Prediction of onset of crystallization from experimental relaxation times. II. Comparison between predicted and experimental onset times

Journal of Pharmaceutical Sciences

Volumn 97, Issue 1, 2008, Pages 455-472

  Bhugra, Chandan ^a,b   Shmeis, Rama ^b,c   Krill, Steven L ^b   Pikal, Michael J ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^c SANOFI   (France)

Author keywords

Amorphous pharmaceuticals; Calorimetry (TAM); Crystallization prediction; Dielectric relaxation; Glass transition; Growth rate; Induction time; Molecular mobility; Physical stability; Relaxation time

Indexed keywords

FELODIPINE; FLOPROPIONE; INDOMETACIN; KETOCONAZOLE; NIFEDIPINE;

ARTICLE; CALORIMETRY; CRYSTALLIZATION; DIELECTRIC CONSTANT; DRUG STABILITY; HYDROGEN BOND; INFRARED SPECTROSCOPY; MICROSCOPY; RAMAN SPECTROMETRY; RELAXATION TIME; TEMPERATURE SENSITIVITY; THERMODYNAMICS; VISCOSITY; X RAY DIFFRACTION;

EID: 38349180826     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21162     Document Type: Article

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