메뉴 건너뛰기




Volumn 63, Issue 4, 2013, Pages 291-301

Age-related changes in brain support cells: Implications for stroke severity

Author keywords

Aging; Astrocytes; Endothelial cells; Hormones; Stroke

Indexed keywords

ESTRADIOL; ESTROGEN; PROGESTERONE;

EID: 84882485664     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2013.06.013     Document Type: Review
Times cited : (53)

References (258)
  • 2
    • 0033962411 scopus 로고    scopus 로고
    • Inflammatory mediators and modulation of blood-brain barrier permeability
    • DOI 10.1023/A:1007074420772
    • Abbott, N.J., 2000. Inflammatory mediators and modulation of blood-brain barrier permeability. Cell Mol. Neurobiol. 20, 131-147. (Pubitemid 30091452)
    • (2000) Cellular and Molecular Neurobiology , vol.20 , Issue.2 , pp. 131-147
    • Abbott, N.J.1
  • 3
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • DOI 10.1038/nrn1824
    • Abbott, N.J., Ronnback, L., Hansson, E., 2006. Astrocyte-endothelial interactions at the blood-brain barrier. Nat. Rev. Neurosci. 7, 41-53. (Pubitemid 41828930)
    • (2006) Nature Reviews Neuroscience , vol.7 , Issue.1 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 4
    • 79551646454 scopus 로고    scopus 로고
    • Astrocytes and pericytes differentially modulate blood-brain barrier characteristics during development and hypoxic insult
    • Al Ahmad, A., Taboada, C.B., Gassmann, M., Ogunshola, O.O., 2011. Astrocytes and pericytes differentially modulate blood-brain barrier characteristics during development and hypoxic insult. J. Cereb. Blood Flow Metab. 31, 693-705.
    • (2011) J. Cereb. Blood Flow Metab. , vol.31 , pp. 693-705
    • Al Ahmad, A.1    Taboada, C.B.2    Gassmann, M.3    Ogunshola, O.O.4
  • 6
    • 59649115254 scopus 로고    scopus 로고
    • Neuroscience. Glia - More than just brain glue
    • Allen, N.J., Barres, B.A., 2009. Neuroscience. Glia - more than just brain glue. Nature 457, 675-677.
    • (2009) Nature , vol.457 , pp. 675-677
    • Allen, N.J.1    Barres, B.A.2
  • 7
    • 0036853622 scopus 로고    scopus 로고
    • Sexual differentiation of astrocyte morphology in the developing rat preoptic area
    • DOI 10.1046/j.1365-2826.2002.00858.x
    • Amateau, S.K., McCarthy, M.M., 2002. Sexual differentiation of astrocyte morphology in the developing rat preoptic area. J. Neuroendocrinol. 14, 904-910. (Pubitemid 35378708)
    • (2002) Journal of Neuroendocrinology , vol.14 , Issue.11 , pp. 904-910
    • Amateur, S.K.1    McCarthy, M.M.2
  • 8
    • 80051710005 scopus 로고    scopus 로고
    • Cellular mechanisms of neurovascular damage and repair after stroke
    • Arai, K., Lok, J., Guo, S., Hayakawa, K., Xing, C., Lo, E.H., 2011. Cellular mechanisms of neurovascular damage and repair after stroke. J. Child Neurol. 26, 1193-1198.
    • (2011) J. Child Neurol. , vol.26 , pp. 1193-1198
    • Arai, K.1    Lok, J.2    Guo, S.3    Hayakawa, K.4    Xing, C.5    Lo, E.H.6
  • 9
    • 12844268496 scopus 로고    scopus 로고
    • Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-in a rodent experimental stroke model
    • DOI 10.1161/01.STR.0000153795.38388.72
    • Ardelt, A.A., McCullough, L.D., Korach, K.S., Wang, M.M., Munzenmaier, D.H., Hurn, P.D., 2005. Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor - Alpha in a rodent experimental stroke model. Stroke 36, 337-341. (Pubitemid 40170819)
    • (2005) Stroke , vol.36 , Issue.2 , pp. 337-341
    • Ardelt, A.A.1    McCullough, L.D.2    Korach, K.S.3    Wang, M.M.4    Munzenmaier, D.H.5    Hurn, P.D.6
  • 10
    • 34250657404 scopus 로고    scopus 로고
    • Estradiol augments peri-infarct cerebral vascular density in experimental stroke
    • DOI 10.1016/j.expneurol.2007.04.002, PII S001448860700163X
    • Ardelt, A.A., Anjum, N., Rajneesh, K.F., Kulesza, P., Koehler, R.C., 2007. Estradiol augments peri-infarct cerebral vascular density in experimental stroke. Exp. Neurol. 206, 95-100. (Pubitemid 46935127)
    • (2007) Experimental Neurology , vol.206 , Issue.1 , pp. 95-100
    • Ardelt, A.A.1    Anjum, N.2    Rajneesh, K.F.3    Kulesza, P.4    Koehler, R.C.5
  • 11
    • 25444463573 scopus 로고    scopus 로고
    • Endothelial/pericyte interactions
    • DOI 10.1161/01.RES.0000182903.16652.d7
    • Armulik, A., Abramsson, A., Betsholtz, C., 2005. Endothelial/pericyte interactions. Circ. Res. 97, 512-523. (Pubitemid 41361741)
    • (2005) Circulation Research , vol.97 , Issue.6 , pp. 512-523
    • Armulik, A.1    Abramsson, A.2    Betsholtz, C.3
  • 12
    • 24044471286 scopus 로고    scopus 로고
    • Estrogen suppresses the impact of glucose deprivation on astrocytic calcium levels and signaling independently of the nuclear estrogen receptor
    • DOI 10.1016/j.nbd.2005.02.002, PII S096999610500063X
    • Arnold, S., 2005. Estrogen suppresses the impact of glucose deprivation on astrocytic calcium levels and signaling independently of the nuclear estrogen receptor. Neurobiol. Dis. 20, 82-92. (Pubitemid 41219205)
    • (2005) Neurobiology of Disease , vol.20 , Issue.1 , pp. 82-92
    • Arnold, S.1
  • 16
    • 9444289385 scopus 로고    scopus 로고
    • 17-estradiol differentially regulates blood-brain barrier permeability in young and aging female rats
    • DOI 10.1210/en.2004-0984
    • Bake, S., Sohrabji, F., 2004. 17b-Estradiol differentially regulate blood-brain barrier permeability in young and aging female rats. Endocrinology 145, 5471-5475. (Pubitemid 39564586)
    • (2004) Endocrinology , vol.145 , Issue.12 , pp. 5471-5475
    • Bake, S.1    Sohrabji, F.2
  • 17
    • 71549122565 scopus 로고    scopus 로고
    • Reproductive age-related changes in the blood brain barrier: Expression of IgG and tight junction proteins
    • Bake, S., Friedman, J.A., Sohrabji, F., 2009. Reproductive age-related changes in the blood brain barrier: expression of IgG and tight junction proteins. Microvasc. Res. 78, 413-424.
    • (2009) Microvasc. Res. , vol.78 , pp. 413-424
    • Bake, S.1    Friedman, J.A.2    Sohrabji, F.3
  • 18
    • 84860316413 scopus 로고    scopus 로고
    • Vitamin D deficiency exacerbates experimental stroke injury and dysregulates ischemia-induced inflammation in adult rats
    • Balden, R., Selvamani, A., Sohrabji, F., 2012. Vitamin D deficiency exacerbates experimental stroke injury and dysregulates ischemia-induced inflammation in adult rats. Endocrinology 153, 2420-2435.
    • (2012) Endocrinology , vol.153 , pp. 2420-2435
    • Balden, R.1    Selvamani, A.2    Sohrabji, F.3
  • 19
    • 0030106237 scopus 로고    scopus 로고
    • Intermediate filament change in astrocytes following mild cortical contusion
    • DOI 10.1002/(SICI)1098-1136(199 603)16:3<266::AID-GLIA9>3.0.CO;2-#
    • Baldwin, S.A., Scheff, S.W., 1996. Intermediate filament change in astrocytes following mild cortical contusion. Glia 16, 266-275. (Pubitemid 26309469)
    • (1996) GLIA , vol.16 , Issue.3 , pp. 266-275
    • Baldwin, S.A.1    Scheff, S.W.2
  • 20
    • 0031238648 scopus 로고    scopus 로고
    • Leukemia inhibitory factor is expressed in astrocytes following cortical brain injury
    • DOI 10.1006/exnr.1997.6536
    • Banner, L.R., Moayeri, N.N., Patterson, P.H., 1997. Leukemia inhibitory factor is expressed in astrocytes following cortical brain injury. Exp. Neurol. 147, 1-9. (Pubitemid 27402437)
    • (1997) Experimental Neurology , vol.147 , Issue.1 , pp. 1-9
    • Banner, L.R.1    Moayeri, N.N.2    Patterson, P.H.3
  • 21
    • 0030176199 scopus 로고    scopus 로고
    • Sex differences in susceptibility to viral infection of the central nervous system
    • DOI 10.1016/S0165-5728(96)00022-7
    • Barna, M., Komatsu, T., Bi, Z., Reiss, C.S., 1996. Sex differences in susceptibility to viral infection of the central nervous system. J. Neuroimmunol. 67, 31-39. (Pubitemid 26245701)
    • (1996) Journal of Neuroimmunology , vol.67 , Issue.1 , pp. 31-39
    • Barna, M.1    Komatsu, T.2    Bi, Z.3    Reiss, C.S.4
  • 22
    • 34249994344 scopus 로고    scopus 로고
    • Testosterone decreases reactive astroglia and reactive microglia after brain injury in male rats: Role of its metabolites, oestradiol and dihydrotestosterone
    • DOI 10.1111/j.1460-9568.2007.05563.x
    • Barreto, G., Veiga, S., Azcoitia, I., Garcia-Segura, L.M., Garcia-Ovejero, D., 2007. Testosterone decreases reactive astroglia and reactive microglia after brain injury in male rats: role of its metabolites, oestradiol and dihydrotestosterone. Eur. J. Neurosci. 25, 3039-3046. (Pubitemid 46888812)
    • (2007) European Journal of Neuroscience , vol.25 , Issue.10 , pp. 3039-3046
    • Barreto, G.1    Veiga, S.2    Azcoitia, I.3    Garcia-Segura, L.M.4    Garcia-Ovejero, D.5
  • 23
    • 70350322693 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators decrease reactive astrogliosis in the injured brain: Effects of aging and prolonged depletion of ovarian hormones
    • Barreto, G., Santos-Galindo, M., Diz-Chaves, Y., Pernia, O., Carrero, P., Azcoitia, I., Garcia-Segura, L.M., 2009. Selective estrogen receptor modulators decrease reactive astrogliosis in the injured brain: effects of aging and prolonged depletion of ovarian hormones. Endocrinology 150, 5010-5015.
    • (2009) Endocrinology , vol.150 , pp. 5010-5015
    • Barreto, G.1    Santos-Galindo, M.2    Diz-Chaves, Y.3    Pernia, O.4    Carrero, P.5    Azcoitia, I.6    Garcia-Segura, L.M.7
  • 24
    • 64449086483 scopus 로고    scopus 로고
    • Angiogenesis after cerebral ischemia
    • Beck, H., Plate, K.H., 2009. Angiogenesis after cerebral ischemia. Acta Neuropathol. 117, 481-496.
    • (2009) Acta Neuropathol. , vol.117 , pp. 481-496
    • Beck, H.1    Plate, K.H.2
  • 25
    • 78049279739 scopus 로고    scopus 로고
    • Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging
    • Bell, R.D., Winkler, E.A., Sagare, A.P., Singh, I., LaRue, B., Deane, R., Zlokovic, B.V., 2010. Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron 68, 409-427.
    • (2010) Neuron , vol.68 , pp. 409-427
    • Bell, R.D.1    Winkler, E.A.2    Sagare, A.P.3    Singh, I.4    LaRue, B.5    Deane, R.6    Zlokovic, B.V.7
  • 26
    • 79955483643 scopus 로고    scopus 로고
    • Hypoxia-induced angiogenesis is delayed in aging mouse brain
    • Benderro, G.F., Lamanna, J.C., 2011. Hypoxia-induced angiogenesis is delayed in aging mouse brain. Brain Res. 1389, 50-60.
    • (2011) Brain Res. , vol.1389 , pp. 50-60
    • Benderro, G.F.1    Lamanna, J.C.2
  • 28
    • 0024156737 scopus 로고
    • Age-related changes in regional cerebral blood flow and behavior in Sprague-Dawley rats
    • Berman, R.F., Goldman, H., Altman, H.J., 1988. Age-related changes in regional cerebral blood flow and behavior in Sprague-Dawley rats. Neurobiol. Aging 9, 691-696. (Pubitemid 19264164)
    • (1988) Neurobiology of Aging , vol.9 , Issue.5-6 , pp. 691-696
    • Berman, R.F.1    Goldman, H.2    Altman, H.J.3
  • 29
    • 79955951360 scopus 로고    scopus 로고
    • Phenotypic and gene expression modification with normal brain aging in GFAP-positive astrocytes and neural stem cells
    • Bernal, G.M., Peterson, D.A., 2011. Phenotypic and gene expression modification with normal brain aging in GFAP-positive astrocytes and neural stem cells. Aging Cell 10, 466-482.
    • (2011) Aging Cell , vol.10 , pp. 466-482
    • Bernal, G.M.1    Peterson, D.A.2
  • 30
    • 0028819489 scopus 로고
    • Estradiol enhances brain glucose uptake in ovariectomized rats
    • Bishop, J., Simpkins, J., 1995. Estradiol enhances brain glucose uptake in ovariectomized rats. Brain Res. Bull. 36, 315-320.
    • (1995) Brain Res. Bull. , vol.36 , pp. 315-320
    • Bishop, J.1    Simpkins, J.2
  • 31
    • 0014481056 scopus 로고
    • Junctions between intimately apposed cell membranes in the vertebrate brain
    • Brightman, M.W., Reese, T.S., 1969. Junctions between intimately apposed cell membranes in the vertebrate brain. J. Cell Biol. 40, 648-677.
