-
1
-
-
0029903770
-
DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: Interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites
-
Vinkemeier U, Cohen SL, Moarefi I, Chait BT, Kuriyan J, Darnell JE Jr. DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites. EMBO J. 1996;15(20):5616-5626.
-
(1996)
EMBO J
, vol.15
, Issue.20
, pp. 5616-5626
-
-
Vinkemeier, U.1
Cohen, S.L.2
Moarefi, I.3
Chait, B.T.4
Kuriyan, J.5
Darnell Jr., J.E.6
-
2
-
-
65449119145
-
Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains
-
Wojciak JM, Martinez-Yamout MA, Dyson HJ, Wright PE. Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains. EMBO J. 2009;28(7):948-958.
-
(2009)
EMBO J
, vol.28
, Issue.7
, pp. 948-958
-
-
Wojciak, J.M.1
Martinez-Yamout, M.A.2
Dyson, H.J.3
Wright, P.E.4
-
3
-
-
0028349735
-
Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
-
Zhong Z, Wen Z, Darnell JE Jr. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science. 1994;264(5155):95-98.
-
(1994)
Science
, vol.264
, Issue.5155
, pp. 95-98
-
-
Zhong, Z.1
Wen, Z.2
Darnell Jr., J.E.3
-
4
-
-
0028303977
-
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
-
Akira S, Nishio Y, Inoue M, et al. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell. 1994;77(1): 63-71.
-
(1994)
Cell
, vol.77
, Issue.1
, pp. 63-71
-
-
Akira, S.1
Nishio, Y.2
Inoue, M.3
-
5
-
-
0034612592
-
Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4
-
Hart KC, Robertson SC, Kanemitsu MY, Meyer AN, Tynan JA, Donoghue DJ. Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4. Oncogene. 2000;19(29):3309-3320.
-
(2000)
Oncogene
, vol.19
, Issue.29
, pp. 3309-3320
-
-
Hart, K.C.1
Robertson, S.C.2
Kanemitsu, M.Y.3
Meyer, A.N.4
Tynan, J.A.5
Donoghue, D.J.6
-
6
-
-
0031581070
-
C-Src activates both STAT1 and STAT3 in PDGF-stimulated NIH3T3 cells
-
Cirri P, Chiarugi PMarra F,et al, C-Src activates both STAT1 and STAT3 in PDGF-stimulated NIH3T3 cells. Biochem Biophys Res Commun. 1997;239(2):493-497.
-
(1997)
Biochem Biophys Res Commun
, vol.239
, Issue.2
, pp. 493-497
-
-
Cirri, P.1
Chiarugi, P.2
Marra, F.3
-
7
-
-
0035794217
-
DNA binding specificity of different STAT proteins.Comparison of in vitro specificity with natural target sites
-
Ehret GB, Reichenbach P, Schindler U, et al. DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites. J Biol Chem. 2001;276(9):6675-6688.
-
(2001)
J Biol Chem
, vol.276
, Issue.9
, pp. 6675-6688
-
-
Ehret, G.B.1
Reichenbach, P.2
Schindler, U.3
-
8
-
-
0029739627
-
Cooperative DNA binding and sequenceselective recognition conferred by the STAT amino-terminal domain
-
Xu X, Sun YL, Hoey T. Cooperative DNA binding and sequenceselective recognition conferred by the STAT amino-terminal domain. Science. 1996;273(5276):794-797.
-
(1996)
Science
, vol.273
, Issue.5276
, pp. 794-797
-
-
Xu, X.1
Sun, Y.L.2
Hoey, T.3
-
9
-
-
84876829022
-
Studies of Jak/STAT3 expression and signalling in psoriasis identifies STAT3Ser727 phosphorylation as a modulator of transcriptional activity
-
Andrés RM, Hald A, Johansen C, Kragballe K, Iversen L. Studies of Jak/STAT3 expression and signalling in psoriasis identifies STAT3Ser727 phosphorylation as a modulator of transcriptional activity. Exp Dermatol. 2013;22(5):323-328.
-
(2013)
Exp Dermatol
, vol.22
, Issue.5
, pp. 323-328
-
-
Andrés, R.M.1
Hald, A.2
Johansen, C.3
Kragballe, K.4
Iversen, L.5
-
10
-
-
84855866260
-
Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phosphoTyr705 largely through TC45
-
Wakahara R, Kunimoto H, Tanino K, et al. Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phosphoTyr705 largely through TC45. Genes Cells. 2012;17(2):132-145.
-
(2012)
Genes Cells
, vol.17
, Issue.2
, pp. 132-145
-
-
Wakahara, R.1
Kunimoto, H.2
Tanino, K.3
-
11
-
-
15744385061
-
Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation
-
Wang R, Cherukuri P, Luo J. Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation. J Biol Chem. 2005;280(12):11528-11534.
-
(2005)
J Biol Chem
, vol.280
, Issue.12
, pp. 11528-11534
-
-
Wang, R.1
Cherukuri, P.2
Luo, J.3
-
12
-
-
12244251445
-
Stat3 dimerization regulated by reversible acetylation of a single lysine residue
-
Yuan ZL, Guan YJ, Chatterjee D, Chin YE. Stat3 dimerization regulated by reversible acetylation of a single lysine residue. Science. 2005;307(5707):269-273.
-
(2005)
Science
, vol.307
, Issue.5707
, pp. 269-273
-
-
Yuan, Z.L.1
Guan, Y.J.2
Chatterjee, D.3
Chin, Y.E.4
-
13
-
-
0032803530
-
Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain
-
Sasaki A, Yasukawa H, Suzuki A, et al. Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. Genes Cells. 1999;4(6):339-351.
-
(1999)
Genes Cells
, vol.4
, Issue.6
, pp. 339-351
-
-
Sasaki, A.1
Yasukawa, H.2
Suzuki, A.3
-
14
-
-
20244389693
-
The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
-
Yasukawa H, Misawa H, Sakamoto H, et al. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 1999;18(5):1309-1320.
