Post-weaning chronic social isolation produces profound behavioral dysregulation with decreases in prefrontal cortex synaptic-associated protein expression in female rats

Physiology and Behavior

Volumn 104, Issue 2, 2011, Pages 354-359

  Hermes, Gretchen ^a   Li, Nanxin ^a   Duman, Catharine ^a   Duman, Ronald ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anxiety; Female rats; Glutamate receptor; Isolation rearing; Prefrontal cortex; Social interaction; Synaptic marker

Indexed keywords

GLUTAMATE RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; POSTSYNAPTIC DENSITY PROTEIN 95; SYNAPSIN I;

ANXIETY DISORDER; ARTICLE; BEHAVIOR DISORDER; BIOCHEMISTRY; DOPAMINERGIC SYSTEM; FEMALE; MALE; NONHUMAN; POST WEANING CHRONIC SOCIAL ISOLATION; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCHIZOPHRENIA; SEROTONINERGIC SYSTEM; SOCIAL ISOLATION; SPRAGUE DAWLEY RAT; WEANING;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BEHAVIORAL SYMPTOMS; BODY WEIGHT; ESTRIOL; ESTRUS; EXPLORATORY BEHAVIOR; FEMALE; FOOD DEPRIVATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; PREFRONTAL CORTEX; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; SOCIAL ISOLATION; SYNAPSINS;

EID: 79959240119     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2010.12.019     Document Type: Article

References (43)

