AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation

Cell Death and Disease

Volumn 4, Issue 8, 2013, Pages

  Jackstadt, R ^a   Jung, P ^b   Hermeking, H ^a,c  

^a UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

AP4; C MYC oncogene; Cancer; P16 tumor suppressor; P21; Senescence; Transformation

Indexed keywords

BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; MYC PROTEIN; PROTEIN P16; PROTEIN P19; PROTEIN P21; RAS PROTEIN; TRANSCRIPTION FACTOR AP4; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL TRANSFORMATION; COLONY FORMATION; CONTROLLED STUDY; DNA SYNTHESIS; FIBROBLAST; IN VIVO STUDY; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; SENESCENCE; TUMOR GROWTH; UPREGULATION;

ANIMALS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL AGING; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOWN-REGULATION; HUMANS; MICE; MICE, KNOCKOUT; MUTATION; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-MYC; RAS PROTEINS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84882676636     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.282     Document Type: Article

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