Novel Biodegradable and pH-Sensitive Poly(ester amide) Microspheres for Oral Insulin Delivery

Macromolecular Bioscience

Volumn 12, Issue 4, 2012, Pages 547-556

  He, Pan ^a,c   Tang, Zhaohui ^a   Lin, Lin ^a   Deng, Mingxiao ^b   Pang, Xuan ^a   Zhuang, Xiuli ^a   Chen, Xuesi ^a  

^a CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

^b NORTHEAST NORMAL UNIVERSITY   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Microspheres; Oral insulin delivery; PH sensitive; Poly(ester amide)s

Indexed keywords

DIABETIC RATS; ENCAPSULATION EFFICIENCY; IN-VITRO; ORAL ADMINISTRATION; ORAL DELIVERY; ORAL INSULIN DELIVERY; PH SENSITIVE; PH-DEPENDENT; PLASMA GLUCOSE LEVEL; POLY(ESTER-AMIDE); POLYESTERAMIDES; RELEASE MECHANISM;

AMIDES; AMINO ACIDS; ENCAPSULATION; ESTERIFICATION; ESTERS; GLUCOSE; INSULIN;

MICROSPHERES;

AMINO ACID; GLUCOSE; INSULIN; LEUCINE; MICROSPHERE; POLYESTER AMIDE; POLYMER; STREPTOZOCIN; UNCLASSIFIED DRUG;

AMINO ACID SYNTHESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIODEGRADABILITY; CONTROLLED STUDY; CYTOTOXICITY; DIABETES MELLITUS; DIET RESTRICTION; DRUG DELIVERY SYSTEM; FEASIBILITY STUDY; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PH; RAT;

ADMINISTRATION, ORAL; ANIMALS; BIOCOMPATIBLE MATERIALS; BLOOD GLUCOSE; CELL LINE; CELL SURVIVAL; DIABETES MELLITUS, EXPERIMENTAL; DRUG CARRIERS; DRUG COMPOUNDING; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; HYPOGLYCEMIC AGENTS; INSULIN; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; POLYESTERS; RATS; RATS, WISTAR;

CHAMAECRISTA; CHAMAECRISTA NICTITANS; RATTUS;

EID: 84859711364     PISSN: 16165187     EISSN: 16165195     Source Type: Journal    
DOI: 10.1002/mabi.201100358     Document Type: Article

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