Shear stress and 17β-estradiol modulate cerebral microvascular endothelial Na-K-Cl cotransporter and Na/H exchanger protein levels

American Journal of Physiology - Cell Physiology

Volumn 294, Issue 1, 2008, Pages

  Chang, Elaine ^a   O'Donnell, Martha E ^b   Barakat, Abdul I ^a  

^a University of California   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Endothelium; Estrogen; Flow reduction; Ischemia; Mechanotransduction

Indexed keywords

ESTRADIOL; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; SODIUM PROTON EXCHANGE PROTEIN;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN EDEMA; BRAIN ISCHEMIA; CONTROLLED STUDY; ENDOTHELIUM CELL; MECHANOTRANSDUCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; SHEAR STRESS; VASCULAR ENDOTHELIUM; ANIMAL; CATTLE; CELL SHAPE; MECHANICAL STRESS; METABOLISM; MICROCIRCULATION; PATHOLOGY; PATHOPHYSIOLOGY; PULSATILE FLOW; TIME;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN ISCHEMIA; CATTLE; CELL SHAPE; ENDOTHELIAL CELLS; ESTRADIOL; MECHANOTRANSDUCTION, CELLULAR; MICROCIRCULATION; PULSATILE FLOW; SODIUM-HYDROGEN ANTIPORTER; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS; STRESS, MECHANICAL; TIME FACTORS;

EID: 38349157293     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00045.2007     Document Type: Article

References (53)