-
(1999)
EMBO J
, vol.18
, Issue.5
, pp. 1309-1320
-
-
Yasukawa, H.1
Misawa, H.2
Sakamoto, H.3
-
15
-
-
0030725378
-
Specific inhibition of Stat3 signal transduction by PIAS3
-
Chung CD, Liao J, Liu B, et al. Specific inhibition of Stat3 signal transduction by PIAS3. Science. 1997;278(5344):1803-1805.
-
(1997)
Science
, vol.278
, Issue.5344
, pp. 1803-1805
-
-
Chung, C.D.1
Liao, J.2
Liu, B.3
-
16
-
-
84875204096
-
Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis
-
Nallar SC, Kalakonda S, Lindner DJ, et al. Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis. J Biol Chem. 2013;288(11):7930-7941.
-
(2013)
J Biol Chem
, vol.288
, Issue.11
, pp. 7930-7941
-
-
Nallar, S.C.1
Kalakonda, S.2
Lindner, D.J.3
-
17
-
-
34247189533
-
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T
-
Zhang X, Guo A, Yu J, et al. Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T. Proc Natl Acad Sci U S A. 2007;104(10):4060-4064.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.10
, pp. 4060-4064
-
-
Zhang, X.1
Guo, A.2
Yu, J.3
-
18
-
-
67249088143
-
The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers
-
Veeriah S, Brennan C, Meng S, et al. The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers. Proc Natl Acad Sci U S A. 2009;106(23):9435-9440.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.23
, pp. 9435-9440
-
-
Veeriah, S.1
Brennan, C.2
Meng, S.3
-
19
-
-
0036033161
-
The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation
-
Yamamoto T, Sekine Y, Kashima K, et al. The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation. Biochem Biophys Res Commun. 2002;297(4):811-817.
-
(2002)
Biochem Biophys Res Commun
, vol.297
, Issue.4
, pp. 811-817
-
-
Yamamoto, T.1
Sekine, Y.2
Kashima, K.3
-
20
-
-
69249118196
-
Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia
-
Zhang W, Chan RJ, Chen H, et al. Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia. J Biol Chem. 2009;284(33):22353-22363.
-
(2009)
J Biol Chem
, vol.284
, Issue.33
, pp. 22353-22363
-
-
Zhang, W.1
Chan, R.J.2
Chen, H.3
-
21
-
-
64049109876
-
STAT3 inhibition of gluconeogenesis is downregulated by SirT1
-
Nie Y, Erion DM, Yuan Z, et al. STAT3 inhibition of gluconeogenesis is downregulated by SirT1. Nat Cell Biol. 2009;11(4):492-500.
-
(2009)
Nat Cell Biol
, vol.11
, Issue.4
, pp. 492-500
-
-
Nie, Y.1
Erion, D.M.2
Yuan, Z.3
-
22
-
-
79957582559
-
Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein
-
Bernier M, Paul RK, Martin-Montalvo A, et al. Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein. J Biol Chem. 2011;286(22):19270-19279.
-
(2011)
J Biol Chem
, vol.286
, Issue.22
, pp. 19270-19279
-
-
Bernier, M.1
Paul, R.K.2
Martin-Montalvo, A.3
-
23
-
-
2942595997
-
Stat3 activation in acute lung injury
-
Gao H, Guo R-F, Speyer C, et al. Stat3 activation in acute lung injury. J Immunol. 2004;172(12):7703-7712.
-
(2004)
J Immunol
, vol.172
, Issue.12
, pp. 7703-7712
-
-
Gao, H.1
Guo, R.-F.2
Speyer, C.3
-
24
-
-
84873307871
-
Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation
-
Braun DA, Fribourg M, Sealfon SC. Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation. J Biol Chem. 2013;288(5): 2986-2993.
-
(2013)
J Biol Chem
, vol.288
, Issue.5
, pp. 2986-2993
-
-
Braun, D.A.1
Fribourg, M.2
Sealfon, S.C.3
-
25
-
-
19444385692
-
Stat3 regulates genes common to both wound healing and cancer
-
Dauer DJ, Ferraro B, Song L, et al. Stat3 regulates genes common to both wound healing and cancer. Oncogene. 2005;24(21):3397-3408.
-
(2005)
Oncogene
, vol.24
, Issue.21
, pp. 3397-3408
-
-
Dauer, D.J.1
Ferraro, B.2
Song, L.3
-
26
-
-
0033664369
-
Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice
-
Gallucci RM, Simeonova PP, Matheson JM, et al. Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice. FASEB J. 2000;14(15):2525-2531.
-
(2000)
FASEB J
, vol.14
, Issue.15
, pp. 2525-2531
-
-
Gallucci, R.M.1
Simeonova, P.P.2
Matheson, J.M.3
-
27
-
-
0033198793
-
Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis
-
Sano S, Itami S, Takeda K, et al. Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J. 1999;18(17):4657-4668.
-
(1999)
EMBO J
, vol.18
, Issue.17
, pp. 4657-4668
-
-
Sano, S.1
Itami, S.2
Takeda, K.3
-
28
-
-
67650474246
-
STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
-
Pickert G, Neufert C, Leppkes M, et al. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J Exp Med. 2009;206(7):1465-1472.
-
(2009)
J Exp Med
, vol.206
, Issue.7
, pp. 1465-1472
-
-
Pickert, G.1
Neufert, C.2
Leppkes, M.3
-
29
-
-
0030708926
-
Insulin activates Stat3 independently of p21ras-ERK and PI-3 K signal transduction
-
Coffer PJ, van Puijenbroek A, Burgering BM, et al. Insulin activates Stat3 independently of p21ras-ERK and PI-3 K signal transduction. Oncogene. 1997;15(21):2529-2539.
-
(1997)
Oncogene
, vol.15
, Issue.21
, pp. 2529-2539
-
-
Coffer, P.J.1
van Puijenbroek, A.2
Burgering, B.M.3
-
30
-
-
0035816407
-
Insulin modulates leptin-induced STAT3 activation in rat hypothalamus
-
Carvalheira JB, Siloto RM, Ignacchitti I, et al. Insulin modulates leptin-induced STAT3 activation in rat hypothalamus. FEBS Lett. 2001;500(3):119-124.
