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Volumn 100, Issue 4, 2012, Pages 841-849

Glutamate mediated signaling in the pathophysiology of autism spectrum disorders

Author keywords

Autism spectrum disorder (ASD); Glutamate; Neurotransmitter; Pathology; Signaling; Therapeutic interventions

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 4 AMINOBUTYRIC ACID; ACETYLCHOLINE; AMPA RECEPTOR; ASPARTIC ACID; DOPAMINE; EXCITATORY AMINO ACID TRANSPORTER; G PROTEIN COUPLED RECEPTOR; GLUTAMATE DECARBOXYLASE; GLUTAMIC ACID; GLYCINE; LAMOTRIGINE; MEMANTINE; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2C; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2D; NEUROTENSIN; NORADRENALIN; PLACEBO; REGULATOR PROTEIN; SEROTONIN; SOMATOSTATIN; VASOPRESSIN; VESICULAR GLUTAMATE TRANSPORTER 1;

EID: 84855528326     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2011.06.023     Document Type: Review
Times cited : (99)

References (149)
  • 1
    • 0004235298 scopus 로고
    • American Psychiatric Association. DSM IV, 4th edition Washington, DC: American Psychiatric Association
    • American Psychiatric Association. Diagnostic and statistical manual of mental disorders. DSM IV, 4th edition Washington, DC: American Psychiatric Association; 1994.
    • (1994) Diagnostic and Statistical Manual of Mental Disorders
  • 2
    • 42349095075 scopus 로고    scopus 로고
    • Advances in autism genetics: On the threshold of a new neurobiology
    • DOI 10.1038/nrg2346, PII NRG2346
    • Abrahams BS, Geschwind DH. Advances in autism genetics: on the threshold of a new neurobiology. Nat Rev Genet 2008;9:341-55. (Pubitemid 351556064)
    • (2008) Nature Reviews Genetics , vol.9 , Issue.5 , pp. 341-355
    • Abrahams, B.S.1    Geschwind, D.H.2
  • 4
    • 0037317443 scopus 로고    scopus 로고
    • Differential effects of developmental cerebellar abnormality on cognitive and motor functions in the cerebellum: An fMRI study of autism
    • DOI 10.1176/appi.ajp.160.2.262
    • Allen G, Courchesne E. Differential effects of developmental cerebellar abnormality on cognitive and motor functions in the cerebellum: an fMRI study of autism. Am J Psychiatry 2003;160:262-73. (Pubitemid 41110451)
    • (2003) American Journal of Psychiatry , vol.160 , Issue.2 , pp. 262-273
    • Allen, G.1    Courchesne, E.2
  • 9
    • 33745893228 scopus 로고    scopus 로고
    • The glutamate/GABA-glutamine cycle: Aspects of transport, neurotransmitter homeostasis and ammonia transfer
    • DOI 10.1111/j.1471-4159.2006.03913.x
    • Bak LK, Schousboe A, Waagepetersen HS. The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer. J Neurochem 2006;98:641-53. (Pubitemid 44051266)
    • (2006) Journal of Neurochemistry , vol.98 , Issue.3 , pp. 641-653
    • Bak, L.K.1    Schousboe, A.2    Waagepetersen, H.S.3
  • 10
    • 2542484527 scopus 로고    scopus 로고
    • A comparison of GluR-A-deficient and wild-type mice on a test battery assessing sensorimotor, affective, and cognitive behaviors
    • DOI 10.1037/0735-7044.118.3.643
    • Bannerman DM, Deacon RM, Brady S, Bruce A, Sprengel R, Seeburg PH, et al. A comparison of GluR-A-deficient and wild-type mice on a test battery assessing sensorimotor, affective, and cognitive behaviors. Behav Neurosci 2004;118:643-7. (Pubitemid 38685333)
    • (2004) Behavioral Neuroscience , vol.118 , Issue.3 , pp. 643-647
    • Bannerman, D.M.1    Deacon, R.M.J.2    Brady, S.3    Bruce, A.4    Sprengel, R.5    Seeburg, P.H.6    Rawlins, J.N.P.7
  • 11
  • 12
    • 0021838287 scopus 로고
    • Histoanatomic observations of the brain in early infantile autism
    • Bauman M, Kemper TL. Histoanatomic observations of the brain in early infantile autism. Neurology 1985;35:866-74. (Pubitemid 15025292)
    • (1985) Neurology , vol.35 , Issue.6 , pp. 866-874
    • Bauman, M.1    Kemper, T.L.2
  • 15
    • 77957664714 scopus 로고    scopus 로고
    • An update on the potential role of excitotoxicity in the pathogenesis of Parkinson's disease
    • Blandini F. An update on the potential role of excitotoxicity in the pathogenesis of Parkinson's disease. Funct Neurol 2010;25:65-71.
    • (2010) Funct Neurol , vol.25 , pp. 65-71
    • Blandini, F.1
  • 18
    • 62349130905 scopus 로고    scopus 로고
    • Immune-glutamatergic dysfunction as a central mechanism of the autism spectrum disorders
    • Blaylock RL, Strunecka A. Immune-glutamatergic dysfunction as a central mechanism of the autism spectrum disorders. Curr Med Chem 2009;16:157-70.
    • (2009) Curr Med Chem , vol.16 , pp. 157-170
    • Blaylock, R.L.1    Strunecka, A.2
  • 19
    • 0030346364 scopus 로고    scopus 로고
    • Regional gene expression of the glutamate receptor subtypes GluR 1, GluR 2, and GluR 3 in human postmortem brain
    • Breese CR, Logel J, Adams C, Leonard SS. Regional gene expression of the glutamate receptor subtypes GluR1, GluR2, and GluR3 in human postmortem brain. J Mol Neurosci 1996;7:277-89. (Pubitemid 126718467)
    • (1996) Journal of Molecular Neuroscience , vol.7 , Issue.4 , pp. 277-289
    • Breese, C.R.1    Logel, J.2    Adams, C.3    Leonard, S.S.4
  • 20
    • 67650116714 scopus 로고    scopus 로고
    • Family-based association testing of OCD-associated SNPs of SLC1A1 in an autism sample
    • Brune CW, Kim SJ, Hanna GL, Courchesne E, Lord C, Leventhal BL, et al. Family-based association testing of OCD-associated SNPs of SLC1A1 in an autism sample. Autism Res 2008;1:108-13.
