Worsened outcome from middle cerebral artery occlusion in aged rats receiving 17β-estradiol

Endocrinology

Volumn 153, Issue 7, 2012, Pages 3386-3393

  Leon, Rachel L ^a   Li, Xinlan ^a   Huber, Jason D ^a   Rosen, Charles L ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALTEPLASE; ESTRADIOL; PLACEBO;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN EMBOLISM; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DISEASE EXACERBATION; DRUG EFFECT; DRUG PELLET; ESTRADIOL BLOOD LEVEL; ESTROGEN THERAPY; FEMALE; FIBRIN CLOT; HISTOPATHOLOGY; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RAT; STROKE; TREATMENT OUTCOME;

AGING; ANIMALS; ASTROCYTES; BODY WEIGHT; BRAIN; BRAIN ISCHEMIA; ESTRADIOL; FEMALE; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; NEUROPROTECTIVE AGENTS; PLACEBOS; PLASMINOGEN ACTIVATORS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; REPERFUSION; REPERFUSION INJURY; TREATMENT OUTCOME;

EID: 84862746828     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-1859     Document Type: Article

References (34)

1. Wassertheil-Smoller S, Hendrix SL, Limacher M, Heiss G, Kooperberg C, Baird A, Kotchen T, Curb JD, Black H, Rossouw JE, Aragaki A, Safford M, Stein E, Laowattana S, Mysiw WJ 2003 Effect of estrogen plus progestin on stroke in postmenopausal women: the Women's Health Initiative: a randomized trial. JAMA 289:2673-2684 (Pubitemid 37430138)
2. Bath PM, Gray LJ 2005 Association between hormone replacement therapy and subsequent stroke: a meta-analysis. BMJ 330:342
3. Sare GM, Gray LJ, Bath PM 2008 Association between hormone replacement therapy and subsequent arterial and venous vascular events: a meta-analysis. Eur Heart J 29:2031-2041
4. Simpkins JW, Rajakumar G, Zhang YQ, Simpkins CE, Greenwald D, Yu CJ, Bodor N, Day AL 1997 Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. J Neurosurg 87:724-730
5. Dubal DB, Kashon ML, Pettigrew LC, Ren JM, Finklestein SP, Rau SW, Wise PM 1998 Estradiol protects against ischemic injury. J Cereb Blood Flow Metab 18:1253-1258 (Pubitemid 28509840)
6. Toung TJ, Traystman RJ, Hurn PD 1998 Estrogen-mediated neuroprotection after experimental stroke in male rats. Stroke 29:1666-1670 (Pubitemid 28365591)
7. Culmsee C, Vedder H, Ravati A, Junker V, Otto D, Ahlemeyer B, Krieg JC, Krieglstein J 1999 Neuroprotection by estrogens in a mouse model of focal cerebral ischemia and in cultured neurons: evidence for a receptor-independent antioxidative mechanism. J Cereb Blood Flow Metab 19:1263-1269 (Pubitemid 30176455)
8. Merchenthaler I, Dellovade TL, Shughrue PJ 2003 Neuroprotection by estrogen in animal models of global and focal ischemia. Ann NY Acad Sci 1007:89-100 (Pubitemid 38253657)
9. Rau SW, Dubal DB, Böttner M, Gerhold LM, Wise PM 2003 Estradiol attenuates programmed cell death after stroke-like injury. J Neurosci 23:11420-11426 (Pubitemid 37549698)
10. Hoffman GE, Merchenthaler I, Zup SL 2006 Neuroprotection by ovarian hormones in animal models of neurological disease. Endocrine 29:217-231 (Pubitemid 44097365)
11. Connell BJ, Crosby KM, Richard MJ, Mayne MB, Saleh TM 2007 Estrogen-mediated neuroprotection in the cortex may require NMDA receptor activation. Neuroscience 146:160-169
12. Lebesgue D, Chevaleyre V, Zukin RS, Etgen AM 2009 Estradiol rescues neurons from global ischemia-induced cell death: multiple cellular pathways of neuroprotection. Steroids 74:555-561
13. Rosen CL, Dinapoli VA, Nagamine T, Crocco T 2005 Influence of age on stroke outcome following transient focal ischemia. J Neurosurg 103:687-694 (Pubitemid 43193876)
14. Dinapoli VA, Rosen CL, Nagamine T, Crocco T 2006 Selective MCA occlusion: a precise embolic stroke model. J Neurosci Methods 154:233-238 (Pubitemid 43816728)
15. DiNapoli VA, Huber JD, Houser K, Li X, Rosen CL 2008 Early disruptions of the blood-brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats. Neurobiol Aging 29:753-764
16. Li Y, Chen J, Chen XG, Wang L, Gautam SC, Xu YX, Katakowski M, Zhang LJ, Lu M, Janakiraman N, ChoppM2002 Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery. Neurology 59:514-523 (Pubitemid 34919983)