    • (1969) J. Cell Biol. , vol.40 , pp. 648-677
    • Brightman, M.W.1    Reese, T.S.2
  • 32
    • 19744379517 scopus 로고    scopus 로고
    • Endothelium-derived hyperpolarizing factor: A cousin to nitric oxide and prostacyclin
    • DOI 10.1097/00000542-200506000-00028
    • Bryan Jr., R.M., You, J., Golding, E.M., Marrelli, S.P., 2005. Endothelium-derived hyperpolarizing factor: a cousin to nitric oxide and prostacyclin. Anesthesiology 102, 1261-1277. (Pubitemid 40745846)
    • (2005) Anesthesiology , vol.102 , Issue.6 , pp. 1261-1277
    • Bryan Jr., R.M.1    You, J.2    Golding, E.M.3    Marrelli, S.P.4
  • 38
    • 33746899361 scopus 로고    scopus 로고
    • Cytoarchitecture of fibroblast growth factor receptor 2 (FGFR-2) immunoreactivity in astrocytes of neurogenic and non-neurogenic regions of the young adult and aged rat brain
    • DOI 10.1002/cne.21009
    • Chadashvili, T., Peterson, D.A., 2006. Cytoarchitecture of fibroblast growth factor receptor 2 (FGFR-2) immunoreactivity in astrocytes of neurogenic and non-neurogenic regions of the young adult and aged rat brain. J. Comp. Neurol. 498, 1-15. (Pubitemid 44198730)
    • (2006) Journal of Comparative Neurology , vol.498 , Issue.1 , pp. 1-15
    • Chadashvili, T.1    Peterson, D.A.2
  • 39
    • 38149062166 scopus 로고    scopus 로고
    • Hypoxia, hormones, and endothelial progenitor cells in hemangioma
    • Chang, E.I., Thangarajah, H., Hamou, C., Gurtner, G.C., 2007. Hypoxia, hormones, and endothelial progenitor cells in hemangioma. Lymphat Res. Biol. 5, 237-243.
    • (2007) Lymphat Res. Biol. , vol.5 , pp. 237-243
    • Chang, E.I.1    Thangarajah, H.2    Hamou, C.3    Gurtner, G.C.4
  • 40
    • 38349157293 scopus 로고    scopus 로고
    • Shear stress and 17beta-estradiol modulate cerebral microvascular endothelial na-K-cl cotransporter and na/H exchanger protein levels
    • Chang, E., O'Donnell, M.E., Barakat, A.I., 2008. Shear stress and 17beta-estradiol modulate cerebral microvascular endothelial Na-K-Cl cotransporter and Na/H exchanger protein levels. Am. J. Physiol. Cell Physiol. 294, C363-371.
    • (2008) Am. J. Physiol. Cell Physiol. , vol.294
    • Chang, E.1    O'Donnell, M.E.2    Barakat, A.I.3
  • 41
    • 79959617416 scopus 로고    scopus 로고
    • Circulating endothelial progenitor cells and cellular membrane microparticles in db/db diabetic mouse: Possible implications in cerebral ischemic damage
    • Chen, J., Chen, S., Chen, Y., Zhang, C., Wang, J., Zhang, W., Liu, G., Zhao, B., 2011. Circulating endothelial progenitor cells and cellular membrane microparticles in db/db diabetic mouse: possible implications in cerebral ischemic damage. Am. J. Physiol. Endocrinol. Metab. 301, E62-71.
    • (2011) Am. J. Physiol. Endocrinol. Metab. , vol.301
    • Chen, J.1    Chen, S.2    Chen, Y.3    Zhang, C.4    Wang, J.5    Zhang, W.6    Liu, G.7    Zhao, B.8
  • 42
    • 0036708602 scopus 로고    scopus 로고
    • Effects of 17-estradiol on blood-brain barrier disruption during focal ischemia in rats
    • DOI 10.1055/s-2002-34794
    • Chi, O., Liu, X., Weiss, H., 2002. Effects of 17beta-estradiol on blood-brain barrier disruption during focal ischemia in rats. Horm. Metab. Res. 34, 530-534. (Pubitemid 35192241)
    • (2002) Hormone and Metabolic Research , vol.34 , Issue.9 , pp. 530-534
    • Chi, O.Z.1    Liu, X.2    Weiss, H.R.3
  • 43
    • 2542527642 scopus 로고    scopus 로고
    • 17-Estradiol prevents blood-brain barrier disruption induced by VEGF
    • DOI 10.1055/s-2004-814478
    • Chi, O., Barsoum, S., Wen, Y., Liu, X., Weiss, H., 2004. 17beta-estradiol prevents blood-brain barrier disruption induced by VEGF. Horm. Metab. Res. 36, 272-276. (Pubitemid 38703785)
    • (2004) Hormone and Metabolic Research , vol.36 , Issue.5 , pp. 272-276
    • Chi, O.Z.1    Barsoum, S.2    Wen, Y.3    Liu, X.4    Weiss, H.R.5
  • 44
    • 19944369069 scopus 로고    scopus 로고
    • A receptor inhibition
    • DOI 10.1055/s-2005-861379
    • Chi, O.Z., Hunter, C., Liu, X., Weiss, H.R., 2005. Effects of 17beta-estradiol on blood-brain barrier disruption in focal ischemia during GABA(A) receptor inhibition. Horm. Metab. Res. 37, 209-213. (Pubitemid 40756340)
    • (2005) Hormone and Metabolic Research , vol.37 , Issue.4 , pp. 209-213
    • Chi, O.Z.1    Hunter, C.2    Liu, X.3    Weiss, H.R.4
  • 45
    • 0013278301 scopus 로고    scopus 로고
    • Treatment of neural injury with marrow stromal cells
    • DOI 10.1016/S1474-4422(02)00040-6
    • Chopp, M., Li, Y., 2002. Treatment of neural injury with marrow stromal cells. Lancet Neurol. 1, 92-100. (Pubitemid 37163494)
    • (2002) Lancet Neurology , vol.1 , Issue.2 , pp. 92-100
    • Chopp, M.1    Li, Y.2
  • 46
    • 33846588450 scopus 로고    scopus 로고
    • Neurogenesis, angiogenesis, and MRI indices of functional recovery from stroke
    • DOI 10.1161/01.STR.0000250235.80253.e9, PII 0000767020070200100049
    • Chopp, M., Zhang, Z.G., Jiang, Q., 2007. Neurogenesis, angiogenesis, and MRI indices of functional recovery from stroke. Stroke 38, 827-831. (Pubitemid 46184266)
    • (2007) Stroke , vol.38 , Issue.2 , pp. 827-831
    • Chopp, M.1    Zhang, Z.G.2    Jiang, Q.3
  • 47
    • 44449087015 scopus 로고    scopus 로고
    • Circulating endothelial progenitor cells as a new marker of endothelial dysfunction or repair in acute stroke
    • Chu, K., Jung, K.H., Lee, S.T., et al., 2008. Circulating endothelial progenitor cells as a new marker of endothelial dysfunction or repair in acute stroke. Stroke 39, 1441-1447.
    • (2008) Stroke , vol.39 , pp. 1441-1447
    • Chu, K.1    Jung, K.H.2    Lee, S.T.3
  • 48
    • 0024826077 scopus 로고
    • Increased vesicular transport and decreased mitochondrial content in blood-brain barrier endothelial cells during experimental autoimmune encephalomyelitis
    • Claudio, L., Kress, Y., Norton, W.T., Brosnan, C.F., 1989. Increased vesicular transport and decreased mitochondrial content in blood-brain barrier endothelial cells during experimental autoimmune encephalomyelitis. Am. J. Pathol. 135, 1157-1168. (Pubitemid 20026535)
    • (1989) American Journal of Pathology , vol.135 , Issue.6 , pp. 1157-1168
    • Claudio, L.1    Kress, Y.2    Norton, W.T.3    Brosnan, C.F.4
  • 49
    • 41249092093 scopus 로고    scopus 로고
    • Live imaging of neuroinflammation reveals sex and estrogen effects on astrocyte response to ischemic injury
    • DOI 10.1161/STROKEAHA.107.501460
    • Cordeau Jr., P., Lalancette-Hebert, M., Weng, Y.C., Kriz, J., 2008. Live imaging of neuroinflammation reveals sex and estrogen effects on astrocyte response to ischemic injury. Stroke 39, 935-942. (Pubitemid 351619580)
    • (2008) Stroke , vol.39 , Issue.3 , pp. 935-942
    • Cordeau Jr., P.1    Lalancette-Hebert, M.2    Weng, Y.C.3    Kriz, J.4
  • 50
    • 21644475628 scopus 로고    scopus 로고
    • Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with aging
    • DOI 10.2174/1570161054368616
    • Csiszar, A., Pacher, P., Kaley, G., Ungvari, Z., 2005. Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with aging. Curr. Vasc. Pharmacol. 3, 285-291. (Pubitemid 40933050)
    • (2005) Current Vascular Pharmacology , vol.3 , Issue.3 , pp. 285-291
    • Csiszar, A.1    Pacher, P.2    Kaley, G.3    Ungvari, Z.4
  • 51
    • 55449136486 scopus 로고    scopus 로고
    • Inflammation and endothelial dysfunction during aging: Role of NF-kappaB
    • Csiszar, A., Wang, M., Lakatta, E.G., Ungvari, Z., 2008. Inflammation and endothelial dysfunction during aging: role of NF-kappaB. J. Appl. Physiol. 105, 1333-1341.
    • (2008) J. Appl. Physiol. , vol.105 , pp. 1333-1341
    • Csiszar, A.1    Wang, M.2    Lakatta, E.G.3    Ungvari, Z.4
  • 52
    • 77951264436 scopus 로고    scopus 로고
    • Cardiac aging in mice and humans: The role of mitochondrial oxidative stress
    • Dai, D.F., Rabinovitch, P.S., 2009. Cardiac aging in mice and humans: the role of mitochondrial oxidative stress. Trends Cardiovasc. Med. 19, 213-220.
    • (2009) Trends Cardiovasc. Med. , vol.19 , pp. 213-220
    • Dai, D.F.1    Rabinovitch, P.S.2
  • 53
    • 0027295577 scopus 로고
    • Gonadal steroids regulate the expression of glial fibrillary acidic protein in the adult male rat hippocampus
    • DOI 10.1016/0306-4522(93)90512-E
    • Day, J.R., Laping, N.J., Lampert-Etchells, M., Brown, S.A., O'Callaghan, J.P., McNeill, T.H., Finch, C.E., 1993. Gonadal steroids regulate the expression of glial fibrillary acidic protein in the adult male rat hippocampus. Neuroscience 55, 435-443. (Pubitemid 23211355)
    • (1993) Neuroscience , vol.55 , Issue.2 , pp. 435-443
    • Day, J.R.1    Laping, N.J.2    Lampert-Etchellis, M.3    Brown, S.A.4    O'Callaghan, J.P.5    McNeill, T.H.6    Finch, C.E.7
  • 54
    • 33747417084 scopus 로고    scopus 로고
    • Integrin-matrix interactions in the cerebral microvasculature
    • DOI 10.1161/01.ATV.0000232525.65682.a2, PII 0004360520060900000007
    • del Zoppo, G.J., Milner, R., 2006. Integrin-matrix interactions in the cerebral microvasculature. Arterioscler Thromb Vasc. Biol. 26, 1966-1975. (Pubitemid 44253776)
    • (2006) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.26 , Issue.9 , pp. 1966-1975
    • Del Zoppo, G.J.1    Milner, R.2
  • 56
    • 0032171457 scopus 로고    scopus 로고
    • From neuro-glue ('Nervenkitt') to glia: A prologue
    • DOI 10.1002/(SICI)1098-1136(199 809)24:1<1::AID-GLIA1>3.0.CO;2-A
    • Dermietzel, R., Spray, D.C., 1998. From neuro-glue ('Nervenkitt') to glia: a prologue. Glia 24, 1-7. (Pubitemid 28370207)
    • (1998) GLIA , vol.24 , Issue.1 , pp. 1-7
    • Dermietzel, R.1    Spray, D.C.2
  • 61
    • 0028343330 scopus 로고
    • Gonadal hormone regulation of insulin-like growth factor-I-like immunoreactivity in hypothalamic astroglia of developing and adult rats
    • Duenas, M., Luquin, S., Chowen, J.A., Torres-Aleman, I., Naftolin, F., Garcia-Segura, L.M., 1994. Gonadal hormone regulation of insulin-like growth factor-I-like immunoreactivity in hypothalamic astroglia of developing and adult rats. Neuroendocrinology 59, 528-538. (Pubitemid 24159937)
    • (1994) Neuroendocrinology , vol.59 , Issue.6 , pp. 528-538
    • Duenas, M.1    Luquin, S.2    Chowen, J.A.3    Torres-Aleman, I.4    Naftolin, F.5    Garcia-Segura, L.M.6
  • 62
    • 18244421981 scopus 로고    scopus 로고
    • Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function
    • Edelberg, J.M., Tang, L., Hattori, K., Lyden, D., Rafii, S., 2002. Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function. Circ. Res. 90, E89-93.
    • (2002) Circ. Res. , vol.90
    • Edelberg, J.M.1    Tang, L.2    Hattori, K.3    Lyden, D.4    Rafii, S.5
  • 63
    • 0027252930 scopus 로고
    • Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans
    • Egashira, K., Inou, T., Hirooka, Y., Kai, H., Sugimachi, M., Suzuki, S., Kuga, T., Urabe, Y., Takeshita, A., 1993. Effects of age on endothelium- dependent vasodilation of resistance coronary artery by acetylcholine in humans. Circulation 88, 77-81. (Pubitemid 23195435)
    • (1993) Circulation , vol.88 , Issue.1 , pp. 77-81
    • Egashira, K.1    Inou, T.2    Hirooka, Y.3    Kai, H.4    Sugimachi, M.5    Suzuki, S.6    Kuga, T.7    Urabe, Y.8    Takeshita, A.9
  • 64
    • 41949096047 scopus 로고    scopus 로고
    • Blood-brain barrier: Ageing and microvascular disease - Systematic review and meta-analysis
    • Farrall, A. J. and Wardlaw, J. M. (2007) Blood-brain barrier: Ageing and microvascular disease - systematic review and meta-analysis. Neurobiol. Aging.
    • (2007) Neurobiol. Aging.
    • Farrall, A.J.1    Wardlaw, J.M.2
  • 65
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • DOI 10.1038/nm0603-669
    • Ferrara, N., Gerber, H.P., LeCouter, J., 2003. The biology of VEGF and its receptors. Nat. Med. 9, 669-676. (Pubitemid 36749215)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 669-676
    • Ferrara, N.1    Gerber, H.-P.2    LeCouter, J.3
  • 66
    • 79953687365 scopus 로고    scopus 로고
    • Effects on DHEA levels by estrogen in rat astrocytes and CNS co-cultures via the regulation of CYP7B1-mediated metabolism
    • Fex Svenningsen, A., Wicher, G., Lundqvist, J., Pettersson, H., Corell, M., Norlin, M., 2011. Effects on DHEA levels by estrogen in rat astrocytes and CNS co-cultures via the regulation of CYP7B1-mediated metabolism. Neurochem. Int. 58, 620-624.
    • (2011) Neurochem. Int. , vol.58 , pp. 620-624
    • Fex Svenningsen, A.1    Wicher, G.2    Lundqvist, J.3    Pettersson, H.4    Corell, M.5    Norlin, M.6
  • 67
    • 0020461752 scopus 로고
    • 6 glioma cells
    • Fontana, A., Kristensen, F., Dubs, R., Gemsa, D., Weber, E., 1982. Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells. J. Immunol. 129, 2413-2419. (Pubitemid 13245498)
    • (1982) Journal of Immunology , vol.129 , Issue.6 , pp. 2413-2419
    • Fontana, A.1    Kristensen, F.2    Dubs, R.3
  • 68
    • 80052407109 scopus 로고    scopus 로고
    • Development of a method for the purification and culture of rodent astrocytes
    • Foo, L.C., Allen, N.J., Bushong, E.A., et al., 2011. Development of a method for the purification and culture of rodent astrocytes. Neuron 71, 799-811.
