Investigation of preparation methods on surface/bulk structural relaxation and glass fragility of amorphous solid dispersions

International Journal of Pharmaceutics

Volumn 422, Issue 1-2, 2012, Pages 170-178

  Ke, Peng ^a   Hasegawa, Susumu ^a   Al Obaidi, Hisham ^b   Buckton, Graham ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Amorphous solid dispersion; Glass fragility; Inverse gas chromatography; Stability; Structural relaxation; Zero mobility temperature

Indexed keywords

INDOMETACIN;

ARTICLE; DISPERSION; DRUG SYNTHESIS; GAS CHROMATOGRAPHY; MOLECULE; PRIORITY JOURNAL; SURFACE PROPERTY; TEMPERATURE;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, GAS; DRUG COMPOUNDING; DRUG STABILITY; INDOMETHACIN; MODELS, CHEMICAL; MOLECULAR STRUCTURE; POVIDONE; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; TIME FACTORS;

EID: 84655169195     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.10.047     Document Type: Article

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