Formation and characterization of porous indomethacin-PVP coprecipitates prepared using solvent-free supercritical fluid processing

Journal of Pharmaceutical Sciences

Volumn 94, Issue 12, 2005, Pages 2583-2590

  Gong, K ^a   Viboonkiat, R ^b   Rehman, I U ^a   Buckton, G ^b   Darr, J A ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Amorphous; Drug; Indomethacin; Poly(vinylpyrrolidone); Solid dispersion; Supercritical CO2

Indexed keywords

INDOMETACIN; POVIDONE; SOLVENT;

ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG SOLUBILITY; EVAPORATION; POROSITY; PRECIPITATION; SCANNING ELECTRON MICROSCOPY; SUPERCRITICAL FLUID; THERMAL ANALYSIS; X RAY DIFFRACTION;

EID: 33144459437     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20474     Document Type: Article

References (24)

1. Corrigan OI, Holohan EM, Sabra K. 1984. Amorphous forms of thiazide diuretics prepared by spray-drying. Int J Pharm 18:195-200.
2. Chiou WL, Riegelman S. 1997. Pharmaceutical applications of solid dispersion systems. J Pharm Sci 60:1281-1302.
3. Serajuddin ATM. 1999. Solid dispersion of poorly water soluble drugs: Early promises, subsequent problems and recent breakthroughs. J Pharm Sci 88:696-704.
4. Subramaniam B, Rajewski RA, Snavely K. 1997. Pharmaceutical processing with supercritical carbon dioxide. J Pharm Sci 86:885-890.
5. York P. 1999. Strategies for particle design using supercritical fluid technologies. Pharm Sci Tech Today 2:430-440.
6. 3. Ind Eng Chem Res 34:4087-4091.
7. Jung J, Perrut M. 2001. Particle design using supercritical fluids: Literature and patent survey. J Supercrit Fluids 20:179-219.
8. Alessi P, Cortesi A, Kikic I, Foster NR, Mcnaughton SJ, Colombo I. 1996. Particle production of steroid drugs using supercritical fluid processing. Ind Eng Chem Res 35:4718-4726.
9. Martin HJ, Schmidt PC, Wahl MA, Hils P, Helfgen B, Turk M, Schaber K. 2000. Nanoscale particles for pharmaceutical purpose by rapid expansion of supercritical solutions (RESS): Part II: Characterization or the product and use. Proceedings. 7th Meeting on Supercritical fluids, Tome 1; Perrut M, Reverchon E, editors, ISBN 2-905-267-33-10, Dec 6-8, Antibes, 53-57.
10. Charoenchaitrakool M, Dehghani F, Foster NR, Chan HK. 2000. Micronisation by RESS to enchance the dissolution rates of poorly water-soluble pharmaceuticals. Ind Eng Chem Res 39: 4794-4802.
11. Debenedetti PG, Tom JW, Yeo SD, Lim GB. 1993. Application of supercritical fluids for production of sustained delivery devices. J Control Rel 24:27-44.
12. Weidner E, Knez Z, Novak Z. 1994. A process and equipment for production of fine particles from Gas Saturation Solutions. World patent WO9521688 A1, 15.2.
13. 2. Int J Pharm 148: 123-130.
14. York P, Hanna MH. 1996. Processing of respiratory drug delivery V. Phoenix, AZ, USA, 231-239.
15. York P. 1999. Strategies for particle design using supercritical fluid technologies. Pharm Sci Tech Today 88:1182-1190.
16. Gordon M, Taylor JS. 1952. Ideal co-polymers and the second order transition of synthetic rubbers 1. non-crystalline co-polymers. J Appl Chem 2:493-500.
17. Simha R, Boyer RF. 1962. On a general relation involving the glass temperature and coefficients of expansion of polymers. J Chem Phys 37:1003-1007.
18. Yoshioka M, Hancock BC, Zografi G. 1994. Crystallization of Indomethacin from the amorphous state below and above its glass transition temperature. J Pharm Sci 83:1700-1705.
19. Matsumoto T, Zografi G. 1999. Physical properties of solid molecular dispersion of indomethacin with poly(vinylpyrrolidone) and poly(vinylpyrrolidone-co-vinyl-acetate) in relation to indomethacin crystallization. Pharm Res 16:1722-1728.
20. Summers MP, Enever RP. 1977. Effect of primidone concentration on glass transition temperature and dissolution of solid dispersion systems containing primidone and citric acid. J Pharm Sci 66: 825-828.
21. Yoshioka M, Hancock BC, Zografi G. 1995. Inhibition of indomethacin crystallization in poly(vinylpyrrolidone) coprecipitates. J Pharm Sci 84:983-986.
22. Taylor LS, Zografi G. 1997. Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions. Pharm Res 14:1691-1698.
23. Shamblin SL, Taylor LS, Zografi G. 1998. Mixing behavior of colyophilized binary systems. J Pharm Sci 87:694-701.
24. Hancock BC, Zografi G. 1997. Characteristics and significance of the amorphous state in pharmaceutical systems. J Pharm Sci 86:1-12.