    • (2011) Neuron , vol.71 , pp. 799-811
    • Foo, L.C.1    Allen, N.J.2    Bushong, E.A.3
  • 69
    • 0028134869 scopus 로고
    • Female sex hormones inhibit volume regulation in rat brain astrocyte culture
    • Fraser, C.L., Swanson, R.A., 1994. Female sex hormones inhibit volume regulation in rat brain astrocyte culture. Am. J. Physiol. 267, C909-914.
    • (1994) Am. J. Physiol. , vol.267
    • Fraser, C.L.1    Swanson, R.A.2
  • 70
    • 1342330534 scopus 로고    scopus 로고
    • Steroid Hormones and Growth Factors Act in an Integrated Manner at the Levels of Hypothalamic Astrocytes: A Role in the Neuroendocrine Control of Reproduction
    • DOI 10.1196/annals.1286.016
    • Galbiati, M., Saredi, S., Melcangi, R.C., 2003. Steroid hormones and growth factors act in an integrated manner at the levels of hypothalamic astrocytes: a role in the neuroendocrine control of reproduction. Ann. NY Acad. Sci. 1007, 162-168. (Pubitemid 38253663)
    • (2003) Annals of the New York Academy of Sciences , vol.1007 , pp. 162-168
    • Galbiati, M.1    Saredi, S.2    Melcangi, R.C.3
  • 71
    • 0018833681 scopus 로고
    • 125I-labeled albumin in female rats
    • Gammal, E., Zuk, A., 1980. Effect of ethinyl estradiol on endothelial permeability to 125I-labeled albumin in female rats. Exp. Mol. Pathol. 32, 91-101. (Pubitemid 10131303)
    • (1980) Experimental and Molecular Pathology , vol.32 , Issue.1 , pp. 91-101
    • Gammal, E.B.1    Zuk, A.2
  • 72
    • 70350561897 scopus 로고    scopus 로고
    • Attenuation of brain response to vascular endothelial growth factor-mediated angiogenesis and neurogenesis in aged mice
    • Gao, P., Shen, F., Gabriel, R.A., Law, D., Yang, E., Yang, G.Y., Young, W.L., Su, H., 2009. Attenuation of brain response to vascular endothelial growth factor-mediated angiogenesis and neurogenesis in aged mice. Stroke 40, 3596-3600.
    • (2009) Stroke , vol.40 , pp. 3596-3600
    • Gao, P.1    Shen, F.2    Gabriel, R.A.3    Law, D.4    Yang, E.5    Yang, G.Y.6    Young, W.L.7    Su, H.8
  • 73
    • 0026700490 scopus 로고
    • Expression of insulin-like growth factor I by astrocytes in response to injury
    • Garcia-Estrada, J., Garcia-Segura, L.M., Torres-Aleman, I., 1992. Expression of insulin-like growth factor I by astrocytes in response to injury. Brain Res. 592, 343-347.
    • (1992) Brain Res. , vol.592 , pp. 343-347
    • Garcia-Estrada, J.1    Garcia-Segura, L.M.2    Torres-Aleman, I.3
  • 74
    • 0027520373 scopus 로고
    • Gonadal hormones down-regulate reactive gliosis and astrocyte proliferation after a penetrating brain injury
    • DOI 10.1016/0006-8993(93)90964-O
    • Garcia-Estrada, J., Del Rio, J.A., Luquin, S., Soriano, E., Garcia-Segura, L.M., 1993. Gonadal hormones down-regulate reactive gliosis and astrocyte proliferation after a penetrating brain injury. Brain Res. 628, 271-278. (Pubitemid 23331618)
    • (1993) Brain Research , vol.628 , Issue.1-2 , pp. 271-278
    • Garcia-Estrada, J.1    Del Rio, J.A.2    Luquin, S.3    Soriano, E.4    Garcia-Segura, L.M.5
  • 75
    • 0344492735 scopus 로고    scopus 로고
    • Dehydroepiandrosterone, pregnenolone and sex steroids down-regulate reactive astroglia in the male rat brain after a penetrating brain injury
    • DOI 10.1016/S0736-5748(98)00065-3, PII S0736574898000653
    • Garcia-Estrada, J., Luquin, S., Fernandez, A.M., Garcia-Segura, L.M., 1999. Dehydroepiandrosterone, pregnenolone and sex steroids down-regulate reactive astroglia in the male rat brain after a penetrating brain injury. Int. J. Dev. Neurosci. 17, 145-151. (Pubitemid 29148274)
    • (1999) International Journal of Developmental Neuroscience , vol.17 , Issue.2 , pp. 145-151
    • Garcia-Estrada, J.1    Luquin, S.2    Fernandez, A.M.3    Garcia-Segura, L.M.4
  • 76
    • 0023765747 scopus 로고
    • The distribution of glial fibrillary acidic protein in the adult rat brain is influenced by the neonatal levels of sex steroids
    • Garcia-Segura, L.M., Suarez, I., Segovia, S., Tranque, P.A., Cales, J.M., Aguilera, P., Olmos, G., Guillamon, A., 1988. The distribution of glial fibrillary acidic protein in the adult rat brain is influenced by the neonatal levels of sex steroids. Brain Res. 456, 357-363.
    • (1988) Brain Res. , vol.456 , pp. 357-363
    • Garcia-Segura, L.M.1    Suarez, I.2    Segovia, S.3    Tranque, P.A.4    Cales, J.M.5    Aguilera, P.6    Olmos, G.7    Guillamon, A.8
  • 77
    • 0024400239 scopus 로고
    • Astrocytic shape and glial fibrillary acidic protein immunoreactivity are modified by estradiol in primary rat hypothalamic cultures
    • DOI 10.1016/0165-3806(89)90186-7
    • Garcia-Segura, L.M., Torres-Aleman, I., Naftolin, F., 1989. Astrocytic shape and glial fibrillary acidic protein immunoreactivity are modified by estradiol in primary rat hypothalamic cultures. Brain Res. Dev. Brain Res. 47, 298-302. (Pubitemid 19149875)
    • (1989) Developmental Brain Research , vol.47 , Issue.2 , pp. 298-302
    • Garcia-Segura, L.M.1    Torres-Aleman, I.2    Naftolin, F.3
  • 78
    • 0029758451 scopus 로고    scopus 로고
    • FGF-1-dependent proliferative and migratory responses are impaired in senescent human umbilical vein endothelial cells and correlate with the inability to signal tyrosine phosphorylation of fibroblast growth factor receptor-1 substrates
    • Garfinkel, S., Hu, X., Prudovsky, I.A., McMahon, G.A., Kapnik, E.M., McDowell, S.D., Maciag, T., 1996. FGF-1-dependent proliferative and migratory responses are impaired in senescent human umbilical vein endothelial cells and correlate with the inability to signal tyrosine phosphorylation of fibroblast growth factor receptor-1 substrates. J. Cell Biol. 134, 783-791. (Pubitemid 26269147)
    • (1996) Journal of Cell Biology , vol.134 , Issue.3 , pp. 783-791
    • Garfinkel, S.1    Hu, X.2    Prudovsky, I.A.3    McMahon, G.A.4    Kapnik, E.M.5    McDowell, S.D.6    Maciag, T.7
  • 80
    • 33750879820 scopus 로고    scopus 로고
    • Estrogen reduces myogenic tone through a nitric oxide-dependent mechanism in rat cerebral arteries
    • Geary, G.G., Krause, D.N., Duckles, S.P., 1998. Estrogen reduces myogenic tone through a nitric oxide-dependent mechanism in rat cerebral arteries. Am. J. Physiol. 275, H292-300.
    • (1998) Am. J. Physiol. , vol.275
    • Geary, G.G.1    Krause, D.N.2    Duckles, S.P.3
  • 81
    • 0030006173 scopus 로고    scopus 로고
    • Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans
    • Gerhard, M., Roddy, M.A., Creager, S.J., Creager, M.A., 1996. Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans. Hypertension 27, 849-853. (Pubitemid 26113830)
    • (1996) Hypertension , vol.27 , Issue.4 , pp. 849-853
    • Gerhard, M.1    Roddy, M.-A.2    Creager, S.J.3    Creager, M.A.4
  • 82
    • 0242405617 scopus 로고    scopus 로고
    • Endothelial-pericyte interactions in angiogenesis
    • DOI 10.1007/s00441-003-0745-x
    • Gerhardt, H., Betsholtz, C., 2003. Endothelial-pericyte interactions in angiogenesis. Cell Tissue Res. 314, 15-23. (Pubitemid 37409909)
    • (2003) Cell and Tissue Research , vol.314 , Issue.1 , pp. 15-23
    • Gerhardt, H.1    Betsholtz, C.2
  • 84
    • 84872054233 scopus 로고    scopus 로고
    • Executive summary: Heart disease and stroke statistics-2013 update: A report from the American heart association
    • Go, A.S., Mozaffarian, D., Roger, V.L., et al., 2013. Executive summary: heart disease and stroke statistics-2013 update: a report from the American Heart Association. Circulation 127, 143-152.
    • (2013) Circulation , vol.127 , pp. 143-152
    • Go, A.S.1    Mozaffarian, D.2    Roger, V.L.3
  • 85
    • 0030722556 scopus 로고    scopus 로고
    • Exaggerated astrocyte reactivity after nigrostriatal deafferentation in the aged rat
    • DOI 10.1002/(SICI)1096-9861(1997 1110)388:1<106::AID-CNE7>3.0.CO;2- 5
    • Gordon, M.N., Schreier, W.A., Ou, X., Holcomb, L.A., Morgan, D.G., 1997. Exaggerated astrocyte reactivity after nigrostriatal deafferentation in the aged rat. J. Comp. Neurol. 388, 106-119. (Pubitemid 27485635)
    • (1997) Journal of Comparative Neurology , vol.388 , Issue.1 , pp. 106-119
    • Gordon, M.N.1    Schreier, W.A.2    Ou, X.3    Holcomb, L.A.4    Morgan, D.G.5
  • 86
    • 80053458900 scopus 로고    scopus 로고
    • Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases
    • Grammas, P., Martinez, J., Miller, B., 2011. Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases. Expert Rev. Mol. Med. 13, e19.
    • (2011) Expert Rev. Mol. Med. , vol.13
    • Grammas, P.1    Martinez, J.2    Miller, B.3
  • 87
    • 0031817149 scopus 로고    scopus 로고
    • Angiogenesis and stroke
    • DOI 10.1358/dnp.1998.11.5.657287
    • Greenberg, D.A., 1998. Angiogenesis and stroke. Drug News Perspect 11, 265-270. (Pubitemid 28355863)
    • (1998) Drug News and Perspectives , vol.11 , Issue.5 , pp. 265-270
    • Greenberg, D.A.1
  • 89
    • 84867519244 scopus 로고    scopus 로고
    • Microvascular protection is essential for successful neuroprotection in stroke
    • Gursoy-Ozdemir, Y., Yemisci, M., Dalkara, T., 2012. Microvascular protection is essential for successful neuroprotection in stroke. J. Neurochem. 123 (Suppl 2), 2-11.
    • (2012) J. Neurochem. , vol.123 , Issue.SUPPL. 2 , pp. 2-11
    • Gursoy-Ozdemir, Y.1    Yemisci, M.2    Dalkara, T.3
  • 91
    • 78049253786 scopus 로고    scopus 로고
    • Pericyte mediated regulation of capillary diameter a component of neurovascular coupling in health and disease
    • Hamilton, N.B., Attwell, D., Hall, C.N., 2010. Pericyte mediated regulation of capillary diameter a component of neurovascular coupling in health and disease. Front Neuroenergetics 2.
    • (2010) Front Neuroenergetics , pp. 2
    • Hamilton, N.B.1    Attwell, D.2    Hall, C.N.3
  • 92
    • 0023109637 scopus 로고
    • An immunohistochemical quantification of fibrous astrocytes in the aging human cerebral cortex
    • DOI 10.1016/0197-4580(87)90051-0
    • Hansen, L.A., Armstrong, D.M., Terry, R.D., 1987. An immunohistochemical quantification of fibrous astrocytes in the aging human cerebral cortex. Neurobiol. Aging 8, 1-6. (Pubitemid 17034559)
    • (1987) Neurobiology of Aging , vol.8 , Issue.1 , pp. 1-6
    • Hansen, L.A.1    Armstrong, D.M.2    Terry, R.D.3
  • 93
    • 34047114464 scopus 로고    scopus 로고
    • Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood-brain barrier dysfunction
    • DOI 10.1111/j.1471-4159.2006.04393.x
    • Haorah, J., Ramirez, S.H., Schall, K., Smith, D., Pandya, R., Persidsky, Y., 2007. Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood-brain barrier dysfunction. J. Neurochem. 101, 566-576. (Pubitemid 46525283)
    • (2007) Journal of Neurochemistry , vol.101 , Issue.2 , pp. 566-576
    • Haorah, J.1    Ramirez, S.H.2    Schall, K.3    Smith, D.4    Pandya, R.5    Persidsky, Y.6
  • 94
    • 17644363679 scopus 로고    scopus 로고
    • In search of the astrocytic factor(s) modulating blood-brain barrier functions in brain capillary endothelial cells in vitro
    • DOI 10.1007/s10571-004-1375-x
    • Haseloff, R.F., Blasig, I.E., Bauer, H.C., Bauer, H., 2005. In search of the astrocytic factor(s) modulating blood-brain barrier functions in brain capillary endothelial cells in vitro. Cell Mol. Neurobiol. 25, 25-39. (Pubitemid 40558583)
    • (2005) Cellular and Molecular Neurobiology , vol.25 , Issue.1 , pp. 25-39
    • Haseloff, R.F.1    Blasig, I.E.2    Bauer, H.-C.3    Bauer, H.4
  • 95
    • 0031036530 scopus 로고    scopus 로고
    • Induction of various blood-brain barrier properties in non-neural endothelial cells by close apposition to co-cultured astrocytes
    • DOI 10.1002/(SICI)1098-1136(199 701)19:1<13::AID-GLIA2>3.0.CO;2-B
    • Hayashi, Y., Nomura, M., Yamagishi, S., Harada, S., Yamashita, J., Yamamoto, H., 1997. Induction of various blood-brain barrier properties in non-neural endothelial cells by close apposition to co-cultured astrocytes. Glia 19, 13-26. (Pubitemid 27050446)
    • (1997) GLIA , vol.19 , Issue.1 , pp. 13-26
    • Hayashi, Y.1    Nomura, M.2    Yamagishi, S.-I.3    Harada, S.-I.4    Yamashita, J.5    Yamamoto, H.6
  • 96
    • 71549137764 scopus 로고    scopus 로고
    • Aging decreases expression and activity of glutathione peroxidase-1 in human endothelial progenitor cells
    • He, T., Joyner, M.J., Katusic, Z.S., 2009. Aging decreases expression and activity of glutathione peroxidase-1 in human endothelial progenitor cells. Microvasc. Res. 78, 447-452.
