An overview of natural polymers for oral insulin delivery

Drug Discovery Today

Volumn 17, Issue 13-14, 2012, Pages 784-792

  Sonia, T A ^a   Sharma, Chandra P ^a  

^a SREE CHITRA TIRUNAL INSTITUTE FOR MEDICAL SCIENCES AND TECHNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALGINIC ACID; CASEIN; CHITOSAN; CYCLODEXTRIN; DEXTRAN; DRUG CARRIER; GELATIN; INSULIN; NANOPARTICLE; PECTIN; POLYELECTROLYTE; POLYMER; STARCH;

ACYLATION; BIOCOMPATIBILITY; BIODEGRADABILITY; CHEMICAL MODIFICATION; CROSS LINKING; DIABETES MELLITUS; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SAFETY; DRUG STABILITY; ENCAPSULATION; HYDROPHILICITY; HYPOGLYCEMIA; MOLECULAR WEIGHT; REVIEW; STOMACH PH; TREATMENT REFUSAL;

ADMINISTRATION, ORAL; ANIMALS; BIOCOMPATIBLE MATERIALS; BIOLOGICAL PRODUCTS; BIOPOLYMERS; HUMANS; INSULIN; MOLECULAR STRUCTURE; TISSUE DISTRIBUTION;

EID: 84863510349     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2012.03.019     Document Type: Review

References (62)