17. Yang Y, Shuaib A, LiQ1998 Quantification of infarct size on focal cerebral ischemia model of rats using a simple and economical method. J Neurosci Methods 84:9-16
18. Selvamani A, Sohrabji F 2010 Reproductive age modulates the impact of focal ischemia on the forebrain as well as the effects of estrogen treatment in female rats. Neurobiol Aging 31:1618-1628
19. Barreto G, Veiga S, Azcoitia I, Garcia-Segura LM, Garcia-Ovejero D 2007 Testosterone decreases reactive astroglia and reactive microglia after brain injury in male rats: role of its metabolites, oestradiol and dihydrotestosterone. Eur J Neurosci 25:3039-3046 (Pubitemid 46888812)
20. Cordeau Jr P, Lalancette-Hébert M, Weng YC, Kriz J 2008 Live imaging of neuroinflammation reveals sex and estrogen effects on astrocyte response to ischemic injury. Stroke 39:935-942 (Pubitemid 351619580)
21. Barreto G, Santos-Galindo M, Diz-Chaves Y, Pernía O, Carrero P, Azcoitia I, Garcia-SeguraLM2009 Selective estrogen receptor modulators decrease reactive astrogliosis in the injured brain: effects of aging and prolonged depletion of ovarian hormones. Endocrinology 150:5010-5015
22. Pekny M, Eliasson C, Siushansian R, Ding M, Dixon SJ, Pekna M, Wilson JX, Hamberger A 1999 The impact of genetic removal of GFAP and/or vimentin on glutamine levels and transport of glucose and ascorbate in astrocytes. Neurochem Res 24:1357-1362 (Pubitemid 29505944)
23. Dubal DB, Rau SW, Shughrue PJ, Zhu H, Yu J, Cashion AB, Suzuki S, Gerhold LM, Bottner MB, Dubal SB, Merchanthaler I, Kindy MS, Wise PM 2006 Differential modulation of estrogen receptors (ERs) in ischemic brain injury: a role for ERα in estradiol-mediated protection against delayed cell death. Endocrinology 147:3076-3084 (Pubitemid 43764643)
24. Sampei K, Goto S, Alkayed NJ, Crain BJ, Korach KS, Traystman RJ, Demas GE, Nelson RJ, Hurn PD 2000 Stroke in estrogen receptor-alpha-deficient mice. Stroke 31:738-743; discussion 744
25. Dubal DB, Zhu H, Yu J, Rau SW, Shughrue PJ, Merchenthaler I, Kindy MS, Wise PM 2001 Estrogen receptorα, notβ, is a critical link in estradiol-mediated protection against brain injury. Proc Natl Acad Sci USA 98:1952-1957 (Pubitemid 32165604)
26. Wise PM, Dubal DB, Rau SW, Brown CM, Suzuki S 2005 Are estrogens protective or risk factors in brain injury and neurodegeneration? Reevaluation after the Women's Health Initiative. Endocr Rev 26:308-312 (Pubitemid 40686644)
27. Suzuki S, Brown CM, Dela Cruz CD, Yang E, Bridwell DA, Wise PM 2007 Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and antiinflammatory actions. Proc Natl Acad Sci USA 104:6013-6018 (Pubitemid 47175650)
28. Rocca WA, Grossardt BR, Shuster LT 2010 Oophorectomy, reproductive senescence, estrogen, and cognitive aging: the timing hypothesis. Neurodegener Dis 7:163-166
29. Popa-Wagner A, Badan I, Vintilescu R, Walker L, Kessler C 2006 Premature cellular proliferation following cortical infarct in aged rats. Rom J Morphol Embryol 47:215-228
30. Balaban B, Tok F, Yavuz F, Yaar E, Alaca R 2011 Early rehabilitation outcome in patients with middle cerebral artery stroke. Neurosci Lett 498:204-207
31. Lukanova A, Lundin E, Zeleniuch-Jacquotte A, Muti P, Mure A, Rinaldi S, Dossus L, Micheli A, Arslan A, Lenner P, Shore RE, Krogh V, Koenig KL, Riboli E, Berrino F, Hallmans G, Stattin P, Toniolo P, Kaaks R 2004 Body mass index, circulating levels of sex-steroid hormones, IGF-I and IGF-binding protein-3: a cross-sectional study in healthy women. Eur J Endocrinol 150:161-171 (Pubitemid 38312809)
32. McCullough LD, Blizzard K, Simpson ER, Oz OK, Hurn PD 2003 Aromatase cytochrome P450 and extragonadal estrogen play a role in ischemic neuroprotection. J Neurosci 23:8701-8705 (Pubitemid 37176650)
33. Peterson RS, Lee DW, Fernando G, Schlinger BA 2004 Radial glia express aromatase in the injured zebra finch brain. J Comp Neurol 475:261-269 (Pubitemid 38850023)
34. Strom JO, Theodorsson A, Theodorrsson E 2011 Mechanism of estrogens' dose-dependent neuroprotective and neurodamaging effects in experimental models of cerebral ischemia. Int J Mol Sci 12:1533-1562