메뉴 건너뛰기




Volumn 37, Issue 1, 2013, Pages 63-75

Glial activation in AβPP/PS1 mice is associated with infiltration of IFNγ-producing cells

Author keywords

Glial activation; macrophages; natural killer (NK) cells

Indexed keywords

AMYLOID PRECURSOR PROTEIN; GAMMA INTERFERON; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 2; PRESENILIN 1; TUMOR NECROSIS FACTOR ALPHA;

EID: 84883198497     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-130539     Document Type: Article
Times cited : (44)

References (64)
  • 1
    • 33845903037 scopus 로고    scopus 로고
    • 1-42 in the rat hippocampus in vivo
    • DOI 10.1016/j.neuropharm.2006.07.031, PII S0028390806002516
    • Clarke RM, O'Connell F, Lyons A, Lynch MA (2007) The HMG-CoA reductase inhibitor, atorvastatin, attenuates the effects of acute administration of amyloid-beta1-42 in the rat hippocampus in vivo. Neuropharmacology 52, 136-145. (Pubitemid 46026837)
    • (2007) Neuropharmacology , vol.52 , Issue.1 , pp. 136-145
    • Clarke, R.M.1    O'Connell, F.2    Lyons, A.3    Lynch, M.A.4
  • 2
    • 34247346030 scopus 로고    scopus 로고
    • IL-4 attenuates the neuroinflammation induced by amyloid-β in vivo and in vitro
    • DOI 10.1111/j.1471-4159.2006.04370.x
    • Lyons A, Griffin RJ, Costelloe CE, Clarke RM, Lynch MA (2007) IL-4 attenuates the neuroinflammation induced by amyloid-beta in vivo and in vitro. J Neurochem 101, 771-781. (Pubitemid 46633315)
    • (2007) Journal of Neurochemistry , vol.101 , Issue.3 , pp. 771-781
    • Lyons, A.1    Griffin, R.J.2    Costelloe, C.E.3    Clarke, R.M.4    Lynch, M.A.5
  • 4
    • 10344238086 scopus 로고    scopus 로고
    • Tumor necrosis factor-α, interleukin-1β, and interferon-γ stimulate γ-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway
    • DOI 10.1074/jbc.M402034200
    • Liao YF, Wang BJ, Cheng HT, Kuo LH, Wolfe MS (2004) Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNKdependent MAPK pathway. J Biol Chem 279, 49523-49532. (Pubitemid 39625840)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.47 , pp. 49523-49532
    • Liaoi, Y.-F.1    Wang, B.-J.2    Cheng, H.-T.3    Kuo, L.-H.4    Wolfe, M.S.5
  • 5
    • 47349086360 scopus 로고    scopus 로고
    • Interactions between APP secretases and inflammatory mediators
    • Sastre M, Walter J, Gentleman SM (2008) Interactions between APP secretases and inflammatory mediators. J Neuroinflammation 5, 25.
    • (2008) J Neuroinflammation , vol.5 , pp. 25
    • Sastre, M.1    Walter, J.2    Gentleman, S.M.3
  • 6
    • 83755183781 scopus 로고    scopus 로고
    • Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal beta-catenin pathway function in an Alzheimer's disease model
    • Kitazawa M, Cheng D, Tsukamoto MR, Koike MA, Wes PD, Vasilevko V, Cribbs DH, LaFerla FM (2011) Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal beta-catenin pathway function in an Alzheimer's disease model. J Immunol 187, 6539-6549.
    • (2011) J Immunol , vol.187 , pp. 6539-6549
    • Kitazawa, M.1    Cheng, D.2    Tsukamoto, M.R.3    Koike, M.A.4    Wes, P.D.5    Vasilevko, V.6    Cribbs, D.H.7    Laferla, F.M.8
  • 8
    • 84155164228 scopus 로고    scopus 로고
    • Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation
    • Choi SH, Aid S, Kim HW, Jackson SH, Bosetti F (2012) Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation. J Neurochem 120, 292-301.