    • (2009) Microvasc. Res. , vol.78 , pp. 447-452
    • He, T.1    Joyner, M.J.2    Katusic, Z.S.3
  • 99
    • 0023237445 scopus 로고
    • Factors influencing the survival of 451 transient ischemic attack patients
    • Howard, G., Toole, J.F., Frye-Pierson, J., Hinshelwood, L.C., 1987. Factors influencing the survival of 451 transient ischemic attack patients. Stroke 18, 552-557. (Pubitemid 17080566)
    • (1987) Stroke , vol.18 , Issue.3 , pp. 552-557
    • Howard, G.1    Toole, J.F.2    Grye-Pierson, J.3    Hinshelwood, L.C.4
  • 100
    • 0023505509 scopus 로고
    • Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
    • Ignarro, L.J., Buga, G.M., Wood, K.S., Byrns, R.E., Chaudhuri, G., 1987. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. USA 84, 9265-9269.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 9265-9269
    • Ignarro, L.J.1    Buga, G.M.2    Wood, K.S.3    Byrns, R.E.4    Chaudhuri, G.5
  • 101
    • 24144438187 scopus 로고    scopus 로고
    • Estrogen reduces endothelial progenitor cell senescence through augmentation of telomerase activity
    • Imanishi, T., Hano, T., Nishio, I., 2005. Estrogen reduces endothelial progenitor cell senescence through augmentation of telomerase activity. J. Hypertens 23, 1699-1706. (Pubitemid 41233430)
    • (2005) Journal of Hypertension , vol.23 , Issue.9 , pp. 1699-1706
    • Imanishi, T.1    Hano, T.2    Nishio, I.3
  • 103
    • 0346157997 scopus 로고    scopus 로고
    • Estrogen-Mediated, Endothelial Nitric Oxide Synthase-Dependent Mobilization of Bone Marrow-Derived Endothelial Progenitor Cells Contributes to Reendothelialization after Arterial Injury
    • DOI 10.1161/01.CIR.0000106906.56972.83
    • Iwakura, A., Luedemann, C., Shastry, S., Hanley, A., Kearney, M., Aikawa, R., Isner, J.M., Asahara, T., Losordo, D.W., 2003. Estrogen-mediated, endothelial nitric oxide synthase-dependent mobilization of bone marrow-derived endothelial progenitor cells contributes to reendothelialization after arterial injury. Circulation 108, 3115-3121. (Pubitemid 38031801)
    • (2003) Circulation , vol.108 , Issue.25 , pp. 3115-3121
    • Iwakura, A.1    Luedemann, C.2    Shastry, S.3    Hanley, A.4    Kearney, M.5    Aikawa, R.6    Isner, J.M.7    Asahara, T.8    Losordo, D.W.9
  • 104
    • 0023108382 scopus 로고
    • Astrocytes induce blood-brain barrier properties in endothelial cells
    • DOI 10.1038/325253a0
    • Janzer, R.C., Raff, M.C., 1987. Astrocytes induce blood-brain barrier properties in endothelial cells. Nature 325, 253-257. (Pubitemid 17049884)
    • (1987) Nature , vol.325 , Issue.6101 , pp. 253-257
    • Janzer, R.C.1    Raff, M.C.2
  • 105
    • 0026673586 scopus 로고
    • Age related alterations in the response of the pial arterioles to adenosine in the rat
    • Jiang, H.X., Chen, P.C., Sobin, S.S., Giannotta, S.L., 1992. Age related alterations in the response of the pial arterioles to adenosine in the rat. Mech. Ageing Dev. 65, 257-276.
    • (1992) Mech. Ageing Dev. , vol.65 , pp. 257-276
    • Jiang, H.X.1    Chen, P.C.2    Sobin, S.S.3    Giannotta, S.L.4
  • 108
    • 33646104927 scopus 로고    scopus 로고
    • Temporal expression of IL-1beta protein and mRNA in the brain after systemic LPS injection is affected by age and estrogen
    • Johnson, A.B., Bake, S., Lewis, D.K., Sohrabji, F., 2006. Temporal expression of IL-1beta protein and mRNA in the brain after systemic LPS injection is affected by age and estrogen. J. Neuroimmunol. 174, 82-91.
    • (2006) J. Neuroimmunol. , vol.174 , pp. 82-91
    • Johnson, A.B.1    Bake, S.2    Lewis, D.K.3    Sohrabji, F.4
  • 109
    • 0022458934 scopus 로고
    • Prediction of function after stroke: A critical review
    • Jongbloed, L., 1986. Prediction of function after stroke: a critical review. Stroke 17, 765-776. (Pubitemid 16066554)
    • (1986) Stroke , vol.17 , Issue.4 , pp. 765-776
    • Jongbloed, L.1
  • 110
    • 0033391684 scopus 로고    scopus 로고
    • The blood-brain barrier and cerebrovascular pathology in Alzheimer's disease
    • Kalaria, R.N., 1999. The blood-brain barrier and cerebrovascular pathology in Alzheimer's disease. Ann. NY. Acad. Sci. 893, 113-125. (Pubitemid 30038071)
    • (1999) Annals of the New York Academy of Sciences , vol.893 , pp. 113-125
    • Kalaria, R.N.1
  • 112
    • 16844382946 scopus 로고    scopus 로고
    • Sex differences in stroke care and outcomes: Results from the registry of the canadian stroke network
    • Kapral, M.K., Fang, J., Hill, M.D., Silver, F., Richards, J., Jaigobin, C., Cheung, A.M., 2005. Sex differences in stroke care and outcomes: results from the Registry of the Canadian Stroke Network. Stroke 36, 809-814.
    • (2005) Stroke , vol.36 , pp. 809-814
    • Kapral, M.K.1    Fang, J.2    Hill, M.D.3    Silver, F.4    Richards, J.5    Jaigobin, C.6    Cheung, A.M.7
  • 113
    • 80052422926 scopus 로고    scopus 로고
    • Quantitative MRI reveals the elderly ischemic brain is susceptible to increased early blood-brain barrier permeability following tissue plasminogen activator related to claudin 5 and occludin disassembly
    • Kaur, J., Tuor, U.I., Zhao, Z., Barber, P.A., 2011. Quantitative MRI reveals the elderly ischemic brain is susceptible to increased early blood-brain barrier permeability following tissue plasminogen activator related to claudin 5 and occludin disassembly. J. Cereb. Blood Flow Metab. 31, 1874-1885.
    • (2011) J. Cereb. Blood Flow Metab. , vol.31 , pp. 1874-1885
    • Kaur, J.1    Tuor, U.I.2    Zhao, Z.3    Barber, P.A.4
  • 114
    • 0035652348 scopus 로고    scopus 로고
    • Photothrombotic brain infarction results in seizure activity in aging Fischer 344 and Sprague Dawley rats
    • DOI 10.1016/S0920-1211(01)00294-7, PII S0920121101002947
    • Kelly, K.M., Kharlamov, A., Hentosz, T.M., Kharlamova, E.A., Williamson, J.M., Bertram 3rd, E.H., Kapur, J., Armstrong, D.M., 2001. Photothrombotic brain infarction results in seizure activity in aging Fischer 344 and Sprague Dawley rats. Epilepsy Res. 47, 189-203. (Pubitemid 34008463)
    • (2001) Epilepsy Research , vol.47 , Issue.3 , pp. 189-203
    • Kelly, K.M.1    Kharlamov, A.2    Hentosz, T.M.3    Kharlamova, E.A.4    Williamson, J.M.5    Bertram III, E.H.6    Kapur, J.7    Armstrong, D.M.8
  • 115
    • 69449084641 scopus 로고    scopus 로고
    • NOX2 inhibition with apocynin worsens stroke outcome in aged rats
    • Kelly, K.A., Li, X., Tan, Z., VanGilder, R.L., Rosen, C.L., Huber, J.D., 2009. NOX2 inhibition with apocynin worsens stroke outcome in aged rats. Brain Res. 1292, 165-172.
    • (2009) Brain Res. , vol.1292 , pp. 165-172
    • Kelly, K.A.1    Li, X.2    Tan, Z.3    VanGilder, R.L.4    Rosen, C.L.5    Huber, J.D.6
  • 116
    • 0028893614 scopus 로고
    • Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 after focal cerebral ischemia in the rat
    • Kim, J.S., Gautam, S.C., Chopp, M., Zaloga, C., Jones, M.L., Ward, P.A., Welch, K.M., 1995. Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 after focal cerebral ischemia in the rat. J. Neuroimmunol. 56, 127-134.
    • (1995) J. Neuroimmunol. , vol.56 , pp. 127-134
    • Kim, J.S.1    Gautam, S.C.2    Chopp, M.3    Zaloga, C.4    Jones, M.L.5    Ward, P.A.6    Welch, K.M.7
  • 118
    • 84857726639 scopus 로고    scopus 로고
    • Functional recovery after ischemic stroke - A matter of age: Data from the Austrian stroke unit registry
    • Knoflach, M., Matosevic, B., Rucker, M., et al., 2012. Functional recovery after ischemic stroke - a matter of age: data from the Austrian Stroke Unit Registry. Neurology 78, 279-285.
    • (2012) Neurology , vol.78 , pp. 279-285
    • Knoflach, M.1    Matosevic, B.2    Rucker, M.3
  • 119
    • 0028836894 scopus 로고
    • Increases of glial fibrillary acidic protein in the aging female mouse brain
    • Kohama, S.G., Goss, J.R., Finch, C.E., McNeill, T.H., 1995. Increases of glial fibrillary acidic protein in the aging female mouse brain. Neurobiol. Aging 16, 59-67.
    • (1995) Neurobiol. Aging , vol.16 , pp. 59-67
    • Kohama, S.G.1    Goss, J.R.2    Finch, C.E.3    McNeill, T.H.4
  • 120
    • 84873142495 scopus 로고    scopus 로고
    • Brain penetration of the OAB drug trospium chloride is not increased in aged mice
    • Kranz, J., Petzinger, E., Geyer, J., 2013. Brain penetration of the OAB drug trospium chloride is not increased in aged mice. World J. Urol. 31, 219-224.
    • (2013) World J. Urol. , vol.31 , pp. 219-224
    • Kranz, J.1    Petzinger, E.2    Geyer, J.3
  • 121
    • 33749321675 scopus 로고    scopus 로고
    • Influence of sex steroid hormones on cerebrovascular function
    • DOI 10.1152/japplphysiol.01095.2005
    • Krause, D.N., Duckles, S.P., Pelligrino, D.A., 2006. Influence of sex steroid hormones on cerebrovascular function. J. Appl. Physiol. 101, 1252-1261. (Pubitemid 44497571)
    • (2006) Journal of Applied Physiology , vol.101 , Issue.4 , pp. 1252-1261
    • Krause, D.N.1    Duckles, S.P.2    Pelligrino, D.A.3
  • 123
    • 79961021467 scopus 로고    scopus 로고
    • Progesterone attenuates astro- and microgliosis and enhances oligodendrocyte differentiation following spinal cord injury
    • Labombarda, F., Gonzalez, S., Lima, A., Roig, P., Guennoun, R., Schumacher, M., De Nicola, A.F., 2011. Progesterone attenuates astro- and microgliosis and enhances oligodendrocyte differentiation following spinal cord injury. Exp. Neurol. 231, 135-146.
    • (2011) Exp. Neurol. , vol.231 , pp. 135-146
    • Labombarda, F.1    Gonzalez, S.2    Lima, A.3    Roig, P.4    Guennoun, R.5    Schumacher, M.6    De Nicola, A.F.7
  • 125
    • 0035083678 scopus 로고    scopus 로고
    • Astrocytes produce and release interleukin-1, interleukin-6, tumor necrosis factor alpha and interferon-gamma following traumatic and metabolic injury
    • Lau, L.T., Yu, A.C., 2001. Astrocytes produce and release interleukin-1, interleukin-6, tumor necrosis factor alpha and interferon-gamma following traumatic and metabolic injury. J. Neurotrauma 18, 351-359. (Pubitemid 32230637)
    • (2001) Journal of Neurotrauma , vol.18 , Issue.3 , pp. 351-359
    • Lau, L.T.1    Yu, A.C.-H.2
  • 126
    • 3042838912 scopus 로고    scopus 로고
    • Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity
    • DOI 10.1523/JNEUROSCI.1643-04.2004
    • Lee, J.K., Kim, J.E., Sivula, M., Strittmatter, S.M., 2004. Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity. J. Neurosci. 24, 6209-6217. (Pubitemid 38891112)
    • (2004) Journal of Neuroscience , vol.24 , Issue.27 , pp. 6209-6217
    • Lee, J.-K.1    Kim, J.-E.2    Sivula, M.3    Strittmatter, S.M.4
  • 127
    • 84860653702 scopus 로고    scopus 로고
    • Transforming growth factor-alpha mediates estrogen-induced upregulation of glutamate transporter GLT-1 in rat primary astrocytes
    • Lee, E., Sidoryk-Wegrzynowicz, M., Yin, Z., Webb, A., Son, D.S., Aschner, M., 2012a. Transforming growth factor-alpha mediates estrogen-induced upregulation of glutamate transporter GLT-1 in rat primary astrocytes. Glia 60, 1024-1036.
    • (2012) Glia , vol.60 , pp. 1024-1036
    • Lee, E.1    Sidoryk-Wegrzynowicz, M.2    Yin, Z.3    Webb, A.4    Son, D.S.5    Aschner, M.6
  • 128
    • 84862793270 scopus 로고    scopus 로고
    • Effects of aging on blood brain barrier and matrix metalloproteases following controlled cortical impact in mice
    • Lee, P., Kim, J., Williams, R., Sandhir, R., Gregory, E., Brooks, W.M., Berman, N.E., 2012b. Effects of aging on blood brain barrier and matrix metalloproteases following controlled cortical impact in mice. Exp. Neurol. 234, 50-61.
    • (2012) Exp. Neurol. , vol.234 , pp. 50-61
    • Lee, P.1    Kim, J.2    Williams, R.3    Sandhir, R.4    Gregory, E.5    Brooks, W.M.6    Berman, N.E.7
  • 129
    • 84862746828 scopus 로고    scopus 로고
    • Worsened outcome from middle cerebral artery occlusion in aged rats receiving 17beta-estradiol
    • Leon, R.L., Li, X., Huber, J.D., Rosen, C.L., 2012. Worsened outcome from middle cerebral artery occlusion in aged rats receiving 17beta-estradiol. Endocrinology 153, 3386-3393.
