Rosiglitazone improves spatial memory and decreases insoluble Aβ 1-42 in APP/PS1 mice

Journal of Neuroimmune Pharmacology

Volumn 7, Issue 1, 2012, Pages 140-144

  O'Reilly, Julie Ann ^a   Lynch, Marina ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; PRESENILIN 1; ROSIGLITAZONE;

ANIMAL TISSUE; ARTICLE; FEMALE; LEARNING; MAZE TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPATIAL MEMORY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; FEMALE; MAZE LEARNING; MEMORY; MICE; NEUROPROTECTIVE AGENTS; THIAZOLIDINEDIONES;

EID: 84860742408     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-011-9282-7     Document Type: Article

References (11)

1. Escribano L, Simon AM, Gimeno E, Cuadrado-Tejedor M, Lopez de Maturana R, Garcia-Osta A, Ricobaraza A, Perez-Mediavilla A, Del Rio J, Frechilla D (2010) Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology. Neuropsychopharmacology 35:1593-1604
2. Filali M, Lalonde R, Rivest S (2011) Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer's disease. Neuropharmacology 60:930-936
3. Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, Prada C, Greenberg SM, Bacskai BJ, Frosch MP (2006) Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiol Dis 24:516-524 (Pubitemid 44716680)
4. Kapadia R, Yi JH, Vemuganti R (2008) Mechanisms of antiinflammatory and neuroprotective actions of PPAR-gamma agonists. Front Biosci 13:1813-1826 (Pubitemid 351599735)
5. Koenigsknecht-Talboo J, Landreth GE (2005) Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines. J Neurosci 25:8240-8249 (Pubitemid 41292118)
6. Liu L, Ikonen S, Heikkinen T, Tapiola T, van Groen T, Tanila H (2002) The effects of long-term treatment with metrifonate, a cholinesterase inhibitor, on cholinergic activity, amyloid pathology, and cognitive function in APP and PS1 doubly transgenic mice. Exp Neurol 173:196-204 (Pubitemid 34151371)
7. Loane DJ, Deighan BF, Clarke RM, Griffin RJ, Lynch AM, Lynch MA (2009) Interleukin-4 mediates the neuroprotective effects of rosiglitazone in the aged brain. Neurobiol Aging 30:920-931
8. McArthur S, Cristante E, Paterno M, Christian H, Roncaroli F, Gillies GE, Solito E (2010) Annexin A1: a central player in the antiinflammatory and neuroprotective role of microglia. J Immunol 185:6317-6328
9. Pedersen WA, McMillan PJ, Kulstad JJ, Leverenz JB, Craft S, Haynatzki GR (2006) Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice. Exp Neurol 199:265-273 (Pubitemid 43928978)
10. Puolivali J, Wang J, Heikkinen T, Heikkila M, Tapiola T, van Groen T, Tanila H (2002) Hippocampal A beta 42 levels correlate with spatial memory deficit in APP and PS1 double transgenic mice. Neurobiol Dis 9:339-347 (Pubitemid 34442081)
11. Toledo EM, Inestrosa NC (2010) Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer's disease. Mol Psychiatry 15(272- 285):228