology 2009, 12:143-153.
48. Kholmanskikh S.S., Koeller H.B., Wynshaw-Boris A., Gomez T., Letourneau P.C., Ross M.E. Calcium-dependent interaction of Lis1 with IQGAP1 and Cdc42 promotes neuronal motility. Nature Neuroscience 2006, 9:50-57.
49. Kim C.H., Takamiya K., Petralia R.S., Sattler R., Yu S., Zhou W., et al. Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1. Nature Neuroscience 2005, 8:985-987.
50. Kim M.H., Choi J., Yang J., Chung W., Kim J.H., Paik S.K., et al. Enhanced NMDA receptor-mediated synaptic transmission, enhanced long-term potentiation, and impaired learning and memory in mice lacking IRSp53. Journal of Neuroscience 2009, 29:1586-1595.
51. Kim J.H., Liao D., Lau L.F., Huganir R.L. SynGAP: A synaptic RasGAP that associates with the PSD-95/SAP90 protein family. Neuron 1998, 20:683-691.
52. Kiraly D.D., Lemtiri-Chlieh F., Levine E.S., Mains R.E., Eipper B.A. Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function. Journal of Neuroscience 2011, 31:12554-12565.
53. Komiyama N.H., Watabe A.M., Carlisle H.J., Porter K., Charlesworth P., Monti J., et al. SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. Journal of Neuroscience 2002, 22:9721-9732.
54. Krapivinsky G., Medina I., Krapivinsky L., Gapon S., Clapham D.E. SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Neuron 2004, 43:563-574.
55. Krepischi A.C., Rosenberg C., Costa S.S., Crolla J.A., Huang S., Vianna-Morgante A.M. A novel de novo microdeletion spanning the SYNGAP1 gene on the short arm of chromosome 6 associated with mental retardation. American Journal of Medical Genetics Part A 2010, 152A:2376-2378.
56. Lennertz L., Wagner M., Wölwer W., Schuhmacher A., Frommann I., Berning J., et al. A promoter variant of SHANK1 affects auditory working memory in schizophrenia patients and in subjects clinically at risk for psychosis. European Archives Psychiatry Clinical Neurosience 2012, 262:117-124.
57. Lemtiri-Chlieh F., Zhao L., Kiraly D.D., Eipper B.A., Mains R.E., Levine E.S. Kalirin-7 is necessary for normal NMDA receptor-dependent synaptic plasticity. BMC Neuroscience 2011, 12:126.
58. Leuba G., Savioz A., Vernay A., Carnal B., Kraftsik R., Tardif E., et al. Differential changes in synaptic proteins in the Alzheimer frontal cortex with marked increase in PSD-95 postsynaptic protein. Journal of Alzheimer's Disease 2008, 15:139-151.
59. Liaw W.J., Zhu X.G., Yaster M., Johns R.A., Gauda E.B., Tao Y.X. Distinct expression of synaptic NR2A and NR2B in the central nervous system and impaired morphine tolerance and physical dependence in mice deficient in postsynaptic density-93 protein. Molecular Pain 2008, 4:45.
60. Lipsky R.H., Goldman D. Genomics and variation of ionotropic glutamate receptors. Annals of the New York Academy of Sciences 2003, 1003:22-35.
61. Mains R.E., Kiraly D.D., Eipper-Mains J.E., Ma X.M., Eipper B.A. Kalrn promoter usage and isoform expression respond to chronic cocaine exposure. BMC Neuroscience 2011, 12:20.
62. Ma X.M., Kiraly D.D., Gaier E.D., Wang Y., Kim E.J., Levine E.S., et al. Kalirin-7 is required for synaptic structure and function. Journal of Neuroscience 2008, 28:12368-12382.
63. Mandela P., Ma X.M. Kalirin, a key player in synapse formation, is implicated in human diseases. Neural Plasticity 2012, 2012:728161.
64. Mao L., Yang L., Tang Q., Samdani S., Zhang G., Wang J.Q. The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons. Journal of Neuroscience 2005, 25:2741-2752.
65. Mazzone C.M., Larese T.P., Kiraly D.D., Eipper B.A., Mains R.E. Analysis of kalirin-7 knockout mice reveals different effects in female mice. Molecular Pharmacology 2012, 82:1241-1249.
66. Matigian N., Windus L., Smith H., Filippich C., Pantelis C., McGrath J., et al. Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway. Molecular Psychiatry 2007, 12:815-825.
67. McGee A.W., Topinka J.R., Hashimoto K., Petralia R.S., Kakizawa S., Kauer F.W., et al. PSD-93 knock-out mice reveal that neuronal MAGUKs are not required for development or function of parallel fiber synapses in cerebellum. Journal of Neuroscience 2001, 21:3085-3091.
