Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity

Journal of Medicinal Chemistry

Volumn 56, Issue 15, 2013, Pages 6200-6215

  Teguh, Silvia C ^a,b   Klonis, Nectarios ^a,b   Duffy, Sandra ^d   Lucantoni, Leonardo ^d   Avery, Vicky M ^d   Hutton, Craig A ^a,b   Baell, Jonathan B ^c   Tilley, Leann ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d GRIFFITH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIMETHYL 4 (N METHYLACETAMIDO)QUINOLINIUM IODIDE; 2 [2 (1H INDOL 3 YL)VINYL]QUINOLIN 4 AMINE; 4 (N METHYLACETAMIDO) 1 METHYL 2 [2 (2 METHYL 3A H INDOL 3 YL)VINYL]QUINOLINIUM IODIDE; 4 (N METHYLAMINO) 1 METHYL 2 [2 (2 METHYL 3AH INDOL 3YL)VINYL]QUINOLINIUM IODIDE; 4 ACETAMIDO 7 CHLORO N, 2 DIMETHYLQUINOLINIUM IODIDE; 4 ACETAMIDO N BUTYL 2 METHYLQUINOLINIUM IODIDE; 4 ACETAMIDO N, 2 DIMETHYLQUINOLINIUM IODIDE; 4 AMINO 1 BUTYL 2 [2 (3AH INDOL 3 YL)VINYL]QUINOLINIUM IODIDE; 4 AMINO 1 METHYL 2 [2 (2 METHYL 3A H INDOL 3 YL)VINYL]QUINOLINIUM IODIDE; 4 AMINO 1 METHYL 2 [2 (3AH INDAZOL 3 YL)VINYL]QUINOLINIUM IODIDE; 4 AMINO 1 METHYL 2 [2 (3AH INDOLE 3 YL)VINYL]QUINOLINIUM IODIDE; 4 AMINO 1 METHYL 2 [2 (6 FLUORO 3AH INDOL 3 YL)VINYL]QUINOLINIUM IODIDE; 4 AMINO 1 METHYL 2 [2 (7 AZA 3AH INDOL 3 YL)VINYL]QUINOLINIUM IODIDE; 4 AMINO 7 CHLORO 1 METHYL 2 [2 (3AH INDOL 3 YL)VINYL]QUINOLINIUM IODIDE; 4 AMINOQUINOLINE DERIVATIVE; 4,6 DIAMINO 1,2 DIHYDRO 2,2 DIMETHYL 1 [3 (2,4,5 TRICHLOROPHENOXY)PROPOXY] 1,3,5 TRIAZINE; AMINOQUINOLIUM INDOLE CONJUGATE; ANTHELMINTIC AGENT; ANTIMALARIAL AGENT; ANTINEOPLASTIC AGENT; ARTESUNATE; INDOLE DERIVATIVE; METHYLENE BLUE; N (2 METHYLQUINOLIN 4 YL)ACETAMIDE; N (7 CHLORO 2 METHYLQUINOLIN 4 YL)ACETAMIDE; N [5 (DIETHYLAMINO)PENTAN 2 YL) 2 METHYLQUINOLIN 4 AMINE; N METHYL N (2 METHYLQUINOLIN 4 YL)ACETAMIDE; N, 2 DIMETHYLQUINOLIN 4 AMINE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTHELMINTIC ACTIVITY; ANTIMALARIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONJUGATE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; MITOCHONDRION; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

AMINOQUINOLINES; ANTIMALARIALS; CHLOROQUINE; DRUG RESISTANCE; HEK293 CELLS; HEMEPROTEINS; HEMOGLOBINS; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84881452814     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400656s     Document Type: Article

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