The production of IFN-γ by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4

Journal of Immunology

Volumn 166, Issue 5, 2001, Pages 3075-3082

  Schindler, H ^a   Lutz, M B ^a   Rollinghoff M ^a   Bogdan, C ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 4; MESSENGER RNA; OLIGONUCLEOTIDE; STAT4 PROTEIN; STAT6 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CELL TYPE; CONTROLLED STUDY; CYTOKINE PRODUCTION; MACROPHAGE ACTIVATION; MACROPHAGE FUNCTION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0035284905     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.5.3075     Document Type: Article

References (39)

1. The molecular cell biology of interferon-γ and its receptor
2. Interferon-γ and host antimicrobial defense: Current and future clinical applications
3. Induction of γ interferon production in human alveolar macrophages by Mycobacterium tuberculosis
4. Interferon-γ upregulates its own gene expression in mouse peritoneal macrophages
5. IL-12 induces IFN-γ expression and secretion in mouse peritoneal macrophages
6. Induction of IFN-γ in macrophages by lipopolysaccharide
7. Autoregulation by interferons provides an endogenous 'priming' signal for LPS-responsive macrophages
8. IL-12 is dysregulated in macrophages from IRF-1 and IRF-2 knockout mice
9. Murine macrophages secrete interferon-γ upon combined stimulation with IL-12 and IL-18: A novel pathway of autocrine macrophage activation
10. + lymphoid dendritic cells
11. Macrophages are a significant source of type 1 cytokines during mycobacterial infection
12. Interleukin-12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4
13. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
14. A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells
15. Requirement for type 2 NO-synthase for IL-12 responsiveness in innate immunity
16. + T cells
17. IL-12 acts directly on DC to promote nuclear localization of NF-κB and primes DC for IL-12 production
18. IL-12 responsiveness and expression of IL-12 receptor in human peripheral blood monocyte-derived dendritic cells
19. Stat4 is expressed in activated peripheral blood monocytes, dendritic cells, and macrophages at sites of Th1-mediated inflammation
20. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
21. Requirement vor Vα14 NKT cells in IL-12-mediated rejection of tumors
22. Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major
23. Regulation of type 2 NO synthase by type I interferons in macrophages infected with Leishmania major
24. Analysis of cytokine mRNA levels in interleukin-4-transgenic mice by quantitative polymerase-chain-reaction
25. Type 1 interferon (IFN-α/β) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite
26. Binding sequence of STAT4: STAT4 complex recognizes the IFN-γ activation site (GAS)-like sequence (T/A)TTCC(C/G)GGAA(T/A)
27. IL-2 induces STAT4 activation in primary NK cells and NK cell lines, but not in T cells
28. IL-4-induced expression of the IL-1 receptor antagonist gene is mediated by STAT6
29. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase
30. Rapid detection of octamer binding proteins with "mini-extracts", prepared from a small number of cells
31. IL-17 stimulates the production and expression of proinflammatory cytokines, IL-1β and TNF-α, by human macrophages
32. Modulation of macrophage function by transforming growth factor-β, interleukin 4 and interleukin 10
33. IL-11 regulates macrophage effector function through the inhibition of nuclear factor-κB
34. Interleukin-4 and interleukin-13: Their similarities and discrepancies
35. Differential utilization of Janus kinase-signal transducer and activator of transcription signaling pathways in the stimulation of human natural killer cells by IL-2, IL-12, and IFN-α
36. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
37. 1GIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates 1RAK and NFκB
38. Interleukin-18 induces interferon-γ production through NF-κB and NFAT activation in murine T helper type 1 cells
39. IL-4-induced STAT6 suppresses IFN-γ-stimulated STAT1-dependent transcription in mouse macrophages