Hypoxia Modulates Free Radical Formation in Brain Microvascular Endothelium

Acta Neurochirurgica, Supplement

Volumn 1997, Issue 70, 1997, Pages 8-11

  Strasser, A ^a   Stanimirovic, D ^a   Kawai, N ^a   McCarron, R M ^a   Spatz, M ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Blood brain barrier; Cerebral hypoxia; Free radical formation; Microvascular endothelium

Indexed keywords

FREE RADICAL; REACTIVE OXYGEN METABOLITE;

ANIMAL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN HYPOXIA; METABOLISM; PHYSIOLOGY; RAT; VASCULAR ENDOTHELIUM;

ANIMALS; BLOOD-BRAIN BARRIER; ENDOTHELIUM, VASCULAR; FREE RADICALS; HYPOXIA, BRAIN; RATS; REACTIVE OXYGEN SPECIES;

EID: 0031300156     PISSN: 00651419     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-6837-0_3     Document Type: Article

References (15)

1. Baechner RL, Boxer LA, Davis J (1976) The biochemical basis of nitroblue tetrazolium reduction in normal human and chronic granulomatous disease polymorphonuclear leukocytes. Blood 48: 309-313
2. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA (1990) Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87: 1620-1624
3. Chan PH (1989) The role of oxygen radicals in brain injury and edema. Chapter 30. In: Chow CK (ed) Cellular antioxidant defense mechanisms, Vol III. CRC, Boca Raton, Florida, pp 89-109
4. Chan PH, Schmidley JW, Fishman RA, Longar SM (1984) Brain injury, edema, and vascular permeability changes induced by oxygen-derived free radicals. Neurology 34: 315-320
5. Halliwell B (1992) Reactive oxygen species and the central nervous system. J Neurochem 59: 1609-1623
6. Halliwell B (1993) The role of oxygen radicals in human disease, with particular reference to the vascular system. Haemostasis 23 [Suppl 1]: 118-126
7. Lowry OH, Passonneau JV (1972) A flexible system of enzymatic analysis. Academic Press, New York
8. McCarron RM, Uematsu S, Merkel N, Long D, Bembry J, Spatz M (1990) The role of arachidonic acid and oxygen radicals on cerebromicrovascular endothelial permeability. Acta Neurochir (Wien) [Suppl] 51: 61-64
9. Menger MD, Lehr H-A, Messmer K (1991) Role of oxygen radicals in the microcirculatory manifestations of postischemic injury. Klin Wochenschr 69: 1050-1055
10. Moncada S, Palmer RM, Higgs EA (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109-142
11. Mrsulja BB, Djuric BM, Crejic V, Mrsulja BJ, Abe K, Spatz M, Klatzo I (1980) Biochemistry of experimental ischemic edema. Adv Neurol 28: 217-230
12. Spatz M, Bembry J, Dodson RF, Hervonen H, Murray, MR (1980) Endothelial cell culture derived from isolated cerebral microvessels. Brain Res 191: 577-582
13. Stanimirovic DB, Bertrand N, McCarron R, Uematsu S, Spatz M (1994) Arachidonic acid release and permeability changes induced by endothelins in human cerebromicrovascular endothelium. Acta Neurochir (Wien) [Suppl] 60: 71-75
14. Vercellotti GM, Dolson M, Schorer AE, Moldow CR (1988) Endothelial cell heterogeneity: antioxidant profiles determine vulnerability to oxidant injury. Proc Soc Exp Biol Med 187: 181-189
15. Villacara A, Spatz M, Dodson RF, Corn C, Bembry J (1989) Effect of arachidonic acid on cultured cerebromicrovascular endothelium: permeability, lipid peroxidation and membrane fluidity. Acta Neuropathol (Berl) 78: 310-316