Oral delivery of protein drugs: Driver for personalized medicine?

Current Issues in Molecular Biology

Volumn 13, Issue 1, 2011, Pages 13-24

  Müller, Günter ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD37 ANTIGEN; GLYCOSYLPHOSPHATIDYLINOSITOL; INSULIN; INSULIN RECEPTOR; LIPOSOME; NANOPARTICLE; PHOSPHODIESTERASE INHIBITOR; PROTEIN; PROTEIN GCE1; UNCLASSIFIED DRUG;

ADIPOCYTE; ARTICLE; CELL TRANSPORT; CONTROLLED RELEASE FORMULATION; COVALENT BOND; CYTOPLASM; DIABETES MELLITUS; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG DOSAGE FORM COMPARISON; DRUG RECEPTOR BINDING; DRUG RELEASE; DRUG TARGETING; DRUG TRANSPORT; ENCAPSULATION; HUMAN; INTESTINE CELL; LIPID RAFT; NONHUMAN; ORAL DRUG ADMINISTRATION; PERSONALIZED MEDICINE; PROTEIN MODIFICATION; SECRETORY VESICLE;

ADMINISTRATION, ORAL; DRUG DELIVERY SYSTEMS; DRUG DISCOVERY; HUMANS; INDIVIDUALIZED MEDICINE; PHARMACEUTICAL PREPARATIONS; PROTEINS;

EID: 79751475120     PISSN: 14673037     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (83)

1. Aoki,N., Jin-no,S., Nakagawa,Y., Asai,N., Arakawa,E., and Tamura,N. (2007). Identification and characterization of microvesicles secreted by 3T3-L1 adipocytes: redoxand hormone-dependent induction of milk fat globuleepidermal growth factor 8-associated microvesicles. Endocrinology 148, 3850-3862.
2. Billingsley,M.L. (2008). Druggable targets and targeted drugs: enhancing the development of new therapeutics. Pharmacology 82, 239-244.
3. Black,P.N. (1980). Shedding from normal and cancer-cell surfaces. N. Engl. J. Med. 303, 1415-1420.
4. Brewis,I.A., Ferguson,M.A.J., Mehlert,A., Turner,A.J., and Hooper,N.M. (1995). Structures of the glycosylphosphatidylinositol anchors of porcine and human eythrocyte renal membrane dipeptidase. Comprehensive structural studies on the porcine anchor and interspecies comparison of the glycan core structures. J. Biol. Chem. 270, 22946-22956.
5. Brown,D.A. (1992). Interactions between GPI-anchored proteins and membrane lipids. Trends Cell Biol. 2, 338-343.
6. Brown,D.A., and London,L. (1998). Functions of lipid rafts in biological membranes. Annu. Rev. Cell. Dev. Biol. 14, 111-136.
7. Bütikofer,P., and Brodbeck,U. (1993). Partial purification and characterization of a (glycosyl) inositol phospholipidspecific phospholipase C from peanut. J. Biol. Chem. 268, 17794-17799.
8. Civenni,G., Test,S.T., Brodbeck,U., and Bütikofer,P. (1998). In vitro incorporation of GPI-anchored proteins into human erythrocytes and their fate in the membrane. Blood 9, 11784-11792.
9. Cocucci,E., Racchetti,G., and Meldolesi,J. (2009). Shedding microvesicles: artefacts no more. Trends Cell Biol. 19, 43-51.
10. Danielsen,E.M., and Hansen,G.H. (2008). Lipid raft organization and function in the small intestinal brush border. J. Physiol. Biochem. 64, 377-382.
11. Danielsen,E.M., and Hansen,G.H. (2006). Lipid raft organization and function in brush borders of epithelial cells. Mol. Membr. Biol. 23, 71-79.
12. Ebbesen,M., and Jensen,T.G. (2006). Nanomedicine: techniques, potentials, and ethical implications. J. Biomed. Biotechnol. DOI10.1155/JBB/2006/51516.
