Down-regulation of AP-4 inhibits proliferation, induces cell cycle arrest and promotes apoptosis in human gastric cancer cells

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Liu, Xinghua ^a   Zhang, Bo ^a   Guo, Yan ^a   Liang, Qi ^a   Wu, Changyao ^a   Wu, Lei ^a   Tao, Kaixiong ^a   Wang, Guobin ^a   Chen, Jianying ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 4 PHOSPHONOBUTYRIC ACID; CASPASE 8; CASPASE 9; CHOLECYSTOKININ OCTAPEPTIDE; CYCLIN D1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P21; PROTEIN P53;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE REGULATION; CELL PROLIFERATION; CHEMOSENSITIVITY; CONTROLLED STUDY; DIMERIZATION; DOWN REGULATION; ENZYME INHIBITION; ENZYME REPRESSION; FLOW CYTOMETRY; GENE SEQUENCE; GENE SILENCING; GENETIC TRAIT; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SEQUENCE ANALYSIS; STOMACH CANCER; WESTERN BLOTTING;

ADAPTOR PROTEIN COMPLEX 4; APOPTOSIS; BCL-X PROTEIN; CASPASE 9; CELL CYCLE CHECKPOINTS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; RNA, SMALL INTERFERING; STOMACH NEOPLASMS;

EID: 84861217899     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037096     Document Type: Article

References (50)