1. Sdi1/Cip1/Waf1. Circ Res 86: 185-190, 2000.
2. Betz AL. Alterations in cerebral endothelial cell function in ischemia. Adv Neurol 71: 301-311, 1996.
3. Denker SP, Barber DL. Ion transport proteins anchor and regulate the cytoskeleton. Curr Opin Cell Biol 14: 214-220, 2002.
4. + translocation. Mol Cell 6: 1425-1436, 2000.
5. Desai SY, Marroni M, Cucullo L, Krizanac-Bengez L, Mayberg MR, Hossain MT, Grant GG, Janigro D. Mechanisms of endothelial survival under shear stress. Endothelium 9: 89-102, 2002.
6. Dubal DB, Kashon ML, Pettigrew LC, Ren JM, Finklestein SP, Rau SW, Wise PM. Estradiol protects against ischemic injury. J Cereb Blood Flow Metab 18: 1253-1258, 1998.
7. + exchange in human endothelial cells. Am J Physiol Cell Physiol 259: C640-C646, 1990.
8. - cotransporter. Am J Physiol Cell Physiol 289: C1492-C1501, 2005.
9. Haynes MP, Sinha D, Russell KS, Collinge M, Fulton D, Morales-Ruiz M, Sessa WC, Bender JR. Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells. Circ Res 87: 677-682, 2000.
10. + exchange. Cardiovasc Res 69: 916-924, 2006.
11. Hisamoto K, Ohmichi M, Kurachi H, Hayakawa J, Kanda Y, Nishio Y, Adachi K, Tasaka K, Miyoshi E, Fujiwara N, Taniguchi N, Murata Y. Estrogen induces the Akt-dependent activation of endothelial nitricoxide synthase in vascular endothelial cells. J Biol Chem 276: 3459-3467, 2001.
12. Hurn PD, Macrae IM. Estrogen as a neuroprotectant in stroke. J Cereb Blood Flow Metab 20: 631-652, 2000.
13. Iadecola C. Mechanisms of cerebral ischemic damage. In: Cerebral Ischemia: Molecular and Cellular Pathophysiology, edited by Walz W. Totowa, NJ: Humana, 1999, p. 3-34.
14. Jojart I, Joo F, Siklos L, Laszlo FA. Immunoelectronhistochemical evidence for innervation of brain microvessels by vasopressin-immunoreactive neurons in the rat. Neurosci Lett 51: 259-264, 1984.
15. - cotransport system in brain capillary endothelial cells: response to endothelin and hypoxia. Neurochem Res 21: 1259-1266, 1996.
16. Kelly MJ, Qiu J, Ronnekleiv OK. Estrogen modulation of G-protein-coupled receptor activation of potassium channels in the central nervous system. Ann NY Acad Sci 1007: 6-16, 2003.
17. + exchanger reduces infarct volume of focal cerebral ischemia in rats. Brain Res 922: 223-228, 2001.
18. Krizanac-Bengez L, Mayberg MR, Cunningham E, Hossain M, Ponnampalam S, Parkinson FE, Janigro D. Loss of shear stress induces leukocyte-mediated cytokine release and blood-brain barrier failure in dynamic in vitro blood-brain barrier model. J Cell Physiol 206: 68-77, 2006.
19. 2+ oscillations in lung capillaries. Am J Physiol Lung Cell Mol Physiol 282: L917-L923, 2002.
20. + exchange inhibitor, in transient cerebral ischemia in rats. Eur J Pharmacol 383: 163-168, 1999.
21. Lam TI, Wise PM, O'Donnell ME. Na/H exchange of cerebral microvascular endothelial cells: evidence for the presence of NHE1 and NHE2 isoforms and stimulation by ischemic conditions (Abstract). In: 2006 Neuroscience Meeting Planner, Atlanta, GA (Online). Society for Neuroscience, Washington, D. C. Program no. 8318. http://www.sfn.org/am2006/? CFID=13481835&CFTOKEN=89473827 [7 Dec. 2007].
22. Landgraf R. Central release of vasopressin: stimuli, dynamics, consequences. Prog Brain Res 91: 29-39, 1992.
23. MacAulay N, Hamann S, Zeuthen T. Water transport in the brain: role of cotransporters. Neuroscience 129: 1031-1044, 2004.
24. McEwen BS, Alves SE. Estrogen actions in the central nervous system. Endocr Rev 20: 279-307, 1999.
25. Menzies SA, Betz AL, Hoff JT. Contributions of ions and albumin to the formation and resolution of ischemic brain edema. J Neurosurg 78: 257-266, 1993.
26. Murphy SJ, McCullough LD, Smith JM. Stroke in the female: role of biological sex and estrogen. ILAR J 45: 147-159, 2004.
27. - current by hypotonic volume increase in human endothelial cells. J Gen Physiol 103: 787-805, 1994.
28. O'Donnell ME. Role of Na-K-Cl cotransport in vascular endothelial cell volume regulation. Am J Physiol Cell Physiol 264: C1316-C1326, 1993.
29. O'Donnell ME, Brandt JD, Curry FR. Na-K-Cl cotransport regulates intracellular volume and monolayer permeability of trabecular meshwork cells. Am J Physiol Cell Physiol 268: C1067-C1074, 1995.