68. Migaud M., Charlesworth P., Dempster M., Webster L.C., Watabe A.M., Makhinson M., et al. Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein. Nature 1998, 396:433-439.
69. Minatohara K., Ichikawa S.H., Seki T., Fujiyoshi Y., Doi T. Ligand binding of PDZ domains has various roles in the synaptic clustering of SAP102 and PSD-95. Neuroscience Letters 2013, 533:44-49.
70. Mizutani A., Kuroda Y., Futatsugi A., Furuichi T., Mikoshiba K. Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells. Journal of Neuroscience 2008, 28:5369-5382.
71. Moessner R., Marshall C.R., Sutcliffe J.S., Skaug J., Pinto D., Vincent J., et al. Contribution of SHANK3 mutations to autism spectrum disorder. American Journal of Human Genetics 2007, 81:1289-1297.
72. Mori H., Mishina M. Roles of diverse glutamate receptors in brain functions elucidated by subunit-specific and region-specific gene targeting. Life Sciences 2003, 74:329-336.
73. Muhia M., Feldon J., Knuesel I., Yee B.K. Appetitively motivated instrumental learning in SynGAP heterozygous knockout mice. Behavioral Neuroscience 2009, 123:1114-1128.
74. Muhia M., Yee B.K., Feldon J., Markopoulos F., Knuesel I. Disruption of hippocampus-regulated behavioural and cognitive processes by heterozygous constitutive deletion of SynGAP. European Journal of Neuroscience 2010, 31:529-543.
75. Nagura H., Ishikawa Y., Kobayashi K., Takao K., Tanaka T., Nishikawa K., et al. Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice. Molecular Brain 2012, 5:43.
76. Nakagawa T., Futai K., Lashuel H.A., Lo I., Okamoto K., Walz T., et al. Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactions. Neuron 2004, 44:453-467.
77. Nikonenko I., Boda B., Steen S., Knott G., Welker E., Muller D. PSD-95 promotes synaptogenesis and multiinnervated spine formation through nitric oxide signaling. Journal of Cell Biology 2008, 183:1115-1127.
78. Norton N., Williams H.J., Williams N.M., Spurlock G., Zammit S., Jones G., et al. Mutation screening of the Homer gene family and association analysis in schizophrenia. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 2003, 120B:18-21.
79. Okvist A., Fagergren P., Whittard J., Garcia-Osta A., Drakenberg K., Horvath M.C., et al. Dysregulated postsynaptic density and endocytic zone in the amygdala of human heroin and cocaine abusers. Biological Psychiatry 2011, 69:245-252.
80. Peca J., Feliciano C., Ting J.T., Wang W., Wells M.F., Venkatraman T.N., et al. Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature 2011, 472:437-442.
81. Penzes P., Johnson R.C., Sattler R., Zhang X., Huganir R.L., Kambampati V., et al. The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis. Neuron 2001, 29:229-242.
82. Penzes P., Remmers C. Kalirin signaling: Implications for synaptic pathology. Molecular Neurobiology 2012, 45:109-118.
83. Pittenger C., Sanacora G., Krystal J.H. The NMDA receptor as a therapeutic target in major depressive disorder. CNS and Neurological Disorders Drug Targets 2007, 6:101-115.
84. Potkin S.G., Turner J.A., Guffanti G., Lakatos A., Fallon J.H., Nguyen D.D., et al. A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. Schizophrenia Bulletin 2009, 35:96-108.
85. Proctor D.T., Coulson E.J., Dodd P.R. Reduction in post-synaptic scaffolding PSD-95 and SAP-102 protein levels in the Alzheimer inferior temporal cortex is correlated with disease pathology. Journal of Alzheimer's Disease 2010, 21:795-811.
86. Radwanska K., Medvedev N.I., Pereira G.S., Engmann O., Thiede N., Moraes M.F., et al. Mechanism for long-term memory formation when synaptic strengthening is impaired. Proceedings of the National Academy of Sciences of the United States of America 2011, 108:18471-18475.
87. Rastogi A., Zai C., Likhodi O., Kennedy J.L., Wong A.H. Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia. Schizophrenia Research 2009, 114:39-49.
88. Reiner O., Sapoznik S., Sapir T. Lissencephaly 1 linking to multiple diseases: Mental retardation, neurodegeneration, schizophrenia, male sterility, and more. Neuromolecular Medicine 2006, 8:547-565.
89. Roche K.W., Tu J.C., Petralia R.S., Xiao B., Wenthold R.J., Worley P.F. Homer1b regulates the trafficking of group I metabotropic glutamate receptors. Journal of Biological Chemistry 1999, 274:25953-25957.