    • (2008) Autism Res , vol.1 , pp. 108-113
    • Brune, C.W.1    Kim, S.J.2    Hanna, G.L.3    Courchesne, E.4    Lord, C.5    Leventhal, B.L.6
  • 25
    • 0031880046 scopus 로고    scopus 로고
    • Hypothesis: Is infantile autism a hypoglutamatergic disorder? Relevance of glutamate-serotonin interactions for pharmacotherapy
    • DOI 10.1007/s007020050076
    • Carlsson ML. Hypothesis: is infantile autism a hypoglutamatergic disorder? Relevance of glutamate - serotonin interactions for pharmacotherapy. J Neural Transm 1998;105:525-35. (Pubitemid 28365035)
    • (1998) Journal of Neural Transmission , vol.105 , Issue.4-5 , pp. 525-535
    • Carlsson, M.L.1
  • 26
    • 0033844601 scopus 로고    scopus 로고
    • Regulation of neurotransmitter release by metabotropic glutamate receptors
    • DOI 10.1046/j.1471-4159.2000.0750889.x
    • Cartmell J, Schoepp DD. Regulation of neurotransmitter release by metabotropic glutamate receptors. J Neurochem 2000;75:889-907. (Pubitemid 30660476)
    • (2000) Journal of Neurochemistry , vol.75 , Issue.3 , pp. 889-907
    • Cartmell, J.1    Schoepp, D.D.2
  • 28
    • 0034105111 scopus 로고    scopus 로고
    • Anticonvulsant activity of two metabotropic glutamate Group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893)
    • DOI 10.1016/S0028-3908(99)00242-7, PII S0028390899002427
    • Chapman AG, Nanan K, Williams M, Meldrum BS. Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893). Neuropharmacology 2000;39:1567-74. (Pubitemid 30330873)
    • (2000) Neuropharmacology , vol.39 , Issue.9 , pp. 1567-1574
    • Chapman, A.G.1    Nanan, K.2    Williams, M.3    Meldrum, B.S.4
  • 29
    • 34250731835 scopus 로고    scopus 로고
    • Memantine as adjunctive therapy in children diagnosed with autistic spectrum disorders: An observation of initial clinical response and maintenance tolerability
    • DOI 10.1177/0883073807302611
    • Chez MG, Burton Q, Dowling T, Chang M, Khanna P, Kramer C. Memantine as adjunctive therapy in children diagnosed with autistic spectrum disorders: an observation of initial clinical response and maintenance tolerability. J Child Neurol 2007;22:574-9. (Pubitemid 46951501)
    • (2007) Journal of Child Neurology , vol.22 , Issue.5 , pp. 574-579
    • Chez, M.G.1    Burton, Q.2    Dowling, T.3    Chang, M.4    Khanna, P.5    Kramer, C.6
  • 32
    • 0032483516 scopus 로고    scopus 로고
    • Molecular cloning of aralar, a new member of the mitochondrial carrier superfamily that binds calcium and is present in human muscle and brain
    • DOI 10.1074/jbc.273.36.23327
    • del Arco A, Satrustegui J. Molecular cloning of Aralar, a new member of the mitochondrial carrier superfamily that binds calcium and is present in human muscle and brain. J Biol Chem 1998;273:23327-34. (Pubitemid 28417520)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.36 , pp. 23327-23334
    • Del, A.A.1    Satrustegui, J.2
  • 33
    • 33846558995 scopus 로고    scopus 로고
    • Regulatory mechanisms of AMPA receptors in synaptic plasticity
    • DOI 10.1038/nrn2055, PII NRN2055
    • Derkach VA, Oh MC, Guire ES, Soderling TR. Regulatory mechanisms of AMPA receptors in synaptic plasticity. Nat Rev Neurosci 2007;8:101-13. (Pubitemid 46151040)
    • (2007) Nature Reviews Neuroscience , vol.8 , Issue.2 , pp. 101-113
    • Derkach, V.A.1    Oh, M.C.2    Guire, E.S.3    Soderling, T.R.4
  • 35
    • 40949090052 scopus 로고    scopus 로고
    • Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome
    • DOI 10.1113/jphysiol.2008.150722
    • Dolen G, Bear MF. Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome. J Physiol 2008;586:1503-8. (Pubitemid 351404955)
    • (2008) Journal of Physiology , vol.586 , Issue.6 , pp. 1503-1508
    • Dolen, G.1    Bear, M.F.2
  • 38
  • 40
    • 39749165772 scopus 로고    scopus 로고
    • The hyperglutamatergic hypothesis of autism
    • author reply 912-3
    • Fatemi SH. The hyperglutamatergic hypothesis of autism. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:911. author reply 912-3.
    • (2008) Prog Neuropsychopharmacol Biol Psychiatry , vol.32 , pp. 911
    • Fatemi, S.H.1
  • 41
    • 0037108019 scopus 로고    scopus 로고
    • Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar cortices
    • Fatemi SH, Halt AR, Stary JM, Kanodia R, Schulz SC, Realmuto GR. Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar cortices. Biol Psychiatry 2002;52:805-10.
