Novel oral insulin delivery systems based on complexation polymer hydrogels: Single and multiple administration studies in type 1 and 2 diabetic rats

Journal of Controlled Release

Volumn 110, Issue 3, 2006, Pages 587-594

  Morishita, Mariko ^a   Goto, Takahiro ^a   Nakamura, Koji ^a,d   Lowman, Anthony M ^b   Takayama, Kozo ^a   Peppas, Nicholas A ^c  

^a HOSHI UNIVERSITY   (Japan)

^b Drexel University   (United States)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^d TERUMO CORPORATION   (Japan)

Author keywords

Complexation polymers; Delivery; Insulin; Multiple administration; Oral

Indexed keywords

BLOOD; COMPLEXATION; DRUG THERAPY; GLUCOSE; HYDROGELS; INSULIN; POLYMERS;

COMPLEXATION POLYMERS; DELIVERY; MULTIPLE ADMINISTRATION; ORAL;

CONTROLLED DRUG DELIVERY;

INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; COMPLEX FORMATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG SYNTHESIS; HYDROGEL; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MALE; MICROPARTICLE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG DELIVERY SYSTEMS; HYDROGELS; INSULIN; MALE; POLYMERS; RATS; RATS, WISTAR;

EID: 31544432290     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.10.029     Document Type: Article

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