-
(2001)
FEBS Lett
, vol.500
, Issue.3
, pp. 119-124
-
-
Carvalheira, J.B.1
Siloto, R.M.2
Ignacchitti, I.3
-
31
-
-
33645579324
-
Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
-
Inoue H, Ogawa W, Asakawa A, et al. Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metab. 2006;3(4):267-275.
-
(2006)
Cell Metab
, vol.3
, Issue.4
, pp. 267-275
-
-
Inoue, H.1
Ogawa, W.2
Asakawa, A.3
-
32
-
-
0034685906
-
Mechanism of STAT3 activation by insulin-like growth factor I receptor
-
Zong CS, Chan J, Levy DE, Horvath C, Sadowski HB, Wang LH. Mechanism of STAT3 activation by insulin-like growth factor I receptor. J Biol Chem. 2000;275(20):15099-15105.
-
(2000)
J Biol Chem
, vol.275
, Issue.20
, pp. 15099-15105
-
-
Zong, C.S.1
Chan, J.2
Levy, D.E.3
Horvath, C.4
Sadowski, H.B.5
Wang, L.H.6
-
33
-
-
84877335478
-
Direct interaction between STAT3 and EIF2AK2 controls fatty acid-induced autophagy
-
Niso-Santano M, Shen S, Adjemian S, et al. Direct interaction between STAT3 and EIF2AK2 controls fatty acid-induced autophagy. Autophagy. 2013;9(3):415-417.
-
(2013)
Autophagy
, vol.9
, Issue.3
, pp. 415-417
-
-
Niso-Santano, M.1
Shen, S.2
Adjemian, S.3
-
34
-
-
0030935260
-
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
-
Takeda K, Noguchi K, Shi W, et al. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci U S A. 1997;94(8):3801-3804.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, Issue.8
, pp. 3801-3804
-
-
Takeda, K.1
Noguchi, K.2
Shi, W.3
-
35
-
-
0034868746
-
Stat3 in thymic epithelial cells is essential for postnatal maintenance of thymic architecture and thymocyte survival
-
Sano S, Takahama Y, Sugawara T, et al. Stat3 in thymic epithelial cells is essential for postnatal maintenance of thymic architecture and thymocyte survival. Immunity. 2001;15(2):261-273.
-
(2001)
Immunity
, vol.15
, Issue.2
, pp. 261-273
-
-
Sano, S.1
Takahama, Y.2
Sugawara, T.3
-
36
-
-
0033214903
-
Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3
-
Chapman RS, Lourenco PC, Tonner E, et al. Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev. 1999;13(19): 2604-2616.
-
(1999)
Genes Dev
, vol.13
, Issue.19
, pp. 2604-2616
-
-
Chapman, R.S.1
Lourenco, P.C.2
Tonner, E.3
-
37
-
-
1042302005
-
The STATs of cancer - new molecular targets come of age
-
Yu H, Jove R. The STATs of cancer - new molecular targets come of age. Nat Rev Cancer. 2004;4(2):97-105.
-
(2004)
Nat Rev Cancer
, vol.4
, Issue.2
, pp. 97-105
-
-
Yu, H.1
Jove, R.2
-
38
-
-
84866002291
-
The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data
-
Cerami E, Gao J, Dogrusoz U, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012;2(5):401-404.
-
(2012)
Cancer Discov
, vol.2
, Issue.5
, pp. 401-404
-
-
Cerami, E.1
Gao, J.2
Dogrusoz, U.3
-
39
-
-
84874789333
-
STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1
-
Wang Z, Zhu S, Shen M, et al. STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1. Carcinogenesis. 2013; 34(3):678-688.
-
(2013)
Carcinogenesis
, vol.34
, Issue.3
, pp. 678-688
-
-
Wang, Z.1
Zhu, S.2
Shen, M.3
-
40
-
-
84866431328
-
Targeting Stat3 abrogates EGFR inhibitor resistance in cancer
-
Sen M, Joyce S, Panahandeh M, et al. Targeting Stat3 abrogates EGFR inhibitor resistance in cancer. Clin Cancer Res. 2012;18(18): 4986-4996.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.18
, pp. 4986-4996
-
-
Sen, M.1
Joyce, S.2
Panahandeh, M.3
-
41
-
-
0029916933
-
Activation and association of Stat3 with Src in v-Src-transformed cell lines
-
Cao X, Tay A, Guy GR, Tan YH. Activation and association of Stat3 with Src in v-Src-transformed cell lines. Mol Cell Biol. 1996;16(4): 1595-1603.
-
(1996)
Mol Cell Biol
, vol.16
, Issue.4
, pp. 1595-1603
-
-
Cao, X.1
Tay, A.2
Guy, G.R.3
Tan, Y.H.4
-
42
-
-
0031893214
-
Stat3 activation is required for cellular transformation by v-src
-
Bromberg J., Horvath CM, Besser D, Lathem WW, Darnell JE. Stat3 activation is required for cellular transformation by v-src. Mol Cell Biol. 1998;18(5):2553-2558.
-
(1998)
Mol Cell Biol
, vol.18
, Issue.5
, pp. 2553-2558
-
-
Bromberg, J.1
Horvath, C.M.2
Besser, D.3
Lathem, W.W.4
Darnell, J.E.5
-
43
-
-
0031953831
-
Stat3 activation by Src induces specific gene regulation and is required for cell transformation
-
Turkson J, Bowman T, Garcia R, Caldenhoven E, De Groot RP, Jove R. Stat3 activation by Src induces specific gene regulation and is required for cell transformation. Mol Cell Biol. 1998;18(5): 2545-2552.
-
(1998)
Mol Cell Biol
, vol.18
, Issue.5
, pp. 2545-2552
-
-
Turkson, J.1
Bowman, T.2
Garcia, R.3
Caldenhoven, E.4
de Groot, R.P.5
Jove, R.6
-
44
-
-
85047691138
-
Stat3 is required for the development of skin cancer
-
Pedranzini L, Leitch A, Bromberg J. Stat3 is required for the development of skin cancer. J Clin Invest. 2004;114(5):619-622.