13. Fevrier,B., and Raposo,G. (2004). Exosomes: endosomalderived vesicles shipping extracellular messages. Curr. Opin. Cell Biol. 16, 415-421.
14. Fivaz,M., Vilbois,F., Thurnheer,S., Pasquali,C., Abrami,L., Bickel,P.E., Parton,R.G., van der Goot,F.G. (2002). Differential sorting and fate of endocytosed GPI-anchored proteins. EMBO J. 21, 3989-4000.
15. Florez,J.C. (2008). The genetics of type 2 diabetes: a realistic appraisal in 2008. J. Clin. Endocrinol. Metab. 93, 4633-4642.
16. Gibson,G. (2009). Decanalization and the origin of complex disease. Nature 10, 134-140.
17. Gullotti,E., and Yeo,Y. (2009). Extracellularly activated nanocarriers: A new paradigm of tumor targeted drug delivery. Mol. Pharmaceut. 6, 1041-1051.
18. Hoener,M.C., Stieger,S., and Brodbeck,U. (1990). Isolation and characterization of a phosphatidylinositol-glycananchor- specific phospholipase D from bovine brain. Eur. J. Biochem. 190, 593-600.
19. Ikezawa,H. (2002). Glyosylphosphatidylinositol (GPI)- anchored proteins. Biol. Pharm. Bull. 25, 409-417.
20. Ilangumaran,S., Robinson,P.J., and Hoessli,D.C. (1996). Transfer of exogenous glycosylinositol (GPI)-linked molecules to plasma membranes. Trends Cell Biol. 6, 163-169.
21. Janssens,A.C.J.W., Pardo,M.C., Steyerberg,E.W., and van Dujin,C.M. (2004). Revisiting the clinical validity of multiplex genetic testing in complex diseases. Am. J. Hum. Genet. 74, 585-588.
22. Keller,S., Sanderson,M.P., Stoeck,A., and Altevogt,P. (2006). Exosomes: from biogenesis and secretion to biological function. Immunol. Lett. 107, 102-108.
23. Kirpotin,D.B., Drummond,D.C., Shao,Y., Shalaby,M.R., Hong,K.L., Nielsen,U.B., Marks,J.D., Benz,C.C., and Park,J.W. (2006). Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. Cancer Res. 66, 6732-6740.
24. Kooyman,D.L., Byrne,G.W., and Logan,J.S. (1998). Glycosyl phosphatidylinositol anchor. Exp. Nephrol. 6, 148-151.
25. Küng,M., Bütikofer,P., Brodbeck,U., and Stadelmann,B. (1997). Expression of intracellular and GPI-anchored forms of GPI-specific phospholipase D in COS-1 cells. Biochem. Biophys. Acta 1357, 329-338.
26. Li,S.D., and Huang,L. (2007). Non-viral is superior to viral gene delivery. J. Controlled Release 123, 181-183.
27. Lin,Y.H., Mi,F.L., Chen,C.T., Chang,W.C., Peng,S.F., Liang,H.F., and Sung,H.W. (2007). Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery. Biomacromolecules 8, 146-152.
28. Lindgren,C.M. (2007). Mechanisms of disease: genetic insights into the etiology of type 2 diabetes and obesity. Nature Clin. Pract. 4, 156-163.
29. Lisanti,M.P., Scherer,P.E., Tang,Z.L., and Sargiacomo,M. (1994). Caveolae, caveolin and caveolin-rich membrane domains: A signalling hypothesis. Trends Cell Biol. 4, 231-238.
30. Lusis,A.J., Attie,A.D., and Reue,K. (2008). Metabolic syndrome: from epidemiology to systems biology. Nature Genet. 9, 819-830.
31. Mathiowitz,E. (2008). Drug delivery system. Toxicol. Pathol. 36, 16-22.
32. Mathiowitz,E., Jacob,J.S., Jong,Y.S., Carino,G.P., Chickering,D.E., Chaturvedi,P., Santos,C.A., Vijayaraghavan, K., Montgomery,S., Bassett,M., and Morrell,C. (1997). Biologically erodable microspheres as potential oral drug delivery systems. Nature 386, 410-414.
