The use of charge-coupled polymeric microparticles and micromagnets for modulating the bioavailability of orally delivered macromolecules

Biomaterials

Volumn 29, Issue 9, 2008, Pages 1216-1223

  Teply, Benjamin A ^a,b   Tong, Rong ^c   Jeong, Seok Y ^a   Luther, Gaurav ^a   Sherifi, Ines ^a,b   Yim, Christopher H ^a   Khademhosseini, Ali ^b,d   Farokhzad, Omid C ^b,d   Langer, Robert S ^a,d   Cheng, Jianjun ^c  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c University of Illinois at Urbana Champaign   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Drug delivery; Drug release; Magnetism; Microsphere; Protein

Indexed keywords

DRUG DELIVERY; MAGNETISM; MICROSPHERES; POLYMERS; PROTEINS;

BIOAVAILABILITY;

MACROMOLECULES;

GLUCOSE; HUMAN INSULIN; INSULIN; INSULIN I 125; ISOPHANE INSULIN; POLYGLACTIN; POLYMER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; COMPLEX FORMATION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; ENCAPSULATION; GASTROINTESTINAL TRACT; IN VITRO STUDY; MACROMOLECULE; MAGNET; MAGNETIC FIELD; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ANIMALS; BIOCOMPATIBLE MATERIALS; BIOLOGICAL AVAILABILITY; DRUG DELIVERY SYSTEMS; INSULIN; LACTIC ACID; MAGNETICS; MATERIALS TESTING; MICE; PARTICLE SIZE; POLYGLYCOLIC ACID; POLYMERS; PROTEINS;

MUS;

EID: 38349019669     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2007.11.018     Document Type: Article

References (19)

1. Delie F. Evaluation of nano- and microparticle uptake by the gastrointestinal tract. Adv Drug Deliv Rev 34 (1998) 221-233
2. Mathiowitz E., Jacob J.S., Jong Y.S., Carino G.P., Chickering D.E., Chaturvedi P., et al. Biologically erodable microsphere as potential oral drug delivery system. Nature 386 (1997) 410-414
3. Goldberg M., and Gomez-Orellana I. Challenges for the oral delivery of macromolecules. Nat Rev Drug Discov 2 (2003) 289-295
4. Fasano A., and Uzzau S. Modulation of intestinal tight junctions by zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model. J Clin Invest 99 (1997) 1158-1164
5. Sandri G., Bonferoni M.C., Rossi S., Ferrari F., Gibin S., Zambito Y., et al. Nanoparticles based on N-trimethylchitosan: evaluation of absorption properties using in vitro (Caco-2 cells) and ex vivo (excised rat jejunum) models. Eur J Pharm Biopharm 65 (2007) 68-77
6. Chickering D.E., Jacob J.S., Desai T.A., Harrison M., Harris W.P., Morrell C.N., et al. Bioadhesive microspheres. 3. An in vivo transit and bioavailability study of drug-loaded alginate and poly(fumaric-co-sebacic anhydride) microspheres. J Control Release 48 (1997) 35-46
7. Ponchel G., and Irache J.M. Specific and non-specific bioadhesive particulate systems for oral delivery to the gastrointestinal tract. Adv Drug Deliv Rev 34 (1998) 191-219
8. Carino G.P., Jacob J.S., and Mathiowitz E. Nanosphere based oral insulin delivery. J Control Release 65 (2000) 261-269
9. Vila A., Sanchez A., Tobio M., Calvo P., and Alonso M.J. Design of biodegradable particles for protein delivery. J Control Release 78 (2002) 15-24
10. Chen H.M., and Langer R. Magnetically-responsive polymerized liposomes as potential oral delivery vehicles. Pharm Res 14 (1997) 537-540
11. Cheng J.J., Teply B.A., Jeong S.Y., Yim C.H., Ho D., Sherifi I., et al. Magnetically responsive polymeric microparticles for oral delivery of protein drugs. Pharm Res 23 (2006) 557-564
12. Hafeli U.O. Magnetically modulated therapeutic systems. Int J Pharm 277 (2004) 19-24
13. Wassermann E.M., and Lisanby S.H. Therapeutic application of repetitive transcranial magnetic stimulation: a review. Clin Neurophysiol 112 (2001) 1367-1377
14. Arruebo M., Fernandez-Pacheco R., Ibarra M.R., and Santamaria J. Magnetic nanoparticles for drug delivery. Nano Today 2 (2007) 22-32
15. Kararli T.T. Comparison of the gastrointestinal anatomy, physiology and biochemistry of humans and commonly used laboratory-animals. Biopharm Drug Dispos 16 (1995) 351-380
16. Pettersson G., Ahlman H., and Kewenter J. Comparison of small intestinal transit-time between rat and guinea-pig. Acta Chir Scand 142 (1976) 537-540
17. Bilati U., Allemann E., and Doelker E. Nanoprecipitation versus emulsion-based techniques for the encapsulation of proteins into biodegradable nanoparticles and process-related stability issues. Aaps Pharmscitech 6 (2005) E594-E604
18. Florence A.T., Hillery A.M., Hussain N., and Jani P.U. Nanoparticles as carriers for oral peptide absorption-studies on particle uptake and fate. J Control Release 36 (1995) 39-46
19. Whitehead K., Shen Z.C., and Mitragotri S. Oral delivery of macromolecules using intestinal patches: applications for insulin delivery. J Control Release 98 (2004) 37-45