    • (2012) Endocrinology , vol.153 , pp. 3386-3393
    • Leon, R.L.1    Li, X.2    Huber, J.D.3    Rosen, C.L.4
  • 130
    • 77956063135 scopus 로고    scopus 로고
    • Evaluating the effects of estradiol on endothelial nitric oxide stimulated by erythrocyte-derived ATP using a microfluidic approach
    • Letourneau, S., Hernandez, L., Faris, A.N., Spence, D.M., 2010. Evaluating the effects of estradiol on endothelial nitric oxide stimulated by erythrocyte-derived ATP using a microfluidic approach. Anal. Bioanal. Chem. 397, 3369-3375.
    • (2010) Anal. Bioanal. Chem. , vol.397 , pp. 3369-3375
    • Letourneau, S.1    Hernandez, L.2    Faris, A.N.3    Spence, D.M.4
  • 131
    • 41949104261 scopus 로고    scopus 로고
    • Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats
    • Lewis, D.K., Johnson, A.B., Stoehlgren, S., Harms, A., Sohrabji, F., 2008a. Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats. J. Neuroimmunol. 195, 47-59.
    • (2008) J. Neuroimmunol. , vol.195 , pp. 47-59
    • Lewis, D.K.1    Johnson, A.B.2    Stoehlgren, S.3    Harms, A.4    Sohrabji, F.5
  • 132
    • 56849115188 scopus 로고    scopus 로고
    • Astrocytes from acyclic female rats exhibit lowered capacity for neuronal differentiation
    • DOI 10.1111/j.1474-9726.2008.00430.x
    • Lewis, D.K., Woodin, H.R., Sohrabji, F., 2008b. Astrocytes from acyclic female rats exhibit lowered capacity for neuronal differentiation. Aging Cell 7, 836-849. (Pubitemid 352749438)
    • (2008) Aging Cell , vol.7 , Issue.6 , pp. 836-849
    • Lewis, D.K.1    Woodin, H.R.2    Sohrabji, F.3
  • 133
    • 84859491886 scopus 로고    scopus 로고
    • Age-related severity of focal ischemia in female rats is associated with impaired astrocyte function
    • Lewis, D.K., Thomas, K.T., Selvamani, A., Sohrabji, F., 2012. Age-related severity of focal ischemia in female rats is associated with impaired astrocyte function. Neurobiol. Aging 33 (1123), e1121-1116.
    • (2012) Neurobiol. Aging , vol.33 , Issue.1123
    • Lewis, D.K.1    Thomas, K.T.2    Selvamani, A.3    Sohrabji, F.4
  • 134
    • 78649339985 scopus 로고    scopus 로고
    • An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke
    • Li, S., Overman, J.J., Katsman, D., et al., 2010. An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke. Nat. Neurosci. 13, 1496-1504.
    • (2010) Nat. Neurosci. , vol.13 , pp. 1496-1504
    • Li, S.1    Overman, J.J.2    Katsman, D.3
  • 135
    • 84878622870 scopus 로고    scopus 로고
    • Early effects of high fat diet on neurovascular function and focal ischemic brain injury
    • Li, W., Prakash, R., Chawla, D., et al., 2013. Early effects of high fat diet on neurovascular function and focal ischemic brain injury. Am. J. Physiol. Regul. Integr. Comp. Physiol. 304, R1001-1008.
    • (2013) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.304
    • Li, W.1    Prakash, R.2    Chawla, D.3
  • 136
    • 0035910642 scopus 로고    scopus 로고
    • Association of serum estrogen level and ischemic neuroprotection in female rats
    • DOI 10.1016/S0304-3940(00)01704-3, PII S0304394000017043
    • Liao, S., Chen, W., Kuo, J., Chen, C., 2001. Association of serum estrogen level and ischemic neuroprotection in female rats. Neurosci. Lett. 297, 159-162. (Pubitemid 32011298)
    • (2001) Neuroscience Letters , vol.297 , Issue.3 , pp. 159-162
    • Liao, S.-L.1    Chen, W.-Y.2    Kuo, J.-S.3    Chen, C.-J.4
  • 137
    • 0024203038 scopus 로고
    • Is astrocyte laminin involved in axon guidance in the mammalian CNS?
    • DOI 10.1016/0012-1606(88)90366-1
    • Liesi, P., Silver, J., 1988. Is astrocyte laminin involved in axon guidance in the mammalian CNS? Dev. Biol. 130, 774-785. (Pubitemid 19016105)
    • (1988) Developmental Biology , vol.130 , Issue.2 , pp. 774-785
    • Liesi, P.1    Silver, J.2
  • 138
    • 26944469603 scopus 로고    scopus 로고
    • 17-Estradiol attenuates blood-brain barrier disruption induced by cerebral ischemia-reperfusion injury in female rats
    • DOI 10.1016/j.brainres.2005.08.048, PII S0006899305012072
    • Liu, R., Wen, Y., Perez, E., Wang, X., Day, A.L., Simpkins, J.W., Yang, S.H., 2005. 17beta-Estradiol attenuates blood-brain barrier disruption induced by cerebral ischemia-reperfusion injury in female rats. Brain Res. 1060, 55-61. (Pubitemid 41483589)
    • (2005) Brain Research , vol.1060 , Issue.1-2 , pp. 55-61
    • Liu, R.1    Wen, Y.2    Perez, E.3    Wang, X.4    Day, A.L.5    Simpkins, J.W.6    Yang, S.-H.7
  • 141
    • 80053370515 scopus 로고    scopus 로고
    • SC1/hevin and reactive gliosis after transient ischemic stroke in young and aged rats
    • Lively, S., Moxon-Emre, I., Schlichter, L.C., 2011. SC1/hevin and reactive gliosis after transient ischemic stroke in young and aged rats. J. Neuropathol. Exp. Neurol. 70, 913-929.
    • (2011) J. Neuropathol. Exp. Neurol. , vol.70 , pp. 913-929
    • Lively, S.1    Moxon-Emre, I.2    Schlichter, L.C.3
  • 142
    • 77649126524 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2010 update: A report from the American heart association
    • Lloyd-Jones, D., Adams, R.J., Brown, T.M., et al., 2010. Heart disease and stroke statistics-2010 update: a report from the American Heart Association. Circulation 121, e46-e215.
    • (2010) Circulation , vol.121
    • Lloyd-Jones, D.1    Adams, R.J.2    Brown, T.M.3
  • 143
    • 33845926865 scopus 로고    scopus 로고
    • Plasma proteins in edematous white matter after intracerebral hemorrhage confound immunoblots: An ELISA to quantify contamination
    • DOI 10.1089/neu.2006.23.1904
    • Loftspring, M.C., Beiler, S., Beiler, C., Wagner, K.R., 2006. Plasma proteins in edematous white matter after intracerebral hemorrhage confound immunoblots: an ELISA to quantify contamination. J. Neurotrauma 23, 1904-1911. (Pubitemid 46034459)
    • (2006) Journal of Neurotrauma , vol.23 , Issue.12 , pp. 1904-1911
    • Loftspring, M.C.1    Beiler, S.2    Beiler, C.3    Wagner, K.R.4
  • 144
    • 80051743256 scopus 로고    scopus 로고
    • Estradiol decreases cortical reactive astrogliosis after brain injury by a mechanism involving cannabinoid receptors
    • Lopez Rodriguez, A.B., Mateos Vicente, B., Romero-Zerbo, S.Y., 2011. Estradiol decreases cortical reactive astrogliosis after brain injury by a mechanism involving cannabinoid receptors. Cereb. Cortex 21, 2046-2055.
    • (2011) Cereb. Cortex , vol.21 , pp. 2046-2055
    • Lopez Rodriguez, A.B.1    Mateos Vicente, B.2    Romero-Zerbo, S.Y.3
  • 145
    • 33846590099 scopus 로고    scopus 로고
    • Disturbed cross talk between insulin-like growth factor I and AMP-activated protein kinase as a possible cause of vascular dysfunction in the amyloid precursor protein/presenilin 2 mouse model of Alzheimer's disease
    • DOI 10.1523/JNEUROSCI.4345-06.2007
    • Lopez-Lopez, C., Dietrich, M.O., Metzger, F., Loetscher, H., Torres-Aleman, I., 2007. Disturbed cross talk between insulin-like growth factor I and AMP-activated protein kinase as a possible cause of vascular dysfunction in the amyloid precursor protein/presenilin 2 mouse model of Alzheimer's disease. J. Neurosci. 27, 824-831. (Pubitemid 46174501)
    • (2007) Journal of Neuroscience , vol.27 , Issue.4 , pp. 824-831
    • Lopez-Lopez, C.1    Dietrich, M.O.2    Metzger, F.3    Loetscher, H.4    Torres-Aleman, I.5
  • 146
    • 0025952994 scopus 로고
    • NGF gene expression in actively growing brain glia
    • Lu, B., Yokoyama, M., Dreyfus, C.F., Black, I.B., 1991. NGF gene expression in actively growing brain glia. J. Neurosci. 11, 318-326.
    • (1991) J. Neurosci. , vol.11 , pp. 318-326
    • Lu, B.1    Yokoyama, M.2    Dreyfus, C.F.3    Black, I.B.4
  • 147
    • 0024600330 scopus 로고
    • Cerebral aging: A quantitative study of gliosis in old nude mice
    • DOI 10.1007/BF00687252
    • Mandybur, T.I., Ormsby, I., Zemlan, F.P., 1989. Cerebral aging: a quantitative study of gliosis in old nude mice. Acta Neuropathol. 77, 507-513. (Pubitemid 19095415)
    • (1989) Acta Neuropathologica , vol.77 , Issue.5 , pp. 507-513
    • Mandybur, T.I.1    Ormsby, I.2    Zemlan, F.P.3
  • 149
    • 0033902012 scopus 로고    scopus 로고
    • Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia
    • Marti, H.J., Bernaudin, M., Bellail, A., Schoch, H., Euler, M., Petit, E., Risau, W., 2000. Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia. Am. J. Pathol. 156, 965-976. (Pubitemid 30626954)
    • (2000) American Journal of Pathology , vol.156 , Issue.3 , pp. 965-976
    • Marti, H.J.H.1    Bernaudin, M.2    Bellail, A.3    Schoch, H.4    Euler, M.5    Petit, E.6    Risau, W.7
  • 151
    • 84855767605 scopus 로고    scopus 로고
    • Estrogen and progesterone play pivotal roles in endothelial progenitor cell proliferation
    • Matsubara, Y., Matsubara, K., 2012. Estrogen and progesterone play pivotal roles in endothelial progenitor cell proliferation. Reprod. Biol. Endocrinol. 10, 2.
    • (2012) Reprod. Biol. Endocrinol. , vol.10 , pp. 2
    • Matsubara, Y.1    Matsubara, K.2
  • 152
    • 0038617335 scopus 로고    scopus 로고
    • Functional analysis of tight junctions
    • DOI 10.1016/S1046-2023(03)00029-X
    • Matter, K., Balda, M.S., 2003. Functional analysis of tight junctions. Methods 30, 228-234. (Pubitemid 36677557)
    • (2003) Methods , vol.30 , Issue.3 , pp. 228-234
    • Matter, K.1    Balda, M.S.2
  • 153
    • 0034745252 scopus 로고    scopus 로고
    • Postischemic estrogen reduces hypoperfusion and secondary ischemia after experimental stroke
    • McCullough, L.D., Alkayed, N.J., Traystman, R.J., Williams, M.J., Hurn, P.D., 2001. Postischemic estrogen reduces hypoperfusion and secondary ischemia after experimental stroke. Stroke 32, 796-802.
    • (2001) Stroke , vol.32 , pp. 796-802
    • McCullough, L.D.1    Alkayed, N.J.2    Traystman, R.J.3    Williams, M.J.4    Hurn, P.D.5
  • 154
    • 0032860804 scopus 로고    scopus 로고
    • Chronic estrogen treatment increases levels of endothelial nitric oxide synthase protein in rat cerebral microvessels
    • McNeill, A.M., Kim, N., Duckles, S.P., Krause, D.N., Kontos, H.A., 1999. Chronic estrogen treatment increases levels of endothelial nitric oxide synthase protein in rat cerebral microvessels. Stroke 30, 2186-2190. (Pubitemid 29473269)
    • (1999) Stroke , vol.30 , Issue.10 , pp. 2186-2190
    • McNeill, A.M.1    Kim, N.2    Duckles, S.P.3    Krause, D.N.4
  • 155
    • 84860885387 scopus 로고    scopus 로고
    • Aging brain microenvironment decreases hippocampal neurogenesis through wnt-mediated survivin signaling
    • Miranda, C.J., Braun, L., Jiang, Y., et al., 2012. Aging brain microenvironment decreases hippocampal neurogenesis through Wnt-mediated survivin signaling. Aging Cell 11, 542-552.
    • (2012) Aging Cell , vol.11 , pp. 542-552
    • Miranda, C.J.1    Braun, L.2    Jiang, Y.3
  • 156
    • 0037159611 scopus 로고    scopus 로고
    • i increase and cell damage in cultured rat cerebral endothelial cells
    • DOI 10.1016/S0006-8993(02)03488-1, PII S0006899302034881
    • Mogami, M., Hida, H., Hayashi, Y., Kohri, K., Kodama, Y., Gyun Jung, C., Nishino, H., 2002. Estrogen blocks 3-nitropropionic acid-induced Ca2+i increase and cell damage in cultured rat cerebral endothelial cells. Brain Res. 956, 116-125. (Pubitemid 35335564)
    • (2002) Brain Research , vol.956 , Issue.1 , pp. 116-125
    • Mogami, M.1    Hida, H.2    Hayashi, Y.3    Kohri, K.4    Kodama, Y.5    Gyun Jung, C.6    Nishino, H.7
  • 157
    • 33745773543 scopus 로고    scopus 로고
    • Treatment with an estrogen receptor ligand is neuroprotective in experimental autoimmune encephalomyelitis
    • DOI 10.1523/JNEUROSCI.0453-06.2006
    • Morales, L.B.J., Loo, K.K., Liu, H.-B., Peterson, C., Tiwari-Woodruff, S., Voskuhl, R.R., 2006. Treatment with an estrogen receptora ligand is neuroprotective in experimental autoimmune encephalomyelitis. J. Neurosci. 26, 6823-6833. (Pubitemid 44315243)
    • (2006) Journal of Neuroscience , vol.26 , Issue.25 , pp. 6823-6833
    • Morales, L.B.J.1    Kyi, K.L.2    Liu, H.-B.3    Peterson, C.4    Tiwari-Woodruff, S.5    Voskuhl, R.R.6
  • 158
    • 79960993418 scopus 로고    scopus 로고
    • Manganese-induced NF-kappaB activation and nitrosative stress is decreased by estrogen in juvenile mice
    • Moreno, J.A., Streifel, K.M., Sullivan, K.A., Hanneman, W.H., Tjalkens, R.B., 2011. Manganese-induced NF-kappaB activation and nitrosative stress is decreased by estrogen in juvenile mice. Toxicol. Sci. 122, 121-133.