-
(2004)
J Clin Invest
, vol.114
, Issue.5
, pp. 619-622
-
-
Pedranzini, L.1
Leitch, A.2
Bromberg, J.3
-
45
-
-
0035912763
-
Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis
-
Bowman T, Broome MA, Sinibaldi D, et al. Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis. Proc Natl Acad Sci U S A. 2001;98(13):7319-7324.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, Issue.13
, pp. 7319-7324
-
-
Bowman, T.1
Broome, M.A.2
Sinibaldi, D.3
-
46
-
-
0037030518
-
STAT3 activation is required for interleukin-6 induced transformation in tumor-promotion sensitive mouse skin epithelial cells
-
Yu CY, Wang L, Khaletskiy A, et al. STAT3 activation is required for interleukin-6 induced transformation in tumor-promotion sensitive mouse skin epithelial cells. Oncogene. 2002;21(25):3949-3960.
-
(2002)
Oncogene
, vol.21
, Issue.25
, pp. 3949-3960
-
-
Yu, C.Y.1
Wang, L.2
Khaletskiy, A.3
-
47
-
-
20944435271
-
Stat3 is required for ALKmediated lymphomagenesis and provides a possible therapeutic target
-
Chiarle R, Simmons WJ, Cai H, et al. Stat3 is required for ALKmediated lymphomagenesis and provides a possible therapeutic target. Nat Med. 2005;11(6):623-629.
-
(2005)
Nat Med
, vol.11
, Issue.6
, pp. 623-629
-
-
Chiarle, R.1
Simmons, W.J.2
Cai, H.3
-
48
-
-
23044447001
-
Stat3 is required for full neoplastic transformation by the Simian Virus 40 large tumor antigen
-
Vultur A, Arulanandam R, Turkson J, Niu G, Jove R, Raptis L. Stat3 is required for full neoplastic transformation by the Simian Virus 40 large tumor antigen. Mol Biol Cell. 2005;16(8):3832-3846.
-
(2005)
Mol Biol Cell
, vol.16
, Issue.8
, pp. 3832-3846
-
-
Vultur, A.1
Arulanandam, R.2
Turkson, J.3
Niu, G.4
Jove, R.5
Raptis, L.6
-
49
-
-
60349107511
-
Stat3 activation is required for the growth of U87 cell-derived tumours in mice
-
Dasgupta A, Raychaudhuri B, Haqqi T, et al. Stat3 activation is required for the growth of U87 cell-derived tumours in mice. Eur J Cancer. 2009;45(4):677-684.
-
(2009)
Eur J Cancer
, vol.45
, Issue.4
, pp. 677-684
-
-
Dasgupta, A.1
Raychaudhuri, B.2
Haqqi, T.3
-
50
-
-
54049120220
-
Activating mutations in ALK provide a therapeutic target in neuroblastoma
-
George RE, Sanda T, Hanna M, et al. Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature. 2008;455(7215): 975-978.
-
(2008)
Nature
, vol.455
, Issue.7215
, pp. 975-978
-
-
George, R.E.1
Sanda, T.2
Hanna, M.3
-
51
-
-
79551623658
-
β-catenin is constitutively active and increases STAT3 expression/activation in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma
-
Anand M, Lai R, Gelebart P. β-catenin is constitutively active and increases STAT3 expression/activation in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Haematologica. 2011;96(2):253-261.
-
(2011)
Haematologica
, vol.96
, Issue.2
, pp. 253-261
-
-
Anand, M.1
Lai, R.2
Gelebart, P.3
-
52
-
-
21344467318
-
Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders
-
Jones AV, Kreil S, Zoi K, et al. Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders. Blood. 2005;106(6):2162-2168.
-
(2005)
Blood
, vol.106
, Issue.6
, pp. 2162-2168
-
-
Jones, A.V.1
Kreil, S.2
Zoi, K.3
-
53
-
-
27144466017
-
The V617F JAK2 mutation is uncommon in cancers and in myeloid malignancies other than the classic myeloproliferative disorders
-
Scott LM, Campbell PJ, Baxter EJ, et al. The V617F JAK2 mutation is uncommon in cancers and in myeloid malignancies other than the classic myeloproliferative disorders. Blood. 2005;106(8):2920-2921.
-
(2005)
Blood
, vol.106
, Issue.8
, pp. 2920-2921
-
-
Scott, L.M.1
Campbell, P.J.2
Baxter, E.J.3
-
54
-
-
33344471678
-
V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis
-
Campbell PJ, Griesshammer M,Döhner K, et al., V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis. Blood. 2006;107(5):2098-2100.
-
(2006)
Blood
, vol.107
, Issue.5
, pp. 2098-2100
-
-
Campbell, P.J.1
Griesshammer, M.2
Döhner, K.3
-
55
-
-
77954613886
-
JAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activation
-
Oku S, Takenaka K, Kuriyama T, et al. JAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activation. Br J Haematol. 2010;150(3):334-344.
-
(2010)
Br J Haematol
, vol.150
, Issue.3
, pp. 334-344
-
-
Oku, S.1
Takenaka, K.2
Kuriyama, T.3
-
56
-
-
0026793260
-
Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors
-
Fleming TP, Saxena A, Clark WC, et al. Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors. Cancer Res. 1992;52(16):4550-4553.
-
(1992)
Cancer Res
, vol.52
, Issue.16
, pp. 4550-4553
-
-
Fleming, T.P.1
Saxena, A.2
Clark, W.C.3
-
57
-
-
33746238953
-
Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion
-
Yeh HH, Lai WW, Chen HH, Liu HS, Su WC. Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion. Oncogene. 2006;25(31): 4300-4309.
-
(2006)
Oncogene
, vol.25
, Issue.31
, pp. 4300-4309
-
-
Yeh, H.H.1
Lai, W.W.2
Chen, H.H.3
Liu, H.S.4
Su, W.C.5
-
58
-
-
0013689209
-
Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro
-
Grandis JR, Drenning SD, Chakraborty A, et al. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro. J Clin Invest. 1998;102(7):1385-1392.