    • (2012) J Neurochem , vol.120 , pp. 292-301
    • Choi, S.H.1    Aid, S.2    Kim, H.W.3    Jackson, S.H.4    Bosetti, F.5
  • 9
    • 78449254879 scopus 로고    scopus 로고
    • Deletion of CD14 attenuates Alzheimer's disease pathology by influencing the brain's inflammatory milieu
    • Reed-Geaghan EG, Reed QW, Cramer PE, Landreth GE (2010) Deletion of CD14 attenuates Alzheimer's disease pathology by influencing the brain's inflammatory milieu. J Neurosci 30, 15369-15373.
    • (2010) J Neurosci , vol.30 , pp. 15369-15373
    • Reed-Geaghan, E.G.1    Reed, Q.W.2    Cramer, P.E.3    Landreth, G.E.4
  • 11
    • 0023912573 scopus 로고
    • The characterization of experimental gliosis by quantitative nuclear magnetic resonance imaging
    • Barnes D, McDonald WI, Landon DN, Johnson G (1988) The characterization of experimental gliosis by quantitative nuclear magnetic resonance imaging. Brain 111(Pt 1), 83-94.
    • (1988) Brain , vol.111 , Issue.PART 1 , pp. 83-94
    • Barnes, D.1    McDonald, W.I.2    Landon, D.N.3    Johnson, G.4
  • 12
    • 84855801337 scopus 로고    scopus 로고
    • Modest amyloid deposition is associated with iron dysregulation, microglial activation, and oxidative stress
    • Gallagher JJ, Finnegan ME, Grehan B, Dobson J, Collingwood JF, Lynch MA (2012) Modest amyloid deposition is associated with iron dysregulation, microglial activation, and oxidative stress. J Alzheimers Dis 28, 147-161.
    • (2012) J Alzheimers Dis , vol.28 , pp. 147-161
    • Gallagher, J.J.1    Finnegan, M.E.2    Grehan, B.3    Dobson, J.4    Collingwood, J.F.5    Lynch, M.A.6
  • 16
    • 44449097256 scopus 로고    scopus 로고
    • MRI detection of secondary damage after stroke: Chronic iron accumulation in the thalamus of the rat brain
    • Justicia C, Ramos-Cabrer P, Hoehn M (2008) MRI detection of secondary damage after stroke: Chronic iron accumulation in the thalamus of the rat brain. Stroke 39, 1541-1547.
    • (2008) Stroke , vol.39 , pp. 1541-1547
    • Justicia, C.1    Ramos-Cabrer, P.2    Hoehn, M.3
  • 19
    • 78650900647 scopus 로고    scopus 로고
    • ImmunoRatio: A publicly available web application for quantitative image analysis of estrogen receptor (ER), progesterone receptor (PR), and Ki-67
    • Tuominen VJ, Ruotoistenmaki S, Viitanen A, Jumppanen M, Isola J (2010) ImmunoRatio: A publicly available web application for quantitative image analysis of estrogen receptor (ER), progesterone receptor (PR), and Ki-67. Breast Cancer Res 12, R56.
    • (2010) Breast Cancer Res , vol.12
    • Tuominen, V.J.1    Ruotoistenmaki, S.2    Viitanen, A.3    Jumppanen, M.4    Isola, J.5
  • 21
    • 0025061972 scopus 로고
    • Interleukin-2 suppresses established long-term potentiation and inhibits its induction in the rat hippocampus
    • DOI 10.1016/0006-8993(90)91331-A
    • Tancredi V, Zona C, Velotti F, Eusebi F, Santoni A (1990) Interleukin-2 suppresses established long-term potentiation and inhibits its induction in the rat hippocampus. Brain Res 525, 149-151. (Pubitemid 20257727)
    • (1990) Brain Research , vol.525 , Issue.1 , pp. 149-151
    • Tancredi, V.1    Zona, C.2    Velotti, F.3    Eusebi, F.4    Santoni, A.5
  • 27
    • 84860742408 scopus 로고    scopus 로고
    • Rosiglitazone improves spatial memory and decreases insoluble Abeta(1-42) in APP/PS1 mice
    • O'Reilly JA, Lynch M (2012) Rosiglitazone improves spatial memory and decreases insoluble Abeta(1-42) in APP/PS1 mice. J Neuroimmune Pharmacol 7, 140-144.
