Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of schizophrenia

Neuropsychopharmacology

Volumn 34, Issue 7, 2009, Pages 1659-1672

  Guo, Xiaochuan ^a   Hamilton, Peter J ^b,d   Reish, Nicholas J ^a,c   Sweatt, J David ^a   Miller, Courtney A ^a   Rumbaugh, Gavin ^a,b  

^a University of Alabama at Birmingham   (United States)

^b UAB Summer Program in Neuroscience (SPIN)

^c UAB Medical Scientist Training Program (MSTP)

^d NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Fear conditioning; Hyperactivity; NMDA receptor; Plasticity; Postsynaptic density; Schizophrenia

Indexed keywords

CLOZAPINE; DIZOCILPINE; DRUG VEHICLE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SYNAPTIC GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONDITIONING; DRUG EFFECT; FEMALE; MALE; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; SCHIZOPHRENIA; SENSORIMOTOR FUNCTION; SIGNAL TRANSDUCTION; STARTLE REFLEX; WORKING MEMORY;

ACOUSTIC STIMULATION; ANALYSIS OF VARIANCE; ANIMALS; ANTIPSYCHOTIC AGENTS; BEHAVIOR, ANIMAL; BEHAVIORAL SYMPTOMS; CLOZAPINE; CROSS-OVER STUDIES; DISEASE MODELS, ANIMAL; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; EXPLORATORY BEHAVIOR; GENE EXPRESSION REGULATION; INHIBITION (PSYCHOLOGY); LOCOMOTION; MEMORY DISORDERS; MEMORY, SHORT-TERM; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; NEUROPSYCHOLOGICAL TESTS; RAS GTPASE-ACTIVATING PROTEINS; SCHIZOPHRENIA; SOCIAL BEHAVIOR; STARTLE REACTION; STEREOTYPED BEHAVIOR;

EID: 67349261457     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/npp.2008.223     Document Type: Article

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