Comparison of the physical stability and physicochemical properties of amorphous indomethacin prepared by co-milling and supercritical anti-solvent co-precipitation

Journal of Supercritical Fluids

Volumn 79, Issue , 2013, Pages 186-201

  Lim, Ron Tau Yee ^a,b   Ng, Wai Kiong ^a   Widjaja, Effendi ^a   Tan, Reginald B H ^a,b  

^a INSTITUTE OF CHEMICAL AND ENGINEERING SCIENCES   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Amorphization; Co milling; Indomethacin; Physical stability; Poly(vinylpyrrolidone); Supercritical fluid

Indexed keywords

AMORPHIZATION; EFFLUENT TREATMENT; FOURIER TRANSFORM INFRARED SPECTROSCOPY; GAS CHROMATOGRAPHY; INVERSE PROBLEMS; MILLING (MACHINING); POWDERS; PRECIPITATES; SCANNING ELECTRON MICROSCOPY; SOLVENTS; STABILITY; STRUCTURAL RELAXATION; SUPERCRITICAL FLUIDS; THERMOGRAVIMETRIC ANALYSIS;

CO-MILLING; INDOMETHACIN; INTERMOLECULAR HYDROGEN BONDS; INVERSE GAS CHROMATOGRAPHY; PHYSICAL STABILITY; POLY(VINYL PYRROLIDONE); POORLY WATER-SOLUBLE DRUGS; X-RAY POWDER DIFFRACTOMETRY;

HYDROGEN BONDS;

EID: 84883657289     PISSN: 08968446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.supflu.2013.02.017     Document Type: Article

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