    • (2012) J Neuroimmune Pharmacol , vol.7 , pp. 140-144
    • O'Reilly, J.A.1    Lynch, M.2
  • 28
    • 68349127365 scopus 로고    scopus 로고
    • Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer's mice
    • Sanchez-Ramos J, Song S, Sava V, Catlow B, Lin X, Mori T, Cao C, ArendashGW(2009) Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer's mice. Neuroscience 163, 55-72.
    • (2009) Neuroscience , vol.163 , pp. 55-72
    • Sanchez-Ramos, J.1    Song, S.2    Sava, V.3    Catlow, B.4    Lin, X.5    Mori, T.6    Cao, C.7    Arendash, G.W.8
  • 31
    • 17644397044 scopus 로고    scopus 로고
    • Histological co-localization of iron in Aβ plaques of PS/APP transgenic mice
    • DOI 10.1007/s11064-004-2442-x
    • Falangola MF, Lee SP, Nixon RA, Duff K, Helpern JA (2005) Histological co-localization of iron in Abeta plaques of PS/APP transgenic mice. Neurochem Res 30, 201-205. (Pubitemid 40569203)
    • (2005) Neurochemical Research , vol.30 , Issue.2 , pp. 201-205
    • Falangola, M.F.1    Lee, S.-P.2    Nixon, R.A.3    Duff, K.4    Helpern, J.A.5
  • 32
    • 33645053770 scopus 로고    scopus 로고
    • Age-related evolution of amyloid burden, iron load, and MR relaxation times in a transgenic mouse model of Alzheimer's disease
    • ElTannir ElTayara N, Delatour B, Le Cudennec C, GueganM, Volk A, Dhenain M (2006) Age-related evolution of amyloid burden, iron load, and MR relaxation times in a transgenic mouse model of Alzheimer's disease. Neurobiol Dis 22, 199-208.
    • (2006) Neurobiol Dis , vol.22 , pp. 199-208
    • Eltannir Eltayara, N.1    Delatour, B.2    Le Cudennec, C.3    Guegan, M.4    Volk, A.5    Dhenain, M.6
  • 33
    • 77957877855 scopus 로고    scopus 로고
    • Astroglial connexin immunoreactivity is specifically altered at beta-amyloid plaques in beta-amyloid precursor protein/presenilin1 mice
    • MeiX, Ezan P, Giaume C,KoulakoffA(2010) Astroglial connexin immunoreactivity is specifically altered at beta-amyloid plaques in beta-amyloid precursor protein/presenilin1 mice. Neuroscience 171, 92-105.
    • (2010) Neuroscience , vol.171 , pp. 92-105
    • Mei, X.1    Ezan, P.2    Giaume, C.3    Koulakoff, A.4
  • 35
    • 0036174969 scopus 로고    scopus 로고
    • The effects of long-term treatment with metrifonate, a cholinesterase inhibitor, on cholinergic activity, amyloid pathology, and cognitive function in APP and PS1 doubly transgenic mice
    • DOI 10.1006/exnr.2001.7819
    • Liu L, Ikonen S, Heikkinen T, Tapiola T, van Groen T, Tanila H (2002) The effects of long-term treatment with metrifonate, a cholinesterase inhibitor, on cholinergic activity, amyloid pathology, and cognitive function in APP and PS1 doubly transgenic mice. Exp Neurol 173, 196-204. (Pubitemid 34151371)
    • (2002) Experimental Neurology , vol.173 , Issue.2 , pp. 196-204
    • Liu, L.1    Ikonen, S.2    Heikkinen, T.3    Tapiola, T.4    Van Groen, T.5    Tanila, H.6
  • 36
    • 33750353034 scopus 로고    scopus 로고
    • Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the rat
    • DOI 10.1016/j.neuroscience.2006.08.017, PII S0306452206010712
    • Rosi S, Vazdarjanova A, Ramirez-Amaya V, Worley PF, Barnes CA, Wenk GL (2006) Memantine protects against LPS-induced neuroinflammation, restores behaviorally induced gene expression and spatial learning in the rat. Neuroscience 142, 1303-1315. (Pubitemid 44636069)
