Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis

Journal of Biological Chemistry

Volumn 288, Issue 11, 2013, Pages 7930-7941

  Nallar, Shreeram C ^a   Kalakonda, Sudhakar ^a   Lindner, Daniel J ^b   Lorenz, Robert R ^c   Lamarre, Eric ^c   Weihua, Xiao ^d   Kalvakolanu, Dhananjaya V ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b TAUSSIG CANCER INSTITUTE   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL RESPONSE; CELLULAR TRANSFORMATION; CONSTITUTIVELY ACTIVES; HEAD-AND-NECK TUMOR; SIGNAL TRANSDUCERS; SOMATIC MUTATION; TRANSCRIPTIONAL ACTIVITY; TUMOR GROWTH;

AMINO ACIDS; CELL DEATH; CELL PROLIFERATION; CHEMICAL ACTIVATION; TRANSDUCERS; TUMORS;

TRANSCRIPTION;

MESSENGER RNA; RETINOID INTERFERON INDUCED MORTALITY 19; STAT3 PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CELL MOTILITY; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENE REPRESSION; GENE SILENCING; GENETIC ASSOCIATION; HEAD AND NECK TUMOR; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MALIGNANT TRANSFORMATION; MOUSE; MOUTH SQUAMOUS CELL CARCINOMA; MUTANT; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RETINOID INTERFERON INDUCED MORTALITY 19 GENE; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 GENE; SOMATIC MUTATION; WILD TYPE;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; ELECTRON TRANSPORT COMPLEX I; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MICE, NUDE; MOLECULAR CHAPERONES; MOUTH NEOPLASMS; MUTATION; NADH, NADPH OXIDOREDUCTASES; NEOPLASM METASTASIS; RATS; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC;

EID: 84875204096     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.440610     Document Type: Article

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