    • (2002) Biol Psychiatry , vol.52 , pp. 805-810
    • Fatemi, S.H.1    Halt, A.R.2    Stary, J.M.3    Kanodia, R.4    Schulz, S.C.5    Realmuto, G.R.6
  • 42
    • 33748924690 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors
    • DOI 10.1007/s00441-006-0266-5
    • Ferraguti F, Shigemoto R. Metabotropic glutamate receptors. Cell Tissue Res 2006;326:483-504. (Pubitemid 44435821)
    • (2006) Cell and Tissue Research , vol.326 , Issue.2 , pp. 483-504
    • Ferraguti, F.1    Shigemoto, R.2
  • 44
    • 0036348597 scopus 로고    scopus 로고
    • Epidemiological trends in rates of autism
    • Fombonne E. Epidemiological trends in rates of autism. Mol Psychiatry 2002;7(Suppl 2):S4-6.
    • (2002) Mol Psychiatry , vol.7 , Issue.SUPPL. 2
    • Fombonne, E.1
  • 45
    • 0141427915 scopus 로고    scopus 로고
    • Epidemiological surveys of autism and other pervasive developmental disorders: An update
    • DOI 10.1023/A:1025054610557
    • Fombonne E. Epidemiological surveys of autism and other pervasive developmental disorders: an update. J Autism Dev Disord 2003;33:365-82. (Pubitemid 37127933)
    • (2003) Journal of Autism and Developmental Disorders , vol.33 , Issue.4 , pp. 365-382
    • Fombonne, E.1
  • 47
    • 0031563761 scopus 로고    scopus 로고
    • Cellular and synaptic localization of the neuronal glutamate transporters excitatory amino acid transporter 3 and 4
    • Furuta A, Martin LJ, Lin CL, Dykes-Hoberg M, Rothstein JD. Cellular and synaptic localization of the neuronal glutamate transporters excitatory amino acid transporter 3 and 4. Neuroscience 1997;81:1031-42.
    • (1997) Neuroscience , vol.81 , pp. 1031-1042
    • Furuta, A.1    Martin, L.J.2    Lin, C.L.3    Dykes-Hoberg, M.4    Rothstein, J.D.5
  • 48
    • 77956062448 scopus 로고    scopus 로고
    • Glutamate transporter gene (SLC1A1) single nucleotide polymorphism (rs301430) and repetitive behaviors and anxiety in children with autism spectrum disorder
    • Gadow KD, Roohi J, DeVincent CJ, Kirsch S, Hatchwell E. Glutamate transporter gene (SLC1A1) single nucleotide polymorphism (rs301430) and repetitive behaviors and anxiety in children with autism spectrum disorder. J Autism Dev Disord 2010;40:1139-45.
    • (2010) J Autism Dev Disord , vol.40 , pp. 1139-1145
    • Gadow, K.D.1    Roohi, J.2    DeVincent, C.J.3    Kirsch, S.4    Hatchwell, E.5
  • 49
    • 77955672334 scopus 로고    scopus 로고
    • A role of GABA analogues in the treatment of neurological diseases
    • Gajcy K, Lochynski S, Librowski T. A role of GABA analogues in the treatment of neurological diseases. Curr Med Chem 2010;17:2338-47.
    • (2010) Curr Med Chem , vol.17 , pp. 2338-2347
    • Gajcy, K.1    Lochynski, S.2    Librowski, T.3
  • 52
    • 48849094481 scopus 로고    scopus 로고
    • A critical importance of polyamine site in NMDA receptors for neurite outgrowth and fasciculation at early stages of P19 neuronal differentiation
    • Georgiev D, Taniura H, Kambe Y, Takarada T, Yoneda Y. A critical importance of polyamine site in NMDA receptors for neurite outgrowth and fasciculation at early stages of P19 neuronal differentiation. Exp Cell Res 2008;314:2603-17.
    • (2008) Exp Cell Res , vol.314 , pp. 2603-2617
    • Georgiev, D.1    Taniura, H.2    Kambe, Y.3    Takarada, T.4    Yoneda, Y.5
  • 54
    • 76749102435 scopus 로고    scopus 로고
    • Acetylcholinesterase variants in Alzheimer's disease: From neuroprotection to programmed cell death
    • Greenberg DS, Toiber D, Berson A, Soreq H. Acetylcholinesterase variants in Alzheimer's disease: from neuroprotection to programmed cell death. Neurodegener Dis 2010;7:60-3.
    • (2010) Neurodegener Dis , vol.7 , pp. 60-63
    • Greenberg, D.S.1    Toiber, D.2    Berson, A.3    Soreq, H.4
  • 55
    • 0027381405 scopus 로고
    • Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6
    • Gregor P, O'Hara BF, Yang X, Uhl GR. Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6. Neuroreport 1993;4:1343-6. (Pubitemid 23297985)
    • (1993) NeuroReport , vol.4 , Issue.12 , pp. 1343-1346
    • Gregor, P.1    O'Hara, B.F.2    Yang, X.3    Uhl, G.R.4
  • 57
    • 33644553074 scopus 로고    scopus 로고
    • AMPA signalling in nascent glutamatergic synapses: There and not there!
    • Groc L, Gustafsson B, Hanse E. AMPA signalling in nascent glutamatergic synapses: there and not there! Trends Neurosci 2006;29:132-9.