90. Ronesi J.A., Collins K.A., Hays S.A., Tsai N.P., Guo W., Birnbaum S.G., et al. Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome. Nature Neuroscience 2012, 15(431-440):S431.
91. Ronesi J.A., Huber K.M. Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation. Journal of Neuroscience 2008, 28:543-547.
92. Ryu J., Futai K., Feliu M., Weinberg R., Sheng M. Constitutively active Rap2 transgenic mice display fewer dendritic spines, reduced extracellular signal-regulated kinase signaling, enhanced long-term depression, and impaired spatial learning and fear extinction. Journal of Neuroscience 2008, 28:8178-8188.
93. Sanda M., Ohara N., Kamata A., Hara Y., Tamaki H., Sukegawa J., et al. Vezatin, a potential target for ADP-ribosylation factor 6, regulates the dendritic formation of hippocampal neurons. Neuroscience Research 2010, 67:126-136.
94. Sawallisch C., Berhorster K., Disanza A., Mantoani S., Kintscher M., Stoenica L., et al. The insulin receptor substrate of 53kDa (IRSp53) limits hippocampal synaptic plasticity. Journal of Biological Chemistry 2009, 284:9225-9236.
95. Schluter O.M., Xu W., Malenka R.C. Alternative N-terminal domains of PSD-95 and SAP97 govern activity-dependent regulation of synaptic AMPA receptor function. Neuron 2006, 51:99-111.
96. Schmeisser M.J., Ey E., Wegener S., Bockmann J., Stempel A.V., Kuebler A., et al. Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Nature 2012, 486:256-260.
97. Sheng M., Hoogenraad C.C. The postsynaptic architecture of excitatory synapses: A more quantitative view. Annual Review of Biochemistry 2007, 76:823-847.
98. Shi J., Levinson D.F., Duan J., Sanders A.R., Zheng Y., Pe'er I., et al. Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature 2009, 460:753-757.
99. Shiraishi-Yamaguchi Y., Furuichi T. The Homer family proteins. Genome Biology 2007, 8:206.
100. Shors T.J., Matzel L.D. Long-term potentiation: What's learning got to do with it?. Behavioral and Brain Sciences 1997, 20:597-614. (discussion 614-555).
101. Silverman J.L., Turner S.M., Barkan C.L., Tolu S.S., Saxena R., Hung A.Y., et al. Sociability and motor functions in Shank1 mutant mice. Brain Research 2011, 1380:120-137.
102. Soltau M., Berhorster K., Kindler S., Buck F., Richter D., Kreienkamp H.J. Insulin receptor substrate of 53kDa links postsynaptic shank to PSD-95. Journal of Neurochemistry 2004, 90:659-665.
103. Strauss J., McGregor S., Freeman N., Tiwari A., George C.J., Kovacs M., et al. Association study of early-immediate genes in childhood-onset mood disorders and suicide attempt. Psychiatry Research 2012, 197:49-54.
104. Swanson C.J., Baker D.A., Carson D., Worley P.F., Kalivas P.W. Repeated cocaine administration attenuates group I metabotropic glutamate receptor-mediated glutamate release and behavioral activation: A potential role for Homer. Journal of Neuroscience 2001, 21:9043-9052.
105. Swiech L., Blazejczyk M., Urbanska M., Pietruszka P., Dortland B.R., Malik A.R., et al. CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology. Journal of Neuroscience 2011, 31:4555-4568.
106. Szumlinski K.K., Toda S., Middaugh L.D., Worley P.F., Kalivas P.W. Evidence for a relationship between Group 1 mGluR hypofunction and increased cocaine and ethanol sensitivity in Homer2 null mutant mice. Ann N Y Acad Sci 2003, 1003:468-471.
107. Szumlinski K.K., Abernathy K.E., Oleson E.B., Klugmann M., Lominac K.D., He D.Y., et al. Homer isoforms differentially regulate cocaine-induced neuroplasticity. Neuropsychopharmacology 2006, 31:768-777.
108. Szumlinski K.K., Ary A.W., Lominac K.D. Homers regulate drug-induced neuroplasticity: Implications for addiction. Biochemical Pharmacology 2008, 75:112-133.
109. Szumlinski K.K., Dehoff M.H., Kang S.H., Frys K.A., Lominac K.D., Klugmann M., et al. Homer proteins regulate sensitivity to cocaine. Neuron 2004, 43:401-413.
110. Szumlinski K.K., Lominac K.D., Kleschen M.J., Oleson E.B., Dehoff M.H., Schwarz M.K., et al. Behavioral and neurochemical phenotyping of Homer1 mutant mice: Possible relevance to schizophrenia. Genes, Brain, and Behavior 2005, 4:273-288.