    • (2011) Toxicol. Sci. , vol.122 , pp. 121-133
    • Moreno, J.A.1    Streifel, K.M.2    Sullivan, K.A.3    Hanneman, W.H.4    Tjalkens, R.B.5
  • 160
    • 0037159620 scopus 로고    scopus 로고
    • Age and gender effects on microglia and astrocyte numbers in brains of mice
    • DOI 10.1016/S0006-8993(02)03475-3, PII S0006899302034753
    • Mouton, P.R., Long, J.M., Lei, D.L., Howard, V., Jucker, M., Calhoun, M.E., Ingram, D.K., 2002. Age and gender effects on microglia and astrocyte numbers in brains of mice. Brain Res. 956, 30-35. (Pubitemid 35335553)
    • (2002) Brain Research , vol.956 , Issue.1 , pp. 30-35
    • Mouton, P.R.1    Long, J.M.2    Lei, D.-L.3    Howard, V.4    Jucker, M.5    Calhoun, M.E.6    Ingram, D.K.7
  • 161
    • 77955089623 scopus 로고    scopus 로고
    • Mitochondrial dysfunction: Common final pathway in brain aging and alzheimer's disease - Therapeutic aspects
    • Muller, W.E., Eckert, A., Kurz, C., Eckert, G.P., Leuner, K., 2010. Mitochondrial dysfunction: common final pathway in brain aging and Alzheimer's disease - therapeutic aspects. Mol. Neurobiol. 41, 159-171.
    • (2010) Mol. Neurobiol. , vol.41 , pp. 159-171
    • Muller, W.E.1    Eckert, A.2    Kurz, C.3    Eckert, G.P.4    Leuner, K.5
  • 162
    • 84858342300 scopus 로고    scopus 로고
    • Brain regional angiogenic potential at the neurovascular unit during normal aging
    • Murugesan, N., Demarest, T.G., Madri, J.A., Pachter, J.S., 2012. Brain regional angiogenic potential at the neurovascular unit during normal aging. Neurobiol. Aging 33 (1004), e1001-e1016.
    • (2012) Neurobiol. Aging , vol.33 , Issue.1004
    • Murugesan, N.1    Demarest, T.G.2    Madri, J.A.3    Pachter, J.S.4
  • 163
    • 0028273120 scopus 로고
    • The influence of age on stroke outcome: The Copenhagen Stroke Study
    • Nakayama, H., Jorgensen, H.S., Raaschou, H.O., Olsen, T.S., 1994. The influence of age on stroke outcome. The copenhagen stroke study. Stroke 25, 808-813. (Pubitemid 24111328)
    • (1994) Stroke , vol.25 , Issue.4 , pp. 808-813
    • Nakayama, H.1    Jorgensen, H.S.2    Raaschou, H.O.3    Olsen, T.S.4
  • 164
    • 79251604405 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 (HIF-1)-independent microvascular angiogenesis in the aged rat brain
    • Ndubuizu, O.I., Tsipis, C.P., Li, A., LaManna, J.C., 2010. Hypoxia-inducible factor-1 (HIF-1)-independent microvascular angiogenesis in the aged rat brain. Brain Res. 1366, 101-109.
    • (2010) Brain Res. , vol.1366 , pp. 101-109
    • Ndubuizu, O.I.1    Tsipis, C.P.2    Li, A.3    LaManna, J.C.4
  • 165
    • 0027169639 scopus 로고
    • GFAP mRNA increases with age in rat and human brain
    • DOI 10.1016/0197-4580(93)90100-P
    • Nichols, N.R., Day, J.R., Laping, N.J., Johnson, S.A., Finch, C.E., 1993. GFAP mRNA increases with age in rat and human brain. Neurobiol. Aging 14, 421-429. (Pubitemid 23270006)
    • (1993) Neurobiology of Aging , vol.14 , Issue.5 , pp. 421-429
    • Nichols, N.R.1    Day, J.R.2    Laping, N.J.3    Johnson, S.A.4    Finch, C.E.5
  • 167
  • 168
    • 0037123756 scopus 로고    scopus 로고
    • Age-related changes in cerebral blood flow and glucose metabolism in conscious rhesus monkeys
    • DOI 10.1016/S0006-8993(02)02558-1, PII S0006899302025581
    • Noda, A., Ohba, H., Kakiuchi, T., Futatsubashi, M., Tsukada, H., Nishimura, S., 2002. Age-related changes in cerebral blood flow and glucose metabolism in conscious rhesus monkeys. Brain Res. 936, 76-81. (Pubitemid 34461935)
    • (2002) Brain Research , vol.936 , Issue.1-2 , pp. 76-81
    • Noda, A.1    Ohba, H.2    Kakiuchi, T.3    Futatsubashi, M.4    Tsukada, H.5    Nishimura, S.6
  • 169
    • 33749033087 scopus 로고    scopus 로고
    • Estradiol reduces activity of the blood-brain barrier Na-K-Cl cotransporter and decreases edema formation in permanent middle cerebral artery occlusion
    • DOI 10.1038/sj.jcbfm.9600278, PII 9600278
    • O'Donnell, M.E., Lam, T.I., Tran, L.Q., Foroutan, S., Anderson, S.E., 2006. Estradiol reduces activity of the blood-brain barrier Na-K-Cl cotransporter and decreases edema formation in permanent middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 26, 1234-1249. (Pubitemid 44444595)
    • (2006) Journal of Cerebral Blood Flow and Metabolism , vol.26 , Issue.10 , pp. 1234-1249
    • O'Donnell, M.E.1    Lam, T.I.2    Tran, L.Q.3    Foroutan, S.4    Anderson, S.E.5
  • 170
    • 0019850529 scopus 로고
    • Regional cerebral blood flow during development and aging of the rat brain
    • Ohata, M., Sundaram, U., Fredericks, W.R., London, E.D., Rapoport, S.I., 1981. Regional cerebral blood flow during development and ageing of the rat brain. Brain 104, 319-332. (Pubitemid 12183324)
    • (1981) Brain , vol.104 , Issue.2 , pp. 319-332
    • Ohata, M.1    Sundaram, U.2    Fredericks, W.R.3
  • 171
    • 80053927984 scopus 로고    scopus 로고
    • Reduction in paracrine wnt3 factors during aging causes impaired adult neurogenesis
    • Okamoto, M., Inoue, K., Iwamura, H., Terashima, K., Soya, H., Asashima, M., Kuwabara, T., 2011. Reduction in paracrine Wnt3 factors during aging causes impaired adult neurogenesis. FASEB J. 25, 3570-3582.
    • (2011) FASEB J. , vol.25 , pp. 3570-3582
    • Okamoto, M.1    Inoue, K.2    Iwamura, H.3    Terashima, K.4    Soya, H.5    Asashima, M.6    Kuwabara, T.7
  • 172
    • 0017487289 scopus 로고
    • The large apparent work capability of the blood-brain barrier: A study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat
    • Oldendorf, W.H., Cornford, M.E., Brown, W.J., 1977. The large apparent work capability of the blood-brain barrier: a study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat. Ann. Neurol. 1, 409-417.
    • (1977) Ann. Neurol. , vol.1 , pp. 409-417
    • Oldendorf, W.H.1    Cornford, M.E.2    Brown, W.J.3
  • 173
    • 84856211599 scopus 로고    scopus 로고
    • Reactive oxygen species and ischemic cerebrovascular disease
    • Olmez, I., Ozyurt, H., 2012. Reactive oxygen species and ischemic cerebrovascular disease. Neurochem. Int. 60, 208-212.
    • (2012) Neurochem. Int. , vol.60 , pp. 208-212
    • Olmez, I.1    Ozyurt, H.2
  • 174
    • 77957370115 scopus 로고    scopus 로고
    • Female survival advantage relates to male inferiority rather than female superiority: A hypothesis based on the impact of age and stroke severity on 1-week to 1-year case fatality in 40,155 men and women
    • Olsen, T.S., Andersen, K.K., 2010. Female survival advantage relates to male inferiority rather than female superiority: A hypothesis based on the impact of age and stroke severity on 1-week to 1-year case fatality in 40,155 men and women. Gend. Med. 7, 284-295.
    • (2010) Gend. Med. , vol.7 , pp. 284-295
    • Olsen, T.S.1    Andersen, K.K.2
  • 175
    • 84892370488 scopus 로고    scopus 로고
    • Stroke in centenarians
    • http://dx.doi.org/10.1111/ggi.12058 [Epub ahead of print]
    • Olsen, T.S., Andersen, K.K., 2013. Stroke in centenarians. Geriatr. Gerontol. Int. http://dx.doi.org/10.1111/ggi.12058 [Epub ahead of print].
    • (2013) Geriatr. Gerontol. Int.
    • Olsen, T.S.1    Andersen, K.K.2
  • 176
    • 77950821270 scopus 로고    scopus 로고
    • Spinal cord injury causes a wide-spread, persistent loss of kir4.1 and glutamate transporter 1: Benefit of 17 beta-oestradiol treatment
    • Olsen, M.L., Campbell, S.C., McFerrin, M.B., Floyd, C.L., Sontheimer, H., 2010. Spinal cord injury causes a wide-spread, persistent loss of Kir4.1 and glutamate transporter 1: benefit of 17 beta-oestradiol treatment. Brain 133, 1013-1025.
    • (2010) Brain , vol.133 , pp. 1013-1025
    • Olsen, M.L.1    Campbell, S.C.2    McFerrin, M.B.3    Floyd, C.L.4    Sontheimer, H.5
  • 177
    • 0027398089 scopus 로고
    • Selective vulnerability and early progression of hippocampal CA1 pyramidal cell degeneration and GFAP-positive astrocyte reactivity in the rat four-vessel occlusion model of transient global ischemia
    • DOI 10.1006/exnr.1993.1014
    • Ordy, J.M., Wengenack, T.M., Bialobok, P., Coleman, P.D., Rodier, P., Baggs, R.B., Dunlap, W.P., Kates, B., 1993. Selective vulnerability and early progression of hippocampal CA1 pyramidal cell degeneration and GFAP-positive astrocyte reactivity in the rat four-vessel occlusion model of transient global ischemia. Exp. Neurol. 119, 128-139. (Pubitemid 23074250)
    • (1993) Experimental Neurology , vol.119 , Issue.1 , pp. 128-139
    • Ordy, J.M.1    Wengenack, T.M.2    Bialobok, P.3    Coleman, P.D.4    Rodier, P.5    Baggs, R.B.6    Dunlap, W.P.7    Kates, B.8
  • 178
    • 0034597430 scopus 로고    scopus 로고
    • Vascular niche for adult hippocampal neurogenesis
    • Palmer, T.D., Willhoite, A.R., Gage, F.H., 2000. Vascular niche for adult hippocampal neurogenesis. J. Comp. Neurol. 425, 479-494.
    • (2000) J. Comp. Neurol. , vol.425 , pp. 479-494
    • Palmer, T.D.1    Willhoite, A.R.2    Gage, F.H.3
  • 180
    • 22744439476 scopus 로고    scopus 로고
    • Regulation of glutamate transporter GLAST and GLT-1 expression in astrocytes by estrogen
    • DOI 10.1016/j.molbrainres.2004.10.043, PII S0169328X04005893
    • Pawlak, J., Brito, V., Kuppers, E., Beyer, C., 2005. Regulation of glutamate transporter GLAST and GLT-1 expression in astrocytes by estrogen. Mol. Brain Res. 138, 1-7. (Pubitemid 41032924)
    • (2005) Molecular Brain Research , vol.138 , Issue.1 , pp. 1-7
    • Pawlak, J.1    Brito, V.2    Kuppers, E.3    Beyer, C.4
  • 182
    • 0038748620 scopus 로고    scopus 로고
    • Age-related decline of inducible nitric oxide synthase gene expression in primary cultured rat hepatocytes
    • Pie, J.E., Baek, S.Y., Kim, H.P., Ryu, S.D., Chung, W.G., Cha, Y.N., Park, C.S., 2002. Age-related decline of inducible nitric oxide synthase gene expression in primary cultured rat hepatocytes. Mol. Cells 13, 399-406.
    • (2002) Mol. Cells , vol.13 , pp. 399-406
    • Pie, J.E.1    Baek, S.Y.2    Kim, H.P.3    Ryu, S.D.4    Chung, W.G.5    Cha, Y.N.6    Park, C.S.7
  • 183
    • 26944486635 scopus 로고    scopus 로고
    • 17-estradiol rescues spinal motoneurons from AMPA-induced toxicity: A role for glial cells
    • DOI 10.1016/j.nbd.2005.03.025, PII S0969996105001087
    • Platania, P., Seminara, G., Aronica, E., Troost, D., Vincenza, C., Angela, S., 2005. 17beta-estradiol rescues spinal motoneurons from AMPA-induced toxicity: a role for glial cells. Neurobiol. Dis. 20, 461-470. (Pubitemid 41476272)
    • (2005) Neurobiology of Disease , vol.20 , Issue.2 , pp. 461-470
    • Platania, P.1    Seminara, G.2    Aronica, E.3    Troost, D.4    Catania, M.V.5    Sortino, M.A.6
  • 185
    • 33947410259 scopus 로고    scopus 로고
    • Accelerated infarct development, cytogenesis and apoptosis following transient cerebral ischemia in aged rats
    • DOI 10.1007/s00401-006-0164-7
    • Popa-Wagner, A., Badan, I., Walker, L., Groppa, S., Patrana, N., Kessler, C., 2007. Accelerated infarct development, cytogenesis and apoptosis following transient cerebral ischemia in aged rats. Acta Neuropathol. 113, 277-293. (Pubitemid 46443563)
    • (2007) Acta Neuropathologica , vol.113 , Issue.3 , pp. 277-293
    • Popa-Wagner, A.1    Badan, I.2    Walker, L.3    Groppa, S.4    Patrana, N.5    Kessler, C.6
  • 186
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: Role of the HIF system
    • DOI 10.1038/nm0603-677
    • Pugh, C.W., Ratcliffe, P.J., 2003. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat. Med. 9, 677-684. (Pubitemid 36749216)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 187
    • 84880157511 scopus 로고    scopus 로고
    • Factors associated with length of hospitalization in patients admitted with transient ischemic attack in United States
    • Qureshi, A.I., Adil, M.M., Zacharatos, H., Suri, M.F., 2013. Factors associated with length of hospitalization in patients admitted with transient ischemic attack in United States. Stroke 44, 1601-1605.