    • (2006) Neuroscience , vol.142 , Issue.4 , pp. 1303-1315
    • Rosi, S.1    Vazdarjanova, A.2    Ramirez-Amaya, V.3    Worley, P.F.4    Barnes, C.A.5    Wenk, G.L.6
  • 38
    • 33846433513 scopus 로고    scopus 로고
    • Differential susceptibility following β-amyloid peptide-(1-40) administration in C57BL/6 and Swiss albino mice: Evidence for a dissociation between cognitive deficits and the glutathione system response
    • DOI 10.1016/j.bbr.2006.11.032, PII S0166432806006450
    • Prediger RD, Franco JL, Pandolfo P, Medeiros R, Duarte FS, Di Giunta G, Figueiredo CP, Farina M, Calixto JB, Takahashi RN, Dafre AL (2007) Differential susceptibility following beta-amyloid peptide-(1-40) administration in C57BL/6 and Swiss albino mice: Evidence for a dissociation between cognitive deficits and the glutathione system response. Behav Brain Res 177, 205-213. (Pubitemid 46149914)
    • (2007) Behavioural Brain Research , vol.177 , Issue.2 , pp. 205-213
    • Prediger, R.D.S.1    Franco, J.L.2    Pandolfo, P.3    Medeiros, R.4    Duarte, F.S.5    Di Giunta, G.6    Figueiredo, C.P.7    Farina, M.8    Calixto, J.B.9    Takahashi, R.N.10    Dafre, A.L.11
  • 39
    • 84655160769 scopus 로고    scopus 로고
    • Amyloid beta: Linking synaptic plasticity failure to memory disruption in Alzheimer's disease
    • Ma T, Klann E (2012) Amyloid beta: Linking synaptic plasticity failure to memory disruption in Alzheimer's disease. J Neurochem 120(Suppl 1), 140-148.
    • (2012) J Neurochem , vol.120 , Issue.SUPPL. 1 , pp. 140-148
    • Ma, T.1    Klann, E.2
  • 42
    • 43649097836 scopus 로고    scopus 로고
    • Aged wild-type and APP, PS1, and APP+PS1 mice present similar deficits in associative learning and synaptic plasticity independent of amyloid load
    • Gruart A, Lopez-Ramos JC, Munoz MD, Delgado-Garcia JM (2008) Aged wild-type and APP, PS1, and APP+PS1 mice present similar deficits in associative learning and synaptic plasticity independent of amyloid load. Neurobiol Dis 30, 439-450.
    • (2008) Neurobiol Dis , vol.30 , pp. 439-450
    • Gruart, A.1    Lopez-Ramos, J.C.2    Munoz, M.D.3    Delgado-Garcia, J.M.4
  • 44
    • 0033579382 scopus 로고    scopus 로고
    • Microglial activation resulting from CD40-CD40l interaction after β- amyloid stimulation
    • DOI 10.1126/science.286.5448.2352
    • Tan J, Town T, Paris D, Mori T, Suo Z, Crawford F, Mattson MP, Flavell RA, Mullan M (1999) Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation. Science 286, 2352-2355. (Pubitemid 30016899)
    • (1999) Science , vol.286 , Issue.5448 , pp. 2352-2355
    • Tan, J.1    Town, T.2    Paris, D.3    Mori, T.4    Suo, Z.5    Crawford, F.6    Mattson, M.P.7    Flavell, R.A.8    Mullan, M.9
  • 45
    • 84455193348 scopus 로고    scopus 로고
    • Endogenous conversion of omega-6 into omega-3 fatty acids improves neuropathology in an animal model of Alzheimer's disease
    • Lebbadi M, Julien C, Phivilay A, Tremblay C, EmondV, Kang JX, Calon F (2011) Endogenous conversion of omega-6 into omega-3 fatty acids improves neuropathology in an animal model of Alzheimer's disease. J Alzheimers Dis 27, 853-869.