    • (2006) Trends Neurosci , vol.29 , pp. 132-139
    • Groc, L.1    Gustafsson, B.2    Hanse, E.3
  • 58
    • 33846614076 scopus 로고    scopus 로고
    • Recent Advances in the Genetics of Autism
    • DOI 10.1016/j.biopsych.2006.06.020, PII S0006322306008122, Advances in Understending and Treating Autism Spectrum Disorders
    • Gupta AR, State MW. Recent advances in the genetics of autism. Biol Psychiatry 2007;61:429-37. (Pubitemid 46185337)
    • (2007) Biological Psychiatry , vol.61 , Issue.4 , pp. 429-437
    • Gupta, A.R.1    State, M.W.2
  • 59
    • 0023119185 scopus 로고
    • The regulation of neurite outgrowth, growth cone mobility, and electrical synaptogenesis by serotonin
    • DOI 10.1002/neu.480180206
    • Haydon PG, McCobb DP, Kater SB. The regulation of neurite outgrowth, growth cone motility, and electrical synaptogenesis by serotonin. J Neurobiol 1987;18:197-215. (Pubitemid 17028471)
    • (1987) Journal of Neurobiology , vol.18 , Issue.2 , pp. 197-215
    • Haydon, P.G.1    McCobb, D.P.2    Kater, S.B.3
  • 60
    • 0034907230 scopus 로고    scopus 로고
    • Neurotransmitters and neuromodulators during early human development
    • DOI 10.1016/S0378-3782(01)00189-X, PII S037837820100189X
    • Herlenius E, Lagercrantz H. Neurotransmitters and neuromodulators during early human development. Early Hum Dev 2001;65:21-37. (Pubitemid 32743368)
    • (2001) Early Human Development , vol.65 , Issue.1 , pp. 21-37
    • Herlenius, E.1    Lagercrantz, H.2
  • 61
    • 0025768411 scopus 로고
    • The effects of NMDA receptor blockade on the acquisition of a conditioned emotional response
    • Hoehn-Saric R, McLeod DR, Glowa JR. The effects of NMDA receptor blockade on the acquisition of a conditioned emotional response. Biol Psychiatry 1991;30:170-6.
    • (1991) Biol Psychiatry , vol.30 , pp. 170-176
    • Hoehn-Saric, R.1    McLeod, D.R.2    Glowa, J.R.3
  • 63
    • 0141540782 scopus 로고    scopus 로고
    • Kainate receptors and synaptic transmission
    • DOI 10.1016/S0301-0082(03)00122-9
    • Huettner JE. Kainate receptors and synaptic transmission. Prog Neurobiol 2003;70:387-407. (Pubitemid 37159280)
    • (2003) Progress in Neurobiology , vol.70 , Issue.5 , pp. 387-407
    • Huettner, J.E.1
  • 64
    • 0035871209 scopus 로고    scopus 로고
    • Further characterization of the autism susceptibility locus AUTS1 on chromosome 7q
    • IMGSAC IMGSoAC
    • IMGSAC IMGSoAC. Further characterization of the autism susceptibility locus AUTS1 on chromosome 7q. Hum Mol Genet 2001;10:973-82.
    • (2001) Hum Mol Genet , vol.10 , pp. 973-982
  • 65
    • 79960370155 scopus 로고    scopus 로고
    • Family-based association testing of glutamate transporter genes in autism
    • [Epub ahead of print]. doi:10.1097/YPG.0b013e328341a323
    • Jacob S, Brune CW, Badner JA, Ernstrom K, Courchesne E, Lord C, et al. Family-based association testing of glutamate transporter genes in autism. Psychiatr Genet 2010; [Epub ahead of print]. doi:10.1097/YPG.0b013e328341a323.
    • (2010) Psychiatr Genet
    • Jacob, S.1    Brune, C.W.2    Badner, J.A.3    Ernstrom, K.4    Courchesne, E.5    Lord, C.6
  • 68
    • 0028874967 scopus 로고
    • Neurotransmitters and vulnerability of the developing brain
    • Johnston MV. Neurotransmitters and vulnerability of the developing brain. Brain Dev 1995;17:301-6.
    • (1995) Brain Dev , vol.17 , pp. 301-306
    • Johnston, M.V.1
  • 70
    • 0025668423 scopus 로고
    • Amphetamine behavioral sensitization and the excitatory amino acids
    • Karler R, Chaudhry IA, Calder LD, Turkanis SA. Amphetamine behavioral sensitization and the excitatory amino acids. Brain Res 1990;537:76-82.
    • (1990) Brain Res , vol.537 , pp. 76-82
    • Karler, R.1    Chaudhry, I.A.2    Calder, L.D.3    Turkanis, S.A.4
  • 71
    • 0042626390 scopus 로고    scopus 로고
    • Purkinje cell vulnerability and autism: A possible etiological connection
    • DOI 10.1016/S0387-7604(03)00056-1
    • Kern JK. Purkinje cell vulnerability and autism: a possible etiological connection. Brain Dev 2003;25:377-82. (Pubitemid 36957865)
    • (2003) Brain and Development , vol.25 , Issue.6 , pp. 377-382
    • Kern, J.K.1
  • 72
    • 17744387125 scopus 로고    scopus 로고
    • Ionotropic and metabotropic glutamate receptor structure and pharmacology
    • DOI 10.1007/s00213-005-2200-z
    • Kew JN, Kemp JA. Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacology (Berl) 2005;179:4-29. (Pubitemid 40576690)
    • (2005) Psychopharmacology , vol.179 , Issue.1 , pp. 4-29
    • Kew, J.N.C.1    Kemp, J.A.2
  • 73
    • 79960689550 scopus 로고    scopus 로고
    • Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: Opportunities for developing novel therapeutics
    • [Epub ahead of print]. doi:10.1002/jcp.22609
    • Kim K, Lee SG, Kegelman TP, Su ZZ, Das SK, Dash R, et al. Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics. J Cell Physiol 2010; [Epub ahead of print]. doi:10.1002/jcp.22609.
    • (2010) J Cell Physiol
    • Kim, K.1    Lee, S.G.2    Kegelman, T.P.3    Su, Z.Z.4    Das, S.K.5    Dash, R.6
  • 74
    • 0027905017 scopus 로고
    • Modulation of neuronal migration by NMDA receptors
    • Komuro H, Rakic P. Modulation of neuronal migration by NMDA receptors. Science 1993;260:95-7. (Pubitemid 23122752)
    • (1993) Science , vol.259 , Issue.5104 , pp. 95-97
    • Komuro, H.1    Rakic, P.2
  • 75
    • 0033711412 scopus 로고    scopus 로고
    • Neurotransmitters, neuropeptides and calcium binding proteins in developing human cerebellum: A review
    • Kwong WH, Chan WY, Lee KK, Fan M, Yew DT. Neurotransmitters, neuropeptides and calcium binding proteins in developing human cerebellum: a review. Histochem J 2000;32:521-34.