33. Matsumara,Y. (2008). Polymeric micellar delivery systems in oncology. Jpn. J. Clin. Oncology 38, 793-802.
34. Mayor,S., Rothberg,K.G., and Maxfield,F.R. (1994). Sequestration of GPI-anchor proteins in caveolae triggered by cross-linking. Science 264, 1948-1951.
35. McHugh,R.S., Ahmed,S.N., Wang,Y.C., Sell,K.W., and Selvavaj, P. (1995). Construction, purification, and functional incorporation on tumor cells of glycolipidanchored human B7-1 (CD80). Proc. Natl. Acad. Sci. USA 92, 8059-8063.
36. Medof,M.E., Nagarajan,S., and Tykocinski,M.L. (1996). Cell-surface engineering with GPI-anchored proteins. FASEB J. 10, 574-586.
37. Milhiet,P.-E., Giocondi,M.-C., Baghdadi,O., Ronzon,F., Roux,B., and Le Grimellec,C. (2002). Spontaneous insertion and partitioning of alkaline phosphatase into model lipid rafts. EMBO reports 3, 485-490.
38. Mok,H., Bae,K.H., Ahn,C.-H., and Park,T.G. (2009). PEGylated and MMP-2 specifically dePEGylated quantum dots: Comparative evaluation of cellular uptake. Langmuir 25, 1645-1650.
39. Morandat,S., Bortolato,M., and Roux,B. (2002). Cholesteroldependent insertion of glycosylphosphatidylinositolanchored enzyme. Biochim. Biophys. Acta 1564, 473-478.
40. Müller,G. (2005). The mode of action of glimepiride - beyond insulin secretion. Curr. Med. Chem. 5, 499-518.
41. Müller,G. (2010). Personalized prognosis and diagnosis of type II diabetes - vision or fiction? Pharmacology 85, 168-187.
42. Müller,G., and Frick,W. (1999). Signalling via caveolin: Involvement in the cross-talk between phosphoinositolglycans and insulin. Cell. Mol. Life Sci. 56, 945-970.
43. Müller,G., Dearey,E.-A., Korndörfer,A., and Bandlow,W. (1994a). Stimulation of a glycosyl-phosphatidylinositolspecific phospholipase by insulin and the sulfonylurea, glimepiride, in rat adipocytes depends on increased glucose transport. J. Cell Biol. 126, 1267-1276.
44. Müller,G., Wetekam,E.-M., Jung,C., and Bandlow,W. (1994b). Membrane association of lipoprotein lipase and a cAMP-binding ectoprotein in rat adipocytes. Biochemistry 33, 12149-12159.
45. Müller,G., Jung,C., Wied,S., Welte,S., and Frick,W. (2001a). Insulin-mimetic signaling by the sulfonylurea glimepiride and phosphoinositolglycans involves distinct mechanisms for redistribution of lipid raft components. Biochemistry 40, 14603-14620.
46. Müller,G., Jung,C., Wied,S., Welte,S., Jordan,H., and Frick,W. (2001b). Redistribution of glycolipid raft domain components induces insulin-mimetic signaling in rat adipocytes. Mol. Cell. Biol. 21, 4553-4567.
47. Müller,G., Hanekop,N., Kramer,W., Bandlow,W., and Frick,W. (2002a). Interaction of phosphoinositolglycan(-peptides) with plasma membrane lipid rafts of rat adipocytes. Arch. Biochem. Biophys. 408, 17-32.
48. Müller,G., Jung,C., Frick,W., Bandlow,W., and Kramer,W. (2002b). Interaction of phosphoinositolglycan(-peptides) with plasma membrane lipid rafts triggers insulin-mimetic signaling in rat adipocytes. Arch. Biochem. Biophys. 408, 7-16.
49. Müller,G., Schulz,A., Wied,S., and Frick,W. (2005). Regulation of lipid raft proteins by glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C in rat adipocytes. Biochem. Pharmacol. 69, 761-780.