    • (2011) J Alzheimers Dis , vol.27 , pp. 853-869
    • Lebbadi, M.1    Julien, C.2    Phivilay, A.3    Tremblay, C.4    Emond, V.5    Kang, J.X.6    Calon, F.7
  • 47
    • 65549163176 scopus 로고    scopus 로고
    • A synthetic NCAM-derived mimetic peptide, FGL, exerts anti-inflammatory properties via IGF-1 and interferon-gamma modulation
    • Downer EJ, Cowley TR, Cox F, Maher FO, Berezin V, Bock E, Lynch MA (2009) A synthetic NCAM-derived mimetic peptide, FGL, exerts anti-inflammatory properties via IGF-1 and interferon-gamma modulation. J Neurochem 109, 1516-1525.
    • (2009) J Neurochem , vol.109 , pp. 1516-1525
    • Downer, E.J.1    Cowley, T.R.2    Cox, F.3    Maher, F.O.4    Berezin, V.5    Bock, E.6    Lynch, M.A.7
  • 48
    • 0344825120 scopus 로고    scopus 로고
    • Molecular regulation of CD40 gene expression in macrophages and microglia
    • DOI 10.1016/j.bbi.2003.09.001
    • Benveniste EN, Nguyen VT, Wesemann DR (2004) Molecular regulation of CD40 gene expression in macrophages and microglia. Brain Behav Immun 18, 7-12. (Pubitemid 37476278)
    • (2004) Brain, Behavior, and Immunity , vol.18 , Issue.1 , pp. 7-12
    • Benveniste, E.N.1    Nguyen, V.T.2    Wesemann, D.R.3
  • 49
    • 79953212988 scopus 로고    scopus 로고
    • Atorvastatin prevents age-related and amyloid-beta-induced microglial activation by blocking interferon-gamma release from natural killer cells in the brain
    • Lyons A, Murphy KJ, Clarke R, Lynch MA (2011) Atorvastatin prevents age-related and amyloid-beta-induced microglial activation by blocking interferon-gamma release from natural killer cells in the brain. J Neuroinflammation 8, 27.
    • (2011) J Neuroinflammation , vol.8 , pp. 27
    • Lyons, A.1    Murphy, K.J.2    Clarke, R.3    Lynch, M.A.4
  • 50
    • 36849058725 scopus 로고    scopus 로고
    • Synergistic effects of IL-2, IL-12 and IL-18 on cytolytic activity, perforin expression and IFN-γ production of porcine natural killer cells
    • DOI 10.1016/j.vetimm.2007.08.009, PII S0165242707002796
    • Pintaric M, GernerW, SaalmullerA(2008) Synergistic effects of IL-2, IL-12 and IL-18 on cytolytic activity, perforin expression and IFN-gamma production of porcine natural killer cells. Vet Immunol Immunopathol 121, 68-82. (Pubitemid 350235651)
    • (2008) Veterinary Immunology and Immunopathology , vol.121 , Issue.1-2 , pp. 68-82
    • Pintaric, M.1    Gerner, W.2    Saalmuller, A.3
  • 51
    • 0035284905 scopus 로고    scopus 로고
    • The production of IFN-γ by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4
    • Schindler H, Lutz MB, Rollinghoff M, Bogdan C (2001) The production of IFN-gamma by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4. J Immunol 166, 3075-3082. (Pubitemid 33117303)
    • (2001) Journal of Immunology , vol.166 , Issue.5 , pp. 3075-3082
    • Schindler, H.1    Lutz, M.B.2    Rollinghoff, M.3    Bogdan, C.4
  • 52
    • 61349102361 scopus 로고    scopus 로고
    • Blood-brain barrier permeability in Alzheimer's disease: Acase-control MRI study
    • Starr JM, Farrall AJ, Armitage P, McGurn B, Wardlaw J (2009) Blood-brain barrier permeability in Alzheimer's disease: Acase-control MRI study. Psychiatry Res 171, 232-241.
    • (2009) Psychiatry Res , vol.171 , pp. 232-241
    • Starr, J.M.1    Farrall, A.J.2    Armitage, P.3    McGurn, B.4    Wardlaw, J.5
  • 53
    • 58549098084 scopus 로고    scopus 로고
    • Blood-brain barrier: Ageing and microvascular disease-systematic review and metaanalysis
    • Farrall AJ, Wardlaw JM (2009) Blood-brain barrier: Ageing and microvascular disease-systematic review and metaanalysis. Neurobiol Aging 30, 337-352.
