Cryogenic grinding of indomethacin polymorphs and solvates: Assessment of amorphous phase formation and amorphous phase physical stability

Journal of Pharmaceutical Sciences

Volumn 91, Issue 2, 2002, Pages 492-507

  Zografi, George ^a   Crowley, Kieran J ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Amorphous phase; Cryogenic grinding; Isothermal and nonisothermal crystallization; Polymorphs; Solvates

Indexed keywords

BENZYL THIOCYANATE; GLASS; INDOMETACIN; INDOMETACIN DERIVATIVE; INDOMETACIN METHANOLATE; INDOMETACIN TERT BUTANOLATE; METHANOL; PLASTICIZER; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DESICCATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DEGRADATION; DRUG FORMULATION; DRUG STABILITY; DRUG STRUCTURE; GRINDING; PARTICLE SIZE; PHASE TRANSITION; SOLID STATE; TEMPERATURE SENSITIVITY; THERMAL ANALYSIS; X RAY POWDER DIFFRACTION;

EID: 0036171845     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10028     Document Type: Article

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