Circuit-selective striatal synaptic dysfunction in the sapap3 knockout mouse model of obsessive-compulsive disorder

Biological Psychiatry

Volumn 75, Issue 8, 2014, Pages 623-630

  Wan, Yehong ^a   Ade, Kristen K ^a   Caffall, Zachary ^a   Ilcim Ozlu, M ^c   Eroglu, Cagla ^b,c   Feng, Guoping ^d   Calakos, Nicole ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b Department of Neurobiology ^*  (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Corticostriatal; DLGAP3; GKAP; obsessive compulsive disorder; SAPAP3; striatum; thalamostriatal

Indexed keywords

AMPA RECEPTOR; FLUORESCENT DYE; MEMBRANE PROTEIN; POSTSYNAPTIC DENSITY PROTEIN 95 ASSOCIATED PROTEIN 3; UNCLASSIFIED DRUG; NERVE PROTEIN; SAPAP3 PROTEIN, MOUSE; SLC17A6 PROTEIN, MOUSE; SLC17A7 PROTEIN, MOUSE; VESICULAR GLUTAMATE TRANSPORTER 1; VESICULAR GLUTAMATE TRANSPORTER 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; CONTROLLED STUDY; CORPUS STRIATUM; ELECTROPHYSIOLOGICAL PROCEDURES; EXCITATORY POSTSYNAPTIC POTENTIAL; GENETIC HETEROGENEITY; GLOBUS PALLIDUS; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MOUSE; MOUSE MODEL; NERVE PROJECTION; NERVE TRACT; NONHUMAN; OBSESSIVE COMPULSIVE DISORDER; PRIORITY JOURNAL; SUBSTANTIA NIGRA; SYNAPTIC TRANSMISSION; THALAMUS; ANIMAL; DISEASE MODEL; GENETICS; IN VITRO STUDY; METABOLISM; NERVE CELL; PATCH CLAMP TECHNIQUE; PATHOPHYSIOLOGY; PHYSIOLOGY; SYNAPSE; TRANSGENIC MOUSE;

ANIMALS; CEREBRAL CORTEX; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; EXCITATORY POSTSYNAPTIC POTENTIALS; IN VITRO TECHNIQUES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NEURAL PATHWAYS; NEURONS; OBSESSIVE-COMPULSIVE DISORDER; PATCH-CLAMP TECHNIQUES; RECEPTORS, AMPA; SYNAPSES; THALAMUS; VESICULAR GLUTAMATE TRANSPORT PROTEIN 1; VESICULAR GLUTAMATE TRANSPORT PROTEIN 2;

EID: 84897107762     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2013.01.008     Document Type: Article

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