    • (2009) Neurobiol Aging , vol.30 , pp. 337-352
    • Farrall, A.J.1    Wardlaw, J.M.2
  • 54
    • 3442894794 scopus 로고    scopus 로고
    • Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model
    • DOI 10.1038/sj.mn.7800212
    • Ujiie M, Dickstein DL, Carlow DA, Jefferies WA (2003) Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model. Microcirculation 10, 463-470. (Pubitemid 39004272)
    • (2003) Microcirculation , vol.10 , Issue.6 , pp. 463-470
    • Ujiie, M.1    Dickstein, D.L.2    Carlow, D.A.3    Jefferies, W.A.4
  • 55
    • 34547791784 scopus 로고    scopus 로고
    • Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease
    • DOI 10.1084/jem.20070304
    • Paul J, Strickland S, Melchor JP (2007) Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease. J Exp Med 204, 1999-2008. (Pubitemid 47236333)
    • (2007) Journal of Experimental Medicine , vol.204 , Issue.8 , pp. 1999-2008
    • Paul, J.1    Strickland, S.2    Melchor, J.P.3
  • 56
    • 80052330506 scopus 로고    scopus 로고
    • Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's disease
    • Biron KE, Dickstein DL, Gopaul R, Jefferies WA (2011) Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's disease. PLoS One 6, e23789.
    • (2011) PLoS One , vol.6
    • Biron, K.E.1    Dickstein, D.L.2    Gopaul, R.3    Jefferies, W.A.4
  • 57
    • 33644788171 scopus 로고    scopus 로고
    • Interaction between interferon γ and insulin-like growth factor-1 in hippocampus impacts on the ability of rats to sustain long-term potentiation
    • DOI 10.1111/j.1471-4159.2006.03664.x
    • Maher FO, Clarke RM, Kelly A, Nally RE, LynchMA(2006) Interaction between interferongammaand insulin-like growth factor-1 in hippocampus impacts on the ability of rats to sustain long-term potentiation. J Neurochem 96, 1560-1571. (Pubitemid 43351616)
    • (2006) Journal of Neurochemistry , vol.96 , Issue.6 , pp. 1560-1571
    • Maher, F.O.1    Clarke, R.M.2    Kelly, A.3    Nally, R.E.4    Lynch, M.A.5
  • 59
    • 70349838221 scopus 로고    scopus 로고
    • Taking advantage of the systemic immune system to cure brain diseases
    • Yong VW, Rivest S (2009) Taking advantage of the systemic immune system to cure brain diseases. Neuron 64, 55-60.
    • (2009) Neuron , vol.64 , pp. 55-60
    • Yong, V.W.1    Rivest, S.2
  • 60
  • 61
    • 34547680192 scopus 로고    scopus 로고
    • CD200 ligand-receptor interaction modulates microglial activation in vivo and in vitro: A role for IL-4
    • DOI 10.1523/JNEUROSCI.1781-07.2007
    • Lyons A, Downer EJ, Crotty S, Nolan YM, Mills KH, Lynch MA (2007) CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: A role for IL-4. J Neurosci 27, 8309-8313. (Pubitemid 47219605)
    • (2007) Journal of Neuroscience , vol.27 , Issue.31 , pp. 8309-8313
    • Lyons, A.1    Downer, E.J.2    Crotty, S.3    Nolan, Y.M.4    Mills, K.H.G.5    Lynch, M.A.6
  • 63
  • 64
    • 24644438615 scopus 로고    scopus 로고
    • Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: Implications for Alzheimer therapeutics
    • Morgan D, GordonMN,Tan J,Wilcock D, RojianiAM(2005) Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: Implications for Alzheimer therapeutics. J Neuropathol Exp Neurol 64, 743-753. (Pubitemid 41285806)
    • (2005) Journal of Neuropathology and Experimental Neurology , vol.64 , Issue.9 , pp. 743-753
    • Morgan, D.1    Gordon, M.N.2    Tan, J.3    Wilcock, D.4    Rojiani, A.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.