50. Müller,G., Jung,C., and Wied,S. (2008a). Translocation of glycosylphosphatidylinositol-anchored proteins from plasma membrane microdomains to lipid droplets in rat adipocytes is induced by palmitate, H2O2 and the sulfonylurea drug, glimepiride. Mol. Pharmacol. 73, 1513-1529.
51. Müller,G., Over,S., Wied,S., and Frick,W. (2008b). Association of (c)AMP-degrading glycosylphosphatidylinositolanchored proteins with lipid droplets is induced by palmitate, H2O2 and the sulfonylurea drug, glimepiride, in rat adipocytes. Biochemistry 47, 1274-1287.
52. Müller,G., Wied,S., Jung,C., and Over,S. (2008c). Translocation of glycosylphosphatidylinositol-anchored proteins to lipid droplets and inhibition of lipolysis in rat adipocytes is mediated by reactive oxygen species. Br. J. Pharmacol. 154, 901-913.
53. Müller,G., Wied,S., Jung,C., and Straub,J. (2008d). Coordinated regulation of esterification and lipolysis by palmitate, H2O2 and the anti-diabetic sulfonylurea drug, glimepiride, in rat adipocytes. Eur. J. Pharmacol. 597, 6-18.
54. Müller,G., Wied,S., Over,S., and Frick,W. (2008e). Inhibition of lipolysis by palmitate, H2O2 and the sulfonylurea drug, glimepiride, in rat adipocytes depends on cAMP degradation by lipid droplets. Biochemistry 47, 1259-1273.
55. Müller,G., Jung,C., Straub,J., Wied,S., and Kramer,W. (2009a). Induced release of membrane vesicles from rat adipocytes containing glycosylphosphatidylinositolanchored microdomain and lipid droplet signalling proteins. Cell. Signal. 21, 324-338.
56. Müller,G., Jung,C., Wied,S., and Biemer-Daub,G. (2009b). Induced translocation of glycosylphosphatidylinositolanchored proteins from lipid droplets to adiposomes in rat adipocytes. Br. J. Pharmacol. 158, 749-770.
57. Müller,G., Schulz,A., Dearey,E.-A., Wetekam,E.-M., Wied,S., and Frick,W. (2010a). Synthetic phosphoinositolglycans regulate lipid metabolism between rat adipocytes via release of GPI-protein-harbouring adiposomes. Arch. Physiol. Biochem., 116, 97-115.
58. Müller,G., Schulz,A., Hartz,D., Dearey,E.-A., Wetekam,E.-M., Ökonomopulos,R., Crecelius,A., Wied,S., and Frick,W. (2010b). Novel glimepiride derivatives with potential as double-edged swords against type II diabetes? Arch. Physiol. Biochem. 116, 3-20.
59. Müller,G., Wied,S., Jung,C., Biemer-Daub,G., and Frick,W. (2010c). Transfer of glycosylphosphatidylinositolanchored 5'-nucleotidase CD73 from adiposomes into rat adipocytes stimulates lipid synthesis. Br. J. Pharmacol. 160, 878-891.
60. Müller,G., Wied,S., Jung,C., Frick,W., and Biemer-Daub,G. (2010d). Inhibition of lipolysis by adiposomes containing glycosylphosphatidylinositol-anchored Gce1 protein in rat adipocytes. Arch. Physiol. Biochem. 116, 28-41.
61. Nelson,K.E., and The Human Microbiome Jumpstart Reference Strains Consortium. (2010). A Catalog of Reference Genomes from the Human Microbiome. Science 328, 994-999.
62. Nosjean,O., Briolay,A., and Roux,B. (1997). Mammalian GPI proteins: sorting, membrane residence and functions. Biochim. Biophys. Acta 1331, 153-186.
63. Nosjean,O., and Roux, B. (1999). Ectoplasmic insertion of a glycosylphosphatidylinositol-anchored protein in glycosphingolipid- and cholesterol-containing phosphatidylcholine vesicles. Eur. J. Biochem. 263, 865-870.