30. O'Donnell ME, Lam TI, Tran LQ, Foroutan S, Anderson SE. Estradiol reduces activity of the blood-brain barrier Na-K-Cl cotransporter and decreases edema formation in permanent middle cerebral artery occlusion. J Cereb Blood Flow Metab 26: 1234-1249, 2006.
31. O'Donnell ME, Martinez A, Sun D. Endothelial Na-K-Cl cotransport regulation by tonicity and hormones: phosphorylation of cotransport protein. Am J Physiol Cell Physiol 269: C1513-C1523, 1995.
32. O'Donnell ME, Tran L, Lam T, Liu XB, Anderson SE. Bumetanide inhibition of the blood-brain barrier Na-K-Cl cotransporter reduces edema formation in the rat middle cerebral artery occlusion model of stroke. J Cereb Blood Flow Metab 24: 1046-1056, 2004.
33. - cotransporter in the heart, brain and blood. Am J Physiol Regul Integr Comp Physiol 291: R1-R25, 2006.
34. + exchanger, NHE1: structure, regulation, and cellular actions. Annu Rev Pharmacol Toxicol 42: 527-552, 2002.
35. Rau SW, Dubal DB, Bottner M, Gerhold LM, Wise PM. Estradiol attenuates programmed cell death after stroke-like injury. J Neurosci 23: 11420-11426, 2003.
36. Russell JM. Sodium-potassium-chloride cotransport. Physiol Rev 80: 211-276, 2000.
37. Schwartz EA, Bizios R, Medow MS, Gerritsen ME. Exposure of human vascular endothelial cells to sustained hydrostatic pressure stimulates proliferation: involvement of the alphaV integrins. Circ Res 84: 315-322, 1999.
38. Singh M, Sétáló G Jr, Guan X, Warren M, Toran-Allerand CD. Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: convergence of estrogen and neurotrophin signaling pathways. J Neurosci Res 19: 1179-1188, 1999.
39. Singh M, Sétáló G, Guan X, Frail D, Toran-Allerand CD. Estrogen-induced activation of the mitogen-activated protein kinase cascade in the cerebral cortex of estrogen receptor-α knock-out mice. J Neurosci 20: 1694-1700, 2000.
40. + exchanger. Biochem Cell Biol 80: 499-508, 2002.
41. Spatz M, Kawai N, Merkel N, Bembry J, McCarron RM. Functional properties of cultured endothelial cells derived from large microvessels of human brain. Am J Physiol Cell Physiol 272: C231-C239, 1997.
42. Sun D, O'Donnell ME. Astroglial-mediated phosphorylation of the Na-K-Cl cotransporter in brain microvessel endothelial cells. Am J Physiol Cell Physiol 271: C620-C627, 1996.
43. Suvatne J, Barakat AI, O'Donnell ME. Flow-induced expression of endothelial Na-K-Cl cotransport: dependence on K and Cl channels. Am J Physiol Cell Physiol 280: C216-C227, 2001.
44. Topper JN, Wasserman SM, Anderson KR, Cai J, Falb D, Gimbrone MA Jr. Expression of the bumetanide-sensitive Na-K-Cl cotransporter BSC2 is differentially regulated by fluid mechanical and inflammatory cytokine stimuli in vascular endothelium. J Clin Invest 99: 2941-2949, 1997.
45. Toung TJK, Traystman RJ, Hurn PD. Estrogen-mediated neuroprotection after experimental stroke in male rats. Stroke 29: 1666-1670, 1998.
46. Tran LQ, Anderson SE, O'Donnell ME. HOE-642 and bumetanide reduce edema formation and infarct following permanent rat middle cerebral artery occlusion (Abstract). FASEB J 18: A1069, 2004.
47. - cotransporter of brain capillary endothelial cells. Properties and regulation by endothelins, hyperosmolar solutions, calyculin A, and interleukin-1. J Biol Chem 269: 19925-19930, 1994.
48. Watters JJ, Dorsa DM. Transcriptional effects of estrogen on neuronal neurotensin gene expression involve cAMP/protein kinase A-dependent signaling mechanisms. J Neurosci 18: 6672-6680, 1998.
49. Yang SH, Shi J, Day AL, Simpkins JW. Estradiol exerts neuroprotective effects when administered after ischemic insult. Stroke 31: 745-750, 2000.
50. Yerby TR, Vibat CR, Sun D, Payne JA, O'Donnell ME. Molecular characterization of the Na-K-Cl cotransporter of bovine aortic endothelial cells. Am J Physiol Cell Physiol 273: C188-C197, 1997.
51. Zhang YQ, Shi J, Rajakumar G, Day AL, Simpkins JW. Effects of gender and estradiol treatment on focal brain ischemia. Brain Res 784: 321-324, 1998.
52. Ziegelstein RC, Blank PS, Cheng L, Capogrossi MC. Cytosolic alkalinization of vascular endothelial cells produced by an abrupt reduction in fluid shear stress. Circ Res 82: 803-809, 1998.
53. Ziegelstein RC, Cheng L, Capogrossi MC. Flow-dependent cytosolic acidification of vascular endothelial cells. Science 656-659: 1992.