    • (2013) Stroke , vol.44 , pp. 1601-1605
    • Qureshi, A.I.1    Adil, M.M.2    Zacharatos, H.3    Suri, M.F.4
  • 190
    • 0242636129 scopus 로고    scopus 로고
    • In vivo cerebrovascular actions of amyloid peptides and the protective effect of conjugated estrogens
    • Rhodin, J.A., Thomas, T.N., Clark, L., Garces, A., Bryant, M., 2003. In vivo cerebrovascular actions of amyloid beta-peptides and the protective effect of conjugated estrogens. J. Alzheimer's Dis. 5, 275-286. (Pubitemid 37411775)
    • (2003) Journal of Alzheimer's Disease , vol.5 , Issue.4 , pp. 275-286
    • Rhodin, J.A.1    Thomas, T.N.2    Clark, L.3    Garces, A.4    Bryant, M.5
  • 191
    • 0030697366 scopus 로고    scopus 로고
    • Reactive astrocytes: Cellular and molecular cues to biological function
    • DOI 10.1016/S0166-2236(97)01139-9
    • Ridet, J., Malhotra, S., Privat, A., Gage, F., 1997. Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci. 20, 570-577. (Pubitemid 27508969)
    • (1997) Trends in Neurosciences , vol.20 , Issue.12 , pp. 570-577
    • Ridet, J.L.1    Malhotra, S.K.2    Privat, A.3    Gage, F.H.4
  • 192
    • 16644391766 scopus 로고    scopus 로고
    • CNS neurotrophins are biologically active and expressed by multiple cell types
    • DOI 10.1007/s10735-004-0778-9
    • Riley, C., Cope, T., Buck, C., 2004. CNS neurotrophins are biologically active and expressed by multiple cell types. J. Mol. Histol. 35, 771-783. (Pubitemid 41404623)
    • (2004) Journal of Molecular Histology , vol.35 , Issue.8-9 , pp. 771-783
    • Riley, C.P.1    Cope, T.C.2    Buck, C.R.3
  • 193
    • 0025218499 scopus 로고
    • Development of the blood-brain barrier
    • Risau, W., Wolburg, H., 1990. Development of the blood-brain barrier. Trends Neurosci. 13, 174-178. (Pubitemid 20145137)
    • (1990) Trends in Neurosciences , vol.13 , Issue.5 , pp. 174-178
    • Risau, W.1    Wolburg, H.2
  • 196
    • 79751531393 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2011 update: A report from the American heart association
    • Roger, V.L., Go, A.S., Lloyd-Jones, D.M., et al., 2011. Heart disease and stroke statistics-2011 update: a report from the American Heart Association. Circulation 123, e18-e209.
    • (2011) Circulation , vol.123
    • Roger, V.L.1    Go, A.S.2    Lloyd-Jones, D.M.3
  • 197
    • 0031960552 scopus 로고    scopus 로고
    • Age-related activation of microglia and astrocytes: In vitro studies show persistent phenotypes of aging, increased proliferation, and resistance to down-regulation
    • DOI 10.1016/S0197-4580(97)00169-3, PII S0197458097001693
    • Rozovsky, I., Finch, C., Morgan, T., 1998. Age-related activation of microglia and astrocytes: in vitro studies show persistent phenotypes of aging, increased proliferation, and resistance to down-regulation. Neurobiol. Aging 19, 97-103. (Pubitemid 28167802)
    • (1998) Neurobiology of Aging , vol.19 , Issue.1 , pp. 97-103
    • Rozovsky, I.1    Finch, C.E.2    Morgan, T.E.3
  • 198
    • 58549101921 scopus 로고    scopus 로고
    • Estradiol-induced, endothelial progenitor cell-mediated neovascularization in male mice with hind-limb ischemia
    • Ruifrok, W.P., de Boer, R.A., Iwakura, A., Silver, M., Kusano, K., Tio, R.A., Losordo, D.W., 2009. Estradiol-induced, endothelial progenitor cell-mediated neovascularization in male mice with hind-limb ischemia. Vasc. Med. 14, 29-36.
    • (2009) Vasc. Med. , vol.14 , pp. 29-36
    • Ruifrok, W.P.1    De Boer, R.A.2    Iwakura, A.3    Silver, M.4    Kusano, K.5    Tio, R.A.6    Losordo, D.W.7
  • 200
    • 79959834906 scopus 로고    scopus 로고
    • Effects of estradiol on ischemic factor-induced astrocyte swelling and AQP4 protein abundance
    • Rutkowsky, J.M., Wallace, B.K., Wise, P.M., O'Donnell, M.E., 2011. Effects of estradiol on ischemic factor-induced astrocyte swelling and AQP4 protein abundance. Am. J. Physiol. Cell Physiol. 301, C204-212.
    • (2011) Am. J. Physiol. Cell Physiol. , vol.301
    • Rutkowsky, J.M.1    Wallace, B.K.2    Wise, P.M.3    O'Donnell, M.E.4
  • 202
    • 4143049088 scopus 로고    scopus 로고
    • Excessive testosterone treatment and castration induce reactive astrocytes and fos immunoreactivity in suprachiasmatic nucleus of mice
    • DOI 10.1016/j.brainres.2004.06.020, PII S0006899304009588
    • Satriotomo, I., Miki, T., Gonzalez, D., Matsumoto, Y., Li, H.P., Gu, H., Takeuchi, Y., 2004. Excessive testosterone treatment and castration induce reactive astrocytes and fos immunoreactivity in suprachiasmatic nucleus of mice. Brain Res. 1020, 130-139. (Pubitemid 39092978)
    • (2004) Brain Research , vol.1020 , Issue.1-2 , pp. 130-139
    • Satriotomo, I.1    Miki, T.2    Gonzalez, D.3    Matsumoto, Y.4    Li, H.-P.5    Gu, H.6    Takeuchi, Y.7
  • 203
    • 20444458775 scopus 로고    scopus 로고
    • Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: Proof of concept for the clinical importance of endogenous vascular repair
    • DOI 10.1161/CIRCULATIONAHA.104.504340
    • Schmidt-Lucke, C., Rossig, L., Fichtlscherer, S., Vasa, M., Britten, M., Kamper, U., Dimmeler, S., Zeiher, A.M., 2005. Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation 111, 2981-2987. (Pubitemid 40814192)
    • (2005) Circulation , vol.111 , Issue.22 , pp. 2981-2987
    • Schmidt-Lucke, C.1    Rossig, L.2    Fichtlscherer, S.3    Vasa, M.4    Britten, M.5    Kamper, U.6    Dimmeler, S.7    Zeiher, A.M.8
  • 204
    • 0017718021 scopus 로고
    • Uptake and metabolism of glutamate in astrocytes cultured from dissociated mouse brain hemispheres
    • Schousboe, A., Svenneby, G., Hertz, L., 1977. Uptake and metabolism of glutamate in astrocytes cultured from dissociated mouse brain hemispheres. J. Neurochem. 29, 999-1005. (Pubitemid 8226890)
    • (1977) Journal of Neurochemistry , vol.29 , Issue.6 , pp. 999-1005
    • Schousboe, A.1    Svenneby, G.2    Hertz, L.3
  • 205
    • 0033588402 scopus 로고    scopus 로고
    • Age-related changes in regional cerebral blood flow among young to mid- life adults
    • Schultz, S.K., O'Leary, D.S., Boles Ponto, L.L., Watkins, G.L., Hichwa, R.D., Andreasen, N.C., 1999. Age-related changes in regional cerebral blood flow among young to mid-life adults. Neuroreport 10, 2493-2496. (Pubitemid 29418125)
    • (1999) NeuroReport , vol.10 , Issue.12 , pp. 2493-2496
    • Schultz, S.K.1    O'Leary, D.S.2    Boles Ponto, L.L.3    Watkins, G.L.4    Hichwa, R.D.5    Andreasen, N.C.6
  • 206
    • 0027967687 scopus 로고
    • Neurotrophic factor gene expression in astrocytes during development and following injury
    • DOI 10.1016/0361-9230(94)90151-1
    • Schwartz, J.P., Nishiyama, N., 1994. Neurotrophic factor gene expression in astrocytes during development and following injury. Brain Res. Bull. 35, 403-407. (Pubitemid 24342089)
    • (1994) Brain Research Bulletin , vol.35 , Issue.5-6 , pp. 403-407
    • Schwartz, J.P.1    Nishiyama, N.2
  • 207
    • 77954957493 scopus 로고    scopus 로고
    • Reproductive age modulates the impact of focal ischemia on the forebrain as well as the effects of estrogen treatment in female rats
    • Selvamani, A., Sohrabji, F., 2010a. Reproductive age modulates the impact of focal ischemia on the forebrain as well as the effects of estrogen treatment in female rats. Neurobiol. Aging 31, 1618-1628.
    • (2010) Neurobiol. Aging , vol.31 , pp. 1618-1628
    • Selvamani, A.1    Sohrabji, F.2
  • 208
    • 77952626873 scopus 로고    scopus 로고
    • The neurotoxic effects of estrogen on ischemic stroke in older female rats is associated with age-dependent loss of insulin-like growth factor-1
    • Selvamani, A., Sohrabji, F., 2010b. The neurotoxic effects of estrogen on ischemic stroke in older female rats is associated with age-dependent loss of insulin-like growth factor-1. J. Neurosci. 30, 6852-6861.
    • (2010) J. Neurosci. , vol.30 , pp. 6852-6861
    • Selvamani, A.1    Sohrabji, F.2
  • 209
    • 58149263484 scopus 로고    scopus 로고
    • Proinflammatory reactants as determinants of stroke severity in elderly
    • Shakarishvili, R., Beridze, M., 2008. Proinflammatory reactants as determinants of stroke severity in elderly. Georgian Med. News, 23-27.
    • (2008) Georgian Med. News , pp. 23-27
    • Shakarishvili, R.1    Beridze, M.2
  • 210
    • 0027319870 scopus 로고
    • Pericyte physiology
    • Shepro, D., Morel, N.M., 1993. Pericyte physiology. FASEB J. 7, 1031-1038. (Pubitemid 23243445)
    • (1993) FASEB Journal , vol.7 , Issue.11 , pp. 1031-1038
    • Shepro, D.1    Morel, N.M.L.2
  • 211
    • 0030609088 scopus 로고    scopus 로고
    • Effects of 17-estradiol on glucose transporter 1 expression and endothelial cell survival following focal ischemia in the rats
    • DOI 10.1007/s002210050216
    • Shi, J., Zhang, Y., Simpkins, J., 1997. Effects of 17beta-estradiol on glucose transporter 1 expression and endothelial cell survival following focal ischemia in the rats. Exp. Brain Res. 117, 200-206. (Pubitemid 27488781)
    • (1997) Experimental Brain Research , vol.117 , Issue.2 , pp. 200-206
    • Shi, J.1    Zhang, Y.Q.2    Simpkins, J.W.3
  • 214
    • 84940626480 scopus 로고
    • Immunocytochemical studies of astrocytes following injury to the cerebral cortex of the rat
    • Singh, D.N., Mathew, T.C., 1989. Immunocytochemical studies of astrocytes following injury to the cerebral cortex of the rat. Acta Anat. (Basel) 134, 156-159. (Pubitemid 19102705)
    • (1989) Acta Anatomica , vol.134 , Issue.2 , pp. 156-159
    • Singh, D.N.P.1    Mathew, T.C.2
  • 215
    • 85027923032 scopus 로고    scopus 로고
    • Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans
    • Smith, C.J., Santhanam, L., Bruning, R.S., Stanhewicz, A., Berkowitz, D.E., Holowatz, L.A., 2011. Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans. Hypertension 58, 935-942.
    • (2011) Hypertension , vol.58 , pp. 935-942
    • Smith, C.J.1    Santhanam, L.2    Bruning, R.S.3    Stanhewicz, A.4    Berkowitz, D.E.5    Holowatz, L.A.6
  • 216
    • 84869501803 scopus 로고    scopus 로고
    • Increased levels of circulating endothelial progenitor cells in patients with ischaemic stroke treated with statins during acute phase
    • Sobrino, T., Blanco, M., Perez-Mato, M., Rodriguez-Yanez, M., Castillo, J., 2012. Increased levels of circulating endothelial progenitor cells in patients with ischaemic stroke treated with statins during acute phase. Eur. J. Neurol. 19, 1539-1546.
    • (2012) Eur. J. Neurol. , vol.19 , pp. 1539-1546
    • Sobrino, T.1    Blanco, M.2    Perez-Mato, M.3    Rodriguez-Yanez, M.4    Castillo, J.5
  • 217
    • 25144502374 scopus 로고    scopus 로고
    • Estrogen: A neuroprotective or proinflammatory hormone? Emerging evidence from reproductive aging models
    • DOI 10.1196/annals.1347.006
    • Sohrabji, F., 2005. Estrogen: a neuroprotective or proinflammatory hormone? Emerging evidence from reproductive aging models. Ann. NY Acad. Sci. 1052, 75-90. (Pubitemid 41338959)
    • (2005) Annals of the New York Academy of Sciences , vol.1052 , pp. 75-90
    • Sohrabji, F.1
  • 218
    • 0030795556 scopus 로고    scopus 로고
    • Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1
    • DOI 10.1210/en.138.8.3515
    • Sonntag, W.E., Lynch, C.D., Cooney, P.T., Hutchins, P.M., 1997. Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1. Endocrinology 138, 3515-3520. (Pubitemid 27345707)
    • (1997) Endocrinology , vol.138 , Issue.8 , pp. 3515-3520
    • Sonntag, W.E.1    Lynch, C.D.2    Cooney, P.T.3    Hutchins, P.M.4
  • 220
    • 79957723865 scopus 로고    scopus 로고
    • Neuroprotection mediated through estrogen receptor - Alpha in astrocytes
    • Spence, R.D., Hamby, M.E., Umeda, E., et al., 2011. Neuroprotection mediated through estrogen receptor - Alpha in astrocytes. Proc. Natl. Acad. Sci. USA 108, 8867-8872.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 8867-8872
    • Spence, R.D.1    Hamby, M.E.2    Umeda, E.3
  • 221
    • 25144524774 scopus 로고    scopus 로고
    • Estrogen increases mitochondrial efficiency and reduces oxidative stress in cerebral blood vessels
    • DOI 10.1124/mol.105.014662
    • Stirone, C., Duckles, S.P., Krause, D.N., Procaccio, V., 2005. Estrogen increases mitochondrial efficiency and reduces oxidative stress in cerebral blood vessels. Mol. Pharmacol. 68, 959-965. (Pubitemid 41345787)
    • (2005) Molecular Pharmacology , vol.68 , Issue.4 , pp. 959-965
    • Stirone, C.1    Duckles, S.P.2    Krause, D.N.3    Procaccio, V.4
  • 224
    • 0041743159 scopus 로고    scopus 로고
    • VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
    • DOI 10.1172/JCI200317977
    • Sun, Y., Jin, K., Xie, L., Childs, J., Mao, X.O., Logvinova, A., Greenberg, D.A., 2003. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J. Clin. Invest. 111, 1843-1851. (Pubitemid 38057729)
    • (2003) Journal of Clinical Investigation , vol.111 , Issue.12 , pp. 1843-1851
    • Sun, Y.1    Jin, K.2    Xie, L.3    Childs, J.4    Mao, X.O.5    Logvinova, A.6    Greenberg, D.A.7
  • 225
    • 80053632127 scopus 로고    scopus 로고
    • Sex-and brain region-specific role of cytochrome c oxidase in 1-methyl-4-phenylpyridinium-mediated astrocyte vulnerability
    • Sundar Boyalla, S., Barbara Victor, M., Roemgens, A., Beyer, C., Arnold, S., 2011. Sex-and brain region-specific role of cytochrome c oxidase in 1-methyl-4-phenylpyridinium-mediated astrocyte vulnerability. J. Neurosci. Res. 89, 2068-2082.