    • (2000) Histochem J , vol.32 , pp. 521-534
    • Kwong, W.H.1    Chan, W.Y.2    Lee, K.K.3    Fan, M.4    Yew, D.T.5
  • 76
    • 33646057412 scopus 로고    scopus 로고
    • Neurochemical correlates of autistic disorder: A review of the literature
    • Lam KS, Aman MG, Arnold LE. Neurochemical correlates of autistic disorder: a review of the literature. Res Dev Disabil 2006;27:254-89.
    • (2006) Res Dev Disabil , vol.27 , pp. 254-289
    • Lam, K.S.1    Aman, M.G.2    Arnold, L.E.3
  • 78
    • 0141643240 scopus 로고    scopus 로고
    • 2+-sensitive aspartate/ glutamate carrier increases mitochondrial ATP production in agonist-stimulated Chinese hamster ovary cells
    • DOI 10.1074/jbc.M304988200
    • Lasorsa FM, Pinton P, Palmieri L, Fiermonte G, Rizzuto R, Palmieri F. Recombinant expression of the Ca(2+)-sensitive aspartate/glutamate carrier increases mitochondrial ATP production in agonist-stimulated Chinese hamster ovary cells. J Biol Chem 2003;278:38686-92. (Pubitemid 37221765)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.40 , pp. 38686-38692
    • Lasorsa, F.M.1    Pinton, P.2    Palmieri, L.3    Fiermonte, G.4    Rizzuto, R.5    Palmieri, F.6
  • 79
    • 33845313589 scopus 로고    scopus 로고
    • A quantitative regional expression profile of EAAT2 known and novel splice variants reopens the question of aberrant EAAT2 splicing in disease
    • DOI 10.1016/j.neuint.2006.08.014, PII S0197018606002750
    • Lauriat TL, Richler E, McInnes LA. A quantitative regional expression profile of EAAT2 known and novel splice variants reopens the question of aberrant EAAT2 splicing in disease. Neurochem Int 2007;50:271-80. (Pubitemid 44879685)
    • (2007) Neurochemistry International , vol.50 , Issue.1 , pp. 271-280
    • Lauriat, T.L.1    Richler, E.2    McInnes, L.A.3
  • 80
    • 78549263438 scopus 로고    scopus 로고
    • Prevalence of pervasive developmental disorders among children at the English Montreal School Board
    • Lazoff T, Zhong L, Piperni T, Fombonne E. Prevalence of pervasive developmental disorders among children at the English Montreal School Board. Can J Psychiatry 2010;55:715-20.
    • (2010) Can J Psychiatry , vol.55 , pp. 715-720
    • Lazoff, T.1    Zhong, L.2    Piperni, T.3    Fombonne, E.4
  • 83
    • 33845774851 scopus 로고    scopus 로고
    • Expression of the exon 3 skipping form of GLAST, GLAST1a, in brain and retina
    • DOI 10.1097/WNR.0b013e328010b898, PII 0000175620061218000007
    • Macnab LT, Williams SM, Pow DV. Expression of the exon 3 skipping form of GLAST, GLAST1a, in brain and retina. Neuroreport 2006;17:1867-70. (Pubitemid 46006288)
    • (2006) NeuroReport , vol.17 , Issue.18 , pp. 1867-1870
    • Macnab, L.T.1    Williams, S.M.2    Pow, D.V.3
  • 84
    • 0033578855 scopus 로고    scopus 로고
    • Long-term potentiation - A decade of progress?
    • Malenka RC, Nicoll RA. Long-term potentiation - a decade of progress? Science 1999;285:1870-4.
    • (1999) Science , vol.285 , pp. 1870-1874
    • Malenka, R.C.1    Nicoll, R.A.2
  • 85
    • 0033586670 scopus 로고    scopus 로고
    • Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8
    • DOI 10.1016/S0169-328X(99)00050-9, PII S0169328X99000509
    • Malherbe P, Kratzeisen C, Lundstrom K, Richards JG, Faull RL, Mutel V. Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Brain Res Mol Brain Res 1999;67:201-10. (Pubitemid 29193176)
    • (1999) Molecular Brain Research , vol.67 , Issue.2 , pp. 201-210
    • Malherbe, P.1    Kratzeisen, C.2    Lundstrom, K.3    Richards, J.G.4    Faull, R.L.M.5    Mutel, V.6
  • 87
    • 34249087739 scopus 로고    scopus 로고
    • Neurotransmitters and brain maturation: Early paracrine actions of GABA and glutamate modulate neuronal migration
    • DOI 10.1177/1073858406298918
    • Manent JB, Represa A. Neurotransmitters and brainmaturation: early paracrine actions of GABA and glutamate modulate neuronal migration. Neuroscientist 2007;13:268-79. (Pubitemid 46801760)
    • (2007) Neuroscientist , vol.13 , Issue.3 , pp. 268-279
    • Manent, J.-B.1    Represa, A.2
  • 88
    • 1842524064 scopus 로고    scopus 로고
    • Glutamate transporters: Animal models to neurologic disease
    • DOI 10.1016/j.nbd.2003.12.007, PII S0969996103002729
    • Maragakis NJ, Rothstein JD. Glutamate transporters: animal models to neurologic disease. Neurobiol Dis 2004;15:461-73. (Pubitemid 38429961)
    • (2004) Neurobiology of Disease , vol.15 , Issue.3 , pp. 461-473
    • Maragakis, N.J.1    Rothstein, J.D.2
  • 90
    • 56649124807 scopus 로고    scopus 로고
    • Glutamate and neurotrophic factors in neuronal plasticity and disease
    • Mattson MP. Glutamate and neurotrophic factors in neuronal plasticity and disease. Ann N Y Acad Sci 2008;1144:97-112.