1. Correia M, Machado JC, Ristimaki A, (2009) Basic aspects of gastric cancer. Helicobacter 14 (Suppl 1): 36-40.
2. Alberts SR, Cervantes A, van de Velde CJ, (2003) Gastric cancer: epidemiology, pathology and treatment. Ann Oncol 14 (Suppl 2): ii31-36.
3. Catalano V, Labianca R, Beretta GD, Gatta G, de Braud F, et al. (2009) Gastric cancer. Crit Rev Oncol Hematol 71: 127-164.
4. Jones S, (2004) An overview of the basic helix-loop-helix proteins. Genome Biol 5: 226.
5. Atchley WR, Fitch WM, (1997) A natural classification of the basic helix-loop-helix class of transcription factors. Proc Natl Acad Sci U S A 94: 5172-5176.
6. Lee SU, Song HO, Lee W, Singaravelu G, Yu JR, et al. (2009) Identification and characterization of a putative basic helix-loop-helix (bHLH) transcription factor interacting with calcineurin in C. elegans. Mol Cells 28: 455-461.
7. Mermod N, Williams TJ, Tjian R, (1988) Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro. Nature 332: 557-561.
8. Hu YF, Luscher B, Admon A, Mermod N, Tjian R, (1990) Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity. Genes Dev 4: 1741-1752.
9. Jung P, Menssen A, Mayr D, Hermeking H, (2008) AP4 encodes a c-MYC-inducible repressor of p21. Proc Natl Acad Sci U S A 105: 15046-15051.
10. Jung P, Hermeking H, (2009) The c-MYC-AP4-p21 cascade. Cell Cycle 8: 982-989.
11. Dang CV, Dolde C, Gillison ML, Kato GJ, (1992) Discrimination between related DNA sites by a single amino acid residue of Myc-related basic-helix-loop-helix proteins. Proc Natl Acad Sci U S A 89: 599-602.
12. Sun XH, Copeland NG, Jenkins NA, Baltimore D, (1991) Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol 11: 5603-5611.
13. Bae Y, Kim H, Namgoong H, Baek M, Lee J, et al. (2001) Characterization of microsatellite markers adjacent to AP-4 on chromosome 16p13.3. Mol Cell Probes 15: 313-315.
14. Aranburu A, Carlsson R, Persson C, Leanderson T, (2001) Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements. Biochem J 354: 431-438.
15. Kim MY, Jeong BC, Lee JH, Kee HJ, Kook H, et al. (2006) A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. Proc Natl Acad Sci U S A 103: 13074-13079.
16. Imai K, Okamoto T, (2006) Transcriptional repression of human immunodeficiency virus type 1 by AP-4. J Biol Chem 281: 12495-12505.
17. Tsujimoto K, Ono T, Sato M, Nishida T, Oguma T, et al. (2005) Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis. J Biol Chem 280: 27638-27644.
18. Cao J, Tang M, Li WL, Xie J, Du H, et al. (2009) Upregulation of activator protein-4 in human colorectal cancer with metastasis. Int J Surg Pathol 17: 16-21.
19. Wang R, Zhang YW, Zhang X, Liu R, Hong S, et al. (2006) Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia. FASEB J 20: 1275-1277.
20. Glahder JA, Hansen CN, Vinther J, Madsen BS, Norrild B, (2003) A promoter within the E6 ORF of human papillomavirus type 16 contributes to the expression of the E7 oncoprotein from a monocistronic mRNA. J Gen Virol 84: 3429-3441.
21. Cui Y, Narayanan CS, Zhou J, Kumar A, (1998) Exon-I is involved in positive as well as negative regulation of human angiotensinogen gene expression. Gene 224: 97-107.
22. Unk I, Kiss-Toth E, Boros I, (1994) Transcription factor AP-4 participates in activation of bovine leukemia virus long terminal repeat by p34 Tax. Nucleic Acids Res 22: 4872-4875.
23. Fodor E, Weinrich SL, Meister A, Mermod N, Rutter WJ, (1991) A pancreatic exocrine cell factor and AP4 bind overlapping sites in the amylase 2A enhancer. Biochemistry 30: 8102-8108.
24. Lin TX, Huang J, Xu KW, Cai QQ, Li SY, et al. (2006) Identification of Transcr iption Factor AP-4 as the Regulator that Upregulates the Expr ession of L- plastin in Hormone-Independent Prostate Cancer. Journal of Sun Yat-Sen University(Medical Science) pp. 19-23.
25. Campbell TN, Choy FY, (2005) RNA interference: past, present and future. Curr Issues Mol Biol 7: 1-6.
26. Perrimon N, Ni JQ, Perkins L, (2010) In vivo RNAi: today and tomorrow. Cold Spring Harb Perspect Biol 2: a003640.
27. Karagiannis TC, El-Osta A, (2004) siRNAs: mechanism of RNA interference, in vivo and potential clinical applications. Cancer Biol Ther 3: 1069-1074.
28. Hannon GJ, (2002) RNA interference. Nature 418: 244-251.
29. Bi F, Liu N, Fan D, (2003) Small interfering RNA: a new tool for gene therapy. Curr Gene Ther 3: 411-417.
30. Xinghua L, Bo Z, Yan G, Lei W, Changyao W, et al. (2011) The overexpression of AP-4 as a prognostic indicator for gastric carcinoma. Med Oncol.
31. Lewis PJ, Doherty GP, Clarke J, (2008) Transcription factor dynamics. Microbiology 154: 1837-1844.
32. Pensa S, Watson CJ, Poli V, (2009) Stat3 and the inflammation/acute phase response in involution and breast cancer. J Mammary Gland Biol Neoplasia 14: 121-129.
33. Stein GS, Stein JL, Van Wijnen AJ, Lian JB, Montecino M, et al. (2010) Transcription factor-mediated epigenetic regulation of cell growth and phenotype for biological control and cancer. Adv Enzyme Regul 50: 160-167.
34. Siegel PM, Muller WJ, (2010) Transcription factor regulatory networks in mammary epithelial development and tumorigenesis. Oncogene 29: 2753-2759.
35. Edmondson DG, Olson EN, (1989) A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program. Genes Dev 3: 628-640.
36. Lassar AB, Buskin JN, Lockshon D, Davis RL, Apone S, et al. (1989) MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer. Cell 58: 823-831.
37. Ludwig SR, Habera LF, Dellaporta SL, Wessler SR, (1989) Lc, a member of the maize R gene family responsible for tissue-specific anthocyanin production, encodes a protein similar to transcriptional activators and contains the myc-homology region. Proc Natl Acad Sci U S A 86: 7092-7096.
38. Murre C, McCaw PS, Vaessin H, Caudy M, Jan LY, et al. (1989) Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 58: 537-544.
39. Murre C, McCaw PS, Baltimore D, (1989) A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56: 777-783.
40. Buechler S, (2009) Low expression of a few genes indicates good prognosis in estrogen receptor positive breast cancer. BMC Cancer 9: 243.
41. Andriamanalijaona R, Felisaz N, Kim SJ, King-Jones K, Lehmann M, et al. (2003) Mediation of interleukin-1beta-induced transforming growth factor beta1 expression by activator protein 4 transcription factor in primary cultures of bovine articular chondrocytes: possible cooperation with activator protein 1. Arthritis Rheum 48: 1569-1581.
42. Ou SH, Garcia-Martinez LF, Paulssen EJ, Gaynor RB, (1994) Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function. J Virol 68: 7188-7199.
43. Friez M, Hermansen R, Milavetz B, (1999) Chromatin structure of the simian virus 40 late promoter: a deletional analysis. J Virol 73: 1990-1997.
44. Comb M, Mermod N, Hyman SE, Pearlberg J, Ross ME, et al. (1988) Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription. EMBO J 7: 3793-3805.
45. Xiu Y, Nakamura K, Abe M, Li N, Wen XS, et al. (2002) Transcriptional regulation of Fcgr2b gene by polymorphic promoter region and its contribution to humoral immune responses. J Immunol 169: 4340-4346.
46. Abbas T, Dutta A, (2009) p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer 9: 400-414.
47. Ullrich SJ, Anderson CW, Mercer WE, Appella E, (1992) The p53 tumor suppressor protein, a modulator of cell proliferation. J Biol Chem 267: 15259-15262.
48. Li Z, Wang C, Prendergast GC, Pestell RG, (2006) Cyclin D1 functions in cell migration. Cell Cycle 5: 2440-2442.
49. Philchenkov A, (2004) Caspases: potential targets for regulating cell death. J Cell Mol Med 8: 432-444.
50. Lee CC, Lin YH, Chang WH, Lin PC, Wu YC, et al. (2011) Squamocin modulates histone H3 phosphorylation levels and induces G1 phase arrest and apoptosis in cancer cells. BMC Cancer 11: 58.