64. Orlean,P., and Menon,A.K. (2007). Thematic review series: lipid posttranslational modifications. GPI anchoring of protein in yeast and mammalian cells, or: how we learned to stop worrying and love glycophospholipids. J. Lipid Res. 48, 993-1011.
65. Parton,R.G., Joggerst,B., and Simons,K. (1994). Regulated internalization of caveolae. J. Cell Biol. 127, 1199-1215.
66. Piccin,A., Murphy,W.G., and Smith,O.P. (2007). Circulating microparticles: pathophysiology and clinical implications. Blood Rev. 21, 157-171.
67. Poste,G., and Nicolson,G.L. (1980). Arrest and metastasis of blood-born tumor cells are modified by fusion of plasma membrane vesicles from highly metastatic cells. Proc. Natl. Acad. Sci. USA 77, 399-403.
68. Premkumar,D.R., Fukuoka,Y., Sevlever,D., Brunschwig,E., Rosenberry,T.L., and Tykocinski,M.L. (2001). Properties of exogenously added GPI-anchored proteins following their incorporation into cells. J. Cell. Biochem. 82, 234- 245.
69. Prokopenko,I., McCarthy,M.J., and Lindgren,C.M. (2008). Type 2 diabetes: new genes, new understanding. Trends Genet. 24, 613-621.
70. Rajendran,L., Knölker,H.-J., and Simons,K. (2010). Subcellular targeting strategies for drug design and delivery. Nature Rev. Drug Discovery 9, 29-42.
71. Ridderstrale,M., and Groop,L. (2009). Genetic dissection of type 2 diabetes. Mol. Cell. Endocrinol. 297, 10-17.
72. Ronzon,F., Morandat,S., Roux,B., and Bortolato,M. (2004). Insertion of a glycosylphosphatidylinositol-anchored enzyme into liposomes. J. Membrane Biol. 197, 169-177.
73. Soussan,E., Cassel,S., Blanzat,M., and Rico-Lattes,I. (2009). Drug delivery by soft matter: Matrix and vesicular carriers. Angew. Chem. Int. Ed. 48, 274-288.
74. Stoorvogel,W., Kleijmeer,M.J., Geuze,H., and Raposo,G. (2002). The biogenesis and functions of exosomes. Traffic 3, 321-330.
75. Suzuki,K., and Okumura,Y. (2000). GPI-linked proteins do not transfer spontaneously from erythrocytes to liposomes. New aspects of reorganization of the cell membrane. Biochemistry 39, 9477-9485.
76. Thery,C., Zitvogel,L., and Amigorena,S. (2002). Exosomes: composition, biogenesis and function. Nat. Rev. Immunol. 3, 569-579.
77. Uhrich,K.E., Cannizzaro,S.M., Langer,R.S., and Shakesheff,K.M. (1999). Polymeric systems for controlled drug release. Chem. Rev. 99, 3181-3198.
78. Varma,R., and Mayor,S. (1998). GPI-anchored proteins are organized in submicron domains at the cell surface. Nature 394, 798-801.
79. Yang,T., Choi,M.K., Cui,F.D., Kim,J.S., Chung,S.J., Shim,C.K., and Kim,D.D. (2007). Preparation and evaluation of paclitaxel-loaded PEGylated immunoliposome. J. Controlled Release 120, 169-177.
80. Yokoyama,M. (2005). Drug targeting with nano-sized carrier systems. J. Artif. Organs 8, 77-84.
81. Zhang,F., Schmidt,W.G., Hou,Y., Williams,A.F., and Jacobson,K. (1992). Spontaneous incorporation of the glycosyl-phosphatidylinositol-linked protein Thy-1 into cell membranes. Proc. Natl. Acad. Sci. USA 89, 5231-5235.
82. Zhao,L. (2010). The tale of our other genome. Science 465, 879-880.
83. Zhu,J., Lee,B., Buhman,K.K., and Cheng,J.X. (2009). A dynamic, cytoplasmic triacylglycerol pool in enterocytes revealed by ex vivo and in vivo coherent anti-Stokes Raman scattering imaging. J. Lipid Res. 59, 1080-1089.