1. N.A. Peppas, and N.J. Kavimandan Nanoscale analysis of protein and peptide absorption: insulin absorption using complexation and pH-sensitive hydrogels as delivery vehicles Eur. J. Pharm. Sci. 29 2006 183 197 (Pubitemid 44602406)
2. N.J. Kavimandan, and N.A. Peppas Confocal microscopic analysis of transport mechanisms of insulin across the cell monolayer Int. J. Pharm. 354 2008 143 148
3. G.P. Carino, and E. Mathiowitz Oral insulin delivery Adv. Drug Deliv. Rev. 35 1999 249 257 (Pubitemid 29073617)
4. C. Damgé Nanoparticle strategies for the oral delivery of insulin Expert Opin. Drug Deliv. 5 2008 45 68 (Pubitemid 351234109)
5. M.C. Chen A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery Biomaterials 32 2011 9826 9838
6. M. Shakweh Particle uptake by Peyer's patches: a pathway for drug and vaccine delivery Expert Opin. Drug Deliv. 1 2004 141 163 (Pubitemid 40297962)
7. F. Delie Evaluation of nano- and microparticle uptake by the gastrointestinal tract Adv. Drug Deliv. Rev. 34 1998 221 233 (Pubitemid 28535113)
8. J. Park Strategies for oral delivery of macromolecule drugs Biotechnol. Bioproc. Eng. 15 2010 66 75
9. R.M. Ramesan, and C.P. Sharma Challenges and advances in nanoparticle-based oral insulin delivery Expert Rev. Med. Dev. 6 2009 665 676
10. R.I. Mahato Emerging trends in oral delivery of peptide and protein drugs Crit. Rev. Ther. Drug Carrier Syst. 20 2-3 2003 153 214 (Pubitemid 37237279)
11. E. Allémann Polymeric nano- and microparticles for the oral delivery of peptides and peptidomimetics Adv. Drug Deliv. Rev. 34 1998 171 189 (Pubitemid 28535111)
12. F.J.O. Varum Mucoadhesion and the gastrointestinal tract Crit. Rev. Ther. Drug Carrier Syst. 25 2008 207 258 (Pubitemid 351655041)
13. F. Delie, and M. Blanco-Príeto Polymeric particulates to improve oral bioavailability of peptide drugs Molecules 10 2005 65 80 (Pubitemid 40404886)
14. S. Dumitriu, and E. Chornet Inclusion and release of proteins from polysaccharide-based polyion complexes Adv. Drug Deliv. Rev. 31 1998 223 246 (Pubitemid 28191867)
15. A. Halder Entrapment efficiency and release characteristics of polyethyleneimine-treated or -untreated calcium alginate beads loaded with propranolol-resin complex Int. J. Pharm. 302 2005 84 94 (Pubitemid 41244818)
16. V.R. Sinha, and R. Kumria Polysaccharides in colon-specific drug delivery Int. J. Pharm. 224 2001 19 38 (Pubitemid 32706482)
17. B. Sarmento Alginate/chitosan nanoparticles are effective for oral insulin delivery Pharm. Res. 24 2007 2198 2206 (Pubitemid 350060707)
18. M.W.P. Ramadas Lipoinsulin encapsulated alginate-chitosan capsules: intestinal delivery in diabetic rats J. Microencapsul. 17 2000 405 411
19. C.E. Beneke Polymeric plant-derived excipients in drug delivery Molecules 14 2009 2602 2620
20. M. Mahkam Starch-based polymeric carriers for oral-insulin delivery J. Biomed. Mater. Res. A 92A 2010 1392 1397
21. F. Suzuki Studies on the mode of action of insulin: properties and biological activity of an insulin-dextran complex Endocrinology 90 1972 1220 1230
22. K.B. Chalasani A novel vitamin B12-nanosphere conjugate carrier system for peroral delivery of insulin J. Control. Release 117 2007 421 429 (Pubitemid 46237606)
23. K.B. Chalasani Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles J. Control. Release 122 2007 141 150 (Pubitemid 47361403)
24. F. Loth R.L. Whistler, N. James, J.N. BeMiller, Industrial Gums: Polysaccharides and Their Derivatives 3rd edn 1993 Academic Press
25. C.T. Musabayane Orally administered, insulin-loaded amidated pectin hydrogel beads sustain plasma concentrations of insulin in streptozotocin- diabetic rats J. Endocrinol. 164 2000 1 6 (Pubitemid 30044323)
26. S. Goswami Designing gelatin nanocarriers as a swellable system for controlled release of insulin: an in vitro kinetic study J. Macromol. Sci. A 47 2009 119 130
27. T. Morçöl Calcium phosphate-PEG-insulin-casein (CAPIC) particles as oral delivery systems for insulin Int. J. Pharm. 277 2004 91 97 (Pubitemid 38670424)
28. T. Irie, and K. Uekama Cyclodextrins in peptide and protein delivery Adv. Drug Deliv. Rev. 36 1999 101 123 (Pubitemid 29074479)
29. N. Zhang Effective protection and controlled release of insulin by cationic beta-cyclodextrin polymers from alginate/chitosan nanoparticles Int. J. Pharm. 393 1-2 2010 212 218
30. L.R. Moses Beta cyclodextrin-insulin-encapsulated chitosan/alginate matrix: Oral delivery system J. Appl. Polym. Sci. 75 2000 1089 1096 (Pubitemid 30528001)
31. A. Chaudhury, and S. Das Recent advancement of chitosan-based nanoparticles for oral controlled delivery of insulin and other therapeutic agents AAPS PharmSciTech 12 2011 10 20