    • (2011) J. Neurosci. Res. , vol.89 , pp. 2068-2082
    • Sundar Boyalla, S.1    Barbara Victor, M.2    Roemgens, A.3    Beyer, C.4    Arnold, S.5
  • 226
    • 0021251197 scopus 로고
    • Xenon contrast CT-CBF scanning of the brain differentiates normal age-related changes from multi-infarct dementia and senile dementia of Alzheimer type
    • Tachibana, H., Meyer, J.S., Okayasu, H., Shaw, T.G., Kandula, P., Rogers, R.L., 1984. Xenon contrast CT-CBF scanning of the brain differentiates normal age-related changes from multi-infarct dementia and senile dementia of Alzheimer type. J. Gerontol. 39, 415-423. (Pubitemid 14089809)
    • (1984) Journals of Gerontology , vol.39 , Issue.4 , pp. 415-423
    • Tachibana, H.1    Meyer, J.S.2    Okayasu, H.3
  • 227
    • 0023864095 scopus 로고
    • Immunohistochemical studies on the proliferation of reactive astrocytes and the expression of cytoskeletal proteins following brain injury in rats
    • DOI 10.1016/0165-3806(88)90045-4
    • Takamiya, Y., Kohsaka, S., Toya, S., Otani, M., Tsukada, Y., 1988. Immunohistochemical studies on the proliferation of reactive astrocytes and the expression of cytoskeletal proteins following brain injury in rats. Brain Res. 466, 201-210. (Pubitemid 18057072)
    • (1988) Developmental Brain Research , vol.38 , Issue.2 , pp. 201-210
    • Takamiya, Y.1    Kohsaka, S.2    Toya, S.3    Otani, M.4    Tsukada, Y.5
  • 229
    • 67649401663 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor type 1 derived peptide, EEIIMD, diminishes cortical infarct but fails to improve neurological function in aged rats following middle cerebral artery occlusion
    • Tan, Z., Li, X., Kelly, K.A., Rosen, C.L., Huber, J.D., 2009. Plasminogen activator inhibitor type 1 derived peptide, EEIIMD, diminishes cortical infarct but fails to improve neurological function in aged rats following middle cerebral artery occlusion. Brain Res. 1281, 84-90.
    • (2009) Brain Res. , vol.1281 , pp. 84-90
    • Tan, Z.1    Li, X.2    Kelly, K.A.3    Rosen, C.L.4    Huber, J.D.5
  • 230
    • 77953703128 scopus 로고    scopus 로고
    • 17beta-estradiol protects male mice from cuprizone-induced demyelination and oligodendrocyte loss
    • Taylor, L.C., Puranam, K., Gilmore, W., Ting, J.P., Matsushima, G.K., 2010. 17beta-estradiol protects male mice from cuprizone-induced demyelination and oligodendrocyte loss. Neurobiol. Dis. 39, 127-137.
    • (2010) Neurobiol. Dis. , vol.39 , pp. 127-137
    • Taylor, L.C.1    Puranam, K.2    Gilmore, W.3    Ting, J.P.4    Matsushima, G.K.5
  • 232
    • 0027433602 scopus 로고
    • Synergistic action of estradiol and myelin basic protein on mast cell secretion and brain myelin changes resembling early stages of demyelination
    • DOI 10.1016/0306-4522(93)90030-J
    • Theoharides, T., Dimitriadou, V., Letourneau, R., Rozniecki, J., Vliagoftis, H., Boucher, W., 1993. Synergistic action of estradiol and myelin basic protein on mast cell secretion and brain myelin changes resembling early stages of demyelination. Neuroscience 57, 861-871. (Pubitemid 23350571)
    • (1993) Neuroscience , vol.57 , Issue.3 , pp. 861-871
    • Theoharides, T.C.1    Dimitriadou, V.2    Letourneau, R.3    Rozniecki, J.J.4    Vliagoftis, H.5    Boucher, W.6
  • 233
    • 0024568727 scopus 로고
    • Trauma-induced proliferation of astrocytes in the brains of young and aged rats
    • Topp, K.S., Faddis, B.T., Vijayan, V.K., 1989. Trauma-induced proliferation of astrocytes in the brains of young and aged rats. Glia 2, 201-211.
    • (1989) Glia , vol.2 , pp. 201-211
    • Topp, K.S.1    Faddis, B.T.2    Vijayan, V.K.3
  • 234
    • 0033755647 scopus 로고    scopus 로고
    • Estrogen decreases infarct size after temporary focal ischemia in a genetic model of type 1 diabetes mellitus
    • Toung, T.K., Hurn, P.D., Traystman, R.J., Sieber, F.E., 2000. Estrogen decreases infarct size after temporary focal ischemia in a genetic model of type 1 diabetes mellitus. Stroke 31, 2701-2706.
    • (2000) Stroke , vol.31 , pp. 2701-2706
    • Toung, T.K.1    Hurn, P.D.2    Traystman, R.J.3    Sieber, F.E.4
  • 235
    • 36048994244 scopus 로고    scopus 로고
    • A midlife stroke surge among women in the United States
    • DOI 10.1212/01.wnl.0000268491.89956.c2, PII 0000611420071113000004
    • Towfighi, A., Saver, J.L., Engelhardt, R., Ovbiagele, B., 2007. A midlife stroke surge among women in the United States. Neurology 69, 1898-1904. (Pubitemid 350103453)
    • (2007) Neurology , vol.69 , Issue.20 , pp. 1898-1904
    • Towfighi, A.1    Saver, J.L.2    Engelhardt, R.3    Ovbiagele, B.4
  • 236
    • 33646388397 scopus 로고    scopus 로고
    • Estrogen down-regulates glial activation in male mice following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxication
    • Tripanichkul, W., Sripanichkulchai, K., Finkelstein, D.I., 2006. Estrogen down-regulates glial activation in male mice following 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine intoxication. Brain Res. 1084, 28-37.
    • (2006) Brain Res. , vol.1084 , pp. 28-37
    • Tripanichkul, W.1    Sripanichkulchai, K.2    Finkelstein, D.I.3
  • 237
    • 84860311713 scopus 로고    scopus 로고
    • Cell-based therapy to promote angiogenesis in the brain following ischemic damage
    • Uemura, M., Kasahara, Y., Nagatsuka, K., Taguchi, A., 2012. Cell-based therapy to promote angiogenesis in the brain following ischemic damage. Curr. Vasc. Pharmacol. 10, 285-288.
    • (2012) Curr. Vasc. Pharmacol. , vol.10 , pp. 285-288
    • Uemura, M.1    Kasahara, Y.2    Nagatsuka, K.3    Taguchi, A.4
  • 240
    • 84863393540 scopus 로고    scopus 로고
    • Blood-brain barrier P-glycoprotein function in alzheimer's disease
    • van Assema, D.M., Lubberink, M., Bauer, M., et al., 2012. Blood-brain barrier P-glycoprotein function in Alzheimer's disease. Brain 135, 181-189.
    • (2012) Brain , vol.135 , pp. 181-189
    • Van Assema, D.M.1    Lubberink, M.2    Bauer, M.3
  • 241
    • 0016261856 scopus 로고
    • Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: An electron microscope study
    • Vaughan, D.W., Peters, A., 1974. Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: an electron microscope study. J. Neurocytol. 3, 405-429.
    • (1974) J. Neurocytol. , vol.3 , pp. 405-429
    • Vaughan, D.W.1    Peters, A.2
  • 242
    • 0033566709 scopus 로고    scopus 로고
    • Three-dimensional relationships between hippocampal synapses and astrocytes
    • Ventura, R., Harris, K.M., 1999. Three-dimensional relationships between hippocampal synapses and astrocytes. J. Neurosci. 19, 6897-6906. (Pubitemid 29380118)
    • (1999) Journal of Neuroscience , vol.19 , Issue.16 , pp. 6897-6906
    • Ventura, R.1    Harris, K.M.2
  • 244
    • 23044435896 scopus 로고    scopus 로고
    • Astrocytes, from brain glue to communication elements: The revolution continues
    • DOI 10.1038/nrn1722
    • Volterra, A., Meldolesi, J., 2005. Astrocytes, from brain glue to communication elements: the revolution continues. Nat. Rev. Neurosci. 6, 626-640. (Pubitemid 41059337)
    • (2005) Nature Reviews Neuroscience , vol.6 , Issue.8 , pp. 626-640
    • Volterra, A.1    Meldolesi, J.2
  • 246
    • 0023221277 scopus 로고
    • Extracellular matrix derived from astrocytes stimulates neuritic outgrowth from PC12 cells in vitro
    • DOI 10.1016/0165-3806(87)90198-2
    • Wujek, J., Akeson, R., 1987. Extracellular matrix derived from astrocytes stimulates neuritic outgrowth from PC12 cells in vitro. Dev. Brain Res. 34, 87-97. (Pubitemid 17123948)
    • (1987) Developmental Brain Research , vol.34 , Issue.1 , pp. 87-97
    • Wujek, J.R.1    Akeson, R.A.2
  • 247
    • 77649093444 scopus 로고    scopus 로고
    • Angiogenesis, neurogenesis and brain recovery of function following injury
    • Xiong, Y., Mahmood, A., Chopp, M., 2010. Angiogenesis, neurogenesis and brain recovery of function following injury. Curr. Opin. Invest. Drugs 11, 298-308.
    • (2010) Curr. Opin. Invest. Drugs , vol.11 , pp. 298-308
    • Xiong, Y.1    Mahmood, A.2    Chopp, M.3
  • 248
    • 33747887904 scopus 로고    scopus 로고
    • The influence of aging on recovery following ischemic brain damage
    • DOI 10.1016/j.bbr.2006.06.019, PII S0166432806003159
    • Yager, J.Y., Wright, S., Armstrong, E.A., Jahraus, C.M., Saucier, D.M., 2006. The influence of aging on recovery following ischemic brain damage. Behav. Brain Res. 173, 171-180. (Pubitemid 44291821)
    • (2006) Behavioural Brain Research , vol.173 , Issue.2 , pp. 171-180
    • Yager, J.Y.1    Wright, S.2    Armstrong, E.A.3    Jahraus, C.M.4    Saucier, D.M.5
  • 249
    • 0023659723 scopus 로고
    • Expression of beta-nerve growth factor mRNA in rat glioma cells and astrocytes from rat brain
    • Yamakuni, T., Ozawa, F., Hishinuma, F., Kuwano, R., Takahashi, Y., Amano, T., 1987. Expression of beta-nerve growth factor mRNA in rat glioma cells and astrocytes from rat brain. FEBS Lett. 223, 117-121.
    • (1987) FEBS Lett. , vol.223 , pp. 117-121
    • Yamakuni, T.1    Ozawa, F.2    Hishinuma, F.3    Kuwano, R.4    Takahashi, Y.5    Amano, T.6
  • 251
  • 252
    • 1342309220 scopus 로고    scopus 로고
    • The Use of Estrogens and Related Compounds in the Treatment of Damage from Cerebral Ischemia
    • DOI 10.1196/annals.1286.010
    • Yang, S.H., Liu, R., Wu, S.S., Simpkins, J.W., 2003. The use of estrogens and related compounds in the treatment of damage from cerebral ischemia. Ann. NY Acad. Sci. 1007, 101-107. (Pubitemid 38253658)
    • (2003) Annals of the New York Academy of Sciences , vol.1007 , pp. 101-107
    • Yang, S.-H.1    Liu, R.2    Wu, S.S.3    Simpkins, J.W.4
  • 253
    • 0036843061 scopus 로고    scopus 로고
    • Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats
    • DOI 10.1161/01.STR.0000034399.95249.59
    • Zhang, R., Wang, Y., Zhang, L., Zhang, Z., Tsang, W., Lu, M., Chopp, M., 2002. Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats. Stroke 33, 2675-2680. (Pubitemid 35266440)
    • (2002) Stroke , vol.33 , Issue.11 , pp. 2675-2680
    • Zhang, R.1    Wang, Y.2    Zhang, L.3    Zhang, Z.4    Tsang, W.5    Lu, M.6    Zhang, L.7    Chopp, M.8
  • 254
    • 9444284316 scopus 로고    scopus 로고
    • Intravenous administration of a GPIIb/IIIa receptor antagonist extends the therapeutic window of intra-arterial tenecteplase-tissue plasminogen activator in a rat stroke model
    • DOI 10.1161/01.STR.0000147963.68238.da
    • Zhang, L., Zhang, Z.G., Zhang, C., Zhang, R.L., Chopp, M., 2004. Intravenous administration of a GPIIb/IIIa receptor antagonist extends the therapeutic window of intra-arterial tenecteplase-tissue plasminogen activator in a rat stroke model. Stroke 35, 2890-2895. (Pubitemid 39565190)
    • (2004) Stroke , vol.35 , Issue.12 , pp. 2890-2895
    • Zhang, L.1    Zheng, G.Z.2    Zhang, C.3    Rui, L.Z.4    Chopp, M.5
  • 255
    • 32344447124 scopus 로고    scopus 로고
    • Bone morphogenetic protein-6 is expressed early by activated astrocytes in lesions of rat traumatic brain injury
    • DOI 10.1016/j.neuroscience.2005.11.036, PII S0306452205012996
    • Zhang, Z., Trautmann, K., Artelt, M., Burnet, M., Schluesener, H.J., 2006. Bone morphogenetic protein-6 is expressed early by activated astrocytes in lesions of rat traumatic brain injury. Neuroscience 138, 47-53. (Pubitemid 43222068)
    • (2006) Neuroscience , vol.138 , Issue.1 , pp. 47-53
    • Zhang, Z.1    Trautmann, K.2    Artelt, M.3    Burnet, M.4    Schluesener, H.J.5
  • 256
    • 44649178703 scopus 로고    scopus 로고
    • Gender differences in susceptibility to kainic acid-induced neurodegeneration in aged C57BL/6 mice
    • Zhang, X.M., Zhu, S.W., Duan, R.S., Mohammed, A.H., Winblad, B., Zhu, J., 2008. Gender differences in susceptibility to kainic acid-induced neurodegeneration in aged C57BL/6 mice. Neurotoxicology 29, 406-412.
    • (2008) Neurotoxicology , vol.29 , pp. 406-412
    • Zhang, X.M.1    Zhu, S.W.2    Duan, R.S.3    Mohammed, A.H.4    Winblad, B.5    Zhu, J.6
  • 257
    • 70449397081 scopus 로고    scopus 로고
    • Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation
    • Zhang, Q.G., Raz, L., Wang, R., Han, D., De Sevilla, L., Yang, F., Vadlamudi, R.K., Brann, D.W., 2009. Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation. J. Neurosci. 29, 13823-13836.
    • (2009) J. Neurosci. , vol.29 , pp. 13823-13836
    • Zhang, Q.G.1    Raz, L.2    Wang, R.3    Han, D.4    De Sevilla, L.5    Yang, F.6    Vadlamudi, R.K.7    Brann, D.W.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.