    • (2008) Ann N Y Acad Sci , vol.1144 , pp. 97-112
    • Mattson, M.P.1
  • 91
    • 79953194483 scopus 로고    scopus 로고
    • Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism
    • Mejias R, Adamczyk A, Anggono V, Niranjan T, Thomas GM, Sharma K, et al. Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism. Proc Natl Acad Sci U S A 2011;108:4920-5.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 4920-4925
    • Mejias, R.1    Adamczyk, A.2    Anggono, V.3    Niranjan, T.4    Thomas, G.M.5    Sharma, K.6
  • 92
    • 0034964561 scopus 로고    scopus 로고
    • Anti-epileptic activity of group II metabotropic glutamate receptor agonists (-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (-)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795)
    • DOI 10.1016/S0028-3908(01)00044-2, PII S0028390801000442
    • Moldrich RX, Jeffrey M, Talebi A, Beart PM, Chapman AG, Meldrum BS. Anti-epileptic activity of group II metabotropic glutamate receptor agonists (--)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (--)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795). Neuropharmacology 2001;41:8-18. (Pubitemid 32607640)
    • (2001) Neuropharmacology , vol.41 , Issue.1 , pp. 8-18
    • Moldrich, R.X.1    Jeffrey, M.2    Talebi, A.3    Beart, P.M.4    Chapman, A.G.5    Meldrum, B.S.6
  • 93
    • 0024596865 scopus 로고
    • The excitatory amino acid receptors: Their classes, pharmacology, and distinct properties in the function of the central nervous system
    • Monaghan DT, Bridges RJ, Cotman CW. The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system. Annu Rev Pharmacol Toxicol 1989;29:365-402. (Pubitemid 19107360)
    • (1989) Annual Review of Pharmacology and Toxicology , vol.29 , pp. 365-402
    • Monaghan, D.T.1    Bridges, R.J.2    Cotman, C.W.3
  • 95
    • 53549134467 scopus 로고    scopus 로고
    • Vesicular glutamate transporter acts as a metabolic regulator
    • Moriyama Y, Omote H. Vesicular glutamate transporter acts as a metabolic regulator. Biol Pharm Bull 2008;31:1844-6.
    • (2008) Biol Pharm Bull , vol.31 , pp. 1844-1846
    • Moriyama, Y.1    Omote, H.2
  • 96
    • 40849146966 scopus 로고    scopus 로고
    • Glutamate-mediated neuroplasticity in an animal model of self-injurious behaviour
    • Muehlmann AM, Devine DP. Glutamate-mediated neuroplasticity in an animal model of self-injurious behaviour. Behav Brain Res 2008;189:32-40.
    • (2008) Behav Brain Res , vol.189 , pp. 32-40
    • Muehlmann, A.M.1    Devine, D.P.2
  • 101
    • 0031912995 scopus 로고    scopus 로고
    • Glutamate receptors in the mammalian central nervous system
    • DOI 10.1016/S0301-0082(97)00085-3, PII S0301008297000853
    • Ozawa S, Kamiya H, Tsuzuki K. Glutamate receptors in the mammalian central nervous system. Prog Neurobiol 1998;54:581-618. (Pubitemid 28123327)
    • (1998) Progress in Neurobiology , vol.54 , Issue.5 , pp. 581-618
    • Ozawa, S.1    Kamiya, H.2    Tsuzuki, K.3
  • 102
    • 72949098166 scopus 로고    scopus 로고
    • Altered calcium homeostasis in autism-spectrum disorders: Evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1
    • Palmieri L, Papaleo V, Porcelli V, Scarcia P, Gaita L, Sacco R, et al. Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1. Mol Psychiatry 2010;15:38-52.
    • (2010) Mol Psychiatry , vol.15 , pp. 38-52
    • Palmieri, L.1    Papaleo, V.2    Porcelli, V.3    Scarcia, P.4    Gaita, L.5    Sacco, R.6
  • 105
    • 0029134874 scopus 로고
    • Latent-class analysis of recurrence risks for complex phenotypes with selection and measurement error: A twin and family history study of autism
    • Pickles A, Bolton P, Macdonald H, Bailey A, Le Couteur A, Sim CH, et al. Latent-class analysis of recurrence risks for complex phenotypes with selection and measurement error: a twin and family history study of autism. Am J Hum Genet 1995;57:717-26.
    • (1995) Am J Hum Genet , vol.57 , pp. 717-726
    • Pickles, A.1    Bolton, P.2    Macdonald, H.3    Bailey, A.4    Le Couteur, A.5    Sim, C.H.6
  • 107
    • 0028912822 scopus 로고
    • The metabotropic glutamate receptors: Structure and functions
    • Pin JP, Duvoisin R. The metabotropic glutamate receptors: structure and functions. Neuropharmacology 1995;34:1-26.
