Oral delivery of insulin using pH-responsive complexation gels

Journal of Pharmaceutical Sciences

Volumn 88, Issue 9, 1999, Pages 933-937

  Lowman, A M ^a,c   Morishita, M ^b   Kajita, M ^b   Nagai, T ^b   Peppas, N A ^a  

^a PURDUE UNIVERSITY   (United States)

^b HOSHI UNIVERSITY   (Japan)

^c Drexel University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG CARRIER; INSULIN; MICROSPHERE;

ANIMAL TISSUE; ARTICLE; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG FORMULATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; STOMACH PH; STREPTOZOCIN DIABETES;

EID: 0032823008     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js980337n     Document Type: Article

References (26)

1. Anonymous. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997, 20, 1183-1197.
2. Campbell, R. K.; White, J. R. New Opportunuites in Diabetes Management; Miles Inc.: Terrytown, NY, 1993.
3. Costantino, H. R.; Liauw, S.; Mitragotri, S.; Langer, R.; Klibanov, A. M.; Sluzky, V. The Pharmaceutical Development of Insulin: Historical Perspectives and Future Directions. In Therapeutic Protein and Peptide Formulation and Delivery; Shahrokh, Z., Sluzky, V., Cleland, J. L, Shire, S. J., Randolph, T. W., Eds.; American Chemical Society: Washington, D. C., 1997; pp 29-66.
4. Saffran, M.; Sudesh Kumar, G.; Savariar, C.; Burnham, J. C.; Williams, F.; Neckers, D. C. A New Approach to the Oral Administration of Insulin and Other Peptide Drugs. Science 1986, 233, 1081-1084.
5. Lee, V. H. L.; Dodd-Kashi, S.; Grass, G. M.; Rubas, W. Oral Route of Peptide and Protein Drug Delivery. In Protein and Peptide Drug Delivery; Lee, V. H. L., Ed.; Marcel Dekker Inc.: New York, NY, 1991; pp 691-740.
6. Saffran, M. Oral Colon-Specific Drug Delivery With Emphasis on Insulin. In Oral Colon-Specific Drug Delivery; Friend, D. R., Ed.; CRC Press: Boca Raton, FL, 1992; pp 115-142.
7. Platé, N. A.; Valuev, L. I.; Starosel'tseva, L. K.; Valueva, T. A.; Vanchugova, L. V.; Ul'yanova, M. V.; Valuev, I. L.; Sytov, G. A.; Ametov, A. S.; Knyazhev V. A. Macromolecular Systems Containing Insulin as Related to the Problem of Diabetes. Vysokomol. Soedin. 1994, 36, 1876-1879.
8. Fix, J. A. Oral Controlled Release Technology for Peptides: Status and Future Prospects. Pharm. Res. 1996, 13, 1760-1764.
9. Wang, W. Oral Protein Drug Delivery. J. Drug Targ. 1996, 4, 195-232.
10. Saffran, M.; Pansky, B.; Budd, G. C.; Williams, F. E. Insulin and the Gastrointestinal Tract. J. Controlled Release 1997, 46, 89-98.
11. Touitou, E.; Rubinstein, A. Targeted Enteral Delivery of Insulin to Rats. Int. J. Pharm. 1986, 30, 93-99.
12. Morishita, I.; Morishita, M.; Takayama, K.; Machida, Y.; Nagai, T. Hypoglycemic Effect of Novel Oral Microspheres of Insulin With Protease Inhibitor in Normal and Diabetic Rats. Int. J. Pharm. 1992, 78, 9-16.
13. Mathiowitz, E.; Jacob, J. S.; Jong, Y. S.; Carino, G. P.; Chickering, D. E.; Chaturvedi, P.; Santos, C. A.; Vijayaraghavan, K.; Montgomery, S.; Bassett, M.; Morrell, C. Biologically Erodible Microspheres as Potential Oral Drug Delivery Systems. Nature 1997, 386, 410-414.
14. Langguth, P.; Bohner, V.; Heizmann, J.; Merkle, H. P.; Wolframm, S.; Almidon, G. L.; Yamashita, S. The Challenge of Proteolytic Enzymes in Intestinal Peptide Delivery. J. Controlled Release 1997, 46, 39-57.
15. Lowman, A. M.; Peppas, N. A. Analysis of the Complexation/ Decomplexation Phenomena in Polyelectrolyte Networks. Macromolecules 1997, 30, 4959-4965.
16. Lowman, A. M.; Morishita, M.; Peppas, N. A.; Nagai, T. Novel Bioadhesive Complexation Networks for Oral Protein Drug Delivery. In Materials for Controlled Release Applications; McCulloch, I., Shalaby, S. W., Eds.; American Chemical Society: Washington, DC, 1998; pp 156-164.
17. Peppas, N. A.; Lowman, A. M. Protein Delivery from Novel Bioadhesive Complexation Hydrogels. In Protein and Peptide Drug Research; Frøkjær, S., Christup, L., Krogsgaard-Larsen, P., Eds.; Munksgaard: Copenhagen, 1998; pp 206-216.
18. Drummond, R. K.; Klier, J.; Alameda, J. A.; Peppas, N. A. Preparation of Poly(methacrylic acid-g-ethylene oxide) Microspheres. Macromolecules 1989, 22, 3816-3818.
19. Lowman, A. M.; Peppas, N. A.; Morishita, M.; Takayama, K.; Nagai, T. Evaluation of the Uptake and Release Behavior of pH-Responsive Complexation Networks. J. Controlled Release, submitted.
20. Bektorova, E.; Bimendina, L. Interpolymer Complexes. Adv. Polym. Sci. 1981, 41, 99-147.
21. Harris, J. M. Poly(ethylene glycol) Chemistry; Plenum Press: New York, 1992.
22. Lehr, C. M. Bioadhesion Technologies for the Delivery of Peptide and Protein Drugs to the Gastrointestinal Tract. Crit. Rev. Ther. Drug Carrier Syst. 1994, 11, 119-160.
23. Peppas, N. A.; Sahlin, J. J. Hydrogels as Mucoadhesive and Bioadhesive Materials: A Review. Biomaterials 1996, 17, 1553-1561.
24. am Ende, M. T.; Mikos, A. G. Diffusion-Controlled Delivery of Proteins From Hydrogels and Other Hydrophilic Systems. In Protein Delivery: Physical Systems; Sanders, L. M., Hendren, R. N., Eds.; Plenum Press: New York, 1997; pp 139-165.
25. Mikos, A. G.; Peppas, N. A. Scaling Concepts and Molecular Theories of Adhesion of Synthetic Polymers to Glycoproteinic Networks. In Bioadhesive Drug Delivery Systems; Lenaerts, V., Gurny, R., Eds.; CRC Press: Boca Raton, FL, 1990; pp 25-42.
26. Sahlin, J. J.; Peppas, N. A. Enhanced Hydrogel Adhesion by Polymer Interdiffusion. J. Biomat. Sci., Polym. Ed. 1997, 8, 421-436.