1. Einon D.F., Morgan M.J. A critical period for social isolation in the rat. Dev Psychobiol 1977, 10(2):123-132.
2. Fone K.C., Porkess M.V. Behavioural and neurochemical effects of post-weaning social isolation in rodents-relevance to developmental neuropsychiatric disorders. Neurosci Biobehav Rev 2008, 32(6):1087-1102.
3. Heidbreder C.A., et al. Behavioral, neurochemical and endocrinological characterization of the early social isolation syndrome. Neuroscience 2000, 100(4):749-768.
4. Weiss I.C., et al. Effect of social isolation on stress-related behavioural and neuroendocrine state in the rat. Behav Brain Res 2004, 152(2):279-295.
5. Panksepp J. The ontogeny of play in rats. Dev Psychobiol 1981, 14(4):327-332.
6. Pellis S.M., Pellis V.C. The prejuvenile onset of play fighting in laboratory rats (Rattus norvegicus). Dev Psychobiol 1997, 31(3):193-205.
7. Hol T., et al. Isolation during the play period in infancy decreases adult social interactions in rats. Behav Brain Res 1999, 100(1-2):91-97.
8. van den Berg C.L., et al. Play is indispensable for an adequate development of coping with social challenges in the rat. Dev Psychobiol 1999, 34(2):129-138.
9. Vanderschuren L.J., Niesink R.J., Van Ree J.M. The neurobiology of social play behavior in rats. Neurosci Biobehav Rev 1997, 21(3):309-326.
10. Klein Z.A., Padow V.A., Romeo R.D. The effects of stress on play and home cage behaviors in adolescent male rats. Dev Psychobiol 2010, 52(1):62-70.
11. Spear L.P. The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev 2000, 24(4):417-463.
12. Eslinger P.J., Flaherty-Craig C.V., Benton A.L. Developmental outcomes after early prefrontal cortex damage. Brain Cogn 2004, 55(1):84-103.
13. Anderson S.W., et al. Impairment of social and moral behavior related to early damage in human prefrontal cortex. Nat Neurosci 1999, 2(11):1032-1037.
14. Day-Wilson K.M., et al. Medial prefrontal cortex volume loss in rats with isolation rearing-induced deficits in prepulse inhibition of acoustic startle. Neuroscience 2006, 141(3):1113-1121.
15. Schneider M., Koch M. Deficient social and play behavior in juvenile and adult rats after neonatal cortical lesion: effects of chronic pubertal cannabinoid treatment. Neuropsychopharmacology 2005, 30(5):944-957.
16. Melendez R.I., et al. Impoverished rearing environment alters metabotropic glutamate receptor expression and function in the prefrontal cortex. Neuropsychopharmacology 2004, 29(11):1980-1987.
17. Levine J.B., et al. Isolation rearing and hyperlocomotion are associated with reduced immediate early gene expression levels in the medial prefrontal cortex. Neuroscience 2007, 145(1):42-55.
18. Auger A.P., Olesen K.M. Brain sex differences and the organisation of juvenile social play behaviour. J Neuroendocrinol 2009, 21(6):519-525.
19. Zhao X., et al. Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats. Prog Neuropsychopharmacol Biol Psychiatry 2009, 33(7):1173-1177.
20. Li N., et al. Auditory fear conditioning modulates prepulse inhibition in socially reared rats and isolation-reared rats. Behav Neurosci 2008, 122(1):107-118.
21. Long J.A., Evans H.M. The oestrous cycle in the rat and its associated phenomena. Mem Univ Calif 1922, 6:1-148.
22. Mandl A.M. The phases of the estrous cycle in the adult white rat. J Exp Biol 1951, 28:576-584.
23. Warner-Schmidt J.L., Duman R.S. VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants. Proc Natl Acad Sci USA 2007, 104(11):4647-4652.
24. Santarelli L., et al. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 2003, 301(5634):805-809.
25. File S.E., Seth P. A review of 25years of the social interaction test. Eur J Pharmacol 2003, 463(1-3):35-53.
26. Li N., et al. mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science 2010, 329(5994):959-964.
27. McEwen B.S., et al. Ovarian steroids and the brain: implications for cognition and aging. Neurology 1997, 48(5 Suppl 7):S8-S15.
28. McEwen B., A.K., Alves S., Brake W.G., Bulloch K., Lee S., et al. Tracking the estrogen receptor in neurons: implications for estrogen-induced synapse formation. Proc Natl Acad Sci 2001, 98(13):7093-7100.
29. Jelks K.B., W.R., Floyd C.L., McAllister A.K., Wise P. Estradiol targets synaptic proteins to induce glutamatergic synapse formation in cultured hippocampal neurons: critical role of estrogen receptor-alpha. J Neurosci 2007, 27(26):6903-6913.
30. Meng Q., et al. Peri-adolescence isolation rearing alters social behavior and nociception in rats. Neurosci Lett 2010, 480(1):25-29.
31. Thor D.H., Holloway W.R. Social play soliciting by male and female juvenile rats: effects of neonatal androgenization and sex of cagemates. Behav Neurosci 1986, 100(2):275-279.
32. Meaney M.J., McEwen B.S. Testosterone implants into the amygdala during the neonatal period masculinize the social play of juvenile female rats. Brain Res 1986, 398(2):324-328.
33. Tonjes R., Docke F., Dorner G. Effects of neonatal intracerebral implantation of sex steroids on sexual behaviour, social play behaviour and gonadotrophin secretion. Exp Clin Endocrinol 1987, 90(3):257-263.
34. Casto J.M., Ward O.B., Bartke A. Play, copulation, anatomy, and testosterone in gonadally intact male rats prenatally exposed to flutamide. Physiol Behav 2003, 79(4-5):633-641.
35. Hotchkiss A.K., et al. An environmental antiandrogen, vinclozolin, alters the organization of play behavior. Physiol Behav 2003, 79(2):151-156.
36. Bodnoff S.R., et al. A comparison of the effects of diazepam versus several typical and atypical anti-depressant drugs in an animal model of anxiety. Psychopharmacol Berl 1989, 97(2):277-279.
37. Shelley H.P. Eating behavior: social facilitation or social inhibition?. Psychon Sci 1965, 3:521-522.
38. Mainardi M., et al. A sensitive period for environmental regulation of eating behavior and leptin sensitivity. Proc Natl Acad Sci USA 2010, 107(38):16673-16678.
39. Chaddock L., et al. A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children. Brain Res 2010, 1358:172-183.
40. Hall F.S., et al. The effects of isolation rearing on glutamate receptor NMDAR1A mRNA expression determined by in situ hybridization in Fawn hooded and Wistar rats. Pharmacol Biochem Behav 2002, 73(1):185-191.
41. Sans N., et al. A developmental change in NMDA receptor-associated proteins at hippocampal synapses. J Neurosci 2000, 20(3):1260-1271.
42. Varty G.B., Marsden C.A., Higgins G.A. Reduced synaptophysin immunoreactivity in the dentate gyrus of prepulse inhibition-impaired isolation-reared rats. Brain Res 1999, 824(2):197-203.
43. Bianchi M., et al. Chronic fluoxetine differentially modulates the hippocampal microtubular and serotonergic system in grouped and isolation reared rats. Eur Neuropsychopharmacol 2009, 19(11):778-790.