111. Tarpey P., Parnau J., Blow M., Woffendin H., Bignell G., Cox C., et al. Mutations in the DLG3 gene cause nonsyndromic X-linked mental retardation. American Journal of Human Genetics 2004, 75:318-324.
112. Tronson N.C., Guzman Y.F., Guedea A., Huh K.H., Gao C., Schwarz M.K., et al. Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear. Biological Psychiatry 2010, 68:980-981.
113. van Zundert B., Yoshii A., Constantine-Paton M. Receptor compartmentalization and trafficking at glutamate synapses: A developmental proposal. Trends in Neurosciences 2004, 27:428-437.
114. Verpelli C., Dvoretskova E., Vicidomini C., Rossi F., Chiappalone M., Schoen M., et al. Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. Journal of Biological Chemistry 2011, 286:34839-34850.
115. Verpelli C., Schmeisser M.J., Sala C., Boeckers T.M. Scaffold proteins at the postsynaptic density. Advances in Experimental Medicine and Biology 2012, 970:29-61.
116. von Ossowski I., Oksanen E., von Ossowski L., Cai C., Sundberg M., Goldman A., et al. Crystal structure of the second PDZ domain of SAP97 in complex with a GluR-A C-terminal peptide. FEBS Journal 2006, 273:5219-5229.
117. Wan Y., Ade K.K., Caffall Z., Ilcim Ozlu M., Eroglu C., Feng G., et al. Circuit-selective striatal synaptic dysfunction in the sapap3 knockout mouse model of obsessive-compulsive disorder. Biological Psychiatry 2013.
118. Wang Q., Charych E.I., Pulito V.L., Lee J.B., Graziane N.M., Crozier R.A., et al. The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. Molecular Psychiatry 2011, 16:1006-1023.
119. Wang H., Nong Y., Bazan F., Greengard P., Flajolet M. Norbin: A promising central nervous system regulator. Communicative and Integrative Biology 2010, 3:487-490.
120. Wang H., Westin L., Nong Y., Birnbaum S., Bendor J., Brismar H., et al. Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling. Science 2009, 326:1554-1557.
121. Welch J.M., Lu J., Rodriguiz R.M., Trotta N.C., Peca J., Ding J.D., et al. Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. Nature 2007, 448:894-900.
122. White C.D., Erdemir H.H., Sacks D.B. IQGAP1 and its binding proteins control diverse biological functions. Cellular Signalling 2012, 24:826-834.
123. Won H., Lee H.R., Gee H.Y., Mah W., Kim J.I., Lee J., et al. Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function. Nature 2012, 486:261-265.
124. Xie Z., Cahill M.E., Radulovic J., Wang J., Campbell S.L., Miller C.A., et al. Hippocampal phenotypes in kalirin-deficient mice. Molecular and Cellular Neurosciences 2011, 46:45-54.
125. Xie Z., Srivastava D.P., Photowala H., Kai L., Cahill M.E., Woolfrey K.M., et al. Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spines. Neuron 2007, 56:640-656.
126. Xu W. PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity. Current Opinion in Neurobiology 2011, 21:306-312.
127. Xu W., Schluter O.M., Steiner P., Czervionke B.L., Sabatini B., Malenka R.C. Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD. Neuron 2008, 57:248-262.
128. Xu B., Xu Z.F., Deng Y., Liu W., Yang H.B., Wei Y.G. Protective effects of MK-801 on methylmercury-induced neuronal injury in rat cerebral cortex: Involvement of oxidative stress and glutamate metabolism dysfunction. Toxicology 2012, 300:112-120.
129. Yang M., Bozdagi O., Scattoni M.L., Wohr M., Roullet F.I., Katz A.M., et al. Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice. Journal of Neuroscience 2012, 32:6525-6541.
130. Yao W.D., Gainetdinov R.R., Arbuckle M.I., Sotnikova T.D., Cyr M., Beaulieu J.M., et al. Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity. Neuron 2004, 41:625-638.
131. Yuan P., Zhou R., Wang Y., Li X., Li J., Chen G., et al. Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia. Journal of Affective Disorders 2010, 124:164-169.
132. Zanni G., van Esch H., Bensalem A., Saillour Y., Poirier K., Castelnau L., et al. A novel mutation in the DLG3 gene encoding the synapse-associated protein 102 (SAP102) causes non-syndromic mental retardation. Neurogenetics 2010, 11:251-255.
133. Zheng C.Y., Seabold G.K., Horak M., Petralia R.S. MAGUKs, synaptic development, and synaptic plasticity. Neuroscientist 2011, 17:493-512.
134. Zweifel L.S., Argilli E., Bonci A., Palmiter R.D. Role of NMDA receptors in dopamine neurons for plasticity and addictive behaviors. Neuron 2008, 59:486-496.