    • (1995) Neuropharmacology , vol.34 , pp. 1-26
    • Pin, J.P.1    Duvoisin, R.2
  • 109
    • 33748932824 scopus 로고    scopus 로고
    • Kainate receptors
    • DOI 10.1007/s00441-006-0265-6
    • Pinheiro P, Mulle C. Kainate receptors. Cell Tissue Res 2006;326:457-82. (Pubitemid 44444793)
    • (2006) Cell and Tissue Research , vol.326 , Issue.2 , pp. 457-482
    • Pinheiro, P.1    Mulle, C.2
  • 110
    • 0033979558 scopus 로고    scopus 로고
    • Developmental expression of excitatory amino acid transporter 5: A photoreceptor and bipolar cell glutamate transporter in rat retina
    • DOI 10.1016/S0304-3940(99)00988-X, PII S030439409900988X
    • Pow DV, Barnett NL. Developmental expression of excitatory amino acid transporter 5: a photoreceptor and bipolar cell glutamate transporter in rat retina. Neurosci Lett 2000;280:21-4. (Pubitemid 30069564)
    • (2000) Neuroscience Letters , vol.280 , Issue.1 , pp. 21-24
    • Pow, D.V.1    Barnett, N.L.2
  • 111
    • 0035856428 scopus 로고    scopus 로고
    • Postmortem brain abnormalities of the glutamate neurotransmitter system in autism
    • Purcell AE, Jeon OH, Zimmerman AW, Blue ME, Pevsner J. Postmortem brain abnormalities of the glutamate neurotransmitter system in autism. Neurology 2001;57:1618-28. (Pubitemid 33055480)
    • (2001) Neurology , vol.57 , Issue.9 , pp. 1618-1628
    • Purcell, A.E.1    Jeon, O.H.2    Zimmerman, A.W.3    Blue, M.E.4    Pevsner, J.5
  • 114
    • 2542435173 scopus 로고    scopus 로고
    • A case of autism with an interstitial deletion on 4q leading to hemizygosity for genes encoding for glutamine and glycine neurotransmitter receptor sub-units (AMPA 2, GLRA3, GLRB) and neuropeptide receptors NPY1R, NPY5R
    • Ramanathan S, Woodroffe A, Flodman PL, Mays LZ, Hanouni M, Modahl CB, et al. A case of autism with an interstitial deletion on 4q leading to hemizygosity for genes encoding for glutamine and glycine neurotransmitter receptor sub-units (AMPA 2, GLRA3, GLRB) and neuropeptide receptors NPY1R, NPY5R. BMC Med Genet 2004;5:10.
    • (2004) BMC Med Genet , vol.5 , pp. 10
    • Ramanathan, S.1    Woodroffe, A.2    Flodman, P.L.3    Mays, L.Z.4    Hanouni, M.5    Modahl, C.B.6
  • 118
    • 0031893613 scopus 로고    scopus 로고
    • Neurobiology of autism
    • DOI 10.1002/ana.410430106
    • Rapin I, Katzman R. Neurobiology of autism. Ann Neurol 1998;43:7-14. (Pubitemid 28124643)
    • (1998) Annals of Neurology , vol.43 , Issue.1 , pp. 7-14
    • Rapin, I.1    Katzman, R.2
  • 119
    • 52949138731 scopus 로고    scopus 로고
    • Autism: Definition, neurobiology, screening, diagnosis
    • viii
    • Rapin I, Tuchman RF. Autism: definition, neurobiology, screening, diagnosis. Pediatr Clin North Am 2008;55:1129-46. viii.
    • (2008) Pediatr Clin North Am , vol.55 , pp. 1129-1146
    • Rapin, I.1    Tuchman, R.F.2
  • 121
    • 0033232510 scopus 로고    scopus 로고
    • Role of norepinephrine in the pathophysiology and treatment of mood disorders
    • DOI 10.1016/S0006-3223(99)00127-4, PII S0006322399001274
    • Ressler KJ, Nemeroff CB. Role of norepinephrine in the pathophysiology and treatment of mood disorders. Biol Psychiatry 1999;46:1219-33. (Pubitemid 30114439)
    • (1999) Biological Psychiatry , vol.46 , Issue.9 , pp. 1219-1233
    • Ressler, K.J.1    Nemeroff, C.B.2
  • 122
    • 78149468902 scopus 로고    scopus 로고
    • Altered distribution of mGlu2 receptors in beta-amyloid-affected brain regions of Alzheimer cases and aged PS2APP mice
    • Richards G, Messer J, Faull RL, Stadler H, Wichmann J, Huguenin P, et al. Altered distribution of mGlu2 receptors in beta-amyloid-affected brain regions of Alzheimer cases and aged PS2APP mice. Brain Res 2010;1363:180-90.
    • (2010) Brain Res , vol.1363 , pp. 180-190
    • Richards, G.1    Messer, J.2    Faull, R.L.3    Stadler, H.4    Wichmann, J.5    Huguenin, P.6
  • 126
    • 77950368541 scopus 로고    scopus 로고
    • Slc25a12 disruption alters myelination and neurofilaments: A model for a hypomyelination syndrome and childhood neurodevelopmental disorders
    • Sakurai T, Ramoz N, Barreto M, Gazdoiu M, Takahashi N, Gertner M, et al. Slc25a12 disruption alters myelination and neurofilaments: a model for a hypomyelination syndrome and childhood neurodevelopmental disorders. Biol Psychiatry 2010;67:887-94.
    • (2010) Biol Psychiatry , vol.67 , pp. 887-894
    • Sakurai, T.1    Ramoz, N.2    Barreto, M.3    Gazdoiu, M.4    Takahashi, N.5    Gertner, M.6
  • 128
    • 27744541681 scopus 로고    scopus 로고
    • Confirmation of association between autism and the mitochondrial aspartate/glutamate carrier SLC25A12 gene on chromosome 2q31
    • DOI 10.1176/appi.ajp.162.11.2182
    • Segurado R, Conroy J, Meally E, Fitzgerald M, Gill M, Gallagher L. Confirmation of association between autism and the mitochondrial aspartate/glutamate carrier SLC25A12 gene on chromosome 2q31. Am J Psychiatry 2005;162:2182-4. (Pubitemid 41598278)
    • (2005) American Journal of Psychiatry , vol.162 , Issue.11 , pp. 2182-2184
    • Segurado, R.1    Conroy, J.2    Meally, E.3    Fitzgerald, M.4    Gill, M.5    Gallagher, L.6
  • 129
    • 0037390610 scopus 로고    scopus 로고
    • Themetabotropic glutamate receptor 8 gene at 7q31: Partial duplication and possible association with autism
    • Serajee FJ, Zhong H, Nabi R, Huq AH. Themetabotropic glutamate receptor 8 gene at 7q31: partial duplication and possible association with autism. J Med Genet 2003;40:e42.