-
(1998)
J Clin Invest
, vol.102
, Issue.7
, pp. 1385-1392
-
-
Grandis, J.R.1
Drenning, S.D.2
Chakraborty, A.3
-
59
-
-
0028863853
-
Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene
-
Batra SK, Castelino-Prabhu S, Wikstrand CJ, et al. Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene. Cell Growth Differ. 1995;6(10):1251-1259.
-
(1995)
Cell Growth Differ
, vol.6
, Issue.10
, pp. 1251-1259
-
-
Batra, S.K.1
Castelino-Prabhu, S.2
Wikstrand, C.J.3
-
60
-
-
77249132723
-
Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIIISTAT3 signaling axes
-
Lo HW, Cao X, Zhu H, Ali-Osman F. Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIIISTAT3 signaling axes. Mol Cancer Res. 2010;8(2):232-245.
-
(2010)
Mol Cancer Res
, vol.8
, Issue.2
, pp. 232-245
-
-
Lo, H.W.1
Cao, X.2
Zhu, H.3
Ali-Osman, F.4
-
61
-
-
0345492424
-
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer
-
He B, You L, Uematsu K, et al. SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc Natl Acad Sci U S A. 2003;100(24):14133-14138.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.24
, pp. 14133-14138
-
-
He, B.1
You, L.2
Uematsu, K.3
-
62
-
-
0034726958
-
The JAK-inhibitor, JAB/ SOCS-1 selectively inhibits cytokine-induced, but not v-Src induced JAK-STAT activation
-
Iwamoto T, Senga T, Naito Y, et al. The JAK-inhibitor, JAB/ SOCS-1 selectively inhibits cytokine-induced, but not v-Src induced JAK-STAT activation. Oncogene. 2000;19(41):4795-4801.
-
(2000)
Oncogene
, vol.19
, Issue.41
, pp. 4795-4801
-
-
Iwamoto, T.1
Senga, T.2
Naito, Y.3
-
63
-
-
84874933904
-
Alterations of negative regulators of cytokine signalling in immunodeficiency-related non-Hodgkin lymphoma
-
Capello D, Gloghini A, Baldanzi G, et al. Alterations of negative regulators of cytokine signalling in immunodeficiency-related non-Hodgkin lymphoma. Hematol Oncol. 2013;31(1):22-28.
-
(2013)
Hematol Oncol
, vol.31
, Issue.1
, pp. 22-28
-
-
Capello, D.1
Gloghini, A.2
Baldanzi, G.3
-
64
-
-
84873030748
-
Protein tyrosine phosphatase receptor-like genes are frequently hypermethylated in sporadic colorectal cancer
-
Laczmanska I, Karpinski P, Bebenek M, et al. Protein tyrosine phosphatase receptor-like genes are frequently hypermethylated in sporadic colorectal cancer. J Hum Genet. 2013;58(1):11-15.
-
(2013)
J Hum Genet
, vol.58
, Issue.1
, pp. 11-15
-
-
Laczmanska, I.1
Karpinski, P.2
Bebenek, M.3
-
65
-
-
84872712440
-
GSTP1 negatively regulates Stat3 activation in epidermal growth factor signaling
-
Kou X, Chen N, Feng Z, Luo L, Yin Z. GSTP1 negatively regulates Stat3 activation in epidermal growth factor signaling. Oncol Lett. 2013;5(3):1053-1057.
-
(2013)
Oncol Lett
, vol.5
, Issue.3
, pp. 1053-1057
-
-
Kou, X.1
Chen, N.2
Feng, Z.3
Luo, L.4
Yin, Z.5
-
66
-
-
0036554834
-
Silencing of GSTP1 gene by CpG island DNA hypermethylation in HBVassociated hepatocellular carcinomas
-
Zhong S, Tang MW, Yeo W, Liu C, Lo YM, Johnson PJ. Silencing of GSTP1 gene by CpG island DNA hypermethylation in HBVassociated hepatocellular carcinomas. Clin Cancer Res. 2002;8(4): 1087-1092.
-
(2002)
Clin Cancer Res
, vol.8
, Issue.4
, pp. 1087-1092
-
-
Zhong, S.1
Tang, M.W.2
Yeo, W.3
Liu, C.4
Lo, Y.M.5
Johnson, P.J.6
-
67
-
-
0035893767
-
Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide
-
Lin X, Asgari K, Putzi MJ, et al. Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide. Cancer Res. 2001;61(24):8611-8616.
-
(2001)
Cancer Res
, vol.61
, Issue.24
, pp. 8611-8616
-
-
Lin, X.1
Asgari, K.2
Putzi, M.J.3
-
68
-
-
21344436180
-
Malignant transformation but not normal cell growth depends on signal transducer and activator of transcription 3
-
Schlessinger K, Levy DE. Malignant transformation but not normal cell growth depends on signal transducer and activator of transcription 3. Cancer Res. 2005;65(13):5828-5834.
-
(2005)
Cancer Res
, vol.65
, Issue.13
, pp. 5828-5834
-
-
Schlessinger, K.1
Levy, D.E.2
-
69
-
-
22044437986
-
Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth
-
Corvinus FM, Orth C, Moriggl R, et al. Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth. Neoplasia. 2005;7(6):545-555.
-
(2005)
Neoplasia
, vol.7
, Issue.6
, pp. 545-555
-
-
Corvinus, F.M.1
Orth, C.2
Moriggl, R.3
-
70
-
-
18644380911
-
Roles of activated Src and Stat3 signaling in melanoma tumor cell growth
-
Niu G, Bowman T, Huang M, et al. Roles of activated Src and Stat3 signaling in melanoma tumor cell growth. Oncogene. 2002;21(46): 7001-7010.
-
(2002)
Oncogene
, vol.21
, Issue.46
, pp. 7001-7010
-
-
Niu, G.1
Bowman, T.2
Huang, M.3
-
71
-
-
0037028249
-
Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells
-
Rahaman SO, Harbor PC, Chernova O, Barnett GH, Vogelbaum MA, Haque SJ. Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene. 2002;21(55):8404-8413.
