Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the rat

Neuroscience

Volumn 142, Issue 4, 2006, Pages 1303-1315

  Rosi, S ^a   Vazdarjanova, A ^a,b   Ramirez Amaya, V ^a,c   Worley, P F ^d   Barnes, C A ^a,e   Wenk, G L ^f  

^a UNIVERSITY OF ARIZONA   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^d JOHNS HOPKINS UNIVERSITY   (United States)

^e UNIVERSITY OF ARIZONA   (United States)

^f OHIO STATE UNIVERSITY   (United States)

Author keywords

activated microglia; cognitive impairment; hippocampal function; immediate early gene; NMDA receptor; spatial memory consolidation

Indexed keywords

ACTIVITY REGULATED CYTOSKELETAL ASSOCIATED PROTEIN; CELL PROTEIN; LIPOPOLYSACCHARIDE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; BEHAVIOR; BINDING AFFINITY; CHRONIC DISEASE; CONTROLLED STUDY; DRUG EFFECT; ENCEPHALITIS; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; LEARNING; LOW DRUG DOSE; MALE; MEMORY DISORDER; MICROGLIA; NEUROBIOLOGY; NEUROPROTECTION; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPATIAL MEMORY;

ANIMALS; BEHAVIOR, ANIMAL; CYTOSKELETAL PROTEINS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENCEPHALITIS; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION REGULATION; GLIOSIS; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MALE; MEMANTINE; MEMORY; MEMORY DISORDERS; MICROGLIA; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; RATS; RATS, INBRED F344; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 33750353034     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2006.08.017     Document Type: Article

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