    • (2003) J Med Genet , vol.40
    • Serajee, F.J.1    Zhong, H.2    Nabi, R.3    Huq, A.H.4
  • 130
    • 61349163048 scopus 로고    scopus 로고
    • Combination of oral ketamine and midazolam as a premedication for a severely autistic and combative patient
    • Shah S, Apuya J, Gopalakrishnan S, Martin T. Combination of oral ketamine and midazolam as a premedication for a severely autistic and combative patient. J Anesth 2009;23:126-8.
    • (2009) J Anesth , vol.23 , pp. 126-128
    • Shah, S.1    Apuya, J.2    Gopalakrishnan, S.3    Martin, T.4
  • 134
    • 77954510715 scopus 로고    scopus 로고
    • New therapeutic targets to develop molecules active in drug-resistant epilepsies
    • SidAhmed-Mezi M, Pumain R, Louvel J, Sokoloff P, Laschet J. New therapeutic targets to develop molecules active in drug-resistant epilepsies. Epilepsia 2010;51(Suppl 3):43-7.
    • (2010) Epilepsia , vol.51 , Issue.SUPPL. 3 , pp. 43-47
    • SidAhmed-Mezi, M.1    Pumain, R.2    Louvel, J.3    Sokoloff, P.4    Laschet, J.5
  • 135
    • 76749128438 scopus 로고    scopus 로고
    • Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP
    • Silverman JL, Tolu SS, Barkan CL, Crawley JN. Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP. Neuropsychopharmacology 2010;35:976-89.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 976-989
    • Silverman, J.L.1    Tolu, S.S.2    Barkan, C.L.3    Crawley, J.N.4
  • 137
    • 61849179702 scopus 로고    scopus 로고
    • Recovery of motor and cognitive function after cerebellar lesions in a songbird: Role of estrogens
    • Spence RD, Zhen Y, White S, Schlinger BA, Day LB. Recovery of motor and cognitive function after cerebellar lesions in a songbird: role of estrogens. Eur J Neurosci 2009;29:1225-34.
    • (2009) Eur J Neurosci , vol.29 , pp. 1225-1234
    • Spence, R.D.1    Zhen, Y.2    White, S.3    Schlinger, B.A.4    Day, L.B.5
  • 138
    • 0026489330 scopus 로고
    • Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain
    • Storck T, Schulte S, Hofmann K, Stoffel W. Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain. Proc Natl Acad Sci U S A 1992;89:10955-9.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 10955-10959
    • Storck, T.1    Schulte, S.2    Hofmann, K.3    Stoffel, W.4
  • 139
  • 140
    • 0034672306 scopus 로고    scopus 로고
    • The AMPAR subunit GluR2: Still front and center-stage
    • Tanaka H, Grooms SY, Bennett MV, Zukin RS. The AMPAR subunit GluR2: still front and center-stage. Brain Res 2000;886:190-207.
    • (2000) Brain Res , vol.886 , pp. 190-207
    • Tanaka, H.1    Grooms, S.Y.2    Bennett, M.V.3    Zukin, R.S.4
  • 141
    • 70350055359 scopus 로고    scopus 로고
    • Role of glutamate transporters in the pathophysiology of major mental illnesses
    • Tanaka K. Role of glutamate transporters in the pathophysiology of major mental illnesses. Nihon Shinkei Seishin Yakurigaku Zasshi 2009;29:161-4.
    • (2009) Nihon Shinkei Seishin Yakurigaku Zasshi , vol.29 , pp. 161-164
    • Tanaka, K.1
  • 144
    • 70349956425 scopus 로고    scopus 로고
    • A genome-wide linkage and association scan reveals novel loci for autism
    • Weiss LA, Arking DE, Daly MJ, Chakravarti A. A genome-wide linkage and association scan reveals novel loci for autism. Nature 2009;461:802-8.
    • (2009) Nature , vol.461 , pp. 802-808
    • Weiss, L.A.1    Arking, D.E.2    Daly, M.J.3    Chakravarti, A.4
  • 145
    • 33748060215 scopus 로고    scopus 로고
    • Learning induces long-term potentiation in the hippocampus
    • DOI 10.1126/science.1128134
    • Whitlock JR, Heynen AJ, Shuler MG, Bear MF. Learning induces long-term potentiation in the hippocampus. Science 2006;313:1093-7. (Pubitemid 44300229)
    • (2006) Science , vol.313 , Issue.5790 , pp. 1093-1097
    • Whitlock, J.R.1    Heynen, A.J.2    Shuler, M.G.3    Bear, M.F.4
  • 146
    • 58149393206 scopus 로고    scopus 로고
    • MGluR5 regulates glutamate-dependent development of the mouse somatosensory cortex
    • Wijetunge LS, Till SM, Gillingwater TH, Ingham CA, Kind PC. mGluR5 regulates glutamate-dependent development of the mouse somatosensory cortex. J Neurosci 2008;28:13028-37.
    • (2008) J Neurosci , vol.28 , pp. 13028-13037
    • Wijetunge, L.S.1    Till, S.M.2    Gillingwater, T.H.3    Ingham, C.A.4    Kind, P.C.5
  • 147
    • 34247631067 scopus 로고    scopus 로고
    • Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: Pathophysiological implications
    • DOI 10.1007/s00401-006-0176-3
    • Yip J, Soghomonian JJ, Blatt GJ. Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: pathophysiological implications. Acta Neuropathol 2007;113:559-68. (Pubitemid 46672602)
    • (2007) Acta Neuropathologica , vol.113 , Issue.5 , pp. 559-568
    • Yip, J.1    Soghomonian, J.-J.2    Blatt, G.J.3
  • 148
    • 63449095687 scopus 로고    scopus 로고
    • Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: An in situ hybridization study
    • Yip J, Soghomonian JJ, Blatt GJ. Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: an in situ hybridization study. Autism Res 2009;2:50-9.
    • (2009) Autism Res , vol.2 , pp. 50-59
    • Yip, J.1    Soghomonian, J.J.2    Blatt, G.J.3


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