Evidence for a Relationship between Group 1 mGluR Hypofunction and Increased Cocaine and Ethanol Sensitivity in Homer2 Null Mutant Mice

Annals of the New York Academy of Sciences

Volumn 1003, Issue , 2003, Pages 468-471

  Szumlinski, Karen K ^a   Toda, Shigenobu ^a   Middaugh, Lawrence D ^a   Worley, Paul F ^b   Kalivas, Peter W ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cocaine; Ethanol; Homer proteins; Homer2 null mutant mice; mGluR hypofunction

Indexed keywords

ALCOHOL; COCAINE; HOMER PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; AVERSION; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; FUNCTIONAL ASSESSMENT; HYPERACTIVITY; MOUSE; MOUSE STRAIN; NERVE CELL PLASTICITY; NEUROCHEMISTRY; NONHUMAN; PLACE PREFERENCE; SPECIES COMPARISON;

ANIMALIA;

EID: 0347091889     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1300.055     Document Type: Conference Paper

References (13)

1. BRAKEMAN, P.R., A.A. LANAHAN, R. O'BRIEN, et al. 1997. Homer: a protein that selectively binds metabotropic glutamate receptors. Nature 386: 284-288.
2. XIAO, B., J.C. TU & P.F. WORLEY. 2000. Homer: a link between neural activity and glutamate receptor function. Curr. Opin. Neurobiol. 10: 370-374.
3. KATO, A., F. OZAWA, Y. SAITOH, et al. 1998. Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptors. J. Biol. Chem. 273: 23969-23975.
4. SZUMLINSKI, K.K., M.H. DEHOFF, S.H. KANG, et al. 2003. Homer2 deletion pre-sensitizes cocaine reward and motor activity: role of accumbens glutamate. Proc. Natl. Acad. Sci. Submitted for publication.
5. SWANSON, C.J., D.A. BAKER, D. CARSON, et al. 2001. Repeated cocaine administration attenuates group I metabotropic glutamate receptor-mediated glutamate release and behavioral activation: a potential role for Homer. J. Neurosci. 21: 9043-9052.
6. CHRISTIAN, M., G.Y. SUN & A. SIMONYI. 2002. Chronic ethanol-induced decrease in the expression of metabotropic glutamate receptors in rat hippocampus. Soc. Neurosci. Abstr. no. 339.8.
7. + depolarization in cultured cerebellar Purkinje neurons. Brain Res. 773: 82-89.
8. LOVINGER, D.M., G. WHITE & F.F. WEIGHT. 1989. Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 243: 1721-1724.
9. MINAMI, K., R.W. GEREAU, IV, M. MINAMI, et al. 1998. Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus oocytes. Mol. Pharmacol. 53: 148-156.
10. MOGHADDAM, B. & M.L. BOLINAO. 1994. Biphasic effect of ethanol on extracellular accumulation of glutamate in the hippocampus and the nucleus accumbens. Neurosci. Lett. 178: 99-102.
11. DAHCHOUR, A., A. HOFFMAN, R. DEITRICH & P. DE WITTE. 2000. Effects of ethanol on extracellular amino acid levels in high-and low-alcohol sensitive rats: a microdialysis study. Alcohol Alcohol. 35: 548-553.
12. MCMILLAN, B.A., M.S. CRAWFORD, C.M. KULERS & H.L. WILLIAMS. 2002. Effect of a mGlu5 metabotropic glutamate receptor antagonist on ethanol consumption by genetic drinking rats. Soc. Neurosci. Abstr. no. 607.8.
13. SHARKO, A.C., C.W. HODGE, K. ILLER, et al. 2002. Involvement of metabotropic glutamate receptor subtype 5 (mGlu5) in alcohol self-administration and sedation. Soc. Neurosci. Abstr. no. 783.1.