-
(2002)
Oncogene
, vol.21
, Issue.55
, pp. 8404-8413
-
-
Rahaman, S.O.1
Harbor, P.C.2
Chernova, O.3
Barnett, G.H.4
Vogelbaum, M.A.5
Haque, S.J.6
-
72
-
-
33947197883
-
Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells
-
Bhardwaj A, Sethi G, Vadhan-Raj S, et al. Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood. 2007;109(6):2293-2302.
-
(2007)
Blood
, vol.109
, Issue.6
, pp. 2293-2302
-
-
Bhardwaj, A.1
Sethi, G.2
Vadhan-Raj, S.3
-
73
-
-
34548576919
-
Inhibition of Stat3 activation and tumor growth suppression of non-small cell lung cancer by G-quartet oligonucleotides
-
Weerasinghe P, Garcia GE, Zhu Q, et al. Inhibition of Stat3 activation and tumor growth suppression of non-small cell lung cancer by G-quartet oligonucleotides. Int J Oncol. 2007;31(1):129-136.
-
(2007)
Int J Oncol
, vol.31
, Issue.1
, pp. 129-136
-
-
Weerasinghe, P.1
Garcia, G.E.2
Zhu, Q.3
-
74
-
-
33645067376
-
Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3
-
Leslie K, Lang C, Devgan G, et al. Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3. Cancer Res. 2006;66(5): 2544-2552.
-
(2006)
Cancer Res
, vol.66
, Issue.5
, pp. 2544-2552
-
-
Leslie, K.1
Lang, C.2
Devgan, G.3
-
75
-
-
1642603438
-
The activities of cyclin D1 that drive tumorigenesis
-
Ewen ME, Lamb J. The activities of cyclin D1 that drive tumorigenesis. Trends Mol Med. 2004;10(4):158-162.
-
(2004)
Trends Mol Med
, vol.10
, Issue.4
, pp. 158-162
-
-
Ewen, M.E.1
Lamb, J.2
-
76
-
-
84875214999
-
Stat3 inhibits WTX expression through up-regulation of microRNA-370 in Wilms tumor
-
Cao X, Liu D, Yan X, et al. Stat3 inhibits WTX expression through up-regulation of microRNA-370 in Wilms tumor. FEBS Lett. 2013;587(6):639-644.
-
(2013)
FEBS Lett
, vol.587
, Issue.6
, pp. 639-644
-
-
Cao, X.1
Liu, D.2
Yan, X.3
-
77
-
-
33947598446
-
Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma
-
Zhuang L, Lee CS, Scolyer RA, et al. Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma. Mod Pathol. 2007;20(4):416-426.
-
(2007)
Mod Pathol
, vol.20
, Issue.4
, pp. 416-426
-
-
Zhuang, L.1
Lee, C.S.2
Scolyer, R.A.3
-
78
-
-
0032984589
-
Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
-
Catlett-Falcone R, Landowski TH, Oshiro MM, et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity. 1999;10(1):105-115.
-
(1999)
Immunity
, vol.10
, Issue.1
, pp. 105-115
-
-
Catlett-Falcone, R.1
Landowski, T.H.2
Oshiro, M.M.3
-
79
-
-
0032578721
-
STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells
-
Zushi S, Shinomura Y, Kiyohara T, et al. STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells. Int J Cancer. 1998;78(3):326-330.
-
(1998)
Int J Cancer
, vol.78
, Issue.3
, pp. 326-330
-
-
Zushi, S.1
Shinomura, Y.2
Kiyohara, T.3
-
80
-
-
0037206950
-
Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells
-
Real PJ, Sierra A, De Juan A, Segovia JC, Lopez-Vega JM, Fernandez-Luna JL. Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells. Oncogene. 2002;21(50):7611-7618.
-
(2002)
Oncogene
, vol.21
, Issue.50
, pp. 7611-7618
-
-
Real, P.J.1
Sierra, A.2
de Juan, A.3
Segovia, J.C.4
Lopez-Vega, J.M.5
Fernandez-Luna, J.L.6
-
81
-
-
84872834298
-
STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain
-
Timofeeva OA, Tarasova NI, Zhang X, et al. STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain. Proc Natl Acad Sci U S A. 2013;110(4):1267-1272.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.4
, pp. 1267-1272
-
-
Timofeeva, O.A.1
Tarasova, N.I.2
Zhang, X.3
-
82
-
-
33645532055
-
Activation of stat3 in human melanoma promotes brain metastasis
-
Xie TX, Huang FJ, Aldape KD, et al. Activation of stat3 in human melanoma promotes brain metastasis. Cancer Res. 2006;66(6): 3188-3196.
-
(2006)
Cancer Res
, vol.66
, Issue.6
, pp. 3188-3196
-
-
Xie, T.X.1
Huang, F.J.2
Aldape, K.D.3
-
83
-
-
33644526633
-
Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells
-
Itoh M, Murata T, Suzuki T, et al. Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells. Oncogene. 2006;25(8):1195-1204.
-
(2006)
Oncogene
, vol.25
, Issue.8
, pp. 1195-1204
-
-
Itoh, M.1
Murata, T.2
Suzuki, T.3
-
84
-
-
84873292873
-
Intercellular contact augments epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3)activation which increases podoplanin-expression in order to promote squamous cell carcinoma motility
-
Fujii M, Honma M, Takahashi H, Ishida-Yamamoto A, Iizuka H. Intercellular contact augments epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3)activation which increases podoplanin-expression in order to promote squamous cell carcinoma motility. Cell Signal. 2013;25(4):760-765.
-
(2013)
Cell Signal
, vol.25
, Issue.4
, pp. 760-765
-
-
Fujii, M.1
Honma, M.2
Takahashi, H.3
Ishida-Yamamoto, A.4
Iizuka, H.5
-
85
-
-
33745885674
-
STAT3 is required but not sufficient for EGF receptor-mediated migration and invasion of human prostate carcinoma cell lines
-
Zhou W, Grandis JR, Wells A. STAT3 is required but not sufficient for EGF receptor-mediated migration and invasion of human prostate carcinoma cell lines. Br J Cancer. 2006;95(2):164-171.