32. C.K.S. Pillai Chitin and chitosan polymers: chemistry, solubility and fiber formation Prog. Polym. Sci. 34 2009 641 678
33. P. Artursson Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2) Pharm. Res. 11 1994 1358 1361 (Pubitemid 24287420)
34. J.M. Staddon Evidence that tyrosine phosphorylation may increase tight junction permeability J. Cell Sci. 108 1995 609 619
35. Z. Ma Pharmacological activity of peroral chitosan-insulin nanoparticles in diabetic rats Int. J. Pharm. 293 2005 271 280 (Pubitemid 40381099)
36. M. Jelvehgari Development of pH-sensitive insulin nanoparticles using eudragit l100-55 and chitosan with different molecular weights AAPS PharmSciTech 11 2010 1237 1242
37. E. Lee A novel approach to oral delivery of insulin by conjugating with low molecular weight chitosan Bioconjug. Chem. 21 2010 1720 1723
38. L. Shi, and K.D. Caldwell Mucin adsorption to hydrophobic surfaces J. Colloid Interface Sci. 224 2000 372 381 (Pubitemid 30215144)
39. M.R. Rekha, and C.P. Sharma Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption J. Control. Release 135 2009 144 151
40. R. Shelma, and C. Sharma Acyl modified chitosan derivatives for oral delivery of insulin and curcumin J. Mater. Sci. Mater. Med. 21 2010 2133 2140
41. T.A. Sonia Bioadhesive hydrophobic chitosan microparticles for oral delivery of insulin: in vitro characterization and in vivo uptake studies J. Appl. Polym. Sci. 119 2011 2902 2910
42. M. Werle, and A. Bernkop-Schnürch Thiolated chitosans: useful excipients for oral drug delivery J. Pharm. Pharmacol. 60 2008 273 281 (Pubitemid 351269813)
43. A. Bernkop-Schnürch Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: thiomer/GSH systems J. Control. Release 93 2003 95 103 (Pubitemid 37421352)
44. K. Maculotti Preparation and in vitro evaluation of thiolated chitosan microparticles J. Microencapsul. 22 2005 459 470
45. S. Hartig Multifunctional nanoparticulate polyelectrolyte complexes Pharm. Res. 24 2007 2353 2369 (Pubitemid 350060722)
46. K. Sonaje Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: oral delivery using pH-responsive nanoparticles vs. subcutaneous injection Biomaterials 31 2010 6849 6858
47. Y.-H. Lin Multi-ion-crosslinked nanoparticles with pH-responsive characteristics for oral delivery of protein drugs J. Control. Release 132 2008 141 149
48. F.-L. Mi Oral delivery of peptide drugs using nanoparticles self-assembled by poly(γ-glutamic acid) and a chitosan derivative functionalized by trimethylation Bioconjug. Chem. 19 2008 1248 1255 (Pubitemid 351874948)
49. A. Bayat Preparation and characterization of insulin nanoparticles using chitosan and its quaternized derivatives Nanomedicine 4 2008 115 120
50. T.A. Sonia, and C.P. Sharma In vitro evaluation of N-(2-hydroxy) propyl-3-trimethyl ammonium chitosan for oral insulin delivery Carbohydr. Polym. 84 2011 103 109
51. S. Mao Uptake and transport of PEG-graft-trimethyl-chitosan copolymer-insulin nanocomplexes by epithelial cells Pharm. Res. 22 2005 2058 2068 (Pubitemid 41821585)
52. G. Sandri Nanoparticles based on N-trimethylchitosan: evaluation of absorption properties using in vitro (Caco-2 cells) and ex vivo (excised rat jejunum) models Eur. J. Pharm. Biopharm. 65 2007 68 77 (Pubitemid 44827693)
53. L. Yin Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery Biomaterials 30 2009 5691 5700
54. F. Qian Chitosan graft copolymer nanoparticles for oral protein drug delivery: preparation and characterization Biomacromolecules 7 2006 2722 2727 (Pubitemid 44615253)
55. Y. Jin Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport Biomaterials 33 2012 1573 1582
56. H.L. Lueben Mucoadhesive polymers in peroral peptide drug delivery. IV. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal mucosae in vitro J. Control. Release 45 1997 15 23
57. F.-Y. Su Protease inhibition and absorption enhancement by functional nanoparticles for effective oral insulin delivery Biomaterials 33 2012 2801 2811
58. C.B. Woitiski Pharmacological effect of orally delivered insulin facilitated by multilayered stable nanoparticles Eur. J. Pharm. Sci. 41 2010 556 563
59. C.P. Reis Nanoparticulate delivery system for insulin: design, characterization and in vitro/in vivo bioactivity Eur. J. Pharm. Sci. 30 2007 392 397 (Pubitemid 46442785)
60. A.H. Krauland Oral insulin delivery: the potential of thiolated chitosan-insulin tablets on non-diabetic rats J. Control. Release 95 2004 547 555 (Pubitemid 38340504)
61. B. Sarmento Oral bioavailability of insulin contained in polysaccharide nanoparticles Biomacromolecules 8 2007 3054 3060 (Pubitemid 350011625)
62. Y. Pan Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo Int. J. Pharm. 249 2002 139 147 (Pubitemid 35333440)