-
(2006)
Br J Cancer
, vol.95
, Issue.2
, pp. 164-171
-
-
Zhou, W.1
Grandis, J.R.2
Wells, A.3
-
86
-
-
84879407793
-
STAT3 silencing inhibits glioma single cell infiltration and tumor growth
-
Priester M, Copanaki E, Vafaizadeh V, et al. STAT3 silencing inhibits glioma single cell infiltration and tumor growth. Neuro-oncology. 2013;15(7):840-852.
-
(2013)
Neuro-oncology
, vol.15
, Issue.7
, pp. 840-852
-
-
Priester, M.1
Copanaki, E.2
Vafaizadeh, V.3
-
87
-
-
69249227496
-
Expression of angiogenic regulators, VEGF and leptin, is regulated by the EGF/PI3K/STAT3 pathway in colorectal cancer cells
-
Cascio S, Ferla R, D'Andrea A, et al. Expression of angiogenic regulators, VEGF and leptin, is regulated by the EGF/PI3K/STAT3 pathway in colorectal cancer cells. J Cell Physiol. 2009;221(1):189-194.
-
(2009)
J Cell Physiol
, vol.221
, Issue.1
, pp. 189-194
-
-
Cascio, S.1
Ferla, R.2
D'Andrea, A.3
-
88
-
-
0037435011
-
Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway
-
Wei LH, Kuo ML, Chen CA, et al. Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway. Oncogene. 2003;22(10):1517-1527.
-
(2003)
Oncogene
, vol.22
, Issue.10
, pp. 1517-1527
-
-
Wei, L.H.1
Kuo, M.L.2
Chen, C.A.3
-
89
-
-
0036484836
-
In vivo activation of JAK2/STAT-3 pathway during angiogenesis induced by GM-CSF
-
Valdembri D, Serini G, Vacca A, Ribatti D, Bussolino F. In vivo activation of JAK2/STAT-3 pathway during angiogenesis induced by GM-CSF. FASEB J. 2002;16(2):225-227.
-
(2002)
FASEB J
, vol.16
, Issue.2
, pp. 225-227
-
-
Valdembri, D.1
Serini, G.2
Vacca, A.3
Ribatti, D.4
Bussolino, F.5
-
90
-
-
79960890780
-
JAK2/STAT3 signaling pathway activation mediates tumor angiogenesis by upregulation of VEGF and bFGF in non-small-cell lung cancer
-
Zhao M, Gao FH, Wang JY, et al. JAK2/STAT3 signaling pathway activation mediates tumor angiogenesis by upregulation of VEGF and bFGF in non-small-cell lung cancer. Lung Cancer. 2011;73(3):366-374.
-
(2011)
Lung Cancer
, vol.73
, Issue.3
, pp. 366-374
-
-
Zhao, M.1
Gao, F.H.2
Wang, J.Y.3
-
91
-
-
0038581774
-
Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system
-
Sriuranpong V, Park JI, Amornphimoltham P, Patel V, Nelkin BD, Gutkind JS. Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. Cancer Res. 2003;63(11):2948-2956.
-
(2003)
Cancer Res
, vol.63
, Issue.11
, pp. 2948-2956
-
-
Sriuranpong, V.1
Park, J.I.2
Amornphimoltham, P.3
Patel, V.4
Nelkin, B.D.5
Gutkind, J.S.6
-
92
-
-
85047695527
-
Constitutive Stat3 activity upregulates VEGF expression and tumor angiogenesis
-
Niu G, Wright KL, Huang M, et al. Constitutive Stat3 activity upregulates VEGF expression and tumor angiogenesis. Oncogene. 2002;21(13):2000-2008.
-
(2002)
Oncogene
, vol.21
, Issue.13
, pp. 2000-2008
-
-
Niu, G.1
Wright, K.L.2
Huang, M.3
-
93
-
-
34547975508
-
Signal transducers and activators of transcription 3 up-regulates vascular endothelial growth factor production and tumor angiogenesis in head and neck squamous cell carcinoma
-
Masuda M, Ruan HY, Ito A, et al. Signal transducers and activators of transcription 3 up-regulates vascular endothelial growth factor production and tumor angiogenesis in head and neck squamous cell carcinoma. Oral Oncol. 2007;43(8):785-790.
-
(2007)
Oral Oncol
, vol.43
, Issue.8
, pp. 785-790
-
-
Masuda, M.1
Ruan, H.Y.2
Ito, A.3
-
94
-
-
58649108302
-
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitisassociated cancer
-
Grivennikov S, Karin E, Terzic J, et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitisassociated cancer. Cancer Cell. 2009;15(2):103-113.
-
(2009)
Cancer Cell
, vol.15
, Issue.2
, pp. 103-113
-
-
Grivennikov, S.1
Karin, E.2
Terzic, J.3
-
95
-
-
84872406787
-
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer
-
Liang J, Nagahashi M, Kim EY, et al. Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. Cancer Cell. 2013;23(1):107-120.
-
(2013)
Cancer Cell
, vol.23
, Issue.1
, pp. 107-120
-
-
Liang, J.1
Nagahashi, M.2
Kim, E.Y.3
-
96
-
-
20144376844
-
Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects
-
Burdelya L, Kujawski M, Niu G, et al. Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects. J Immunol. 2005;174(7):3925-3931.
-
(2005)
J Immunol
, vol.174
, Issue.7
, pp. 3925-3931
-
-
Burdelya, L.1
Kujawski, M.2
Niu, G.3
-
97
-
-
84871336215
-
The role of STAT3 activation in modulating the immune microenvironment of GBM
-
See AP, Han JE, Phallen J, et al. The role of STAT3 activation in modulating the immune microenvironment of GBM. J Neurooncol. 2012;110(3):359-368.
-
(2012)
J Neurooncol
, vol.110
, Issue.3
, pp. 359-368
-
-
See, A.P.1
Han, J.E.2
Phallen, J.3
-
98
-
-
70350212976
-
STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells
-
Sherry MM, Reeves A, Wu JK, Cochran BH. STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem Cells. 2009;27(10):2383-2392.
-
(2009)
Stem Cells
, vol.27
, Issue.10
, pp. 2383-2392
-
-
Sherry, M.M.1
Reeves, A.2
Wu, J.K.3
Cochran, B.H.4
-
99
-
-
84881240641
-
Potent in vivo pharmacology of AZD9150, a next-generation, constrained ethyl-modified antisense oligonucleotide targeting STAT3 in multiple preclinical cancer models [abstract]
-
In:, Apr 6-10; Washington, DC. Philadelphia (PA): AACR; 2013. Abstract nr LB-317
-
Kim Y, Hsu J, Zhou T, et al. Potent in vivo pharmacology of AZD9150, a next-generation, constrained ethyl-modified antisense oligonucleotide targeting STAT3 in multiple preclinical cancer models [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; 2013. Abstract nr LB-317
-
(2013)
Proceedings of the 104th Annual Meeting of the American Association For Cancer Research
-
-
Kim, Y.1
Hsu, J.2
Zhou, T.3
-
100
-
-
84866254673
-
First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: Implications for cancer therapy
-
Sen M, Thomas SM, Kim S, et al. First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy. Cancer Discov. 2012;2(8):694-705.
-
(2012)
Cancer Discov
, vol.2
, Issue.8
, pp. 694-705
-
-
Sen, M.1
Thomas, S.M.2
Kim, S.3
-
101
-
-
33750982120
-
Stattic: A smallmolecule inhibitor of STAT3 activation and dimerization
-
Schust J, Sperl B, Hollis A, Mayer TU, Berg T. Stattic: a smallmolecule inhibitor of STAT3 activation and dimerization. Chem Biol. 2006;13(11):1235-1242.
-
(2006)
Chem Biol
, vol.13
, Issue.11
, pp. 1235-1242
-
-
Schust, J.1
Sperl, B.2
Hollis, A.3
Mayer, T.U.4
Berg, T.5
-
102
-
-
0037294154
-
Identification of a high-affinity phosphopeptide inhibitor of Stat3
-
Ren Z, Cabell LA, Schaefer TS, McMurray JS. Identification of a high-affinity phosphopeptide inhibitor of Stat3. Bioorg Med Chem Lett. 2003;13(4):633-636.
-
(2003)
Bioorg Med Chem Lett
, vol.13
, Issue.4
, pp. 633-636
-
-
Ren, Z.1
Cabell, L.A.2
Schaefer, T.S.3
McMurray, J.S.4
-
103
-
-
77649178678
-
A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes
-
Zhang X, Yue P, Fletcher S, Zhao W, Gunning PT, Turkson J. A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes. Biochem Pharmacol. 2010;79(10):1398-1409.
-
(2010)
Biochem Pharmacol
, vol.79
, Issue.10
, pp. 1398-1409
-
-
Zhang, X.1
Yue, P.2
Fletcher, S.3
Zhao, W.4
Gunning, P.T.5
Turkson, J.6
-
104
-
-
61349138340
-
Design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as STAT3 inhibitors
-
Gomez C, Bai L, Zhang J, et al. Design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as STAT3 inhibitors. Bioorg Med Chem Lett. 2009;19(6):1733-1736.
-
(2009)
Bioorg Med Chem Lett
, vol.19
, Issue.6
, pp. 1733-1736
-
-
Gomez, C.1
Bai, L.2
Zhang, J.3
-
105
-
-
0035136846
-
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
-
Epling-Burnette PK, Liu JH, Catlett-Falcone R, et al. Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J Clin Invest. 2001;107(3):351-362.
-
(2001)
J Clin Invest
, vol.107
, Issue.3
, pp. 351-362
-
-
Epling-Burnette, P.K.1
Liu, J.H.2
Catlett-Falcone, R.3
-
106
-
-
16344380754
-
A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells
-
Song H, Wang R, Wang S, Lin J. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proc Natl Acad Sci U S A. 2005;102(13): 4700-4705.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, Issue.13
, pp. 4700-4705
-
-
Song, H.1
Wang, R.2
Wang, S.3
Lin, J.4
-
107
-
-
63949085226
-
Lack of toxicity of a STAT3 decoy oligonucleotide
-
Sen M, Tosca PJ, Zwayer C, et al. Lack of toxicity of a STAT3 decoy oligonucleotide. Cancer Chemother Pharmacol. 2009;63(6):983-995.
-
(2009)
Cancer Chemother Pharmacol
, vol.63
, Issue.6
, pp. 983-995
-
-
Sen, M.1
Tosca, P.J.2
Zwayer, C.3
-
108
-
-
84856478208
-
STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma
-
Looyenga BD, Hutchings D, Cherni I, Kingsley C, Weiss GJ, Mackeigan J. STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma. PLoS ONE. 2012;7(2):e30820.
-
(2012)
PLoS ONE
, vol.7
, Issue.2
-
-
Looyenga, B.D.1
Hutchings, D.2
Cherni, I.3
Kingsley, C.4
Weiss, G.J.5
Mackeigan, J.6
-
109
-
-
84865401715
-
Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population
-
Korkaya H, Kim GI, Davis A, et al. Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population. Mol Cell. 2012;47(4):570-584.
-
(2012)
Mol Cell
, vol.47
, Issue.4
, pp. 570-584
-
-
Korkaya, H.1
Kim, G.I.2
Davis, A.3
-
110
-
-
55749116156
-
Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance
-
Bewry NN, Nair RR, Emmons MF, Boulware D, Pinilla-Ibarz J, Hazlehurst LA. Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance. Mol Cancer Ther. 2008;7(10):3169-3175.
-
(2008)
Mol Cancer Ther
, vol.7
, Issue.10
, pp. 3169-3175
-
-
Bewry, N.N.1
Nair, R.R.2
Emmons, M.F.3
Boulware, D.4
Pinilla-Ibarz, J.5
Hazlehurst, L.A.6
-
111
-
-
78651285748
-
CDD: A Conserved Domain Database for the functional annotation of proteins
-
Marcher-Bauer A, Lu S, Anderson JB, et al. CDD: a Conserved Domain Database for the functional annotation of proteins. Nuclieic Acids Res. 2011:39; 225-229.
-
(2011)
Nuclieic Acids Res
, vol.39
, pp. 225-229
-
-
Marcher-Bauer, A.1
Lu, S.2
Anderson, J.B.3
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